Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein

European Journal of Medicinal Chemistry

Volumn 85, Issue , 2014, Pages 228-234

  Fuse, Shinichiro ^a   Matsumura, Keisuke ^a   Fujita, Yuki ^b   Sugimoto, Hachiro ^b   Takahashi, Takashi ^c  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b DOSHISHA UNIVERSITY   (Japan)

^c YOKOHAMA COLLEGE OF PHARMACY   (Japan)

Author keywords

Aggregation; Alzheimer's disease; Amyloid ; Suzuki Miyaura coupling; Tau

Indexed keywords

ALDEHYDE DERIVATIVE; AMYLOID BETA PROTEIN; DYE; MALONONITRILE; METHYLENE BLUE; TAU PROTEIN; THIOPHENE DERIVATIVE; HETEROCYCLIC COMPOUND; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT;

ANTI AGGREGATING ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; DRUG ACTIVITY; KNOEVENAGEL CONDENSATION; ONE POT SYNTHESIS; PROTEIN AGGREGATION; PROTON NUCLEAR MAGNETIC RESONANCE; SUZUKI REACTION; ALZHEIMER DISEASE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; IC50; PROTEIN PHOSPHORYLATION; CHEMISTRY; DRUG EFFECTS; HUMAN; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; SYNTHESIS;

AMYLOID BETA-PEPTIDES; DRUG EVALUATION, PRECLINICAL; HETEROCYCLIC COMPOUNDS; HUMANS; INHIBITORY CONCENTRATION 50; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; TAU PROTEINS;

EID: 84905437056     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.095     Document Type: Article

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