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Volumn 97, Issue 1, 2015, Pages 483-504

Bioactive Benzofuran derivatives: A review

Author keywords

Antimicrobial; Antitumor; Benzofurans; Heterocycles Antiviral

Indexed keywords

ANALGESIC AGENT; ANGIOGENESIS INHIBITOR; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; ANTINEOPLASTIC AGENT; ANTIPYRETIC AGENT; ANTIVIRUS AGENT; BENZOFURAN DERIVATIVE; ENDOTHELIN RECEPTOR ANTAGONIST; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OXYTOCIN ANTAGONIST; PEPTIDE DEFORMYLASE INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; BENZOFURAN;

EID: 84934924600     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.11.039     Document Type: Review
Times cited : (449)

References (210)
  • 1
    • 35949000098 scopus 로고    scopus 로고
    • Greener and sustainable approaches to the synthesis of pharmaceutically active heterocycles
    • V. Polshettiwar, R.S. Varma, Greener and sustainable approaches to the synthesis of pharmaceutically active heterocycles, Curr. Opin. Drug Discov. Devel 10 (2007) 723-737.
    • (2007) Curr. Opin. Drug Discov. Devel , vol.10 , pp. 723-737
    • Polshettiwar, V.1    Varma, R.S.2
  • 2
    • 34250021382 scopus 로고    scopus 로고
    • The domino way to heterocycles
    • A. Padwa, S.K. Bur, The domino way to heterocycles, Tetrahedron 63 (2007) 5341-5378.
    • (2007) Tetrahedron , vol.63 , pp. 5341-5378
    • Padwa, A.1    Bur, S.K.2
  • 3
    • 34250627489 scopus 로고    scopus 로고
    • Multi-component syntheses of heterocycles by transition-metal catalysis
    • D.M. D'Souza, T.J. Muller, Multi-component syntheses of heterocycles by transition-metal catalysis, Chem. Soc. Rev. 36 (2007) 1095-1108.
    • (2007) Chem. Soc. Rev. , vol.36 , pp. 1095-1108
    • D'Souza, D.M.1    Muller, T.J.2
  • 4
    • 77955980451 scopus 로고    scopus 로고
    • Synthesis biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors
    • G. Eren, S. Unlu, M.T. Nunez, L. Labeaga, F. Ledo, A. Entrena, E.B. Lu, G. Costantino, M.F. Sahin, Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors, Bioorg. Med. Chem. 18 (2010) 6367-6376.
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 6367-6376
    • Eren, G.1    Unlu, S.2    Nunez, M.T.3    Labeaga, L.4    Ledo, F.5    Entrena, A.6    Lu, E.B.7    Costantino, G.8    Sahin, M.F.9
  • 5
    • 0042160840 scopus 로고
    • A.J. Boulton, A. McKillop (Eds.) Pergamon Press, Oxford
    • J.D. Hepworth, in: A.J. Boulton, A. McKillop (Eds.), Comprehensive Heterocyclic Chemistry, 3, Pergamon Press, Oxford, 1984, pp. 835-840.
    • (1984) Comprehensive Heterocyclic Chemistry , vol.3 , pp. 835-840
    • Hepworth, J.D.1
  • 6
    • 0028318863 scopus 로고
    • Applications of combinatorial technologies to drug discovery 2. Combinatorial organic synthesis library screening strategies, and future directions
    • E. Gordon, R.W. Barrett, W.J. Dower, S.P. Foder, A. Gallop Mark, Applications of combinatorial technologies to drug discovery 2. Combinatorial organic synthesis, library screening strategies, and future directions, J. Med. Chem. 37 (1994) 1385-1401.
    • (1994) J. Med. Chem. , vol.37 , pp. 1385-1401
    • Gordon, E.1    Barrett, R.W.2    Dower, W.J.3    Foder, S.P.4    Gallop Mark, A.5
  • 7
    • 78650122737 scopus 로고    scopus 로고
    • A graphical journey of innovative organic architectures that have improved our lives
    • N.A. McGrath, M. Brichacek, J.T. Njardarson, A graphical journey of innovative organic architectures that have improved our lives, J. Chem. Educ. 87 (2010) 1348-1349.
    • (2010) J. Chem. Educ. , vol.87 , pp. 1348-1349
    • McGrath, N.A.1    Brichacek, M.2    Njardarson, J.T.3
  • 8
    • 35748934487 scopus 로고    scopus 로고
    • The influence of drug-like concepts on decision making in medicinal chemistry
    • P.D. Leeson, B. Springthorpe, The influence of drug-like concepts on decision making in medicinal chemistry, Nat. Rev. Drug Discov. 6 (2007) 881-890.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 881-890
    • Leeson, P.D.1    Springthorpe, B.2
  • 10
    • 54049132967 scopus 로고    scopus 로고
    • Synthesis antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5[(2-benzofuryl) carboxamido] benzoxazoles
    • S.A. Hayta, M. Arisoy, O.T. Arpaci, I. Yildiz, E. Aki, S. Ozkan, F. Kaynak, Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5 [(2-benzofuryl) carboxamido] benzoxazoles, Eur. J. Med. Chem. 43 (2008) 2568-2578.
    • (2008) Eur. J. Med. Chem. , vol.43 , pp. 2568-2578
    • Hayta, S.A.1    Arisoy, M.2    Arpaci, O.T.3    Yildiz, I.4    Aki, E.5    Ozkan, S.6    Kaynak, F.7
  • 12
    • 0037136032 scopus 로고    scopus 로고
    • Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids
    • B. Cottineau, P. Toto, C. Marot, A. Pipaud, J. Chenault, Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids, Bioorg. Med. Chem. Lett. 12 (2002) 2105-2108.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 2105-2108
    • Cottineau, B.1    Toto, P.2    Marot, C.3    Pipaud, A.4    Chenault, J.5
  • 13
    • 84899048566 scopus 로고    scopus 로고
    • Microwave-assisted parallel synthesis of benzofuran-2-carboxamide derivatives bearing anti-inflammatory, analgesic and antipyretic agents
    • Y.-S. Xie, D. Kumar, V.D.V. Bodduri, P.S. Tarani, B.-X. Zhao, J.-Y. Miao, K. Jang, D.-S. Shin, Microwave-assisted parallel synthesis of benzofuran-2-carboxamide derivatives bearing anti-inflammatory, analgesic and antipyretic agents, Tetrahedron Lett. 55 (2014) 2796-2800.
    • (2014) Tetrahedron Lett. , vol.55 , pp. 2796-2800
    • Xie, Y.-S.1    Kumar, D.2    Bodduri, V.D.V.3    Tarani, P.S.4    Zhao, B.-X.5    Miao, J.-Y.6    Jang, K.7    Shin, D.-S.8
  • 14
    • 84881370569 scopus 로고    scopus 로고
    • Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth
    • M. Th-evenin, S. Thoret, P. Grellier, J. Dubois, Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth, Bioorg. Med. Chem. 21 (2013) 4885-4892.
    • (2013) Bioorg. Med. Chem. , vol.21 , pp. 4885-4892
    • Thevenin, M.1    Thoret, S.2    Grellier, P.3    Dubois, J.4
  • 15
    • 27744484132 scopus 로고    scopus 로고
    • Synthesis and antimicrobial activity of some novel derivatives of benzofuran: Part 1. Synthesis and antimicrobial activity of (benzofuran-2-yl)(3-phenyl-3-methylcyclobutyl) ketoxime derivatives
    • M. Koca, S. Servi, C. Kirilmis, M. Ahmedzade, C. Kazaz, B. Ozbek, G. Otük, Synthesis and antimicrobial activity of some novel derivatives of benzofuran: part 1. synthesis and antimicrobial activity of (benzofuran-2-yl)(3-phenyl-3-methylcyclobutyl) ketoxime derivatives, Eur. J. Med. Chem. 40 (2005) 1351-1358.
    • (2005) Eur. J. Med. Chem. , vol.40 , pp. 1351-1358
    • Koca, M.1    Servi, S.2    Kirilmis, C.3    Ahmedzade, M.4    Kazaz, C.5    Ozbek, B.6    Otük, G.7
  • 16
    • 84908304381 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel aurora B kinase inhibitor
    • F. Xie, H. Zhu, H. Zhang, Q. Lang, L. Tang, Q. Huang, L. Yu, In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel aurora B kinase inhibitor, Eur. J. Med. Chem. 89 (2015) 310-319.
    • (2015) Eur. J. Med. Chem. , vol.89 , pp. 310-319
    • Xie, F.1    Zhu, H.2    Zhang, H.3    Lang, Q.4    Tang, L.5    Huang, Q.6    Yu, L.7
  • 17
    • 33947097964 scopus 로고    scopus 로고
    • Characterization of a newly synthesized fluorescent benzofuran derivative and usage as a selective fiber optic sensor for Fe(III)
    • O. Oter, K. Ertekin, C. Kirilmis, M. Koca, M. Ahmedzade, Characterization of a newly synthesized fluorescent benzofuran derivative and usage as a selective fiber optic sensor for Fe(III), Sens. Actuators B: Chem. 122 (2007) 450-456.
    • (2007) Sens. Actuators B: Chem. , vol.122 , pp. 450-456
    • Oter, O.1    Ertekin, K.2    Kirilmis, C.3    Koca, M.4    Ahmedzade, M.5
  • 18
    • 33646814916 scopus 로고    scopus 로고
    • Synthesis and oxidant properties of novel (5-bromobenzofuran-2-yl)(3-methyl-3-mesitylcyclobutyl) ketonethiosemicarbazone
    • F. Karatas, M. Koca, H. Kara, S. Servi, Synthesis and oxidant properties of novel (5-bromobenzofuran-2-yl)(3-methyl-3-mesitylcyclobutyl) ketonethiosemicarbazone, Eur. J. Med. Chem. 41 (2006) 664-669.
    • (2006) Eur. J. Med. Chem. , vol.41 , pp. 664-669
    • Karatas, F.1    Koca, M.2    Kara, H.3    Servi, S.4
  • 19
    • 0000767774 scopus 로고    scopus 로고
    • Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents
    • J. Habermann, S.V. Ley, R. Smits, Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents, J. Chem. Soc. Perkin Trans. 1 (1999) 2421-2423.
    • (1999) J. Chem. Soc. Perkin Trans. , vol.1 , pp. 2421-2423
    • Habermann, J.1    Ley, S.V.2    Smits, R.3
  • 20
    • 27744467004 scopus 로고    scopus 로고
    • Synthesis of 2-arylbenzofuran derivatives using x-(methylsulfinyl) acetophenone
    • Y.W. Kim, H.D. Choi, P.J. Seo, B.W. Son, Synthesis of 2-arylbenzofuran derivatives using x-(methylsulfinyl) acetophenone, J. Korean Chem. Soc. 45 (2001) 391-394.
    • (2001) J. Korean Chem. Soc. , vol.45 , pp. 391-394
    • Kim, Y.W.1    Choi, H.D.2    Seo, P.J.3    Son, B.W.4
  • 21
    • 0035808880 scopus 로고    scopus 로고
    • A convenient synthesis of naturally occurring benzofuran ailanthoidol
    • C.L. Kao, J.W. Chern, A convenient synthesis of naturally occurring benzofuran ailanthoidol, Tetrahedron Lett. 42 (2001) 1111-1113.
    • (2001) Tetrahedron Lett. , vol.42 , pp. 1111-1113
    • Kao, C.L.1    Chern, J.W.2
  • 22
  • 23
  • 24
    • 17844396930 scopus 로고    scopus 로고
    • A furan ring expansion approach to the synthesis of novel pyridazino-psoralen derivatives
    • J.C.G.-Gomez, L. Santana, E. Uriarte, A furan ring expansion approach to the synthesis of novel pyridazino-psoralen derivatives, Tetrahedron 61 (2005) 4805-4810.
    • (2005) Tetrahedron , vol.61 , pp. 4805-4810
    • Gomez, J.C.G.1    Santana, L.2    Uriarte, E.3
  • 25
    • 0019206581 scopus 로고
    • A new synthesis of methoxalen
    • P. Nore, E. Honkanen, A new synthesis of methoxalen, J. Heterocycl. Chem. 17 (1980) 985-987.
    • (1980) J. Heterocycl. Chem. , vol.17 , pp. 985-987
    • Nore, P.1    Honkanen, E.2
  • 26
    • 61949469519 scopus 로고    scopus 로고
    • Some recent approaches to the synthesis of 2-substituted benzofurans
    • L. De Luca, G. Nieddu, A. Porcheddu, G. Giacomelli, Some recent approaches to the synthesis of 2-substituted benzofurans, Curr. Med. Chem. 16 (2009) 1-20.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 1-20
    • De Luca, L.1    Nieddu, G.2    Porcheddu, A.3    Giacomelli, G.4
  • 27
    • 84859219650 scopus 로고    scopus 로고
    • Hypervalent iodine mediated oxidative cyclization of Ohydroxystilbenes into benzo-and naphthofurans
    • F.V. Singh, T. Wirth, Hypervalent iodine mediated oxidative cyclization of Ohydroxystilbenes into benzo-and naphthofurans, Synthesis 44 (2012) 1171-1177.
    • (2012) Synthesis , vol.44 , pp. 1171-1177
    • Singh, F.V.1    Wirth, T.2
  • 28
    • 55449086896 scopus 로고    scopus 로고
    • One-pot synthesis of benzofurans via palladiumcatalyzed enolate arylation with O-bromophenols
    • C. Eidamshaus, J.D. Burch, One-pot synthesis of benzofurans via palladiumcatalyzed enolate arylation with O-bromophenols, Org. Lett. 10 (2008) 4211-4214.
    • (2008) Org. Lett. , vol.10 , pp. 4211-4214
    • Eidamshaus, C.1    Burch, J.D.2
  • 30
    • 70749085501 scopus 로고    scopus 로고
    • Cycloisomerization of aromatic homo-and bis-homopropargylic alcohols via catalytic Ru vinylidenes: Formation of benzofurans and isochromenes
    • A.V.-Fern-andez, C.G.-Rodríguez, J.A. Varela, L. Castedo, C. Sa-a, Cycloisomerization of aromatic homo-and bis-homopropargylic alcohols via catalytic Ru vinylidenes: formation of benzofurans and isochromenes, Org. Lett. 11 (2009) 5350-5353.
    • (2009) Org. Lett. , vol.11 , pp. 5350-5353
    • Fernandez, A.V.1    Rodríguez, C.G.2    Varela, J.A.3    Castedo, L.4    Saa, C.5
  • 31
    • 67749106331 scopus 로고    scopus 로고
    • Cross-coupling reactions of aromatic and heteroaromatic silanolates with aromatic and heteroaromatic halides
    • S.E. Denmark, R.C. Smith, W.-T.T. Chang, J.M. Muhuhi, Cross-coupling reactions of aromatic and heteroaromatic silanolates with aromatic and heteroaromatic halides, J. Am. Chem. Soc. 131 (2009) 3104-3118.
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 3104-3118
    • Denmark, S.E.1    Smith, R.C.2    Chang, W.-T.T.3    Muhuhi, J.M.4
  • 32
    • 84879285900 scopus 로고    scopus 로고
    • Palladium-catalyzed addition of potassium aryltrifluoroborates to aliphatic nitriles: Synthesis of alkyl aryl ketones, diketone compounds, and 2-arylbenzo [b]furans
    • X. Wang, M. Liu, L. Xu, Q. Wang, J. Chen, J. Ding, H. Wu, Palladium-catalyzed addition of potassium aryltrifluoroborates to aliphatic nitriles: synthesis of alkyl aryl ketones, diketone compounds, and 2-arylbenzo [b]furans, J. Org. Chem. 78 (2013) 5273-5281.
    • (2013) J. Org. Chem. , vol.78 , pp. 5273-5281
    • Wang, X.1    Liu, M.2    Xu, L.3    Wang, Q.4    Chen, J.5    Ding, J.6    Wu, H.7
  • 33
    • 84860822041 scopus 로고    scopus 로고
    • Dehydrative C-H alkylation and alkenylation of phenols with alcohols: Expedient synthesis for substituted phenols and benzofurans
    • D.-H. Lee, K.-H. Kwon, C.S. Yi, Dehydrative C-H alkylation and alkenylation of phenols with alcohols: expedient synthesis for substituted phenols and benzofurans, J. Am. Chem. Soc. 134 (2012) 6571-6574.
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 6571-6574
    • Lee, D.-H.1    Kwon, K.-H.2    Yi, C.S.3
  • 35
    • 34248575224 scopus 로고    scopus 로고
    • A facile approach to the synthesis of chiral 2-substituted benzofurans
    • L. De Luca, G. Giacomelli, G. Nieddu, A facile approach to the synthesis of chiral 2-substituted benzofurans, J. Org. Chem. 72 (2007) 3955-3957.
    • (2007) J. Org. Chem. , vol.72 , pp. 3955-3957
    • De Luca, L.1    Giacomelli, G.2    Nieddu, G.3
  • 36
    • 28744458426 scopus 로고    scopus 로고
    • Synthesis of 2, 3-disubstituted benzo [b]furans by the palladium-catalyzed coupling of O-iodoanisoles and terminal alkynes, followed by electrophilic cyclization
    • D. Yue, T. Yao, R.C. Larock, Synthesis of 2, 3-disubstituted benzo [b]furans by the palladium-catalyzed coupling of O-iodoanisoles and terminal alkynes, followed by electrophilic cyclization, J. Org. Chem. 70 (2005) 10292-10296.
    • (2005) J. Org. Chem. , vol.70 , pp. 10292-10296
    • Yue, D.1    Yao, T.2    Larock, R.C.3
  • 37
    • 33744493093 scopus 로고    scopus 로고
    • The new era in cancer research
    • H. Varmus, The new era in cancer research, Science 312 (2006) 1162-1165.
    • (2006) Science , vol.312 , pp. 1162-1165
    • Varmus, H.1
  • 39
    • 0004097423 scopus 로고    scopus 로고
    • W.B. Saunders Company, Philadelphia
    • C.M. Haskell, Cancer treatment, W.B. Saunders Company, Philadelphia, 2001.
    • (2001) Cancer Treatment
    • Haskell, C.M.1
  • 40
    • 11844287538 scopus 로고    scopus 로고
    • Antileishmanial activity, cytotoxicity and QSAR analysis of synthetic dihydrobenzofuran lignans and related benzofurans
    • S.V. Miert, S.V. Dyck, T.J. Schmidt, R. Brun, A. Vlietinck, G. Lemiere, L. Pieters, Antileishmanial activity, cytotoxicity and QSAR analysis of synthetic dihydrobenzofuran lignans and related benzofurans, Bioorg. Med. Chem. 13 (2005) 661-669.
    • (2005) Bioorg. Med. Chem. , vol.13 , pp. 661-669
    • Miert, S.V.1    Dyck, S.V.2    Schmidt, T.J.3    Brun, R.4    Vlietinck, A.5    Lemiere, G.6    Pieters, L.7
  • 42
    • 84893728953 scopus 로고    scopus 로고
    • Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole
    • W.-C. Wan, W. Chen, L.-X. Liu, Y. Li, L.-J. Yang, X.-Y. Deng, H.-Bin Zhang, X.-D. Yang, Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole, Med. Chem. Res. 23 (2014) 1599-1611.
    • (2014) Med. Chem. Res. , vol.23 , pp. 1599-1611
    • Wan, W.-C.1    Chen, W.2    Liu, L.-X.3    Li, Y.4    Yang, L.-J.5    Deng, X.-Y.6    Zhang H.-Bin7    Yang, X.-D.8
  • 43
    • 84870347086 scopus 로고    scopus 로고
    • Antiproliferative potency of novel benzofuran-2-carboxamides on tumour cell lines: Cell death mechanisms and determination of crystal structure
    • M. Hranjec, I. Sovic, I. Ratkaj, G. Pavlovic, N. Ilic, L. Valjalo, K. Pavelic, S.K. Pavelic, G.K.-Zamola, Antiproliferative potency of novel benzofuran-2-carboxamides on tumour cell lines: cell death mechanisms and determination of crystal structure, Eur. J. Med. Chem. 59 (2013) 111-119.
    • (2013) Eur. J. Med. Chem. , vol.59 , pp. 111-119
    • Hranjec, M.1    Sovic, I.2    Ratkaj, I.3    Pavlovic, G.4    Ilic, N.5    Valjalo, L.6    Pavelic, K.7    Pavelic, S.K.8    Zamola, G.K.9
  • 44
    • 0026735063 scopus 로고
    • Protein isoprenylation and methylation at carboxyl-terminal cysteine residues
    • S. Clarke, Protein isoprenylation and methylation at carboxyl-terminal cysteine residues, Annu. Rev. Biochem. 61 (1992) 355-386;
    • (1992) Annu. Rev. Biochem. , vol.61 , pp. 355-386
    • Clarke, S.1
  • 45
    • 0026619185 scopus 로고
    • The ras/cholesterol connection: Implications for ras oncogenicity
    • A.D. Cox, C.J. Der, The ras/cholesterol connection: implications for ras oncogenicity, Crit. Rev. Oncog. 3 (1992) 365-400.
    • (1992) Crit. Rev. Oncog. , vol.3 , pp. 365-400
    • Cox, A.D.1    Der, C.J.2
  • 47
    • 0030865773 scopus 로고    scopus 로고
    • Ras Farnesyltransferase: A new therapeutic target
    • D.M. Leonard, Ras Farnesyltransferase: a new therapeutic target, J. Med. Chem. 40 (1997) 2971-2990;
    • (1997) J. Med. Chem. , vol.40 , pp. 2971-2990
    • Leonard, D.M.1
  • 48
    • 0031932939 scopus 로고    scopus 로고
    • New approaches to anticancer drug design based on the inhibition of farnesyltransferase
    • S.M. Sebti, A.D. Hamilton, New approaches to anticancer drug design based on the inhibition of farnesyltransferase, Drug Discov. Today 3 (1998) 26-33.
    • (1998) Drug Discov. Today , vol.3 , pp. 26-33
    • Sebti, S.M.1    Hamilton, A.D.2
  • 51
    • 0031969264 scopus 로고    scopus 로고
    • Angiogenesis and tumor metastasis
    • B.R. Zetter, Angiogenesis and tumor metastasis, Annu. Rev. Med. 49 (1998) 407-424;
    • (1998) Annu. Rev. Med. , vol.49 , pp. 407-424
    • Zetter, B.R.1
  • 52
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • P. Carmeliet, R.K. Jain, Angiogenesis in cancer and other diseases, Nature 407 (2000) 249-257;
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 53
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • J. Folkman, Role of angiogenesis in tumor growth and metastasis, Semin. Oncol. 29 (2002) 15-18.
    • (2002) Semin. Oncol. , vol.29 , pp. 15-18
    • Folkman, J.1
  • 54
    • 0031413183 scopus 로고    scopus 로고
    • New therapeutic approaches in cancer treatment
    • C. Unger, New therapeutic approaches in cancer treatment, Drugs Future 22 (1997) 1337-1345.
    • (1997) Drugs Future , vol.22 , pp. 1337-1345
    • Unger, C.1
  • 55
    • 18744369947 scopus 로고    scopus 로고
    • Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro
    • J.M. Hur, J.S. Shim, H.J. Jung, H.J. Kwon, Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro, Exp. Mol. Med. 37 (2005) 133-137.
    • (2005) Exp. Mol. Med. , vol.37 , pp. 133-137
    • Hur, J.M.1    Shim, J.S.2    Jung, H.J.3    Kwon, H.J.4
  • 59
    • 61849118035 scopus 로고    scopus 로고
    • Synthesis discovery and preliminary SAR study of benzofuran derivatives as angiogenesis inhibitors
    • Y. Chen, S. Chen, X. Lu, H. Cheng, Y. Oua, H. Cheng, G.-C. Zhou, Synthesis, discovery and preliminary SAR study of benzofuran derivatives as angiogenesis inhibitors, Bioorg. Med. Chem. Lett. 19 (2009) 1851-1854.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 1851-1854
    • Chen, Y.1    Chen, S.2    Lu, X.3    Cheng, H.4    Oua, Y.5    Cheng, H.6    Zhou, G.-C.7
  • 60
    • 77957967569 scopus 로고    scopus 로고
    • Why target PIM1 for cancer diagnosis and treatment
    • N.S. Magnuson, Z. Wang, G. Ding, R. Reeves, Why target PIM1 for cancer diagnosis and treatment Future Oncol. 6 (2010) 1461-1478;
    • (2010) Future Oncol. , vol.6 , pp. 1461-1478
    • Magnuson, N.S.1    Wang, Z.2    Ding, G.3    Reeves, R.4
  • 61
    • 78650606450 scopus 로고    scopus 로고
    • For better or for worse: The role of pim oncogenes in tumorigenesis
    • M.C. Nawijin, A. Alendar, A. Berns, For better or for worse: the role of pim oncogenes in tumorigenesis, Nat. Rev. Cancer 11 (2011) 23-34.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 23-34
    • Nawijin, M.C.1    Alendar, A.2    Berns, A.3
  • 62
    • 0021233675 scopus 로고
    • Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region
    • H.T. Cuypers, G. Selten, W. Quint, M. Zijlstra, E.R.-Manndag, W. Boelens, P. Van Wezenbeek, A. Berns, Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region, Cell 37 (1984) 141-150.
    • (1984) Cell , vol.37 , pp. 141-150
    • Cuypers, H.T.1    Selten, G.2    Quint, W.3    Zijlstra, M.4    Manndag, E.R.5    Boelens, W.6    Van Wezenbeek, P.7    Berns, A.8
  • 66
    • 41149093037 scopus 로고    scopus 로고
    • Docking study yields four novel inhibitors of the protooncogene pim-1 kinase
    • A.C. Pierce, M. Jacobs, C.S.-Moody, Docking study yields four novel inhibitors of the protooncogene pim-1 kinase, J. Med. Chem. 51 (2008) 1972-1975.
    • (2008) J. Med. Chem. , vol.51 , pp. 1972-1975
    • Pierce, A.C.1    Jacobs, M.2    Moody, C.S.3
  • 68
    • 84867776392 scopus 로고    scopus 로고
    • New Ruthenium(II)e Letrozole complexes as anticancer therapeutics
    • A. Castonguay, C. Doucet, M. Juhas, D. Maysinger, New Ruthenium(II)e Letrozole complexes as anticancer therapeutics, J. Med. Chem. 55 (2012) 8799-8806.
    • (2012) J. Med. Chem. , vol.55 , pp. 8799-8806
    • Castonguay, A.1    Doucet, C.2    Juhas, M.3    Maysinger, D.4
  • 69
    • 33750975372 scopus 로고    scopus 로고
    • The role of estrogen in the initiation of breast cancer
    • J. Russo, I.H. Russo, The role of estrogen in the initiation of breast cancer, J. Steroid Biochem. Mol. Biol. 102 (2006) 89-96.
    • (2006) J. Steroid Biochem. Mol. Biol. , vol.102 , pp. 89-96
    • Russo, J.1    Russo, I.H.2
  • 71
    • 0013829730 scopus 로고
    • Hormone therapy for advanced breast cancer
    • B.J. Kennedy, Hormone therapy for advanced breast cancer, Cancer 18 (1965) 1551-1557.
    • (1965) Cancer , vol.18 , pp. 1551-1557
    • Kennedy, B.J.1
  • 72
    • 33845929000 scopus 로고    scopus 로고
    • Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer
    • V.C. Jordan, A.M.H. Brodie, Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer, Steroids 72 (2007) 7-25.
    • (2007) Steroids , vol.72 , pp. 7-25
    • Jordan, V.C.1    Brodie, A.M.H.2
  • 73
    • 0037364074 scopus 로고    scopus 로고
    • Tamoxifen: A most unlikely pioneering medicine
    • V.C. Jordan, Tamoxifen: a most unlikely pioneering medicine, Nat. Rev. Drug Disc. 2 (2003) 205-213.
    • (2003) Nat. Rev. Drug Disc. , vol.2 , pp. 205-213
    • Jordan, V.C.1
  • 74
    • 0020003085 scopus 로고
    • Tamoxifen and metabolites in MCF7 cells: Correlation between binding to estrogen receptor and inhibition of cell growth
    • E. Coezy, J.L. Borgna, H. Rochefort, Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth, Cancer Res. 42 (1982) 317-323.
    • (1982) Cancer Res. , vol.42 , pp. 317-323
    • Coezy, E.1    Borgna, J.L.2    Rochefort, H.3
  • 75
    • 67650334402 scopus 로고    scopus 로고
    • Short-term prophylactic tamoxifen reduces the incidence of antiestrogen-resistant/estrogen receptorepositive/progesterone receptorenegative mammary tumors
    • T.A.R.-Hellekant, A.J. Skildum, O. Zhdankin, A.L. Greene, R.R. Regal, K.D. Kundel, D.W. Kundel, Short-term prophylactic tamoxifen reduces the incidence of antiestrogen-resistant/estrogen receptorepositive/progesterone receptorenegative mammary tumors, Cancer Prev. Res. 2 (2009) 496-502.
    • (2009) Cancer Prev. Res. , vol.2 , pp. 496-502
    • Hellekant, T.A.R.1    Skildum, A.J.2    Zhdankin, O.3    Greene, A.L.4    Regal, R.R.5    Kundel, K.D.6    Kundel, D.W.7
  • 76
    • 84880610438 scopus 로고    scopus 로고
    • 3-Acyl-5-hydroxybenzofuran derivatives as potential anti-estrogen breast cancer agents: A combined experimental and theoretical investigation
    • X.-Y. Li, Bi-F. He, H.-J. Luo, N.-Y. Huang, W.-Q. Deng, 3-Acyl-5-hydroxybenzofuran derivatives as potential anti-estrogen breast cancer agents: a combined experimental and theoretical investigation, Bioorg. Med. Chem. Lett. 23 (2013) 4617-4621.
    • (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 4617-4621
    • Li, X.-Y.1    He, B.-F.2    Luo, H.-J.3    Huang, N.-Y.4    Deng, W.-Q.5
  • 77
    • 29344471072 scopus 로고    scopus 로고
    • Understanding microtubule dynamics for improved cancer therapy
    • S. Honore, E. Pasquier, D. Braguer, Understanding microtubule dynamics for improved cancer therapy, Cell. Mol. Life. Sci. 62 (2005) 3039-3056;
    • (2005) Cell. Mol. Life. Sci. , vol.62 , pp. 3039-3056
    • Honore, S.1    Pasquier, E.2    Braguer, D.3
  • 79
    • 34548436228 scopus 로고    scopus 로고
    • Targeting microtubules to inhibit angiogenesis and disrupt tumour vasculature: Implications for cancer treatment
    • E. Pasquier, N. Andr-e, D. Braguer, Targeting microtubules to inhibit angiogenesis and disrupt tumour vasculature: implications for cancer treatment, Curr. Cancer Drug Target 7 (2007) 566-581.
    • (2007) Curr. Cancer Drug Target , vol.7 , pp. 566-581
    • Pasquier, E.1    Andre, N.2    Braguer, D.3
  • 81
    • 0033619997 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of dihydrobenzofuran lignans and related compounds as potential antitumor agents that inhibit tubulin polymerization
    • L. Pieters, S.V. Dyck, M. Gao, R. Bai, E. Hamel, A. Vlietinck, G. Lemie're, Synthesis and biological evaluation of dihydrobenzofuran lignans and related compounds as potential antitumor agents that inhibit tubulin polymerization, J. Med. Chem. 42 (1999) 5475-5481.
    • (1999) J. Med. Chem. , vol.42 , pp. 5475-5481
    • Pieters, L.1    Dyck, S.V.2    Gao, M.3    Bai, R.4    Hamel, E.5    Vlietinck, A.6    Lemie'Re, G.7
  • 82
    • 0025286104 scopus 로고
    • Molecular cloning and expression of glycogen synthase kinase-3/factor A
    • J.R. Woodgett, Molecular cloning and expression of glycogen synthase kinase-3/factor A, EMBO J. 9 (1990) 2431-2438.
    • (1990) EMBO J. , vol.9 , pp. 2431-2438
    • Woodgett, J.R.1
  • 83
    • 64549112164 scopus 로고    scopus 로고
    • From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl) maleimides as glycogen synthase kinase 3b inhibitors that suppress proliferation and survival of pancreatic cancer cells
    • I.N. Gaisina, F. Gallier, A.V. Ougolkov, K.H. Kim, T. Kurome, S. Guo, D. Holzle, D.N. Luchini, S.Y. Blond, D.D. Billadeau, A.P. Kozikowski, From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl) maleimides as glycogen synthase kinase 3b inhibitors that suppress proliferation and survival of pancreatic cancer cells, J. Med. Chem. 52 (2009) 1853-1863.
    • (2009) J. Med. Chem. , vol.52 , pp. 1853-1863
    • Gaisina, I.N.1    Gallier, F.2    Ougolkov, A.V.3    Kim, K.H.4    Kurome, T.5    Guo, S.6    Holzle, D.7    Luchini, D.N.8    Blond, S.Y.9    Billadeau, D.D.10    Kozikowski, A.P.11
  • 85
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • R.L. Juliano, V. Ling, A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants, Biochim. Biophys. Acta. 455 (1976) 152-162.
    • (1976) Biochim. Biophys. Acta. , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 86
    • 0010389021 scopus 로고
    • Multidrug resistance
    • J.A. Kellen (Ed.) CRC Press, Boca Raton, FL
    • J.A. Kellen, Multidrug resistance, in: J.A. Kellen (Ed.), Reversal of Multidrug Resistance in cancer, CRC Press, Boca Raton, FL, 1994, pp. 1-19.
    • (1994) Reversal of Multidrug Resistance in Cancer , pp. 1-19
    • Kellen, J.A.1
  • 87
    • 0025007511 scopus 로고
    • Pharmacology of drugs that alter multidrug resistance in cancer
    • J.M. Ford, W.N. Hait, Pharmacology of drugs that alter multidrug resistance in cancer, Pharmacol. Rev. 42 (1990) 155-199.
    • (1990) Pharmacol. Rev. , vol.42 , pp. 155-199
    • Ford, J.M.1    Hait, W.N.2
  • 88
    • 0029009203 scopus 로고
    • Synthesis, pharmacologic activity, and structure-activity relationships of a series of propafenone-related modulators of multidrug resistance
    • P. Chiba, S. Burghofer, E. Richter, B. Tell, A. Moser, G. Ecker, Synthesis, pharmacologic activity, and structure-activity relationships of a series of propafenone-related modulators of multidrug resistance, J. Med. Chem. 38 (1995) 2789-2793.
    • (1995) J. Med. Chem. , vol.38 , pp. 2789-2793
    • Chiba, P.1    Burghofer, S.2    Richter, E.3    Tell, B.4    Moser, A.5    Ecker, G.6
  • 89
    • 0030449507 scopus 로고    scopus 로고
    • Structure-activity relationship studies on benzofuran analogs of propafenone-type modulators of tumor cell multidrug resistance
    • G. Ecker, P. Chiba, M. Hitzler, D. Schmid, K. Visser, H.P. Cordes, J. Csollei, J.K. Seydel, K.-J. Schaper, Structure-activity relationship studies on benzofuran analogs of propafenone-type modulators of tumor cell multidrug resistance, J. Med. Chem. 39 (1996) 4767-4774.
    • (1996) J. Med. Chem. , vol.39 , pp. 4767-4774
    • Ecker, G.1    Chiba, P.2    Hitzler, M.3    Schmid, D.4    Visser, K.5    Cordes, H.P.6    Csollei, J.7    Seydel, J.K.8    Schaper, K.-J.9
  • 90
    • 79953212556 scopus 로고    scopus 로고
    • Synthesis of some novel benzofuran-2-yl(4, 5-dihyro-3, 5-substituted diphenylpyrazol-1-yl) methanones and studies on the antiproliferative effects and reversal of multidrug resistance of human MDR1-gene transfected mouse lymphoma cells in vitro
    • S. Parekh, D. Bhavsar, M. Savant, S. Thakrar, A. Bavishi, M. Parmar, H. Vala, A. Radadiya, N. Pandya, J. Serly, J. Moln-ar, A. Shah, Synthesis of some novel benzofuran-2-yl(4, 5-dihyro-3, 5-substituted diphenylpyrazol-1-yl) methanones and studies on the antiproliferative effects and reversal of multidrug resistance of human MDR1-gene transfected mouse lymphoma cells in vitro, Eur. J. Med. Chem. 46 (2011) 1942-1948.
    • (2011) Eur. J. Med. Chem. , vol.46 , pp. 1942-1948
    • Parekh, S.1    Bhavsar, D.2    Savant, M.3    Thakrar, S.4    Bavishi, A.5    Parmar, M.6    Vala, H.7    Radadiya, A.8    Pandya, N.9    Serly, J.10    Moln-ar, J.11    Shah, A.12
  • 92
    • 79960371233 scopus 로고    scopus 로고
    • Identification of benzofuran-4, 5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase
    • C. Antczak, D. Shum, B. Bassit, M.G. Frattini, Y. Li, E. de Stanchina, D.A. Scheinberg, H. Djaballah, Identification of benzofuran-4, 5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase, Bioorg. Med. Chem. Lett. 21 (2011) 4528-4532.
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 4528-4532
    • Antczak, C.1    Shum, D.2    Bassit, B.3    Frattini, M.G.4    Li, Y.5    De Stanchina, E.6    Scheinberg, D.A.7    Djaballah, H.8
  • 93
    • 84879029662 scopus 로고    scopus 로고
    • Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors
    • M.E. Welker, G. Kulik, Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors, Bioorg. Med. Chem. 21 (2013) 4063-4091.
    • (2013) Bioorg. Med. Chem. , vol.21 , pp. 4063-4091
    • Welker, M.E.1    Kulik, G.2
  • 94
    • 84906819342 scopus 로고    scopus 로고
    • Biological function and inhibitors of mTOR: Research advances
    • S. Cao, W. Zhong, Biological function and inhibitors of mTOR: research advances, J. Int. Pharm. Res. 41 (2014) 6-20.
    • (2014) J. Int. Pharm. Res. , vol.41 , pp. 6-20
    • Cao, S.1    Zhong, W.2
  • 96
    • 0345736991 scopus 로고    scopus 로고
    • Restoring functions of tumor suppressors with small molecules
    • I. Smukste, B.R. Stockwell, Restoring functions of tumor suppressors with small molecules, Cancer Cell. 4 (2003) 419-420.
    • (2003) Cancer Cell. , vol.4 , pp. 419-420
    • Smukste, I.1    Stockwell, B.R.2
  • 99
    • 1642286980 scopus 로고    scopus 로고
    • Challenges in antimicrobial drug discovery and the potential of nucleoside antibiotics
    • S. Rachakonda, L. Cartee, Challenges in antimicrobial drug discovery and the potential of nucleoside antibiotics, Curr. Med. Chem. 11 (2004) 775-793.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 775-793
    • Rachakonda, S.1    Cartee, L.2
  • 100
    • 7244245763 scopus 로고    scopus 로고
    • Antibiotics at the crossroads
    • C. Nathan, Antibiotics at the crossroads, Nature 431 (2004) 899-902.
    • (2004) Nature , vol.431 , pp. 899-902
    • Nathan, C.1
  • 101
    • 63249115842 scopus 로고    scopus 로고
    • Epidemiological and resistance issues in multidrug-resistant staphylococci and enterococci
    • R. Leclercq, Epidemiological and resistance issues in multidrug-resistant staphylococci and enterococci, Clin. Microbiol. Infect. 15 (2009) 224-231.
    • (2009) Clin. Microbiol. Infect. , vol.15 , pp. 224-231
    • Leclercq, R.1
  • 102
    • 77955556522 scopus 로고    scopus 로고
    • Design, synthesis, and antitubercular evaluation of novel series of 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1-pyrazolylcarbonyl-4-oxo-naphthyridin analogs
    • K. Manna, Y.K. Agrawal, Design, synthesis, and antitubercular evaluation of novel series of 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1-pyrazolylcarbonyl-4-oxo-naphthyridin analogs, Eur. J. Med. Chem. 45 (2010) 3831-3839.
    • (2010) Eur. J. Med. Chem. , vol.45 , pp. 3831-3839
    • Manna, K.1    Agrawal, Y.K.2
  • 103
    • 69249087377 scopus 로고    scopus 로고
    • Synthesis, structure, and antimycobacterial activity of 6[1(3H)-isobenzofuranylidenemethyl] purines and analogs
    • M. BraEndvang, V. Bakken, L.-L. Gundersen, Synthesis, structure, and antimycobacterial activity of 6 [1(3H)-isobenzofuranylidenemethyl] purines and analogs, Bioorg. Med. Chem. Lett. 17 (2009) 6512-6516.
    • (2009) Bioorg. Med. Chem. Lett. , vol.17 , pp. 6512-6516
    • Braendvang, M.1    Bakken, V.2    Gundersen, L.-L.3
  • 104
    • 84857923972 scopus 로고    scopus 로고
    • Novel N-benzylidene benzofuran-3-carbohydrazide derivatives as antitubercular and antifungal agents
    • V.N. Telveka, A. Belubbi, V.K. Bairwa, K. Satardekar, Novel N-benzylidene benzofuran-3-carbohydrazide derivatives as antitubercular and antifungal agents, Bioorg. Med. Chem. Lett. 22 (2012) 2343-2346.
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 2343-2346
    • Telveka, V.N.1    Belubbi, A.2    Bairwa, V.K.3    Satardekar, K.4
  • 105
    • 84883489839 scopus 로고    scopus 로고
    • Design, synthesis and antitubercular evaluation of novel 2-substituted-3H-benzofuro benzofurans via palladiumecopper catalysed sonagashira coupling reaction
    • T. Yempala, J.P. Sridevi, P. Yogeeswari, D.S.S. Kantevari, Design, synthesis and antitubercular evaluation of novel 2-substituted-3H-benzofuro benzofurans via palladiumecopper catalysed sonagashira coupling reaction, Bioorg. Med. Chem. Lett. 23 (2013) 5393-5396.
    • (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 5393-5396
    • Yempala, T.1    Sridevi, J.P.2    Yogeeswari, P.3    Kantevari, D.S.S.4
  • 106
    • 82755189298 scopus 로고    scopus 로고
    • Synthesis, characterization, antimicrobial and enzymatic activity of 4b, 9b dihydroxy-7, 8-dihydro-4bHindeno[1, 2-b] benzofuran-9, 10 (6H, 9bH)-dione
    • S.H. Mehdi, R. Hashim, R.M. Ghalib, M. F-atima, C.G. da Silva, O. Sulaiman, S.Z. Rahman, V. Murugaiyah, M.M. Marimuthu, Synthesis, characterization, antimicrobial and enzymatic activity of 4b, 9b dihydroxy-7, 8-dihydro-4bHindeno [1, 2-b] benzofuran-9, 10 (6H, 9bH)-dione, J. Mol. Str. 1006 (2011) 318-323.
    • (2011) J. Mol. Str. , vol.1006 , pp. 318-323
    • Mehdi, S.H.1    Hashim, R.2    Ghalib, R.M.3    F-atima, M.4    Da Silva, C.G.5    Sulaiman, O.6    Rahman, S.Z.7    Murugaiyah, V.8    Marimuthu, M.M.9
  • 107
    • 38949201262 scopus 로고    scopus 로고
    • Synthesis and antimicrobial activity of some novel derivatives of benzofuran: Part 2. The synthesis and antimicrobial activity of some novel 1-(1-benzofuran-2-yl)-2 mesitylethanone derivatives
    • C. Kirilmis, M. Ahmedzade, S. Servi, M. Koca, A. Kizirgil, C. Kazaz, Synthesis and antimicrobial activity of some novel derivatives of benzofuran: Part 2. The synthesis and antimicrobial activity of some novel 1-(1-benzofuran-2-yl)-2 mesitylethanone derivatives, Eur. J. Med. Chem. 43 (2008) 300-308.
    • (2008) Eur. J. Med. Chem. , vol.43 , pp. 300-308
    • Kirilmis, C.1    Ahmedzade, M.2    Servi, S.3    Koca, M.4    Kizirgil, A.5    Kazaz, C.6
  • 109
    • 64249130496 scopus 로고    scopus 로고
    • Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4, 5-dihydro-5-aryl-1[4-(aryl)-1, 3-thiazol-2-yl]-1H-pyrazoles
    • B.F. Abdel-Wahab, H.A. Abdel-Aziz, E.M. Ahmed, Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4, 5-dihydro-5-aryl-1 [4-(aryl)-1, 3-thiazol-2-yl]-1H-pyrazoles, Eur. J. Med. Chem. 44 (2009) 2632-2635.
    • (2009) Eur. J. Med. Chem. , vol.44 , pp. 2632-2635
    • Abdel-Wahab, B.F.1    Abdel-Aziz, H.A.2    Ahmed, E.M.3
  • 110
    • 84864405534 scopus 로고    scopus 로고
    • Synthesis and antimicrobial evaluation of 3-methanone-6-substituted benzofuran derivatives
    • J. Liu, F. Jiang, X. Jiang, W. Zhang, J. Liu, W. Liu, L. Fu, Synthesis and antimicrobial evaluation of 3-methanone-6-substituted benzofuran derivatives, Eur. J. Med. Chem. 54 (2012) 879-886.
    • (2012) Eur. J. Med. Chem. , vol.54 , pp. 879-886
    • Liu, J.1    Jiang, F.2    Jiang, X.3    Zhang, W.4    Liu, J.5    Liu, W.6    Fu, L.7
  • 111
    • 65449125022 scopus 로고    scopus 로고
    • Microwave assisted synthesis of new indophenazine 1, 3, 5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity
    • K. Manna, Y.K. Agrawal, Microwave assisted synthesis of new indophenazine 1, 3, 5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity, Bioorg. Med. Chem. Lett. 19 (2009) 2688-2692.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2688-2692
    • Manna, K.1    Agrawal, Y.K.2
  • 114
    • 84885040680 scopus 로고    scopus 로고
    • Synthesis and antiproliferative activity of benzofuran-based analogs of cercosporamide against non-small cell lung cancer cell lines
    • M.-A. Bazin, L. Bodero, C. Tomasoni, B. Rousseau, C. Roussakis, P. Marchand, Synthesis and antiproliferative activity of benzofuran-based analogs of cercosporamide against non-small cell lung cancer cell lines, Eur. J. Med. Chem. 69 (2013) 823-832.
    • (2013) Eur. J. Med. Chem. , vol.69 , pp. 823-832
    • Bazin, M.-A.1    Bodero, L.2    Tomasoni, C.3    Rousseau, B.4    Roussakis, C.5    Marchand, P.6
  • 115
    • 33748259292 scopus 로고    scopus 로고
    • Regioselective suzuki coupling of benzofuran or benzothiophene boronic acids and dibromo substituted naphthalenes: Synthesis of a potent inhibitor of plasminogen activator inhibitor-1
    • Z. Wang, H. Elokdah, G. McFarlane, S. Pan, M. Antane, Regioselective suzuki coupling of benzofuran or benzothiophene boronic acids and dibromo substituted naphthalenes: synthesis of a potent inhibitor of plasminogen activator inhibitor-1, Tetrahedron Lett. 47 (2006) 3365-3369.
    • (2006) Tetrahedron Lett. , vol.47 , pp. 3365-3369
    • Wang, Z.1    Elokdah, H.2    McFarlane, G.3    Pan, S.4    Antane, M.5
  • 116
  • 117
    • 33746742482 scopus 로고    scopus 로고
    • Synthesis and antifungal activities of some aryl[3-(imidazol-1-yl/triazol-1-ylmethyl) benzofuran-2-yl] ketoximes
    • N. Gundogdu-Karaburun, K. Benkli, Y. Tunali, U. Ucucu, S. Demirayak, Synthesis and antifungal activities of some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl) benzofuran-2-yl] ketoximes, Eur. J. Med. Chem. 41 (2006) 651-656.
    • (2006) Eur. J. Med. Chem. , vol.41 , pp. 651-656
    • Gundogdu-Karaburun, N.1    Benkli, K.2    Tunali, Y.3    Ucucu, U.4    Demirayak, S.5
  • 118
    • 70449642410 scopus 로고    scopus 로고
    • Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones
    • H.A. Abdel-Aziz, A.A.I. Mekawey, Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones, Eur. J. Med. Chem. 44 (2009) 4985-4997.
    • (2009) Eur. J. Med. Chem. , vol.44 , pp. 4985-4997
    • Abdel-Aziz, H.A.1    Mekawey, A.A.I.2
  • 119
    • 84873996112 scopus 로고    scopus 로고
    • Synthesis and antimicrobial activity of Coumarin pyrazole pyrimidine 2, 4, 6(1H, 3H, 5H) triones and thioxopyrimidine-4, 6(1H, 5H) diones
    • S.V. Laxmi, B.S. Kuarm, B. Rajitha, Synthesis and antimicrobial activity of Coumarin pyrazole pyrimidine 2, 4, 6(1H, 3H, 5H) triones and thioxopyrimidine-4, 6(1H, 5H) diones, Med. Chem. Res. 22 (2012) 768-774.
    • (2012) Med. Chem. Res. , vol.22 , pp. 768-774
    • Laxmi, S.V.1    Kuarm, B.S.2    Rajitha, B.3
  • 120
    • 84898924793 scopus 로고    scopus 로고
    • Synthesis antimicrobial, and antioxidant activity of benzofuran barbitone and benzofuran thiobarbitone derivatives
    • R. Kenchappa, Y.D. Bodke, B. Asha, S. Telkar, M.A. Sindhe, Synthesis, antimicrobial, and antioxidant activity of benzofuran barbitone and benzofuran thiobarbitone derivatives, Med. Chem. Res. 23 (2014) 3065-3081.
    • (2014) Med. Chem. Res. , vol.23 , pp. 3065-3081
    • Kenchappa, R.1    Bodke, Y.D.2    Asha, B.3    Telkar, S.4    Sindhe, M.A.5
  • 123
    • 84873701204 scopus 로고    scopus 로고
    • Efficient synthesis of 3H, 3H-spiro [benzofuran-2, 10-isobenzofuran]-3, 3-dione as novel skeletons specifically for influenza virus type B inhibition
    • Y. Malpani, R. Achary, S.Y. Kim, H.C. Jeong, P. Kim, S.B. Han, M. Kim, C.-K. Lee, J.N. Kim, Y.-S. Jung, Efficient synthesis of 3H, 3H-spiro [benzofuran-2, 10-isobenzofuran]-3, 3-dione as novel skeletons specifically for influenza virus type B inhibition, Eur. J. Med. Chem. 62 (2013) 534-544.
    • (2013) Eur. J. Med. Chem. , vol.62 , pp. 534-544
    • Malpani, Y.1    Achary, R.2    Kim, S.Y.3    Jeong, H.C.4    Kim, P.5    Han, S.B.6    Kim, M.7    Lee, C.-K.8    Kim, J.N.9    Jung, Y.-S.10
  • 124
    • 84907857581 scopus 로고    scopus 로고
    • Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease
    • L. Huang, H. Miao, Y. Sun, F. Meng, X. Li, Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease, Eur. J. Med. Chem. 87 (2014) 429-439;
    • (2014) Eur. J. Med. Chem. , vol.87 , pp. 429-439
    • Huang, L.1    Miao, H.2    Sun, Y.3    Meng, F.4    Li, X.5
  • 126
    • 84875354777 scopus 로고    scopus 로고
    • Alzheimer's Association, 2013 Alzheimer's disease facts and figures
    • W. Thies, L. Bleiler, Alzheimer's Association, 2013 Alzheimer's disease facts and figures, Alzheimers Dement. 9 (2013) 208-245;
    • (2013) Alzheimers Dement. , vol.9 , pp. 208-245
    • Thies, W.1    Bleiler, L.2
  • 128
    • 84859755505 scopus 로고    scopus 로고
    • Alzheimer's disease and the amyloid cascade hypothesis: A critical review
    • R. Christiane, Alzheimer's disease and the amyloid cascade hypothesis: a critical review, Int. J. Alzheimers Dis. 2012 (2012) 1-11;
    • (2012) Int. J. Alzheimers Dis. , vol.2012 , pp. 1-11
    • Christiane, R.1
  • 129
    • 18244389436 scopus 로고    scopus 로고
    • The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease
    • S. Gandy, The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease, J. Clin. Invest 115 (2005) 1121-1129.
    • (2005) J. Clin. Invest , vol.115 , pp. 1121-1129
    • Gandy, S.1
  • 130
    • 80054024011 scopus 로고    scopus 로고
    • Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders
    • M. Jucker, L.C. Walker, Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders, Ann. Neurol. 70 (2011) 532-540;
    • (2011) Ann. Neurol. , vol.70 , pp. 532-540
    • Jucker, M.1    Walker, L.C.2
  • 131
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • J. Hardy, D.J. Selkoe, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science 297 (2002) 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 132
    • 84907818449 scopus 로고    scopus 로고
    • Structure-activity relationships of sugar-based peptidomimetics as modulators of amyloid b-peptide early oligomerization and fibrillization
    • J. Kaffy, D. Brinet, J.-L. Soulier, L. Khemtemourian, O. Lequin, M. Taverna, B. Crousse, S. Ongeri, Structure-activity relationships of sugar-based peptidomimetics as modulators of amyloid b-peptide early oligomerization and fibrillization, Eur. J. Med. Chem. 86 (2014) 752-758;
    • (2014) Eur. J. Med. Chem. , vol.86 , pp. 752-758
    • Kaffy, J.1    Brinet, D.2    Soulier, J.-L.3    Khemtemourian, L.4    Lequin, O.5    Taverna, M.6    Crousse, B.7    Ongeri, S.8
  • 133
    • 57149145222 scopus 로고    scopus 로고
    • The ratio of monomeric to aggregated forms of Ab40 and Ab42 is an important determinant of amyloidb aggregation, fibrillogenesis, and toxicity
    • A. Jan, O. Gokce, R. Luthi-Carter, H.A. Lashuel, The ratio of monomeric to aggregated forms of Ab40 and Ab42 is an important determinant of amyloidb aggregation, fibrillogenesis, and toxicity, J. Biol. Chem. 283 (2008) 28176-28189;
    • (2008) J. Biol. Chem. , vol.283 , pp. 28176-28189
    • Jan, A.1    Gokce, O.2    Luthi-Carter, R.3    Lashuel, H.A.4
  • 134
    • 0037473750 scopus 로고    scopus 로고
    • Prevention of transthyretin amyloid disease by changing protein misfolding energetic
    • P. Hammarstrom, R.L. Wiseman, E.T. Powers, J.W. Kelly, Prevention of transthyretin amyloid disease by changing protein misfolding energetic, Science 299 (2003) 713-716.
    • (2003) Science , vol.299 , pp. 713-716
    • Hammarstrom, P.1    Wiseman, R.L.2    Powers, E.T.3    Kelly, J.W.4
  • 135
    • 0027526419 scopus 로고
    • Release of excess amyloid beta protein from a mutant amyloid beta protein precursor
    • X.D. Cai, T.E. Golde, S.G. Younkin, Release of excess amyloid beta protein from a mutant amyloid beta protein precursor, Science 259 (1993) 514-516.
    • (1993) Science , vol.259 , pp. 514-516
    • Cai, X.D.1    Golde, T.E.2    Younkin, S.G.3
  • 136
    • 84905179397 scopus 로고    scopus 로고
    • Nanoliposomes presenting on surface a cis-glycofused benzopyran compound display binding affinity and aggregation inhibition ability towards amyloid b1-42 peptide
    • C. Airoldi, S. Mourtas, F. Cardona, C. Zona, E. Sironi, G. D'Orazio, E. Markoutsa, F. Nicotra, S.G. Antimisiaris, B.L. Ferla, Nanoliposomes presenting on surface a cis-glycofused benzopyran compound display binding affinity and aggregation inhibition ability towards amyloid b1-42 peptide, Eur. J. Med. Chem. 85 (2014) 43-50;
    • (2014) Eur. J. Med. Chem. , vol.85 , pp. 43-50
    • Airoldi, C.1    Mourtas, S.2    Cardona, F.3    Zona, C.4    Sironi, E.5    D'Orazio, G.6    Markoutsa, E.7    Nicotra, F.8    Antimisiaris, S.G.9    Ferla, B.L.10
  • 139
    • 84949115587 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer's disease
    • N. Jiang, S.-Y. Li, S.-S. Xie, Z.-R. Li, K.D.G. Wang, X.-B. Wang, L.-Y. Kong, Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer's disease, Eur. J. Med. Chem. 87 (2014) 540-551;
    • (2014) Eur. J. Med. Chem. , vol.87 , pp. 540-551
    • Jiang, N.1    Li, S.-Y.2    Xie, S.-S.3    Li, Z.-R.4    Wang, K.D.G.5    Wang, X.-B.6    Kong, L.-Y.7
  • 140
    • 84905437056 scopus 로고    scopus 로고
    • Development of dual targeting inhibitors against aggregations of amyloid-b and tau protein
    • S. Fuse, K.M.Y. Fujita, H. Sugimoto, T. Takahashi, Development of dual targeting inhibitors against aggregations of amyloid-b and tau protein, Eur. J. Med. Chem. 85 (2014) 228-234;
    • (2014) Eur. J. Med. Chem. , vol.85 , pp. 228-234
    • Fuse, S.1    Fujita, K.M.Y.2    Sugimoto, H.3    Takahashi, T.4
  • 141
    • 0031915681 scopus 로고    scopus 로고
    • A substrate-based difluoro ketone selectively inhibits Alzheimer's g-secretase activity
    • M.S. Wolfe, M. Citron, T.S. Diehl, W. Xia, I.O. Donkor, D.J. Selkoe, A substrate-based difluoro ketone selectively inhibits Alzheimer's g-secretase activity, J. Med. Chem. 41 (1998) 6-9.
    • (1998) J. Med. Chem. , vol.41 , pp. 6-9
    • Wolfe, M.S.1    Citron, M.2    Diehl, T.S.3    Xia, W.4    Donkor, I.O.5    Selkoe, D.J.6
  • 143
    • 84908040362 scopus 로고    scopus 로고
    • Radiolabeled bioactive benzoheterocycles for imaging bamyloid plaques in Alzheimer's disease
    • Y. Yang, M. Cui, Radiolabeled bioactive benzoheterocycles for imaging bamyloid plaques in Alzheimer's disease, Eur. J. Med. Chem. 87 (2014) 703-721;
    • (2014) Eur. J. Med. Chem. , vol.87 , pp. 703-721
    • Yang, Y.1    Cui, M.2
  • 144
    • 0033869349 scopus 로고    scopus 로고
    • Imaging Alzheimer's amyloid
    • D.J. Selkoe, Imaging Alzheimer's amyloid, Nat. Biotechnol. 18 (2000) 823-824.
    • (2000) Nat. Biotechnol. , vol.18 , pp. 823-824
    • Selkoe, D.J.1
  • 145
    • 2342446265 scopus 로고    scopus 로고
    • Imaging b-amyloid plaques and neurofibrillary tangles in the aging human brain
    • C.A. Mathis, Y. Wang, W.E. Klunk, Imaging b-amyloid plaques and neurofibrillary tangles in the aging human brain, Curr. Pharm. Des. 10 (2004) 1469-1492.
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 1469-1492
    • Mathis, C.A.1    Wang, Y.2    Klunk, W.E.3
  • 146
    • 4644283049 scopus 로고    scopus 로고
    • PET imaging of amyloid in Alzheimer's disease
    • A. Nordberg, PET imaging of amyloid in Alzheimer's disease, Lancet Neurol. 3 (2004) 519-527.
    • (2004) Lancet Neurol. , vol.3 , pp. 519-527
    • Nordberg, A.1
  • 147
    • 77958092259 scopus 로고    scopus 로고
    • Fluorinated benzofuran derivatives for PET imaging of b-amyloid plaques in Alzheimer's disease brains
    • Y. Cheng, M. Ono, H. Kimura, S. Kagawa, R. Nishii, H. Kawashima, H. Saji, Fluorinated benzofuran derivatives for PET imaging of b-amyloid plaques in Alzheimer's disease brains, Med. Chem. Lett. 1 (2010) 321-325.
    • (2010) Med. Chem. Lett. , vol.1 , pp. 321-325
    • Cheng, Y.1    Ono, M.2    Kimura, H.3    Kagawa, S.4    Nishii, R.5    Kawashima, H.6    Saji, H.7
  • 148
    • 77956941977 scopus 로고    scopus 로고
    • A novel 18F-labeled pyridyl benzofuran derivative for imaging of b-amyloid plaques in Alzheimer's brains
    • Y. Cheng, M. Ono, H. Kimura, S. Kagawa, R. Nishii, H. Saji, A novel 18F-labeled pyridyl benzofuran derivative for imaging of b-amyloid plaques in Alzheimer's brains, Bioorg. Med. Chem. Lett. 20 (2010) 6141-6144.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 6141-6144
    • Cheng, Y.1    Ono, M.2    Kimura, H.3    Kagawa, S.4    Nishii, R.5    Saji, H.6
  • 149
    • 84858057477 scopus 로고    scopus 로고
    • Technetium-99m labeled pyridyl benzofuran derivatives as single photon emission computed tomography imaging probes for b-amyloid plaques in Alzheimer's brains
    • Y. Cheng, M. Ono, H. Kimura, M. Ueda, H. Saji, Technetium-99m labeled pyridyl benzofuran derivatives as single photon emission computed tomography imaging probes for b-amyloid plaques in Alzheimer's brains, J. Med. Chem. 55 (2012) 2279-2286.
    • (2012) J. Med. Chem. , vol.55 , pp. 2279-2286
    • Cheng, Y.1    Ono, M.2    Kimura, H.3    Ueda, M.4    Saji, H.5
  • 150
    • 0027398576 scopus 로고
    • Hypotensive effect of losartan, a nonpeptide angiotensin II receptor antagonist, in essential hypertension
    • K. Tsunoda, K. Abe, T. Hagino, K. Omata, S. Misawa, Y. Imai, K. Yoshinaga, Hypotensive effect of losartan, a nonpeptide angiotensin II receptor antagonist, in essential hypertension, Am. J. Hyperfens 6 (1993) 28-32.
    • (1993) Am. J. Hyperfens , vol.6 , pp. 28-32
    • Tsunoda, K.1    Abe, K.2    Hagino, T.3    Omata, K.4    Misawa, S.5    Imai, Y.6    Yoshinaga, K.7
  • 154
    • 84901734869 scopus 로고    scopus 로고
    • Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: Design, synthesis and evaluation as potential anti-inflammatory agents
    • G.S. Hassan, S.M. Abou-Seri, G. Kamel, M.M. Ali, Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: design, synthesis and evaluation as potential anti-inflammatory agents, Eur. J. Med. Chem. 76 (2014) 482-493.
    • (2014) Eur. J. Med. Chem. , vol.76 , pp. 482-493
    • Hassan, G.S.1    Abou-Seri, S.M.2    Kamel, G.3    Ali, M.M.4
  • 155
    • 84899535265 scopus 로고    scopus 로고
    • Design, synthesis, docking and antiinflammatory evaluation of novel series of benzofuran based prodrugs
    • P. Yadav, P. Singh, A.K. Tewari, Design, synthesis, docking and antiinflammatory evaluation of novel series of benzofuran based prodrugs, Bioorg. Med. Chem. Lett. 24 (2014) 2251-2255.
    • (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 2251-2255
    • Yadav, P.1    Singh, P.2    Tewari, A.K.3
  • 157
    • 0020600608 scopus 로고
    • Immunochemical evidence for the involvement of prostaglandin H synthase in hydroperoxidedependent oxidations by ram seminal vesicle microsomes
    • W.R. Pagels, R.J. Sachs, L.J. Marnett, D.L. Dewitt, W.L. Smith, Immunochemical evidence for the involvement of prostaglandin H synthase in hydroperoxidedependent oxidations by ram seminal vesicle microsomes, J. Biol. Chem. 258 (1983) 6517-6523.
    • (1983) J. Biol. Chem. , vol.258 , pp. 6517-6523
    • Pagels, W.R.1    Sachs, R.J.2    Marnett, L.J.3    Dewitt, D.L.4    Smith, W.L.5
  • 158
    • 0017091041 scopus 로고
    • Mechanism for irreversible selfdeactivation of prostaglandin synthetase
    • R.W. Egan, J. Paxton, F.A. Kuehl Jr., Mechanism for irreversible selfdeactivation of prostaglandin synthetase, J. Biol. Chem. 251 (1976) 7329-7335.
    • (1976) J. Biol. Chem. , vol.251 , pp. 7329-7335
    • Egan, R.W.1    Paxton, J.2    Kuehl, F.A.3
  • 159
    • 67249094291 scopus 로고
    • Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs
    • C.A. Winter, E.A. Risely, G.W. Nuss, Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs, Proc. Soc. Exp. Biol. Med. 111 (1962) 544-547.
    • (1962) Proc. Soc. Exp. Biol. Med. , vol.111 , pp. 544-547
    • Winter, C.A.1    Risely, E.A.2    Nuss, G.W.3
  • 160
    • 0002261078 scopus 로고
    • A method for determining loss of pain sensation
    • F.E. D'amour, D.L. Smith, A method for determining loss of pain sensation, J. Pharmacol. Exp. Ther. 72 (1941) 74-79.
    • (1941) J. Pharmacol. Exp. Ther. , vol.72 , pp. 74-79
    • D'Amour, F.E.1    Smith, D.L.2
  • 162
    • 70450225514 scopus 로고    scopus 로고
    • Endothelial activation inflammation and premature atherosclerosis in children with familial dyslipidemia
    • O. Guardamagna, F. Abello, P. Saracco, V. Baracco, E. Rolfo, M. Pirro, Endothelial activation, inflammation and premature atherosclerosis in children with familial dyslipidemia, Atherosclerosis 207 (2009) 471-475.
    • (2009) Atherosclerosis , vol.207 , pp. 471-475
    • Guardamagna, O.1    Abello, F.2    Saracco, P.3    Baracco, V.4    Rolfo, E.5    Pirro, M.6
  • 163
    • 84872054233 scopus 로고    scopus 로고
    • Executive summary: Heart disease and stroke statistics-2013 Update: A report from the American Heart Association
    • A.S. Go, D. Mozaffarian, V.L. Roger, E.J. Benjamin, J.D. Berry, W.B. Borden, et al., Executive summary: heart disease and stroke statistics-2013 Update: a report from the American Heart Association, Circulation 127 (2013) 143-152.
    • (2013) Circulation , vol.127 , pp. 143-152
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3    Benjamin, E.J.4    Berry, J.D.5    Borden, W.B.6
  • 164
    • 33846961821 scopus 로고    scopus 로고
    • Differential effects of oral hypoglycemic agents on glucose control and cardiovascular risk
    • G.I. Uwaifo, R.E. Ratner, Differential effects of oral hypoglycemic agents on glucose control and cardiovascular risk, Am. J. Cardiol. 99 (2006) 51-67;
    • (2006) Am. J. Cardiol. , vol.99 , pp. 51-67
    • Uwaifo, G.I.1    Ratner, R.E.2
  • 166
    • 46849105477 scopus 로고    scopus 로고
    • Emerging antidyslipidemic drugs, expert opin
    • R.L. Pollex, T.R. Joy, R.A. Hegele, Emerging antidyslipidemic drugs, expert opin, Emerg. Drugs 13 (2008) 363-381.
    • (2008) Emerg. Drugs , vol.13 , pp. 363-381
    • Pollex, R.L.1    Joy, T.R.2    Hegele, R.A.3
  • 167
    • 77951609723 scopus 로고    scopus 로고
    • AMP-Activated protein kinase (AMPK) activation by benzofurans and coumestans isolated from erythrina abyssinica
    • P.-H. Nguyen, T.-N.-A. Nguyen, T.-T. Dao, H.-W. Kang, D.-T. Ndinteh, J.-T. Mbafor, W.-K. Oh, AMP-Activated protein kinase (AMPK) activation by benzofurans and coumestans isolated from erythrina abyssinica, J. Nat. Prod. 73 (2010) 598-602.
    • (2010) J. Nat. Prod. , vol.73 , pp. 598-602
    • Nguyen, P.-H.1    Nguyen, T.-N.-A.2    Dao, T.-T.3    Kang, H.-W.4    Ndinteh, D.-T.5    Mbafor, J.-T.6    Oh, W.-K.7
  • 168
    • 84861313755 scopus 로고    scopus 로고
    • In vivo antihyperlipidemic activity of new series of N-(Benzoylphenyl) and N-(Acetylphenyl)-1-benzofuran-2-carboxamides in Rats
    • T. Al-Qirim, G. Shattat, K. Sweidan, W. El-Huneidi, G. Abu Sheikha, K. Reema Abu, S. Hikmat, In vivo antihyperlipidemic activity of new series of N-(Benzoylphenyl) and N-(Acetylphenyl)-1-benzofuran-2-carboxamides in Rats, Arch. Pharm. 345 (2012) 401-406.
    • (2012) Arch. Pharm. , vol.345 , pp. 401-406
    • Al-Qirim, T.1    Shattat, G.2    Sweidan, K.3    El-Huneidi, W.4    Abu Sheikha, G.5    Reema Abu, K.6    Hikmat, S.7
  • 169
    • 84881531754 scopus 로고    scopus 로고
    • Hybrid benzofuranebisindole derivatives: New prototypes with promising antihyperlipidemic activities
    • K.V. Sashidhara, R.K. Modukuri, R. Sonkar, K.B. Rao, G. Bhatia, Hybrid benzofuranebisindole derivatives: new prototypes with promising antihyperlipidemic activities, Eur. J. Med. Chem. 68 (2013) 38-46.
    • (2013) Eur. J. Med. Chem. , vol.68 , pp. 38-46
    • Sashidhara, K.V.1    Modukuri, R.K.2    Sonkar, R.3    Rao, K.B.4    Bhatia, G.5
  • 170
    • 0038077495 scopus 로고    scopus 로고
    • Therapeutic role of peroxisome proliferator-activated receptors in obesity, diabetes and inflammation
    • V.J. Ram, Therapeutic role of peroxisome proliferator-activated receptors in obesity, diabetes and inflammation, Prog. Drug Res. 60 (2003) 93-132;
    • (2003) Prog. Drug Res. , vol.60 , pp. 93-132
    • Ram, V.J.1
  • 171
    • 0038460622 scopus 로고    scopus 로고
    • Thiazolidinediones in type 2 diabetes mellitus: Current clinical evidence
    • M. Diamant, R.J. Heine, Thiazolidinediones in type 2 diabetes mellitus: current clinical evidence, Drugs 63 (2003) 1373-1405.
    • (2003) Drugs , vol.63 , pp. 1373-1405
    • Diamant, M.1    Heine, R.J.2
  • 172
    • 0033397879 scopus 로고    scopus 로고
    • Role of protein tyrosine phosphatase-1B in diabetes and obesity
    • B.P. Kennedy, Role of protein tyrosine phosphatase-1B in diabetes and obesity, Biomed. Pharmacother. 53 (1999) 466-470.
    • (1999) Biomed. Pharmacother. , vol.53 , pp. 466-470
    • Kennedy, B.P.1
  • 176
    • 77953710854 scopus 로고    scopus 로고
    • Targeting the endothelin receptor in prostate cancer bone metastasis: Back to the mouse
    • M. Roh, S.A. Abdulkadir, Targeting the endothelin receptor in prostate cancer bone metastasis: back to the mouse Cancer Biol. Ther. 9 (8) (2010) 615-617.
    • (2010) Cancer Biol. Ther. , vol.9 , Issue.8 , pp. 615-617
    • Roh, M.1    Abdulkadir, S.A.2
  • 177
    • 77954816333 scopus 로고    scopus 로고
    • Carotid atherosclerosis in elderly hypertensive patients: Potential role of endothelin and plasma antioxidant capacity
    • A.B. Skalska, T. Grodzicki, Carotid atherosclerosis in elderly hypertensive patients: potential role of endothelin and plasma antioxidant capacity, J. Hum. Hypertens. 24 (2010) 538-544.
    • (2010) J. Hum. Hypertens. , vol.24 , pp. 538-544
    • Skalska, A.B.1    Grodzicki, T.2
  • 178
    • 33845988009 scopus 로고    scopus 로고
    • Endothelin receptor antagonism in pulmonary arterial hypertension-A role for selective ET(A) inhibition
    • A. Jacobs, I.R. Preston, M.G.-Maitland, Endothelin receptor antagonism in pulmonary arterial hypertension-a role for selective ET(A) inhibition Curr. Med. Res. Opin. 22 (2006) 2567-2574.
    • (2006) Curr. Med. Res. Opin. , vol.22 , pp. 2567-2574
    • Jacobs, A.1    Preston, I.R.2    Maitland, M.G.3
  • 179
    • 0028183016 scopus 로고
    • International union of pharmacology nomenclature of endothelin receptors
    • T. Masaki, J.R. Vane, P.M. Vanhoutte, International union of pharmacology nomenclature of endothelin receptors, Pharmacol. Rev. 46 (1994) 137-142.
    • (1994) Pharmacol. Rev. , vol.46 , pp. 137-142
    • Masaki, T.1    Vane, J.R.2    Vanhoutte, P.M.3
  • 181
    • 84887430174 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of benzofuran derivatives as et receptor antagonists
    • J. Cai, J. Chen, M. Cao, P. Wang, C. Feng, M. Ji, Design, synthesis, and biological evaluation of benzofuran derivatives as ET receptor antagonists, Med. Chem. Res. 22 (2013) 5472-5480.
    • (2013) Med. Chem. Res. , vol.22 , pp. 5472-5480
    • Cai, J.1    Chen, J.2    Cao, M.3    Wang, P.4    Feng, C.5    Ji, M.6
  • 182
    • 33750046289 scopus 로고    scopus 로고
    • CPU0507, an endothelin receptor antagonist, improves rat hypoxic pulmonary artery hypertension and constriction in vivo and in vitro
    • S.H. Yuan, D.Z. Dai, L. Guan, Y. Dai, M. Ji, CPU0507, an endothelin receptor antagonist, improves rat hypoxic pulmonary artery hypertension and constriction in vivo and in vitro, Clin. Exp. Pharmacol. Physiol. 33 (2006) 1066-1072.
    • (2006) Clin. Exp. Pharmacol. Physiol. , vol.33 , pp. 1066-1072
    • Yuan, S.H.1    Dai, D.Z.2    Guan, L.3    Dai, Y.4    Ji, M.5
  • 183
    • 84856918822 scopus 로고    scopus 로고
    • The therapeutic potential of GPR119 agonists for type 2 diabetes
    • T. Ohishi, S. Yoshida, The therapeutic potential of GPR119 agonists for type 2 diabetes, Expert Opin. Investig. Drugs 21 (2012) 321-328;
    • (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 321-328
    • Ohishi, T.1    Yoshida, S.2
  • 184
    • 78649429500 scopus 로고    scopus 로고
    • The emergence of GPR119 agonists as antidiabetic agents
    • Jones, J.N. Leonard, The emergence of GPR119 agonists as antidiabetic agents, Annu. Rep. Med. Chem. 44 (2009) 149-170.
    • (2009) Annu. Rep. Med. Chem. , vol.44 , pp. 149-170
    • Jones, J.N.L.1
  • 185
    • 84859069133 scopus 로고    scopus 로고
    • Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways
    • L. Lan, H.V. Lin, C.F. Wang, M.J. Wright, S. Xu, L. Kang, K. Juhl, J.A. Hedrick, T.J. Kowalski, Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways, Br. J. Pharmacol. 165 (2012) 2799-2807.
    • (2012) Br. J. Pharmacol. , vol.165 , pp. 2799-2807
    • Lan, L.1    Lin, H.V.2    Wang, C.F.3    Wright, M.J.4    Xu, S.5    Kang, L.6    Juhl, K.7    Hedrick, J.A.8    Kowalski, T.J.9
  • 187
    • 40349114501 scopus 로고    scopus 로고
    • GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity
    • H.A. Overton, M.C.T. Fyfe, C. Reynet, GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity, Br. J. Pharmacol. 153 (2008) S76-S81.
    • (2008) Br. J. Pharmacol. , vol.153 , pp. S76-S81
    • Overton, H.A.1    Fyfe, M.C.T.2    Reynet, C.3
  • 189
    • 84937460572 scopus 로고    scopus 로고
    • Thomas Pharma® drug report
    • Thomas Pharma® drug report (http://drugnews.thomsonpharma.com/ddn/home.do);
  • 192
    • 84937460575 scopus 로고    scopus 로고
    • PSN821 Structure Has Not Been Disclosed. Its Close Lead PSN408 Was Disclosed Minnesota, MN, June 6-9 oral session 2
    • PSN821 Structure Has Not Been Disclosed. Its Close Lead PSN408 Was Disclosed, See the 32nd Annual National Medicinal Chemistry Symposium, Minnesota, MN, June 6-9, 2010 oral session 2.
    • (2010) 32nd Annual National Medicinal Chemistry Symposium
  • 193
    • 80054988309 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-38431055, a novel GPR119 receptor agonist and potential antidiabetes agent, in healthy male subjects
    • L.B. Katz, J.J. Gambale, P.L. Rothenberg, S.R. Vanapalli, N. Vaccaro, L. Xi, D.C. Polidori, E. Vets, T.C. Sarich, P.P. Stein, Pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-38431055, a novel GPR119 receptor agonist and potential antidiabetes agent, in healthy male subjects, Clin. Pharmacol. Ther. 90 (2011) 685-692;
    • (2011) Clin. Pharmacol. Ther. , vol.90 , pp. 685-692
    • Katz, L.B.1    Gambale, J.J.2    Rothenberg, P.L.3    Vanapalli, S.R.4    Vaccaro, N.5    Xi, L.6    Polidori, D.C.7    Vets, E.8    Sarich, T.C.9    Stein, P.P.10
  • 194
    • 84863307279 scopus 로고    scopus 로고
    • Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes
    • L.B. Katz, J.J. Gambale, P.L. Rothenberg, S.R. Vanapalli, N. Vaccaro, L. Xi, T.C. Sarich, P.P. Stein, Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes, Diabetes Obes. Metab. 14 (2012) 709-716.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 709-716
    • Katz, L.B.1    Gambale, J.J.2    Rothenberg, P.L.3    Vanapalli, S.R.4    Vaccaro, N.5    Xi, L.6    Sarich, T.C.7    Stein, P.P.8
  • 196
    • 0037027939 scopus 로고    scopus 로고
    • Inhaled P2-2 receptor agonists as a treatment for patients with cystic fibrosis lung disease
    • D. Kellerman, R. Evans, D. Mathews, C. Shaffer, Inhaled P2-2 receptor agonists as a treatment for patients with cystic fibrosis lung disease, Adv. Drug Deliv. Rev. 54 (2002) 1463-1473.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1463-1473
    • Kellerman, D.1    Evans, R.2    Mathews, D.3    Shaffer, C.4
  • 199
    • 0036245650 scopus 로고    scopus 로고
    • 2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3', 5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist
    • J.L. Boyer, M. Adams, R.G. Ravi, K.A. Jacobson, T.K. Harden, 2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3', 5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist, Br. J. Pharmacol. 135 (2002) 2004-2010.
    • (2002) Br. J. Pharmacol. , vol.135 , pp. 2004-2010
    • Boyer, J.L.1    Adams, M.2    Ravi, R.G.3    Jacobson, K.A.4    Harden, T.K.5
  • 202
    • 77951073508 scopus 로고    scopus 로고
    • Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
    • J. Chun, H. Hartung, Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis, Clin. Neuropharmacol. 33 (2010) 91-101.
    • (2010) Clin. Neuropharmacol. , vol.33 , pp. 91-101
    • Chun, J.1    Hartung, H.2
  • 204
    • 33645283403 scopus 로고    scopus 로고
    • FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T Cell infiltration
    • H. Kataoka, K. Sugahara, K. Shimano, K. Teshima, M. Koyama, A. Fukunari, K. Chiba, FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T Cell infiltration, Cell. Mol. Immunol. 2 (2005) 439-448.
    • (2005) Cell. Mol. Immunol. , vol.2 , pp. 439-448
    • Kataoka, H.1    Sugahara, K.2    Shimano, K.3    Teshima, K.4    Koyama, M.5    Fukunari, A.6    Chiba, K.7
  • 205
    • 33947168769 scopus 로고    scopus 로고
    • Translation of a novel mechanism into clinical benefit in multiple sclerosis
    • T. Baumruker, A. Billich, V. Brinkmann, Translation of a novel mechanism into clinical benefit in multiple sclerosis, Expert Opin. Invest. Drugs 16 (2007) 283-289.
    • (2007) Expert Opin. Invest. Drugs , vol.16 , pp. 283-289
    • Baumruker, T.1    Billich, A.2    Brinkmann, V.3
  • 206
    • 33745124738 scopus 로고    scopus 로고
    • Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus
    • K. Chiba, H. Matsuyuki, Y. Maeda, K. Sugahara, Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus, Cell. Mol. Immunol. 3 (2006) 11-19.
    • (2006) Cell. Mol. Immunol. , vol.3 , pp. 11-19
    • Chiba, K.1    Matsuyuki, H.2    Maeda, Y.3    Sugahara, K.4
  • 207
    • 77949425176 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptors: Zooming in on ligand-induced intracellular trafficking and its functional implications
    • D. Verzijl, S.L.M. Peters, A.E. Alewijnse, Sphingosine-1-phosphate receptors: zooming in on ligand-induced intracellular trafficking and its functional implications, Mol. Cells 29 (2010) 99-104.
    • (2010) Mol. Cells , vol.29 , pp. 99-104
    • Verzijl, D.1    Peters, S.L.M.2    Alewijnse, A.E.3
  • 209
    • 41049092508 scopus 로고    scopus 로고
    • The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects
    • J.M. Kovarik, M. Lu, G. Riviere, I. Barbet, S. Maton, D.R. Goldwater, R.L. Schmouder, The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects, Eur. J. Clin. Pharmacol. 64 (2008) 457-463.
    • (2008) Eur. J. Clin. Pharmacol. , vol.64 , pp. 457-463
    • Kovarik, J.M.1    Lu, M.2    Riviere, G.3    Barbet, I.4    Maton, S.5    Goldwater, D.R.6    Schmouder, R.L.7


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