메뉴 건너뛰기




Volumn 9, Issue 4, 2009, Pages 389-395

Current and potential inflammation targeted therapies in head and neck cancer

Author keywords

[No Author keywords available]

Indexed keywords

ATLIZUMAB; BORTEZOMIB; CELECOXIB; CETUXIMAB; CURCUMIN; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; ETANERCEPT; GEFITINIB; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN 90 INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLIXIMAB; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; JANUS KINASE; KETOROLAC; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SCATTER FACTOR; STAT3 PROTEIN; SULINDAC; THALIDOMIDE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNINDEXED DRUG; VASCULOTROPIN;

EID: 68849108871     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2009.06.005     Document Type: Review
Times cited : (86)

References (50)
  • 2
    • 38449103501 scopus 로고    scopus 로고
    • Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck
    • Allen C.T., Ricker J.L., Chen Z., and Van Waes C. Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck. Head Neck 29 (2007) 959-971
    • (2007) Head Neck , vol.29 , pp. 959-971
    • Allen, C.T.1    Ricker, J.L.2    Chen, Z.3    Van Waes, C.4
  • 3
    • 67349108318 scopus 로고    scopus 로고
    • Dysregulated molecular networks in head and neck carcinogenesis
    • A review highlighting the importance of signal networks in pathogenesis of HNSCC and need for targeting pathways with multiple agents.
    • Molinolo A.A., Amornphimoltham P., Squarize C.H., Castilho R.M., Patel V., and Gutkind J.S. Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 45 (2009) 324-334. A review highlighting the importance of signal networks in pathogenesis of HNSCC and need for targeting pathways with multiple agents.
    • (2009) Oral Oncol , vol.45 , pp. 324-334
    • Molinolo, A.A.1    Amornphimoltham, P.2    Squarize, C.H.3    Castilho, R.M.4    Patel, V.5    Gutkind, J.S.6
  • 4
    • 56549093779 scopus 로고    scopus 로고
    • Genetic association of cytokine DNA polymorphisms with head and neck cancer
    • Serefoglou Z., Yapijakis C., Nkenke E., and Vairaktaris E. Genetic association of cytokine DNA polymorphisms with head and neck cancer. Oral Oncol 44 (2008) 1093-1099
    • (2008) Oral Oncol , vol.44 , pp. 1093-1099
    • Serefoglou, Z.1    Yapijakis, C.2    Nkenke, E.3    Vairaktaris, E.4
  • 6
    • 33750046899 scopus 로고    scopus 로고
    • Role of cytokines in head and neck squamous cell carcinoma
    • Pries R., Nitsch S., and Wollenberg B. Role of cytokines in head and neck squamous cell carcinoma. Expert Rev Anticancer Ther 6 (2006) 1195-1203
    • (2006) Expert Rev Anticancer Ther , vol.6 , pp. 1195-1203
    • Pries, R.1    Nitsch, S.2    Wollenberg, B.3
  • 7
    • 33644867711 scopus 로고    scopus 로고
    • Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas
    • Lee T.L., Yeh J., Van Waes C., and Chen Z. Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas. Mol Cancer Ther 5 (2006) 8-19
    • (2006) Mol Cancer Ther , vol.5 , pp. 8-19
    • Lee, T.L.1    Yeh, J.2    Van Waes, C.3    Chen, Z.4
  • 8
    • 35348918435 scopus 로고    scopus 로고
    • A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status
    • This is the first study to demonstrate an interaction between TP53 status and activation of NF-κB and proinflammatory and prosurvival genes in HNSCC.
    • Lee T.L., Yang X.P., Yan B., Friedman J., Duggal P., Bagain L., Dong G., Yeh N.T., Wang J., Zhou J., et al. A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status. Clin Cancer Res 13 (2007) 5680-5691. This is the first study to demonstrate an interaction between TP53 status and activation of NF-κB and proinflammatory and prosurvival genes in HNSCC.
    • (2007) Clin Cancer Res , vol.13 , pp. 5680-5691
    • Lee, T.L.1    Yang, X.P.2    Yan, B.3    Friedman, J.4    Duggal, P.5    Bagain, L.6    Dong, G.7    Yeh, N.T.8    Wang, J.9    Zhou, J.10
  • 9
    • 34250679751 scopus 로고    scopus 로고
    • Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinoma
    • Demonstrates proinflammatory cytokines can be used as markers of treatment response and recurrence.
    • Allen C., Duffy S., Teknos T., Islam M., Chen Z., Albert P.S., Wolf G., and Van Waes C. Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinoma. Clin Cancer Res 13 (2007) 3182-3190. Demonstrates proinflammatory cytokines can be used as markers of treatment response and recurrence.
    • (2007) Clin Cancer Res , vol.13 , pp. 3182-3190
    • Allen, C.1    Duffy, S.2    Teknos, T.3    Islam, M.4    Chen, Z.5    Albert, P.S.6    Wolf, G.7    Van Waes, C.8
  • 10
    • 23844435559 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma
    • Worden B., Yang X.P., Lee T.L., Bagain L., Yeh N.T., Cohen J.G., Van Waes C., and Chen Z. Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma. Cancer Res 65 (2005) 7071-7080
    • (2005) Cancer Res , vol.65 , pp. 7071-7080
    • Worden, B.1    Yang, X.P.2    Lee, T.L.3    Bagain, L.4    Yeh, N.T.5    Cohen, J.G.6    Van Waes, C.7    Chen, Z.8
  • 13
    • 33947202249 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in development, prevention, and therapy of cancer
    • Van Waes C. Nuclear factor-kappaB in development, prevention, and therapy of cancer. Clin Cancer Res 13 (2007) 1076-1082
    • (2007) Clin Cancer Res , vol.13 , pp. 1076-1082
    • Van Waes, C.1
  • 14
    • 33644773438 scopus 로고    scopus 로고
    • STAT3 as a therapeutic target in head and neck cancer
    • Leeman R.J., Lui V.W., and Grandis J.R. STAT3 as a therapeutic target in head and neck cancer. Expert Opin Biol Ther 6 (2006) 231-241
    • (2006) Expert Opin Biol Ther , vol.6 , pp. 231-241
    • Leeman, R.J.1    Lui, V.W.2    Grandis, J.R.3
  • 15
    • 40749103000 scopus 로고    scopus 로고
    • A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
    • Lee T.L., Yeh J., Friedman J., Yan B., Yang X., Yeh N.T., Van Waes C., and Chen Z. A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. Int J Cancer 122 (2008) 1987-1998
    • (2008) Int J Cancer , vol.122 , pp. 1987-1998
    • Lee, T.L.1    Yeh, J.2    Friedman, J.3    Yan, B.4    Yang, X.5    Yeh, N.T.6    Van Waes, C.7    Chen, Z.8
  • 17
    • 33846850209 scopus 로고    scopus 로고
    • Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101
    • Duan J., Friedman J., Nottingham L., Chen Z., Ara G., and Van Waes C. Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101. Mol Cancer Ther 6 (2007) 37-50
    • (2007) Mol Cancer Ther , vol.6 , pp. 37-50
    • Duan, J.1    Friedman, J.2    Nottingham, L.3    Chen, Z.4    Ara, G.5    Van Waes, C.6
  • 18
    • 48249140693 scopus 로고    scopus 로고
    • Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer
    • Allen C., Saigal K., Nottingham L., Arun P., Chen Z., and Van Waes C. Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer. Clin Cancer Res 14 (2008) 4175-4185
    • (2008) Clin Cancer Res , vol.14 , pp. 4175-4185
    • Allen, C.1    Saigal, K.2    Nottingham, L.3    Arun, P.4    Chen, Z.5    Van Waes, C.6
  • 19
    • 34548848541 scopus 로고    scopus 로고
    • Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma
    • Van Waes C., Yu M., Nottingham L., and Karin M. Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma. Clin Cancer Res 13 (2007) 4956-4959
    • (2007) Clin Cancer Res , vol.13 , pp. 4956-4959
    • Van Waes, C.1    Yu, M.2    Nottingham, L.3    Karin, M.4
  • 20
    • 33746160746 scopus 로고    scopus 로고
    • Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells
    • Yu M., Yeh J., and Van Waes C. Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells. Cancer Res 66 (2006) 6722-6731
    • (2006) Cancer Res , vol.66 , pp. 6722-6731
    • Yu, M.1    Yeh, J.2    Van Waes, C.3
  • 21
    • 48549102989 scopus 로고    scopus 로고
    • The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth
    • First paper to demonstrate a novel transcription factor formed by member of TP53 and NF-κB family, which modulates cell growth (and cytokine expression).
    • King K.E., Ponnamperuma R.M., Allen C., Lu H., Duggal P., Chen Z., Van Waes C., and Weinberg W.C. The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth. Cancer Res 68 (2008) 5122-5131. First paper to demonstrate a novel transcription factor formed by member of TP53 and NF-κB family, which modulates cell growth (and cytokine expression).
    • (2008) Cancer Res , vol.68 , pp. 5122-5131
    • King, K.E.1    Ponnamperuma, R.M.2    Allen, C.3    Lu, H.4    Duggal, P.5    Chen, Z.6    Van Waes, C.7    Weinberg, W.C.8
  • 23
    • 36749031733 scopus 로고    scopus 로고
    • Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer
    • Friedman J., Nottingham L., Duggal P., Pernas F.G., Yan B., Yang X.P., Chen Z., and Van Waes C. Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer. Clin Cancer Res 13 (2007) 6568-6578
    • (2007) Clin Cancer Res , vol.13 , pp. 6568-6578
    • Friedman, J.1    Nottingham, L.2    Duggal, P.3    Pernas, F.G.4    Yan, B.5    Yang, X.P.6    Chen, Z.7    Van Waes, C.8
  • 24
    • 33947148750 scopus 로고    scopus 로고
    • Enhanced lipid peroxidation and nitric oxide products with deranged antioxidant status in patients with head and neck squamous cell carcinoma
    • Rasheed M.H., Beevi S.S., and Geetha A. Enhanced lipid peroxidation and nitric oxide products with deranged antioxidant status in patients with head and neck squamous cell carcinoma. Oral Oncol 43 (2007) 333-338
    • (2007) Oral Oncol , vol.43 , pp. 333-338
    • Rasheed, M.H.1    Beevi, S.S.2    Geetha, A.3
  • 27
    • 65349130024 scopus 로고    scopus 로고
    • Proteomic signatures and responses of epitermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer
    • Pernas F.G., Allen C.T., Winters M.E., Dabir B., Saigal K., Mundinger G.S., Yan B., Friedman J., Xu X., Morris J.C., et al. Proteomic signatures and responses of epitermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer. Clin Cancer Res 15 (2009) 2361-2372
    • (2009) Clin Cancer Res , vol.15 , pp. 2361-2372
    • Pernas, F.G.1    Allen, C.T.2    Winters, M.E.3    Dabir, B.4    Saigal, K.5    Mundinger, G.S.6    Yan, B.7    Friedman, J.8    Xu, X.9    Morris, J.C.10
  • 28
    • 11144239579 scopus 로고    scopus 로고
    • 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma
    • Ricker J.L., Chen Z., Yang X.P., Pribluda V.S., Swartz G.M., and Van Waes C. 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma. Clin Cancer Res 10 (2004) 8665-8673
    • (2004) Clin Cancer Res , vol.10 , pp. 8665-8673
    • Ricker, J.L.1    Chen, Z.2    Yang, X.P.3    Pribluda, V.S.4    Swartz, G.M.5    Van Waes, C.6
  • 30
    • 33947235680 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer
    • Nathan C.O., Amirghahari N., Rong X., Giordano T., Sibley D., Nordberg M., Glass J., Agarwal A., and Caldito G. Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer. Cancer Res 67 (2007) 2160-2168
    • (2007) Cancer Res , vol.67 , pp. 2160-2168
    • Nathan, C.O.1    Amirghahari, N.2    Rong, X.3    Giordano, T.4    Sibley, D.5    Nordberg, M.6    Glass, J.7    Agarwal, A.8    Caldito, G.9
  • 31
    • 68849094648 scopus 로고    scopus 로고
    • Molecular and clinical responses in a Phase I study of gefitinib combined with paclitaxel and radiation in patients with locally advanced head and neck cancers
    • in press
    • Van Waes C, Allen C, Citrin D, Colevas AD, Harold N, Rudy S, Muir C, Chen Z, Singh AK, Albert P, et al.: Molecular and clinical responses in a Phase I study of gefitinib combined with paclitaxel and radiation in patients with locally advanced head and neck cancers. Int J Rad Oncol Biol Phys 2009, in press.
    • (2009) Int J Rad Oncol Biol Phys
    • Van Waes, C.1    Allen, C.2    Citrin, D.3    Colevas, A.D.4    Harold, N.5    Rudy, S.6    Muir, C.7    Chen, Z.8    Singh, A.K.9    Albert, P.10
  • 32
    • 51949107285 scopus 로고    scopus 로고
    • Prostaglandin E(2) pathway in head and neck squamous cell carcinoma
    • Camacho M., Leon X., Fernandez-Figueras M.T., Quer M., and Vila L. Prostaglandin E(2) pathway in head and neck squamous cell carcinoma. Head Neck 30 (2008) 1175-1181
    • (2008) Head Neck , vol.30 , pp. 1175-1181
    • Camacho, M.1    Leon, X.2    Fernandez-Figueras, M.T.3    Quer, M.4    Vila, L.5
  • 33
    • 40449090323 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis
    • Demonstrates potential of inhibition of TNF, a cytokine activator of NF-κB, in pancreatic cancer.
    • Egberts J.H., Cloosters V., Noack A., Schniewind B., Thon L., Klose S., Kettler B., von Forstner C., Kneitz C., Tepel J., Adam D., et al. Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis. Cancer Res 68 (2008) 1443-1450. Demonstrates potential of inhibition of TNF, a cytokine activator of NF-κB, in pancreatic cancer.
    • (2008) Cancer Res , vol.68 , pp. 1443-1450
    • Egberts, J.H.1    Cloosters, V.2    Noack, A.3    Schniewind, B.4    Thon, L.5    Klose, S.6    Kettler, B.7    von Forstner, C.8    Kneitz, C.9    Tepel, J.10    Adam, D.11
  • 36
    • 51049086200 scopus 로고    scopus 로고
    • Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanisms
    • Demonstrates limited activity of proteasome inhibition in patients may be explained by alternative NF-κB as well as STAT3 and MAPK activation.
    • Chen Z., Ricker J.L., Malhotra P.S., Nottingham L., Bagain L., Lee T.L., Yeh N.T., and Van Waes C. Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanisms. Mol Cancer Ther 7 (2008) 1949-1960. Demonstrates limited activity of proteasome inhibition in patients may be explained by alternative NF-κB as well as STAT3 and MAPK activation.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1949-1960
    • Chen, Z.1    Ricker, J.L.2    Malhotra, P.S.3    Nottingham, L.4    Bagain, L.5    Lee, T.L.6    Yeh, N.T.7    Van Waes, C.8
  • 37
    • 68849099383 scopus 로고    scopus 로고
    • Phase I study of bortezomib and cetuximab without or with cisplatin in combination with radiation therapy for advanced head and neck cancer
    • National Library of Medicine (US), Bethesda (MD) [cited 2009 February 19]. Available from: http://clinicaltrials.gov/ct2/show/NCT00629226 NLM Identifier: NCT00629226
    • National Cancer Institute. Phase I study of bortezomib and cetuximab without or with cisplatin in combination with radiation therapy for advanced head and neck cancer. ClinicalTrials.gov [Internet] (2007), National Library of Medicine (US), Bethesda (MD). http://clinicaltrials.gov/ct2/show/NCT00629226 [cited 2009 February 19]. Available from: http://clinicaltrials.gov/ct2/show/NCT00629226 NLM Identifier: NCT00629226
    • (2007) ClinicalTrials.gov [Internet]
    • National Cancer Institute1
  • 39
    • 4043111378 scopus 로고    scopus 로고
    • Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling
    • Aggarwal S., Takada Y., Singh S., Myers J.N., and Aggarwal B.B. Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. Int J Cancer 111 (2004) 679-692
    • (2004) Int J Cancer , vol.111 , pp. 679-692
    • Aggarwal, S.1    Takada, Y.2    Singh, S.3    Myers, J.N.4    Aggarwal, B.B.5
  • 41
    • 51649118928 scopus 로고    scopus 로고
    • Phase II trial of curcumin in patients with advanced pancreatic cancer
    • Trial demonstrates activity of curcumin in pancreatic carcinoma, and inhibitor of NF-κB, despite poor bioavailability.
    • Dhillon N., Aggarwal B.B., Newman R.A., Wolff R.A., Kunnumakkara A.B., Abbruzzese J.L., Ng C.S., Badmaev V., and Kurzrock R. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 14 (2008) 4491-4499. Trial demonstrates activity of curcumin in pancreatic carcinoma, and inhibitor of NF-κB, despite poor bioavailability.
    • (2008) Clin Cancer Res , vol.14 , pp. 4491-4499
    • Dhillon, N.1    Aggarwal, B.B.2    Newman, R.A.3    Wolff, R.A.4    Kunnumakkara, A.B.5    Abbruzzese, J.L.6    Ng, C.S.7    Badmaev, V.8    Kurzrock, R.9
  • 43
    • 47249125723 scopus 로고    scopus 로고
    • Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt
    • Dan H.C., and Baldwin A.S. Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt. J Immunol 180 (2008) 7582-7589
    • (2008) J Immunol , vol.180 , pp. 7582-7589
    • Dan, H.C.1    Baldwin, A.S.2
  • 44
    • 62349132266 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model
    • Demonstrates potential of mTOR inhibitors that block translation of inflammatory and angiogenesis factors to inhibit HNSCC.
    • Czerninski R., Amornphimoltham P., Patel V., Molinolo A.A., and Gutkind J.S. Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. Cancer Prev Res (Phila Pa) 2 (2009) 27-36. Demonstrates potential of mTOR inhibitors that block translation of inflammatory and angiogenesis factors to inhibit HNSCC.
    • (2009) Cancer Prev Res (Phila Pa) , vol.2 , pp. 27-36
    • Czerninski, R.1    Amornphimoltham, P.2    Patel, V.3    Molinolo, A.A.4    Gutkind, J.S.5
  • 47
    • 0036023220 scopus 로고    scopus 로고
    • Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer
    • Lin D.T., Subbaramaiah K., Shah J.P., Dannenberg A.J., and Boyle J.O. Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. Head Neck 24 (2002) 792-799
    • (2002) Head Neck , vol.24 , pp. 792-799
    • Lin, D.T.1    Subbaramaiah, K.2    Shah, J.P.3    Dannenberg, A.J.4    Boyle, J.O.5
  • 48
    • 12144287878 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled Phase IIb trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia
    • A negative controlled study regarding activity of COX inhibitors as an oral rinse.
    • Mulshine J.L., Atkinson J.C., Greer R.O., Papadimitrakopoulou V.A., Van Waes C., Rudy S., Martin J.W., Steinberg S.M., Liewehr D.J., Avis I., et al. Randomized, double-blind, placebo-controlled Phase IIb trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia. Clin Cancer Res 10 (2004) 1565-1573. A negative controlled study regarding activity of COX inhibitors as an oral rinse.
    • (2004) Clin Cancer Res , vol.10 , pp. 1565-1573
    • Mulshine, J.L.1    Atkinson, J.C.2    Greer, R.O.3    Papadimitrakopoulou, V.A.4    Van Waes, C.5    Rudy, S.6    Martin, J.W.7    Steinberg, S.M.8    Liewehr, D.J.9    Avis, I.10
  • 50
    • 68849115570 scopus 로고    scopus 로고
    • Celecoxib in treating patients with head and neck cancer that can be removed by surgery
    • National Library of Medicine (US), Bethesda (MD) [cited 2009 February 19]. Available from: http://clinicaltrials.gov/ct2/show/NCT00357617 NLM Identifier: NCT00357617
    • Centre Hospitalier Universitaire Vaudois. Celecoxib in treating patients with head and neck cancer that can be removed by surgery. ClinicalTrials.gov [Internet] (2006), National Library of Medicine (US), Bethesda (MD). http://clinicaltrials.gov/ct2/show/NCT00357617 [cited 2009 February 19]. Available from: http://clinicaltrials.gov/ct2/show/NCT00357617 NLM Identifier: NCT00357617
    • (2006) ClinicalTrials.gov [Internet]
    • Centre Hospitalier Universitaire Vaudois1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.