Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 87, Issue , 2014, Pages 429-439

  Huang, Ling ^a   Miao, Hui ^a   Sun, Yang ^a   Meng, Fanchao ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; Amyloid beta; Antioxidant; Indanone derivatives

Indexed keywords

2 (4 (DIETHYLAMINO)BENZYLIDENE) 5 METHOXY 6 (2 (PIPERIDIN 1 YL)ETHOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 2 (4 (DIETHYLAMINO)BENZYLIDENE) 5 METHOXY 6 (3 (PIPERIDIN 1 YL)PROPOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 2 (4 (DIETHYLAMINO)BENZYLIDENE) 5 METHOXY 6 (5 (PIPERIDIN 1 YL)PENTYLOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 2 (4 (DIMETHYLAMINO)BENZYLIDENE) 5 METHOXY 6 (2 (PIPERIDIN 1 YL)ETHOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 2 (4 (DIMETHYLAMINO)BENZYLIDENE) 5 METHOXY 6 (3 (PIPERIDIN 1 YL)PROPOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 2 (4 (DIMETHYLAMINO)BENZYLIDENE) 5 METHOXY 6 (5 (PIPERIDIN 1 YL)PENTYLOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 2 (4 (DIPROPYLAMINO)BENZYLIDENE) 5 METHOXY 6 (2 (PIPERIDIN 1 YL)ETHOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 2 (4 (ETHYL(METHYL)AMINO)BENZYLIDENE) 5 METHOXY 6 (2 (PIPERIDIN 1 YL)ETHOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 5 METHOXY 2 (4 (METHYL(PROPYL)AMINO)BENZYLIDENE) 6 (2 (PIPERIDIN 1 YL)ETHOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 5 METHOXY 2 (4 (METHYLAMINO)BENZYLIDENE) 6 (2 (PIPERIDIN 1 YL)ETHOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 5 METHOXY 2 (4 METHOXYBENZYLIDENE) 6 (2 (PIPERIDIN 1 YL)ETHOXY) 2,3 DIHYDRO 1H INDEN 1 ONE; 6 (2 (CYCLOHEXYLAMINO)ETHOXY) 2 (4 (DIMETHYLAMINO) BENZYLIDENE) 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 6 (2 (CYCLOHEXYLAMINO)ETHOXY) 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 6 (3 (CYCLOHEXYLAMINO)PROPOXY) 2 (4-(DIMETHYLAMINO) BENZYLIDENE) 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 6 (3 (CYCLOHEXYLAMINO)PROPOXY) 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 6 (4 (CYCLOHEXYLAMINO)BUTOXY) 2 (4 (DIMETHYLAMINO) BENZYLIDENE) 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 6 (4 (CYCLOHEXYLAMINO)BUTOXY) 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; AMYLOID BETA PROTEIN[1-42]; CHOLINESTERASE INHIBITOR; DONEPEZIL; INDANONE DERIVATIVE; TACRINE; UNCLASSIFIED DRUG; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); ANTIOXIDANT; CHOLINESTERASE; INDACRINONE; INDAN DERIVATIVE; LIGAND; PEPTIDE FRAGMENT; PROTEIN AGGREGATE;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; IC50; IN VITRO STUDY; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; PERMEABILITY; SYNTHESIS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANTIOXIDANTS; BLOOD-BRAIN BARRIER; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; INDANS; INHIBITORY CONCENTRATION 50; LIGANDS; PEPTIDE FRAGMENTS; PERMEABILITY; PROTEIN AGGREGATES;

EID: 84907857581     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.09.081     Document Type: Article

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