Synthesis and structure-activity relationship of dihydrobenzofuran derivatives as novel human GPR119 agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 11, 2014, Pages 2539-2545

  Ye, Xiang Yang ^a   Morales, Christian L ^a   Wang, Ying ^a   Rossi, Karen A ^a   Malmstrom, Sarah E ^a   Abousleiman, Mojgan ^a   Sereda, Larisa ^a   Apedo, Atsu ^a   Robl, Jeffrey A ^a   Miller, Keith J ^a   Krupinski, John ^a   Wacker, Dean A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Agonist; GPR119; Type 2 diabetes

Indexed keywords

DIHYDROBENZOFURAN DERIVATIVE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119 AGONIST; NITROGEN; PIPERAZINE; PIPERIDINE; PYRIMIDINE; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE; GPR119 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIVER MICROSOME; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; AGONISTS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; SYNTHESIS;

BENZOFURANS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899936775     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.096     Document Type: Article

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