The cause of neuronal degeneration in Alzheimer's disease

Progress in Neurobiology

Volumn 60, Issue 2, 2000, Pages 139-165

  Vickers, James C ^a   Dickson, Tracey C ^a   A Adlard, Paul ^a   Saunders, Helen L ^a   King, Carolyn E ^a   McCormack, Graeme ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; CYTOSKELETON PROTEIN; TAU PROTEIN;

ALZHEIMER DISEASE; DEMENTIA; HUMAN; INFLAMMATION; NERVE CELL DEGENERATION; NERVE CELL LESION; NERVE CELL NETWORK; NEUROFIBRILLARY TANGLE; NEUROFILAMENT; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; REVIEW;

ALZHEIMER DISEASE; ANIMALS; HUMANS; NERVE DEGENERATION;

EID: 0033991035     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(99)00023-4     Document Type: Review

References (333)

1. Adle-Biassette H., Duyckaerts C., Wasowicz M., He Y., Fornes P., Foncin J.F., Lecomte D., Hauw J.J. Beta AP deposition and head trauma. Neurobiol. Aging. 17:1996;415-419.
2. Allsop D., Haga S.I., Haga C., Ikeda S.I., Mann D.M., Ishii T. Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons. Neuropathol. Appl Neurobiol. 15:1989;531-542.
3. Arai H., Lee V.M., Otvos L. Jr, Greenberg B.D., Lowery D.E., Sharma S.K., Schmidt M.L., Trojanowski J.Q. Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques. Proc. natl Acad. Sci. USA. 87:1990;2249-2253.
4. Arispe N., Pollard H.B., Rojas E. Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes. Proc. natl Acad. Sci. USA. 90:1993;10573-10577.
5. Arriagada P.V., Marzloff K., Hyman B.T. Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease. Neurology. 42:1992;1681-1688.
6. Arvidsson J., Aldskogius H. Effect of repeated hypoglossal nerve lesions on the number of neurons in the hypoglossal nucleus of adult rats. Exp. Neurol. 75:1982;520-524.
7. Arvin B., Neville L.F., Barone F.C., Feuerstein G.Z. The role of inflammation and cytokines in brain injury. Neurosci. Biobehav. Rev. 20:1996;445-452.
8. Ashford J.W., Soultanian N.S., Zhang S.X., Geddes J.W. Neuropil threads are collinear with MAP2 immunostaining in neuronal dendrites of Alzheimer brain. J. Neuropathol. exp. Neurol. 57:1998;972-978.
9. Barron K.D. Axon reaction and central nervous system regeneration. Seil F.J. Nerve, Organ and Tissue Regeneration: Research Perspectives. 1983;3-36 Academic Press, New York.
10. Bates C.A., Meyer R.L. The heavy neurofilament protein is expressed in regenerating adult but not embryonic mammalian optic fibers in vitro. Exp. Neurol. 119:1993;249-257.
11. Bauer J., Strauss S., Schreiter-Gasser U., Ganter U., Schlegel P., Witt I., Yolk B., Berger M. Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Lett. 285:1991;111-114.
12. Benes F.M., Farol P.A., Majocha R.E., Marotta C.A., Bird E.D. Evidence for axonal loss in regions occupied by senile plaques in Alzheimer cortex. Neuroscience. 42:1991;651-660.
13. Benzing W.W., Ikonomovic M.D., Brady D.R., Mufson E.J., Armstrong D.M. Evidence that transmitter-containing dystrophic neurites precede paired helical filament and Alz50 formation within senile plaques in the amygdala of nondemented elderly and patients with Alzheimer's disease. J. comp. Neurol. 334:1993;176-191.
14. Berg L., McKeel D.W. Jr, Miller J.P., Storandt M., Rubin E.H., Morris J.C., Baty J., Coats M., Norton J., Goate A.M., Price J.L., Gearing M., Mirra S.S., Saunders A.M. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch. Neurol. 55:1998;326-335.
15. Bierer L.M., Hof P.R., Purohit D.P., Carlin L., Schmeidler J., Davis K.L., Perl D.P. Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch. Neurol. 52:1995;81-88.
16. Black M.M., Lasek R.J. Slowing of the rate of axonal regeneration during growth and maturation. Exp. Neurol. 63:1979;108-119.
17. Blasko I., Schmitt T.L., Steiner E., Trieb K., Grubeck-Loebenstein B. Tumor necrosis factor alpha augments amyloid beta protein (25-35) induced apoptosis in human cells. Neurosci. Lett. 238:1997;17-20.
18. Blumbergs P.C., Jones N.R., North J.B. Diffuse axonal injury in head trauma. J. Neurol. Neurosurg. Psychiat. 52:1989;838-841.
19. Blümke S., Nierdorf H.R., Rode J. Axoplasmic alterations in the proximal and distal stumps of transsected nerves. Acta Neuropathol. 7:1966;44-61.
20. Bondareff W., Harrington C.R., Wischik C.M., Hauser D.L., Roth M. Absence of abnormal hyperphosphorylation of tau in intracellular tangles in Alzheimer's disease. J. Neuropathol. exp. Neurol. 54:1995;657-663.
21. Bons N., Mestre N., Petter A. Senile plaques and neurofibrillary changes in the brain of an aged lemurian primate, Microcebus murinus. Neurobiol. Aging. 13:1992;99-105.
22. Boycott B.B., Gray E., Guillery R. Synaptic structure and tis alteration with environmental temperature: a study by light and electron microscopy of the central nervous system of lizards. Proc. R. Soc. B. 154:1961;151-171.
23. Braak H., Braak E. Neuropil threads occur in dendrites of tangle-bearing nerve cells. Neuropathol. Appl. Neurobiol. 14:1988;39-44.
24. Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82:1991;239-259.
25. Bramblett G.T., Goedert M., Jakes R., Merrick S.E., Trojanowski J.Q., Lee V.M. Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron. 10:1993;1089-1099.
26. Breitner J.C. The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease. A. Rev. Med. 47:1996;401-411.
27. Butterfield D.A., Hensley K., Harris M., Mattson M., Carney J. beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease. Biochem. biophys. Res. Commun. 200:1994;710-715.
28. Cammarata S., Mancardi G., Tabaton M. Formic acid treatment exposes hidden neurofilament and tau epitopes in abnormal cytoskeletal filaments from patients with progressive supranuclear palsy and Alzheimer's disease. Neurosci. Lett. 115:1990;351-355.
29. Campbell M.J., Morrison J.H. Monoclonal antibody to neurofilament protein (SMI-32) labels a subpopulation of pyramidal neurons in the human and monkey neocortex. J. comp. Neurol. 282:1989;191-205.
30. Campbell M.J., Hof P.R., Morrison J.H. A subpopulation of primate corticocortical neurons is distinguished by somatodendritic distribution of neurofilament protein. Brain Res. 539:1991;133-136.
31. Carden M., Trojanowski J., Schlaepfer W., Lee V.M-Y. Two-stage expression of neurofilaments during rat neurogenesis with early establishment of adult phosphorylation patterns. J. Neurosci. 7:1987;3489-3504.
32. Chambers C.B., Muma N.A. Tau mRNA isoforms following sciatic nerve axotomy with and without regeneration. Mol. Brain Res. 48:1997;115-124.
33. Chargé S.B., Esiri M.M., Bethune C.A., Hansen B.C., Clark A. Apolipoprotein E is associated with islet amyloid and other amyloidoses: implications for Alzheimer's disease. J. Pathol. 179:1996;443-447.
34. Christman C.W., Salvant J.B. Jr, Walker S.A., Povlishock J.T. Characterization of a prolonged regenerative attempt by diffusely injured axons following traumatic brain injury in adult cat: a light and electron microscopic immunocytochemical study. Acta Neuropathol. 94:1997;329-337.
35. Cole G.M., Masliah E., Shelton E.R., Chan H.W., Terry R.D., Saitoh T. Accumulation of amyloid precursor fragment in Alzheimer plaques. Neurobiol. Aging. 12:1991;85-91.
36. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., Roses A.D., Haines J.L., Pericak-Vance M.A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923.
37. Corder E.H., Saunders A.M., Risch N.J., Strittmatter W.J., Schmechel D.E., Gaskell P.C. Jr, Rimmler J.B., Locke P.A., Conneally P.M., Schmader K.A., Small G.W., Roses A.D., Haines J.L., Pericak-Vance M.A. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat. Genet. 7:1994;180-184.
38. Coria F., Moreno A., Rubio I., Garcia M.A., Morato E., Mayor F. Jr. The cellular pathology associated with Alzheimer b-amyloid deposits in non-demented aged individuals. Neuropathol. Appl. Neurobiol. 19:1993;261-268.
39. Cork L.C., Sternberger N.H., Sternberger L.A., Casanova M.F., Struble R.G., Price D.L. Phosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer's disease. J. Neuropathol. exp. Neurol. 45:1986;56-64.
40. Corral-Debrinski M., Horton T., Lott M.T., Shoffner J.M., McKee A.C., Beal M.F., Graham B.H., Wallace D.C. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains. Genomics. 23:1994;471-476.
41. Cotman C.W. Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol. Aging. 19:1998;S29-32.
42. Cragg B.G. What is the signal for chromatolysis? Brain Res. 23:1970;1-21.
43. Cras P., Kawai M., Lowery D., Gonzalez-DeWhitt P., Greenberg B., Perry G. Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc. natl Acad. Sci. USA. 88:1991;7552-7556.
44. Cras P., Smith M.A., Richey P.L., Siedlak S.L., Mulvihill P., Perry G. Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease. Acta Neuropathol. 89:1995;291-295.
45. Crystal H., Dickson D., Fuld P., Masur D., Scott R., Mehler M., Masdeu J., Kawas C., Aronson M., Wolfson L. Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology. 38:1988;1682-1687.
46. Cummings B.J., Cotman C.W. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity. Lancet. 346:1995;1524-1528.
47. Cummings B.J., Pike C.J., Shankle R., Cotman C.W. Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiol. Aging. 17:1996;921-933.
48. Dahl D., Selkoe D.J., Pero R.T., Bignami A. Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum. J. Neurosci. 2:1982;113-119.
49. Davies L., Wolska B., Hilbich C., Multhaup G., Martins R., Simms G., Beyreuther K., Masters C.L. A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques. Neurology. 38:1988;1688-1693.
50. De la Monte S.M., Sohn Y.K., Wands J.R. Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease. J. Neurol. Sci. 152:1997;73-83.
51. Delaere P., He Y., Fayet G., Duyckaerts C., Hauw J.J. Beta A4 deposits are constant in the brain of the oldest old: an immunocytochemical study of 20 French centenarians. Neurobiol. Aging. 14:1993;191-194.
52. Deller T., Frotscher M. Lesion-induced plasticity of central neurons: sprouting of single fibres in the rat hippocampus after unilateral entorhinal cortex lesion. Prog. Neurobiol. 53:1997;687-727.
53. Deng G., Pike C.J., Cotman C.W. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett. 397:1996;50-54.
54. Dickson D.W. The pathogenesis of senile plaques. J. Neuropath. exp. Neurol. 55:1997;321-339.
55. Dickson D.W., Farlo J., Davies P., Crystal H., Fuld P., Yen S.H. Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques. Am J. Pathol. 132:1988;86-101.
56. Dickson T.C., Saunders H.L., Vickers J.C. Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease. J. Neuropathol. Appl. Neurobiol. 23:1997;483-494.
57. Dickson T.C., King C.E., McCormack G.H., Vickers J.C. Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease. Exp. Neurol. 156:1999;100-110.
58. DiTella M., Feiguin F., Morfini G., Caceres A. Microfilament-associated growth cone component depends upon Tau for its intracellular localization. Cell Motil. Cytoskeleton. 29:1994;117-130.
59. Dräger U.C., Hofbauer A. Antibodies to heavy neurofilament subunit detect a subpopulation of damaged ganglion cells in retina. Nature. 309:1984;624-626.
60. Dragunow M., Faull R.L., Lawlor P., Beilharz E.J., Singleton K., Walker E.B., Mee E. In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. Neuroreport. 6:1995;1053-1057.
61. Dunn-Meynell A.A., Levin B.E. Histological markers of neuronal axonal and astrocytic changes after lateral rigid impact traumatic brain injury. Brain Res. 761:1997;25-41.
62. Edwards P.M., Van der Zee C.E., Verhaagen J., Schotman P., Jennekens F.G., Gispen W.H. Evidence that the neurotrophic actions of alpha-MSH may derive from its ability to mimic the actions of a peptide formed in degenerating nerve stumps. J. Neurol. Sci. 64:1984;333-340.
63. Ehlers M.D., Fung E.T., O'Brien R.J., Huganir R.L. Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments. J. Neurosci. 18:1998;720-730.
64. Eikelenboom P., Zhan S.S., van Gool W.A., Allsop D. Inflammatory mechanisms in Alzheimer's disease. Trends Pharmac. Sci. 15:1994;447-450.
65. Erickson J.C., Sewell A.K., Jensen L.T., Winge D.R., Palmiter R.D. Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF). Brain Res. 649:1994;297-304.
66. Esiri M.M., Pearson R.C.A., Steele J.E., Bowen D.M., Powell T.P.S. A quantitative study of the neurofibrillary tangles and the choline acetyltransferase activity in the cerebral cortex and the amygdala in Alzheimer's disease. J. Neurol. Neurosurg. Psychiat. 3:1990;161-165.
67. Fahnestock M., Scott S.A., Jette N., Weingartner J.A., Crutcher K.A. Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex. Mol. Brain Res. 42:1996;175-178.
68. Ferrer I., Soriano E., Tunon T., Fonseca M., Guionnet N. Parvalbumin immunoreactive neurons in normal human temporal neocortex and in patients with Alzheimer's disease. J. Neurol. Sci. 106:1991;135-141.
69. Fineman I., Hovda D.A., Smith M., Yoshino A., Becker D.P. Concussive brain injury is associated with a prolonged accumulation of calcium: a 45Ca autoradiographic study. Brain Res. 624:1993;94-102.
70. Fonseca M., Soriano E. Calretinin-immunoreactive neurons in the normal human temporal cortex and in Alzheimer's disease. Brain Res. 691:1995;83-91.
71. Forloni G., Chiesa R., Smiroldo S., Verga L., Salmona M., Tagliavini F., Angeretti N. Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35. Neuroreport. 4:1993;523-526.
72. Friedman G., Froom P., Sazabon L., Grinblatt I., Shochina M., Tsenter J., Babaey S., Ben Yehuda A., Groswsser Z. Apolipoprotein E-e4 genotype predicts a poor outcome in survivors of traumatic brain injury. Neurology. 52:1999;244-248.
73. Geddes J.F., Vowles G.H., Robinson S.F.D., Sutcliffe J.C. Neurofibrillary tangles, but not Alzheimer-type pathology, in a young boxer. Neuropathol. Appl. Neurobiol. 22:1996;12-16.
74. Gennarelli T.A. The spectrum of traumatic axonal injury. Neuropathol. Appl. Neurobiol. 22:1996;509-513.
75. Ghiso J., Tagliavini F., Timmers W.F., Frangione B. Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization. Biochem. biophys. Res. Commun. 163:1989;430-437.
76. Giaccone G., Tagliavini F., Linoli G., Bouras C., Frigerio L., Frangione B., Bugiani O. Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques. Neurosci. Lett. 97:1989;232-238.
77. Glenner G.G., Wong C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. biophys. Res. Commun. 120:1994;885-890.
78. Goedert M., Jakes R., Crowther R.A., Six J., Lubke U., Vandermeeren M., Cras P., Trojanowski J.Q., Lee V.M. The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. Proc. natl Acad. Sci. USA. 90:1993;5066-5070.
79. Goedert M., Jakes R., Spillantini M.G., Hasegawa M., Smith M.J., Crowther R.A. Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature. 383:1996;550-553.
80. Goldstein M.E., Cooper H.S., Bruce J., Carden M.J., Lee V.M.Y., Schlaepfer W.W. Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve. J. Neurosci. 7:1987;1586-1594.
81. Gomez-Isla T., Price J.L., McKeel D.W. Jr, Morris J.C., Growdon J.H., Hyman B.T. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 16:1996;4491-4500.
82. Gonatas N.K., Anderson W., Evangelista I. The contribution of altered synapses in the senile plaque: an electron microscopic study in Alzheimer's dementia. J. Neuropathol. exp. Neurol. 26:1967;25-39.
83. Gotow T., Tanaka T., Nakamura Y., Takeda M. Dephosphorylation of the largest neurofilament subunit protein influences the structure of crossbridges in reassembled neurofilaments. J. Cell. Sci. 107:1994;1949-1957.
84. Grady M.S., McLaughlin M.R., Christman C.W., Valadka A.B., Fligner C.L., Povlishock J.T. The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans. J. Neuropathol. exp. Neurol. 52:1993;143-152.
85. Graham D.I. Blunt head injury: prospects for improved outcome. Neuropathol. Appl. Neurobiol. 22:1996;505-509.
86. Gray E.G., Hamlyn L.H. Electron microscopy of experimental degeneration in the avian optic tectum. J. Anat. 96:1962;309-316.
87. Gray E.G., Paula-Barbosa M., Roher A. Alzheimer's disease: paired helical filaments and cytomembranes. Neuropathol. Appl. Neurobiol. 13:1987;91-110.
88. Geula C., Wu C.K., Saroff D., Lorenzo A., Yuan M., Yankner B.A. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat. Med. 4:1998;827-831.
89. Guillery R.W. Some electron microscopical observations of degenerative changes in central nervous synapses. Prog. Brain Res. 14:1965;57-73.
90. Haass C., Schlossmacher M.G., Hung A.Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B.L., Lieberburg I., Koo E.H., Schenk D., Teplow D.B. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature. 359:1992;322-325.
91. Hall G., Lee V. Neurofilament sidearm proteolysis is a prominent early effect of axotomy in lamprey giant central neurons. J. comp. Neurol. 353:1995;38-49.
92. Hall G.F., Poulos A., Cohen M.J. Sprouts emerging from the dendrites of axotomized lamprey central neurons have axonlike ultrastructure. J. Neurosci. 9:1989;588-599.
93. Hardy J.A., Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science. 256:1992;184-185.
94. Hasegawa M., Watanabe A., Takio K., Suzuki M., Arai T., Titani K., Ihara Y. Characterization of two distinct monoclonal antibodies to paired helical filaments: further evidence for fetal-type phosphorylation of the tau in paired helical filaments. J. Neurochem. 60:1993;2068-2077.
95. Hasegawa M., Crowther R.A., Jakes R., Goedert M. Alzheimer-like changes in microtubule-associated protein tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation. J. Biol. Chem. 272:1997;32768.
96. Haugh M.C., Probst A., Ulrich J., Kahn J., Anderton B.H. Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes. J. Neurol. Neurosurg. Psychiat. 49:1986;1213-1220.
97. Henderson A.S., Easteal S., Jorm A.F., Mackinnon A.J., Korten A.E., Christensen H., Croft L., Jacomb P.A. Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample. Lancet. 346:1995;1387-1390.
98. Hensley K., Carney J.M., Mattson M.P., Aksenova M., Harris M., Wu J.F., Floyd R.A., Butterfield D.A. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc. natl Acad. Sci. USA. 91:1994;3270-3274.
99. Higgins G.A., Mufson E.J. NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease. Exp. Neurol. 106:1989;222-236.
100. Hirokawa N. Molecular architecture and dynamics of the neuronal cytoskeleton. Burgoyne R.D. The Neuronal Cytoskeleton. 1991;5-74 Wiley-Liss and Sons, New York.
101. Hiscock J.J., Mackenzie L., Willoughby J.O. Laminar distribution of Fos/calcium-binding protein and Fos/neurofilament protein-labeled neurons in rat motor and sensory cortex after picrotoxin-induced seizures. Exp. Neurol. 149:1998;373-383.
102. Hof P.R., Morrison J.H. Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: II. Primary and secondary visual cortex. J. comp. Neurol. 301:1990;55-64.
103. Hof P.R., Morrison J.H. Neocortical neuronal subpopulations labeled by a monoclonal antibody to calbindin exhibit differential vulnerability in Alzheimer's disease. Exp. Neurol. 111:1991;293-301.
104. Hof P.R., Morrison J.H. The cellular basis of cortical disconnection in Alzheimer disease and related dementing conditions. Terry R.D., Katzman R., Bick K.L. Alzheimer Disease. 1994;197-229 Raven Press, New York.
105. Hof P.R., Cox C., Morrison J.H. Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I Superior frontal and inferior temporal cortex. J. comp. Neurol. 301:1990;44-54.
106. Hof P.R., Cox K., Young W.G., Celio M.R., Rogers J., Morrison J.H. Parvalbumin-immunoreactive neurons in the neocortex are resistant to degeneration in Alzheimer's disease. J. Neuropathol. exp. Neurol. 50:1991;451-462.
107. Hof P.R., Knabe R., Bovier P., Bouras C. Neuropathological observations in a case of autism presenting with self-injury behaviour. Acta Neuropathol. 82:1991;321-326.
108. Hof P.R., Bierer L.M., Perl D.P., Delacourte A., Buee L., Bouras C., Morrison J.H. Evidence for early vulnerability of the medial and inferior aspects of the temporal lobe in an 82-year-old patient with preclinical signs of dementia. Regional and laminar distribution of neurofibrillary tangles and senile plaques. Arch. Neurol. 49:1992;946-953.
109. Hof P.R., Nimchinsky E.T., Celio M.R., Bouras C., Morrison J.H. Calretinin-immunoreactive neocortical interneurons are unaffected in Alzheimer's Disease. Neurosci. Lett. 152:1993;145-149.
110. Hof P.R., Giannakopoulos P., Vickers J.C., Bouras C., Morrison J. The morphologic and neurochemical basis of dementia: aging, hierarchical patterns of lesion distribution and vulnerable neuronal phenotype. Rev. Neurosci. 6:1995;97-124.
111. Hoffman P.N., Cleveland D.W., Griffin J.W., Landes P.W., Cowan N.J., Price D.L. Neurofilament gene expression: a major determinant of axonal calibre. Proc. natl Acad. Sci. USA. 84:1987;3472-3476.
112. Hopkins J.M., Bunge R.P. Regeneration of axons from adult human retina in vitro. Exp. Neurol. 112:1991;243-251.
113. Ikin A.F., Annaert W.G., Takei K., De Camilli P., Jahn R., Greengard P., Buxbaum J.D. Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. J. biol. Chem. 271:1996;31783-31786.
114. Irizarry M.C., Soriano F., Mcnarmara M., Page K.J., Schenk D., Hyman B.T. Abeta deposition is associated with neuropil changes but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. Neuroscience. 17:1997;7053-7059.
115. Ishii T., Kametani F., Haga S., Sato M. The immunohistochemical demonstration of subsequences of the precursor of the amyloid A4 protein in senile plaques in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 15:1989;135-147.
116. Jafari S.S., Maxwell W.L., Neilson M., Graham D.I. Axonal cytoskeletal changes after non-disruptive axonal injury. Neurocytol. 26:1997;207-221.
117. Jakes R., Novak M., Davison M., Wischik C.M. Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease. EMBO J. 10:1991;2725-2729.
118. Janicki S., Monteiro M.J. Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I). J. Cell Biol. 139:1997;485-495.
119. Jensen M.B., Finsen B., Zimmer J. Morphological and immunophenotypic microglial changes in the denervated fascia dentata of adult rats: correlation with blood-brain barrier damage and astroglial reactions. Exp. Neurol. 143:1997;103-116.
120. Jiang X.M., Zhao J.X., Ohnishi A., Itakura C., Mizutani M., Yamamoto T., Murai Y., Ikeda M. Regeneration of myelinated fiber after crush injury is retarded in sciatic nerves of mutant Japanese quails deficient in neurofilaments. Acta Neuropathol. 92:1996;467-472.
121. Jiang Y.Q., Pickett J., Oblinger M.M. Comparison of changes in beta-tubulin and NF gene expression in rat DRG neurons under regeneration-permissive and regeneration-prohibitive conditions. Brain Res. 637:1994;233-241.
122. Joachim C.L., Morris J.H., Selkoe D.J. Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am. J. Pathol. 135:1989;309-319.
123. Johnson S.A., Lampert-Etchells M., Pasinetti G.M., Rozovsky I., Finch C.E. Complement mRNA in the mammalian brain: responses to Alzheimer's disease and experimental brain lesioning. Neurobiol. Aging. 13:1992;641-648.
124. Johnson S.A., Young-Chan C.S., Laping N.J., Finch C.E. Perforant path transection induces complement C9 deposition in hippocampus. Exp. Neurol. 138:1996;198-205.
125. Jordan B.D., Relkin N.R., Ravdin L.D., Jacobs A.R., Bennett A., Gandy S. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. J. Am. Med. Assoc. 278:1997;136-140.
126. Kalaria R.N., Cohen D.L., Premkumar D.R. Cellular aspects of the inflammatory response in Alzheimer's disease. Neurodegeneration. 5:1996;497-503.
127. Kanayama G., Takeda M., Morihara T., Miyamae Y., Shinozaki K., Nishikawa T., Niigawa H., Nishimura T. Temporal and regional profiles of cytoskeletal protein accumulation in the rat brain following traumatic brain injury. Psychiat. Clin. Neurosci. 51:1997;157-165.
128. Kanne S.M., Balota D.A., Storandt M., McKeel D.W. Jr, Morris J.C. Relating anatomy to function in Alzheimer's disease: neuropsychological profiles predict regional neuropathology 5 years later. Neurology. 50:1998;979-985.
129. Katzman R., Kawas C.H. The epidemiology of dementia and Alzheimer's disease. Terry R.D., Katzman R., Bick K.L. Alzheimer Disease. 1994;105-122 Raven Press, New York.
130. Kawas C., Resnick S., Morrison A., Brookmeyer R., Corrada M., Zonderman A., Bacal C., Lingle D.D., Metter E. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore longitudinal study of aging. Neurology. 48:1997;1517-1521.
131. Kindy M.S., King A.R., Perry G., de Beer M.C., de Beer F.C. Association of apolipoprotein E with murine amyloid A protein amyloid. Lab. Invest. 73:1995;469-475.
132. King C.E., Jacobs I., Dickson T.C., Vickers J.C. Physical damage to rat cortical axons mimics early Alzheimer's neuronal pathology. Neuroreport. 8:1997;1663-1665.
133. Kittur S., Hoh J., Endo H., Tourtellotte W., Weeks B.S., Markesbery W., Adler W. Cytoskeletal neurofilament gene expression in brain tissue from Alzheimer's disease patients. I. Decrease in NF-L and NF-M message. J. Geriatr. Psychiat. Neurol. 7:1994;153-158.
134. Klosen P., Anderton B.H., Brion J.P., van den Bosch de Aguilar P. Perikaryal neurofilament phosphorylation in axotomized and 6-OH-dopamine-lesioned CNS neurons. Brain Res. 526:1990;259-269.
135. Koh J.Y., Yang L.L., Cotman C.W. Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 533:1990;315-320.
136. Koliastos V.E., Applegate M.D., Kitt C.A., Walker L.C., Delong M.R., Price D.L. Aberrant phosphorylation of neurofilaments accompanies transmitter-related changes in rat septal neurons following transection of the fimbria-fornix. Brain Res. 482:1989;205-218.
137. Koo E.H., Sisodia S.S., Archer D.R., Martin L.J., Weidemann A., Beyreuther K., Fischer P., Masters C.L., Price D.L. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc. natl Acad. Sci. USA. 87:1990;1561-1565.
138. Kowall N.W., McKee A.C., Yankner B.A., Beal M.F. In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment. Neurobiol. Aging. 13:1992;537-542.
139. Ksiezak-Reding H., Dickson D.W., Davies P., Yen S.H. Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles. Proc. natl Acad. Sci. USA. 84:1987;3410-3414.
140. LaFerla F.M., Tinkle B.T., Bieberich C.J., Haudenschild C.C., Jay G. The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat. Genet. 9:1995;21-30.
141. Lambert M.P., Barlow A.K., Chromy B.A., Edwards C., Freed R., Liosatos M., Morgan T.E., Rozovsky I., Trommer B., Viola K.L., Wals P., Zhang C., Finch C.E., Krafft G.A., Klein W.L. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. natl Acad. Sci. USA. 95:1998;6448-6453.
142. Lampert P.W. A comparative electron microscopic study of reactive, degenerating, regenerating, and dystrophic axons. J. Neuropathol. exp. Neurol. 26:1967;345-368.
143. Lampert P.W., Hardman J.M. Morphological changes in brains of boxers. J. Am. Med. Assoc. 251:1984;2676-2679.
144. Lanners H.N., Grafstein B. Effect of a conditioning lesion on regeneration of goldfish optic axons: ultrastructural evidence of enhanced outgrowth and pinocytosis. Brain Res. 196:1980;547-553.
145. Lassmann H., Bancher C., Breitschopf H., Wegiel J., Bobinski M., Jellinger K., Wisniewski H.M. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol. 89:1995;35-41.
146. Lee V.M., Otvos L. Jr, Schmidt M.L., Trojanowski J.Q. Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins. Proc. natl Acad. Sci. USA. 85:1988;7384-7388.
147. Lee V.M., Balin B.J., Otvos L. Jr, Trojanowski J.Q. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Science. 251:1991;675-678.
148. Leterrier J.F., Rusakov D.A., Nelson B.D., Linden M. Interactions between brain mitochondria and cytoskeleton: evidence for specialized outer membrane domains involved in the association of cytoskeleton-associated proteins to mitochondria in situ and in vitro. Microsci. Res. Technol. 27:1994;233-261.
149. Leuba G., Kraftsik R. Visual cortex in Alzheimer's disease - occurrence of neuronal death and glial proliferation, and correlation with pathological hallmarks. Neurobiol. Aging. 15:1994;29-43.
150. Lewis D.A., Campbell M.J., Terry R.D., Morrison J.H. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. J. Neurosci. 7:1987;1799-1808.
151. Li Y.P., Bushnell A.F., Lee C.M., Perlmutter L.S., Wong S.K. Beta-amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells. Brain Res. 738:1996;196-204.
152. Li W.P., Chan W.Y., Lai H.W., Yew D.T. Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients. J. Mol. Neurosci. 8:1997;75-82.
153. Lieberman A.R. The axon reaction: a review of the principal features of perikaryal responses to axon injury. Int. Rev. Neurobiol. 14:1971;49-124.
154. Lippa C.F., Hamos J.E., Smith T.W., Pulaski-Salo D., Drachman D.A. Vascular amyloid deposition in Alzheimer's disease. Neither necessary nor sufficient for the local formation of plaques or tangles. Arch. Neurol. 50:1993;1088-1092.
155. Loo D.T., Copani A., Pike C.J., Whittemore E.R., Walencewicz A.J., Cotman C.W. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc. natl Acad. Sci. USA. 90:1993;7951-7955.
156. Lorenzo A., Yankner B.A. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. natl Acad. Sci. USA. 91:1994;12243-12247.
157. Lucassen P.J., Chung W.C., Kamphorst W., Swaab D.F. DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology. J. Neuropathol. exp. Neurol. 56:1997;887-900.
158. Lyras L., Cairns N.J., Jenner A., Jenner P., Halliwell B. An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J. Neurochem. 68:1997;2061-2069.
159. Ma J., Yee A., Brewer H.B. Jr, Das S., Potter H. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature. 372:1994;92-94.
160. MacGibbon G.A., Lawlor P.A., Sirimanne E.S., Walton M.R., Connor B., Young D., Williams C., Gluckman P., Faull R.L., Hughes P., Dragunow M. Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus. Brain Res. 750:1997;223-234.
161. Mackenzie I.R., McLachlan R.S., Kubu C.S., Miller L.A. Prospective neuropsychological assessment of nondemented patients with biopsy proven senile plaques. Neurology. 46:1996;425-429.
162. Mahley R.W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 240:1988;622-630.
163. Mann D.M. Pyramidal nerve cell loss in Alzheimer's disease. Neurodegeneration. 5:1996;423-427.
164. Mann D.M.A., Esiri M.M. The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome. J. Neurol. Sci. 89:1989;169-179.
165. Mann D.M.A., Yates P.O., Marcyniuk B., Ravindra C.R. The topography of plaques and tangles in Down's syndrome patients of different ages. Neuropathol. Appl. Neurobiol. 12:1986;447-457.
166. Mansour H., Bignami A., Dahl D. Neurofilament phosphorylation in neuronal perikarya following axotomy: a study of rat spinal cord with ventral and dorsal root transection. J. comp. Neurol. 238:1989;481-485.
167. Martin J.E., Mather K.S., Swash M., Garofalo O., Dale G.E., Leigh P.N., Anderton B.H. Spinal cord trauma in man: studies of phosphorylated neurofilament and ubiquitin expression. Brain. 113:1990;1553-1562.
168. Masliah E., Mallory M., Hansen L., Alford M., DeTeresa R., Terry R. An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease. Am. J. Pathol. 142:1993;871-882.
169. Masliah E., Sisk A., Mallory M., Mucke L., Schenk D., Games D. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J. Neurosci. 16:1996;5795-5811.
170. Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. natl Acad. Sci. USA. 82:1985;4245-4249.
171. Mattson M.P., Cheng B., Davis D., Bryant K., Lieberburg I., Rydel R.E. beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12:1992;376-389.
172. Maxwell W.L., Irvine A., Graham D.I., Adams J.H., Gennarelli T.A., Tipperman R., Sturatis M. Focal axonal injury: the early axonal response to stretch. J. Neurocytol. 20:1991;157-164.
173. Maxwell W.L., Povlishock J.T., Graham D.L. A mechanistic analysis of nondisruptive axonal injury: a review. J. Neurotrauma. 14:1997;419-440.
174. Mayeux R., Ottman R., Maestre G., Ngai C., Tang M.X., Ginsberg H., Chun M., Tycko B., Shelanski M. Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology. 45:1995;555-557.
175. McGeer E.G., McGeer P.L. Aging, neurodegenerative disease and the brain. Can. J. Aging. 16:1997;218-236.
176. McGeer P.L., Akiyama H., Itagaki S., McGeer E.G. Activation of the classical complement pathway in brain tissue of Alzheimer patients. Neurosci. Lett. 107:1989;341-346.
177. McHale M.K., Hall G.F., Cohen M.J. Early cytoskeletal changes following injury of giant spinal axons in the lamprey. J. comp. Neurol. 353:1995;25-37.
178. McKee A.C., Kosik K.S., Kowall N.W. Neuritic pathology and dementia in Alzheimer's disease. Ann. Neurol. 30:1991;156-165.
179. McKee A.C., Kowall N.W., Schumacher J.S., Beal M.F. The neurotoxicity of amyloid beta protein in aged primates. Amyloid. 5:1998;1-9.
180. McKinney R.A., Debanne D., Gahwiler B.H., Thompson S.M. Lesion-induced axonal sprouting and hyperexcitability in the hippocampus in vitro: implications for the genesis of posttraumatic epilepsy. Nat. Med. 3:1997;990-996.
181. McQuarrie I.G. The effect of a conditioning lesion on the regeneration of motor axons. Brain Res. 152:1978;597-602.
182. Mecocci P., MacGarvey U., Beal M.F. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36:1994;747-751.
183. Meller D., Schmidt-Kastner R., Eysel U.T. Immunohistochemical studies on neurofilamentous hypertrophy in degenerating retinal terminals of the olivary pretectal nucleus in the rat. J. comp. Neurol. 331:1993;531-539.
184. Meller D., Eysel U.T., Schmidt-Kastner R. Transient immunohistochemical labelling of rat retinal axons during Wallerian degeneration by a monoclonal antibody to neurofilaments. Brain Res. 648:1994;162-166.
185. Meller K. Early structural changes in the axoplasmic cytoskeleton after axotomy studied by cryofixation. Cell Tissue Res. 250:1987;663-672.
186. Metuzals J., Robitaille Y., Houghton S., Gauthier S., Kang C.Y., Leblanc R. Neuronal transformations in Alzheimer's disease. Cell Tissue Res. 252:1988;239-248.
187. Mikucki S.A., Oblinger M.M. Corticospinal neurons exhibit a novel pattern of cytoskeletal gene expression after injury. J. Neurosci. Res. 30:1991;213-225.
188. Miller C.C., Brion J.P., Calvert R., Chin T.K., Eagles P.A., Downes M.J., Flament-Durand J., Haugh M., Kahn J., Probst A., Ulrich J., Anderton B.H. Alzheimer's paired helical filaments share epitopes with neurofilament side arms. EMBO J. 5:1986;269-276.
189. Mirra S.S., Heyman A., McKeel D., Sumi S.M., Crain B.J., Brownlee L.M., Vogel F.S., Hughes J.P., van Belle G., Berg L. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology. 41:1991;479-486.
190. 2+] in hippocampal neurons. Neuroreport. 9:1998;1553-1558.
191. Morris J.C., McKeel D.W. Jr, Storandt M., Rubin E.H., Price J.L., Grant E.A., Ball M.J., Berg L. Very mild Alzheimer's disease: informant-based clinical, psychometric, and pathologic distinction from normal aging. Neurology. 41:1991;469-478.
192. Morris J.C., Storandt M., McKeel D.W., Rubin E.H., Price J.L., Grant E.A., Berg L. Cerebral amyloid deposition and diffuse plaques in 'normal' aging: evidence from presymptomatic and very mild Alzheimer's disease. Neurology. 46:1996;707-719.
193. Morrison J.H., Lewis D.A., Campbell M.J., Huntley G.W., Benson D.L., Bouras C. A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease. Brain Res. 416:1987;331-336.
194. Moss T.H., Lewkowicz S.J. The axon reaction in motor and sensory neurones of mice studied by a monoclonal antibody marker of neurofilament protein. J. Neurol. Sci. 60:1983;267-280.
195. Motte J., Williams R.S. Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain. Acta Neuropathol. 77:1989;535-546.
196. Mrak R.E., Sheng J.G., Griffin W.S. Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum. Pathol. 26:1995;816-823.
197. Mufson E.J., Kordower J.H. Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease. Proc. natl Acad. Sci. USA. 89:1992;569-573.
198. Mufson E.J., Bothwell M., Kordower J.H. Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain. Exp. Neurol. 105:1989;221-232.
199. Mufson E.J., Conner J.M., Kordower J.H. Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis. Neuroreport. 6:1995;1063-1066.
200. Muma N.A., Hoffman P.N., Slunt H.H., Applegate M.D., Lieberburg I., Price D.L. Alterations in levels of mRNAs coding for neurofilament protein subunits during regeneration. Exp. Neurol. 107:1990;230-235.
201. Nachemson A.K., Hansson H.A., Dahl D., Lundborg G. Visualization of regenerating sciatic nerve fibres by neurofilament immunohistochemistry. Acta Physiol. Scand. 126:1986;485-489.
202. Nagy Z.S., Esiri M.M. Apoptosis-related protein expression in the hippocampus in Alzheimer's disease. Neurobiol. Aging. 18:1997;565-571.
203. Nakamura Y., Hasimoto R., Kashiwagi Y., Miyamae Y., Shinosaki K., Nishikawa T., Hattori H., Kudo T., Tacked M. Abnormal distribution of neurofilament L in neurons with Alzheimer's disease. Neurosci. Lett. 225:1993;201-204.
204. Nakamura M., Araki M., Oguro K., Masuzawa T. Differential distribution of 68 Kd and 200 Kd neurofilament proteins in the gerbil hippocampus and their early distributional changes following transient forebrain ischemia. Exp. Brain Res. 89:1997;31-39.
205. Nathan B.P., Bellosta S., Sanan D.A., Weisgraber K.H., Mahley R.W., Pitas R.E. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science. 264:1994;850-852.
206. Neve R.L., Robakis N.K. Alzheimer's disease: a re-examination of the amyloid hypothesis. Trends Neurosci. 21:1998;15-19.
207. Ng H.K., Mahaliyana R.D., Poon W.S. The pathological spectrum of diffuse axonal injury in blunt head trauma: assessment with axon and myelin strains. Clin. Neurol. Neurosurg. 96:1994;24-31.
208. Nukina N., Kosik K.S., Selkoe D.J. Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. Proc. natl Acad. Sci. USA. 84:1987;3415-3419.
209. Oblinger M.M., Lasek R.J. Axotomy-induced alterations in the synthesis and transport of neurofilaments and microtubules in dorsal root ganglion cells. J. Neurosci. 8:1988;1747-1758.
210. Oblinger M.M., Szumlas R.A., Wong J., Liuzzi F.J. Changes in cytoskeletal gene expression affect the composition of regenerating axonal sprouts elaborated by dorsal root ganglion neurons in vivo. J. Neurosci. 9:1989;2645-2653.
211. Okonkwo D.O., Pettus E.H., Moroi J., Povlishock J.T. Alteration of the neurofilament sidearm and its relation to neurofilament compaction occurring with traumatic axonal injury. Brain Res. 784:1998;1-6.
212. Olichney J.M., Hansen L.A., Galasko D., Saitoh T., Hofstetter C.R., Katzman R., Thal L.J. The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant. Neurology. 47:1996;190-196.
213. Olson L. Regeneration in the adult central nervous system: experimental repair strategies. Nat. Med. 3:1997;1329-1335.
214. O'Meara E.S., Kukull W.A., Sheppard L., Bowen J.D., McCormick W.C., Teri L., Pfanschmidt M., Thompson J.D., Schellenberg G.D., Larson E.B. Head injury and risk of Alzheimer's disease by apolipoprotein E genotype. Am. J. Epidemiol. 146:1997;373-384.
215. Osuntokun B.O., Sahota A., Ogunniyi A.O., Gureje O., Baiyewu O., Adeyinka A., Oluwole S.O., Komolafe O., Hall K.S., Unverzagt F.W., Hui S.L., Yang M., Hendrie H.C. Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians. Ann. Neurol. 38:1995;463-465.
216. Pant H.C. Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain. Biochem. J. 256:1988;665-668.
217. Pappolla M.A., Omar R.A., Sambamurti K., Anderson J.P., Robakis N.K. The genesis of the senile plaque. Further evidence in support of its neuronal origin. Am. J. Pathol. 141:1992;1151-1159.
218. Paradis E., Douillard H., Koutroumanis M., Goodyer C., LeBlanc A. Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons. J. Neurosci. 16:1996;7533-7539.
219. Paula-Barbosa M., Tavares M.A., Cadete-Leite A. A quantitative study of frontal cortex dendritic microtubules in patients with Alzheimer's disease. Brain Res. 417:1987;139-142.
220. Pearson R.C.A., Powell T.P.S. The neuroanatomy of Alzheimer's disease. Rev. Neurosci. 2:1989;101-122.
221. Pearson R.C.A., Esiri M.M., Hiorns R.W., Wilcock G.K., Powell T.P.S. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. Proc. natl Acad. Sci. USA. 82:1985;4531-4534.
222. Perry G., Rizzuto N., Autilio-Gambetti L., Gambetti P. Paired helical filaments from Alzheimer disease patients contain cytoskeletal components. Proc. natl Acad. Sci. USA. 82:1985;3916-3920.
223. Perry G., Lipphardt S., Mulvihill P., Kancherla M., Mijares M., Gambetti P., Sharma S., Maggiora L., Cornette J., Lobl T. Amyloid precursor protein in senile plaques of Alzheimer disease. Lancet. 2:1988;746.
224. Pettus E., Povlishock J. Characterization of a distinct set of intra-axonal ultrastructural changes associated with traumatically induced alteration in axolemmal permeability. Brain Res. 772:1996;1-11.
225. Pijak D.S., Hall G.F., Tenicki P.J., Boulos A.S., Lurie D.I., Selzer M.E. Neurofilament spacing, phosphorylation, and axon diameter in regenerating and uninjured lamprey axons. J. comp. Neurol. 368:1996;569-581.
226. Pike C.J., Walencewicz A.J., Glabe C.G., Cotman C.W. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 563:1991;311-314.
227. Pike C.J., Burdick D., Walencewicz A.J., Glabe C.G., Cotman C.W. Neurodegeneration induced by beta-amyloid peptides in vitro the role of peptide assembly state. J. Neurosci. 13:1993;1676-1687.
228. Pike C.J., Ramezan-Arab N., Cotman C.W. Beta-amyloid neurotoxicity in vitro: evidence of oxidative stress but not protection by antioxidants. J. Neurochem. 69:1997;1601-1611.
229. Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci. 17:1994;525-530.
230. Pope W., Enam S.A., Bawa N., Miller B.E., Ghanbari H.A., Klein W.L. Phosphorylated tau epitope of Alzheimer's disease is coupled to axon development in the avian central nervous system. Exp. Neurol. 120:1993;106-113.
231. Posmantur R.M., Kampfl A., Liu S.J., Heck K., Taft W.C., Clifton G.L., Hayes R.L. Cytoskeletal derangements of cortical neuronal processes three hours after traumatic brain injury in rats: an immunofluorescence study. J. Neuropathol. exp. Neurol. 55:1996;68-80.
232. Povlishock J.T., Christman C.W. The pathobiology of traumatically induced axonal injury in animals and humans: a review of current thoughts. J. Neurotrauma. 4:1995;555-564.
233. Povlishock J.T., Marmarou A., McIntosh T., Trojanowski J.Q., Moroi J. Impact acceleration injury in the rat: evidence for focal axolemmal change and related neurofilament sidearm alteration. J. Neuropathol. exp. Neurol. 56:1997;347-359.
234. Praprotnik D., Smith M.A., Richey P.L., Vinters H.V., Perry G. Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease. Acta Neuropathol. 91:1996;226-235.
235. Pravdenkova S.V., Basnakian A.G., James S.J., Andersen B.A.B. DNA fragmentation and nuclear endonuclease activity in rat brain after severe closed head injury. Brain Res. 729:1996;151-155.
236. Price J.L., Davis P.B., Morris J.C., White D.L. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol. Aging. 12:1991;295-312.
237. Ramon y Cajal S. Degeneration and Regeneration of the Nervous System. 1928;Oxford University Press, London.
238. Rebeck G.W., Reiter J.S., Strickland D.K., Hyman B.T. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron. 11:1993;575-580.
239. 2+-sensitive channel. J. biol. Chem. 273:1998;13379-13382.
240. Roberts G.W., Allsop D., Bruton C. The occult aftermath of boxing. J. Neurol. Neurosurg. Psychiat. 53:1990;373-378.
241. Robinson C.A., Clark A.W., Parhad I.M., Fung T.S., Bou S.S. Gene expression in Alzheimer neocortex as a function of age and pathologic severity. Neurobiol. Aging. 15:1994;681-690.
242. Rogers J., Luber-Narod J., Styren S.D., Civin W.H. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiol. Aging. 9:1988;339-349.
243. Roots B.I. Neurofilament accumulation induced in synapses by leupeptin. Science. 221:1983;971-972.
244. Rosenfeld J., Dorman M.E., Griffin J.W., Sternberger L.A., Sternberger N.H., Price D.L. Distribution of neurofilament antigens after axonal injury. J. Neuropathol. exp. Neurol. 46:1987;269-282.
245. Rosengren L.E., Karlsson J.E., Karlsson J.O., Persson L.I., Wikkelso C. Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF. J. Neurochem. 67:1996;2013-2018.
246. Ross D.T., Meaney D.F., Sabol M.K., Smith D.H., Gennarelli T.A. Distribution of forebrain diffuse axonal injury following inertial closed head injury in miniature swine. Exp. Neurol. 126:1994;291-299.
247. Sampson V.L., Morrison J.H., Vickers J.C. The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease. Exp. Neurol. 145:1997;295-302.
248. Saunders H.L., Dickson T.C., Vickers J.C. Immunolocalisation of β-amyloid precursor protein to plaque-associated synaptic alterations in the early and late stages of Alzheimer's disease. Alzheimer's Rep. 1:1998;111-119.
249. Schlaepfer W.W. Neurofilaments: structure, metabolism and implications in disease. J. Neuropathol. exp. Neurol. 46:1987;117-129.
250. Schlaepfer W.W., Hasler M.B. The persistence and possible externalization of axonal debris during Wallerian degeneration. J. Neuropathol. exp. Neurol. 38:1979;242-252.
251. Schmechel D.E., Saunders A.M., Strittmatter W.J., Crain B.J., Hulette C.M., Joo S.H., Pericak-Vance M.A., Goldgaber D., Roses A.D. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc. natl Acad. Sci. USA. 90:1993;9649-9653.
252. Schmidt M.L., Lee V.M., Trojanowski J.Q. Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles. Am. J. Pathol. 136:1990;1069-1075.
253. Schmidt M.L., Lee V.M., Trojanowski J.Q. Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads. Lab. Invest. 64:1991;352-357.
254. Schmidt M.L., DiDario A.G., Otvos L. Jr, Hooch N., Ant J.A., Lee V.M., Trojanowski J.Q. Plaque-associated neuronal proteins: a recurrent motif in neuritic amyloid deposits throughout diverse cortical areas of the Alzheimer's disease brain. Exp. Neurol. 130:1994;311-322.
255. Schubert W., Prior R., Weidemann A., Dircksen H., Multhaup G., Masters C.L., Beyreuther K. Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites. Brain Res. 563:1991;184-194.
256. Schwab M. Structural plasticity of the adult CNS: negative control by neurite growth inhibitory signals. Int. J. Dev. Neurosci. 14:1996;379-385.
257. Seidl R., Schuller E., Cairns N., Lubec G. Evidence against increased glycoxidation in patients with Alzheimer's disease. Neurosci. Lett. 232:1997;49-52.
258. Selkoe D.J. The molecular pathology of Alzheimer's disease. Neuron. 6:1991;487-498.
259. Selkoe D.J. Alzheimer's disease: a central role for amyloid. J. Neuropathol. exp. Neurol. 53:1994;438-447.
260. Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlosmacher M., Whaley J., Swindlehurst C., McCormack R., Wolfert R., Selkoe D., Lieberburg I., Schenk D.F. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature. 359:1992;325-327.
261. Shah P.T., Yoon K.W., Xu X.M., Broder L. Apoptosis mediates cell death following traumatic injury in rat hippocampal neurons. Neuroscience. 79:1997;999-1004.
262. Shaw G., Winialski D., Reier P. The effect of axotomy and deafferentation on phosphorylation dependent antigenicity of neurofilaments in rat superior cervical ganglion neurons. Brain Res. 460:1988;227-234.
263. Sheng J.G., Mrak R.E., Griffin W.S. Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution. Neuropathol. Appl. Neurobiol. 21:1995;290-301.
264. Sheng J.G., Mrak R.E., Griffin W.S. Progressive neuronal DNA damage associated with neurofibrillary tangle formation in Alzheimer disease. J. Neuropathol. exp. Neurol. 57:1998;323-328.
265. Shoji M., Golde T.E., Ghiso J., Cheung T.T., Estus S., Shaffer L., Cai X.-D., McKay D.M., Tintner R., Frangione B., Younkin S.G. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science. 258:1992;126-129.
266. Shohami E., Novikov M., Bass R., Yamin A., Gallily R. Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue. J. Cereb. Blood Flow Metab. 14:1994;615-619.
267. Siegel S.J., Ginsberg S.D., Hof P.R., Foote S.L., Young W.G., Kraemer G.W., McKinney W.T., Morrison J.H. Effects of social deprivation in prepubescent rhesus monkeys: immunohistochemical analysis of the neurofilament protein triplet in the hippocampal formation. Brain Res. 619:1991;299-305.
268. Silveira L.C., Russelakis-Carneiro M., Perry V. The ganglion cell response to optic nerve injury in the cat: differential responses revealed by neurofibrillar staining. J. Neurocytol. 23:1994;75-86.
269. Smale G., Nichols N.R., Brady D.R., Finch C.E., Horton W.E. Jr. Evidence for apoptotic cell death in Alzheimer's disease. Exp. Neurol. 133:1995;225-230.
270. Smith A.D., Jobst K.A. Use of structural imaging to study the progression of Alzheimer's disease. Br. Med. Bull. 52:1996;575-586.
271. Smith M.A., Sayre L.M., Monnier V.M., Perry G. Radical AGEing in Alzheimer's disease. Trends Neurosci. 18:1995;172-176.
272. Soussan L., Tchernakov K., Bachar-Lavi O., Yuvan T., Wertman E., Michaelson D.M. Antibodies to different isoforms of the heavy neurofilament protein (NF-H) in normal aging and Alzheimer's disease. Mol. Neurobiol. 9:1994;83-91.
273. Stadelmann C., Bruck W., Bancher C., Jellinger K., Lassmann H. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J. Neuropathol. exp. Neurol. 57:1998;456-464.
274. Sternberger L.A., Sternberger N.H. Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc. natl Acad. Sci. USA. 80:1983;6126-6130.
275. Sturchler-Pierrat C., Abramowski D., Duke M., Wiederhold K.H., Mistl C., Rothacher S., Ledermann B., Burki K., Frey P., Paganetti P.A., Waridel C., Calhoun M.E., Jucker M., Probst A., Staufenbiel M., Sommer B. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc. natl Acad. Sci. USA. 9:1997;13287-13292.
276. Su J.H., Anderson A.J., Cummings B.J., Cotman C.W. Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport. 5:1994;2529-2533.
277. Su J.H., Cummings B.J., Cotman C.W. Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res. 739:1996;79-87.
278. Su J.H., Deng G., Cotman C.W. Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology. J. Neuropathol. exp. Neurol. 56:1997;86-93.
279. Su J.H., Cummings B.J., Cotman C.W. Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites. Acta Neuropathol. 96:1998;463-471.
280. Tan S., Pepys M. Amyloidosis. Histopathology. 25:1994;403-414.
281. Tanaka K., Webster H.D. Myelinated fiber regeneration after crush injury is retarded in sciatic nerves of aging mice. J. comp. Neurol. 308:1991;180-187.
282. Tang M.X., Stern Y., Marder K., Bell K., Gurland B., Lantigua R., Andrews H., Feng L., Tycko B., Mayeux R. The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and hispanics. J. Am. Med. Assoc. 279:1998;751-755.
283. Taupin V., Toulmond S., Serrano A., Benavides J., Zavala F. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (psite) benzodiazepine ligand. J. Neuroimmunol. 42:1993;177-185.
284. Tchelingerian J.L., Quinonero J., Booss J., Jacque C. Localization of TNF alpha and IL-1 alpha immunoreactivities in striatal neurons after surgical injury to the hippocampus. Neuron. 10:1993;213-224.
285. Teasdale G.M., Nicoll J.A.R., Murray G., Fiddes M. Association of apolipoprotein E polymorphism with outcome after head injury. Lancet. 350:1997;1069-1071.
286. Te Koppele J.M., Lucassen P.J., Sakkee A.N., Van Asten J.G., Ravid R., Swaab D.F., Van Bezooijen C.F. 8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer's disease. Neurobiol. Aging. 17:1996;819-826.
287. Terai K., Walker D.G., McGeer E.G., McGeer P.L. Neurons express proteins of the classical complement pathway in Alzheimer disease. Brain Res. 769:1997;385-390.
288. Terry R.D., Masliah E., Hansen L.A. Structural basis of the cognitive alterations in Alzheimer disease. Terry R.D., Katzman R., Bick K.L. Alzheimer Disease. 1994;179-196 Raven Press, New York.
289. Tetzlaff W., Bisby M.A. Neurofilament elongation into regenerating facial nerve axons. Neuroscience. 29:1989;659-666.
290. Tetzlaff W., Bisby M.A., Kreutzberg G. Changes in cytoskeletal protein synthesis in the rat facial nucleus following axotomy. J. Neurosci. 8:1988;3181-3189.
291. Tetzlaff W., Leonard C., Krekoski C.A., Parhad I.M., Bisby M.A. Reductions in motoneuronal neurofilament synthesis by successive axotomies: a possible explanation for the conditioning lesion effect on axon regeneration. Exp. Neurol. 139:1996;95-106.
292. Tokuda T., Ikeda S., Yanagisawa N., Ihara Y., Glenner G. Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid b-protein and tau protein. Acta Neuropathol. 82:1991;280-285.
293. Torack R.M., Roth K.A., Miller J.W. Neuronal argyrophilia and phosphorylated neurofilament accumulation secondary to deafferentation. J. Neuropathol. exp. Neurol. 55:1996;466-470.
294. Tortosa A., Lopez E., Ferrer I. Bcl-2 and Bax protein expression in Alzheimer's disease. Acta Neuropathol. 95:1998;407-412.
295. Torvick A. Central chromatolysis and the axon reaction: a reappraisal. Neuropathol. Appl. Neurobiol. 2:1976;423-432.
296. Toulmond S., Rothwell N.J. Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat. Brain Res. 671:1995;261-266.
297. Traub P., Vorgias C.E., Nelson W. Interaction in vitro of the neurofilament triplet proteins from porcine spinal cord with natural RNA and DNA. Mol. Biol. Rep. 10:1985;129-136.
298. Trojanowski J.Q., Lee V.M., Schlaepfer W.W. Neurofilament breakdown products in degenerating rat and human peripheral nerves. Ann. Neurol. 16:1984;349-355.
299. Troncoso J.C., Cataldo A.M., Nixon R.A., Barnett J.L., Lee M.K., Checler F., Fowler D.R., Smialek J.E., Crain B., Martin L.J., Kawas C.H. Neuropathology of preclinical and clinical late-onset Alzheimer's disease. Ann. Neurol. 43:1998;673-676.
300. Troy C.M., Muma N.A., Greene L.A., Price D.L., Shelanski M.L. Regulation of peripherin and neurofilament expression in regenerating rat motor neurons. Brain Res. 529:1990;232-238.
301. Uchida Y., Ihara Y., Tomonaga M. Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats. Biochem. biophys. Res. Commun. 150:1988;1263-1267.
302. Uchida Y., Takio K., Titani K., Ihara Y., Tomonaga M. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron. 7:1991;337-347.
303. Ulrich J. Alzheimer changes in nondemented patients younger than sixty-five: possible early stages of Alzheimer's disease and senile dementia of Alzheimer type. Ann. Neurol. 17:1985;273-277.
304. Vickers J.C. Commentary: a cellular mechanism for the neuronal changes underlying Alzheimer's disease. Neuroscience. 78:1997;629-639.
305. Vickers J.C., Costa M. The neurofilament triplet is present in distinct subpopulations of neurones in the CNS of the guinea-pig. Neuroscience. 49:1992;73-100.
306. Vickers J.C., Costa M., Vitadello M., Dahl D., Marotta C.A. Neurofilament protein-triplet immunoreactivity in distinct subpopulations of peptide-containing neurons in the guinea-pig coeliac ganglion. Neuroscience. 39:1990;743-759.
307. Vickers J.C., Delacourte A., Morrison J.H. Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease. Brain Res. 594:1992;273-278.
308. Vickers J.C., Riederer B.M., Marugg R.A., Buee-Scherrer V., Buee L., Delacourte A., Morrison J.H. Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease. Neuroscience. 62:1994;1-13.
309. Vickers J.C., Huntley G.W., Morrison J.H. Excitatory amino acids and neurotoxicity in the human neocortex. Tracey D., Stone J., Paxinos G. Neurotransmitters in the Human Brain. 1995;79-99 Plenum Press, New York.
310. Vickers J.C., Chin D., Edwards A-M., Sampson V., Harper C., Morrison J. Dystrophic neurite formation associated with age-related β amyloid deposition in the neocortex: clues to the genesis of neurofibrillary pathology. Exp. Neurol. 141:1996;1-11.
311. de Waegh S.M., Lee V.M., Brady S.T. Local modulation of neurofilament phosphorylation axonal calibre and slow axonal transport by myelinating Schwann cells. Cell. 68:1992;451-463.
312. Wang D., Munoz D.G. Qualitative and quantitative differences in senile plaque dystrophic neurites of Alzheimer's disease and normal aged brain. J. Neuropath. exp. Neurol. 54:1995;548-556.
313. Webster S., Lue L.F., Brachova L., Tenner A.J., McGeer P.L., Terai K., Walker D.G., Bradt B., Cooper N.R., Rogers J. Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer's disease. Neurobiol. Aging. 18:1997;415-421.
314. 2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture. J. Neurochem. 62:1994;372-375.
315. Weldon D.T., Rogers S.D., Ghilardi J.R., Finke M.P., Cleary J.P., O'Hare E., Esler W.P., Maggio J.E., Mantyh P.W. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J. Neurosci. 18:1998;2161-2173.
316. Wigley C.B., Berry M. Regeneration of adult rat retinal ganglion cell processes in monolayer culture: comparisons between cultures of adult and neonatal neurons. Brain Res. 470:1988;85-98.
317. Wischik C.M., Novak M., Thogersen H.C., Edwards P.C., Runswick M.J., Jakes R., Walker J.E., Milstein C., Roth M., Klug A. Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc. natl Acad. Sci. USA. 85:1988;4506-4510.
318. Wischik C.M., Edwards P.C., Lai R.Y.K., Gertz H.N.J., Xuereb J.H., Paykel E.S., Brayne C., Huppert F.A., Mukaetovaladinska E.B., Mena R., Roth M., Harrington C.R. Quantitative analysis of tau protein in paired helical filament preparations: implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer's disease. Neurobiol. Aging. 16:1995;409-417.
319. Wisniewski K.E., Wisniewski H.M., Wen G.Y. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 17:1985;272-282.
320. Wisniewski T., Frangione B. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci. Lett. 135:1992;235-238.
321. Wolozin B., Iwasaki K., Vito P., Ganjei J.K., Lacana E., Sunderland T., Zhao B., Kusiak J.W., Wasco W., D'Adamio L. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science. 274:1996;1710-1713.
322. Wujek J.R., Lasek R.J. Correlation of axonal regeneration and slow component B in two branches of a single axon. J. Neurosci. 3:1983;243-251.
323. Yaar M., Zhai S., Pilch P.F., Doyle S.M., Eisenhauer P.B., Fine R.E., Gilchrest B.A. Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J. clin. Invest. 100:1997;2333-2340.
324. Yaghmai A., Povlishock J. Traumatically induced reactive change as visualized through the use of monoclonal antibodies targeted to neurofilament subunits. J. Neuropathol. exp. Neurol. 51:1992;158-176.
325. Yamada E., Hazama F. Different stability of neurofilaments for trypsin treatment after axotomy in the dorsal motor nucleus of the vagal nerve and the hypoglossal nucleus. Brain Res. 612:1993;210-215.
326. Yamasaki H., Itakura C., Mizutani M. Hereditary hypotrophic axonopathy with neurofilament deficiency in a mutant strain of the Japanese quail. Acta Neuropathol. 82:1991;427-434.
327. Yan H.Q., Banos M.A., Herregodts P., Hooghe R., Hooghe-Peters E.L. Expression of interleukin (IL)-1 beta, IL-6 and their respective receptors in the normal rat brain and after injury. Eur. J. Immun. 22:1992;2963-2971.
328. Yan S.D., Chen X., Fu J., Chen M., Zhu H., Roher A., Slattery T., Zhao L., Nagashima M., Morser J., Migheli A., Nawroth P., Stern D., Schmidt A.M. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature. 382:1996;685-691.
329. Yankner B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 16:1996;921-932.
330. Yasuhara O., Kawamata T., Aimi Y., McGeer E.G., McGeer P.L. Two types of dystrophic neurites in senile plaques of Alzheimer disease and elderly non-demented cases. Neurosci. Lett. 171:1994;73-76.
331. Zhan S.S., Kamphorst W., Van Nostrand W.E., Eikelenboom P. Distribution of neuronal growth-promoting factors and cytoskeletal proteins in altered neurites in Alzheimer's disease and non-demented elderly. Acta Neuropathol. 89:1995;356-362.
332. Zhang H., Sternberger N.H., Rubinstein L.J., Herman M.M., Binder L.I., Sternberger L.A. Abnormal processing of multiple proteins in Alzheimer disease. Proc. natl Acad. Sci. USA. 86:1989;8045-8049.
333. Zhu Q., Couillard-Despres S., Julien J. Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments. Exp. Neurol. 148:1997;299-316.