Design, synthesis, and antitubercular evaluation of novel series of 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1- pyrazolylcarbonyl-4-oxo-naphthyridin analogs

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 3831-3839

  Manna, Kuntal ^a   Agrawal, Yadvendra K ^b  

^a NIRMA UNIVERSITY   (India)

^b GUJARAT FORENSIC SCIENCES UNIVERSITY   (India)

Author keywords

Antitubercular activity; Benzofuran; Isonicotinic acid hydrazide; Microwave synthesis; Nalidixic acid hydrazide; Pyrazoline; Structure activity relationship

Indexed keywords

2 [3 BENZO(B)FURAN 2 YL 1 (4 PYRIDYLCARBONYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL]BENZOIC ACID; 3 [3 BENZO[B]FURAN 2 YL 5 (2 CARBOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLYLCARBONYL 1 ETHYL 7 METHYL 1,4 DIHYDRO[1,8]NAPHTHYRIDIN 4 ONE; 3 [3 BENZO[B]FURAN 2 YL 5 (2 CHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOLYLCARBONYL 1 ETHYL 7 METHYL 1,4 DIHYDRO[1,8]NAPHTHYRIDIN 4 ONE; 3 [3 BENZO[B]FURAN 2 YL 5 (2 HYDROXY, 3 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLYLCARBONYL 1 ETHYL 7 METHYL 1,4 DIHYDRO[1,8]NAPHTHYRIDIN 4 ONE; 3 [3 BENZO[B]FURAN 2 YL 5 (2 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLYLCARBONYL 1 ETHYL 7 METHYL 1,4 DIHYDRO[1,8]NAPHTHYRIDIN 4 ONE; 3 [3 BENZO[B]FURAN 2 YL 5 (2 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLYLCARBONYL 1 ETHYL 7 METHYL 1,4 DIHYDRO[1,8]NAPHTHYRIDIN 4 ONE; 3 [3 BENZO[B]FURAN 2 YL 5 (2 NITROPHENYL) 4,5 DIHYDRO 1H PYRAZOLYLCARBONYL 1 ETHYL 7 METHYL 1,4 DIHYDRO[1,8]NAPHTHYRIDIN 4 ONE; 3 [3 BENZO[B]FURAN 2 YL 5 (3 NITROPHENYL) 4,5 DIHYDRO 1H PYRAZOLYLCARBONYL 1 ETHYL 7 METHYL 1,4 DIHYDRO[1,8]NAPHTHYRIDIN 4 ONE; 3 [3 BENZO[B]FURAN 2 YL 5 (4 DIMETHYLAMINOPHENYL) 4,5 DIHYDRO 1H PYRAZOLYLCARBONYL 1 ETHYL 7 METHYL 1,4 DIHYDRO[1,8]NAPHTHYRIDIN 4 ONE; 3 [3 BENZO[B]FURAN 2 YL 5 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLYLCARBONYL 1 ETHYL 7 METHYL 1,4 DIHYDRO[1,8]NAPHTHYRIDIN 4 ONE; 3 [3 BENZO[B]FURAN 2 YL 5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLYLCARBONYL 1 ETHYL 7 METHYL 1,4 DIHYDRO[1,8]NAPHTHYRIDIN 4 ONE; 3 BENZO[B]FURAN 2 YL 5 (2 CHLOROPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 (2 FURYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 (2 HYDROXY 4 METHOXYPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 (2 HYDROXYPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 (2 METHOXYPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 (2 NITROPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 (4 CHLOROPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 (4 DIMETHYLAMINOPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 [2 PHENYL 1 ETHENYL] 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZO[B]FURAN 2 YL 5 PHENYL 4,5 DIHYDRO 1H 1 PYRAZOLYL 4 PYRIDYLMETHANONE; 3 BENZOFURAN 5 ARYL 1 PYRAZOLYL PYRIDYLMETHANONE DERIVATIVE; 3 BENZOFURAN 5 ARYL 1 PYRAZOLYLCARBONYL 4 OXO NAPHTHYRIDIN DERIVATIVE; BENZOFURAN DERIVATIVE; ISONIAZID; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; LUNG; MICROWAVE IRRADIATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SPLEEN; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; BENZOFURANS; CERCOPITHECUS AETHIOPS; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 77955556522     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.05.035     Document Type: Article

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