The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects

European Journal of Clinical Pharmacology

Volumn 64, Issue 5, 2008, Pages 457-463

  Kovarik, John M ^a   Lu, Michael ^a   Riviere, Gilles Jacques ^a   Barbet, Irene ^a   Maton, Steve ^a   Goldwater, D Ronald ^b   Schmouder, Robert L ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b PAREXEL INTERNATIONAL   (United States)

Author keywords

Antihypertensives; Blood pressure; Heart rate; Immunomodulators; Pharmacokinetics

Indexed keywords

ANTIHYPERTENSIVE AGENT; ATENOLOL; DILTIAZEM; FINGOLIMOD;

ADULT; AREA UNDER THE CURVE; ARTICLE; CARDIOVASCULAR RESPONSE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HEADACHE; HEART RATE; HEART VENTRICLE EXTRASYSTOLE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; STEADY STATE; SYNCOPE;

ADOLESCENT; ADULT; ANTIHYPERTENSIVE AGENTS; AREA UNDER CURVE; ATENOLOL; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; CROSS-OVER STUDIES; DILTIAZEM; FEMALE; HEART RATE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; PROPYLENE GLYCOLS; RECEPTORS, LYSOSPHINGOLIPID; SINGLE-BLIND METHOD; SPHINGOSINE;

EID: 41049092508     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-007-0448-4     Document Type: Article

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