Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN

Oncogene

Volumn 20, Issue 11, 2001, Pages 1287-1299

  Pianetti, Stefania ^a   Arsura, Marcello ^a   Romieu Mourez, Raphaëlle ^a   Coffey, Robert J ^b   Sonenshein, Gail E ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Breast cancer; Calpain; EGF receptor; I B ; NF B; Transgenic mice

Indexed keywords

CALPAIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GENE PRODUCT; I KAPPA B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P50; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL CULTURE; CELL GROWTH; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE NEU; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FAMILY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BREAST NEOPLASMS; CALPAIN; DNA-BINDING PROTEINS; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; I-KAPPA B PROTEINS; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, TRANSGENIC; NF-KAPPA B; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MOUSE MAMMARY TUMOR VIRUS; MUS MUSCULUS;

EID: 0035868342     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1204257     Document Type: Article

References (70)