Design, synthesis, and biological evaluation of benzofuran derivatives as et receptor antagonists

Medicinal Chemistry Research

Volumn 22, Issue 11, 2013, Pages 5472-5480

  Cai, Jin ^a   Chen, Junqing ^a   Cao, Meng ^a   Wang, Peng ^a   Feng, Chengliang ^a   Ji, Min ^a  

^a SOUTHEAST UNIVERSITY   (China)

Author keywords

Benzofuran; Endothelin; Pulmonary arterial hypertension; SAR; Synthesis

Indexed keywords

3 METHYL 4 (PENTYLOXY)BENZOFURAN 2 CARBOXYLIC ACID; 3 METHYL 4 [2 (P TOLYLOXY)ETHOXY]BENZOFURAN 2 CARBOXYLIC ACID; 3 METHYL 4 [2 (PYRROLIDIN 1 YL)ETHOXY]BENZOFURAN 2 CARBOXYLIC ACID; 3 METHYL 4 PROPOXYBENZOFURAN 2 CARBOXYLIC ACID; 4 (3 CARBOXY 1 PHENYLPROPOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID; 4 (BENZO[C][1,2,5]OXADIAZOL 5 YLMETHOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID; 4 (BENZO[C][1,2,5]THIADIAZOL 5 YLMETHOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID; 4 (CINNAMYLOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID; 4 [2 (3 CHLOROPHENOXY)ETHOXY] 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID; 4 [2 (4 CHLOROPHENOXY)ETHOXY] 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID; 4 [CARBOXY(PHENYL)METHOXY] 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID; 4 BENZYLOXY) 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID; 4 BUTOXY 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID; 4 ETHOXY 3 METHYLBENZOFURAN 2 CARBOXYLIC ACID; BENZOFURAN DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DIMETHYL SULFOXIDE; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; ETHYL 2 (2 ACETYL 3 HYDROXYPHENOXY)ACETATE; ETHYL 4 HYDROXY 3 METHYLBENZOFURAN 2 CARBOXYLATE; NIFEDIPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING ASSAY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; IC 50; NONHUMAN; PULMONARY HYPERTENSION; RAT; TREATMENT RESPONSE; VASCULAR RING;

EID: 84887430174     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0542-3     Document Type: Article

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