New approaches to anticancer drug design based on the inhibition of farnesyltransferase

Drug Discovery Today

Volumn 3, Issue 1, 1998, Pages 26-33

  Sebti, Saïd M ^a   Hamilton, Andrew D ^b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINOPLANIC ACID B; CHAETOMELLIC ACID A; EPIDERMAL GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE; RAS PROTEIN; SQUALENE SYNTHASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZARAGOZIC ACID A;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL MODEL; CANCER INHIBITION; CARCINOGENESIS; COLON CANCER; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; ENZYME CONFORMATION; ENZYME INHIBITION; GROWTH STIMULATION; MALIGNANT TRANSFORMATION; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONCOGENE RAS; PANCREAS CANCER; REVIEW; SIGNAL TRANSDUCTION; TRANSLATION REGULATION;

EID: 0031932939     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(97)01122-7     Document Type: Review

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