Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 15, 2011, Pages 4528-4532

  Antczak, Christophe ^a   Shum, David ^a   Bassit, Bhramdeo ^a   Frattini, Mark G ^a   Li, Yueming ^a   Stanchina, Elisa De ^a   Scheinberg, David A ^a   Djaballah, Hakim ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Antiproliferative agents; Benzofuran 4,5 diones; Fluorescence polarization; Human peptide deformylase; Structure activity relationships

Indexed keywords

ACTINONIN; ANTINEOPLASTIC AGENT; BENZOFURAN 4,5 DIONE DERIVATIVE; BENZOFURAN DERIVATIVE; HYDROXAMIC ACID; INTERSTITIAL COLLAGENASE; MICROSOMAL AMINOPEPTIDASE; PEPTIDE DEFORMYLASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PILOT STUDY; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

AMIDOHYDROLASES; ANIMALS; ANTINEOPLASTIC AGENTS; BENZOFURANS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; METALLOPROTEASES; MICE; MICE, NUDE; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 79960371233     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.129     Document Type: Article

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