Synthesis and antimicrobial evaluation of 3-methanone-6-substituted- benzofuran derivatives

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 879-886

  Liu, Jingbao ^a   Jiang, Faqin ^a   Jiang, Xizhen ^a   Zhang, Wei ^a   Liu, Jingjing ^a   Liu, Wenlu ^a   Fu, Lei ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Antimicrobial; Benzofuran; Synthesis

Indexed keywords

1 (2 (4 METHOXYPHENYL) 6 (2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY) BENZOFURAN 3 YL) 3 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (2 (4 METHOXYPHENYL) 6 (2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY) BENZOFURAN 3 YL)ETHANONE; 1 (6 (2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY) 2 (5 METHYLFURAN 2 YL)BENZOFURAN 3 YL)ETHANONE; 1 (6 HYDROXY 2 (5 METHYLFURAN 2 YL) BENZOFURAN 3 YL)ETHANONE; 2 (4 METHOXYPHENYL)BENZOFURAN 6 OL; 2 (5 METHYLFURAN 2 YL)BENZOFURAN 6 OL; 2 PHENYLBENZOFURAN 6 OL; 3,4,5 TRIMETHOXY N [[6 (2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY) 2 PHENYL BENZOFURAN 3 YL]METHYL]ANILINE; 3,4,5 TRIMETHOXY N [[6 (2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY) 2 PHENYL BENZOFURAN 3 YL]METHYLENE]ANILINE; 4 (2 (2 (4 METHOXYPHENYL)BENZOFURAN 6 YLOXY)ETHYL) 5 METHYL 2 PHENYLOXAZOLE; 5 METHYL 2 PHENYL 4 (2 (2 PHENYLBENZOFURAN 6 YLOXY)ETHYL)OXAZOLE; 5 METHYL 4 (2 (2 (5 METHYLFURAN 2 YL)BENZOFURAN 6 YLOXY)ETHYL) 2 PHENYL OXAZOLE; 6 (BENZYLOXY) 2 (4 METHOXYPHENYL)BENZOFURAN; 6 (BENZYLOXY) 2 (5 METHYLFURAN 2 YL)BENZOFURAN; 6 (BENZYLOXY) 2 PHENYLBENZOFURAN; BENZOFURAN DERIVATIVE; CEFOTAXIME; CEFRADINE; CEFTAZIDIME; FURAN 2 YL (6 (2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY) 2 (5 METHYLFURAN 2 YL)BENZOFURAN 3 YL)METHANONE; PENICILLIN G SODIUM; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; ENDOSPORE-FORMING RODS AND COCCI; ESCHERICHIA COLI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; SCREENING; STAPHYLOCOCCUS AUREUS; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIA; BENZOFURANS; CHEMISTRY TECHNIQUES, SYNTHETIC; MICROBIAL SENSITIVITY TESTS;

EID: 84864405534     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.013     Document Type: Article

References (25)

1. S. Rachakonda, and L. Cartee Curr. Med. Chem. 11 2004 775 793
2. C. Nathan Nature 431 2004 899 902
3. R. Leclercq Clin. Microbiol. Infect. 15 2009 224
4. K. Manna, and Y.K. Agarwal Bioorg. Med. Chem. Lett. 19 2009 2688 2692
5. A. Urzúa, M.C. Rezende, C. Mascayano, and L. Vásquez Molecules 13 2008 882 891
6. N.K. Gundogdu, B. Kadriya, T. Yagmur, U. Umit, and D. Seref Eur. J. Med. Chem. 41 2006 6516
7. I. Hayakawa, R. Shioya, T. Agatsuma, H. Furukawa, S. Naruto, and Y. Sugano Bioorg. Med. Chem. Lett. 14 2004 455 458
8. S.A. Galal, E.A. Abd, M.M. Abdullah, and H.I. Diwani Bioorg. Med. Chem. Lett. 19 2009 2420 2428
9. A. Hall, A. Billinton, S.H. Brown, N.M. Clayton, A. Chowdhury, G.M.P. Giblin, P. Goldsmith, T.G. Hayhow, D.N. Hurst, I.R. Kilford, A. Naylor, B. Passingham, and L. Winyard Bioorg. Med. Chem. Lett. 18 2008 3392 3399
10. B.S. Dawane, S.G. Konda, N.T. Khandare, S.S. Chobe, B.M. Shaikh, R.G. Bodade, and V.D. Joshi Org. Commun. 3 2010 22 29
11. H.A. Abdel-Aziz, and A.I. Mekawey Eur. J. Med. Chem. 44 2009 4985 4997
12. C. Kirilmis, M. Ahmedzade, S. Servi, M. Koca, A. Kizirgil, and C. Kazaz Eur. J. Med. Chem. 43 2008 300 308
13. M. Cowart, G.A. Gfesser, K.E. Browman, R. Faghih, and T.R. Miller Biochem. Pharmacol. 73 2007 1243 1255
14. H.F. Guo, H.Y. Shao, Z.Y. Yang, S.T. Xue, X. Li, Z.Y. Liu, X.B. He, J.D. Jiang, Y.Q. Zhang, S.Y. Si, and Z.R. Li J. Med. Chem. 53 2010 1819 1829
15. X.Z. Jiang, W.L. Liu, W. Zhang, F.Q. Jiang, Z. Gao, H. Zhuang, and L. Fu Eur. J. Med. Chem. 46 2011 3526 3530
16. W. Zhang, W.L. Liu, X.Z. Jiang, F.Q. Jiang, H. Zhuang, and L. Fu Eur. J. Med. Chem. 46 2011 3639 3650
17. S.M. Michael, P.C. Richard, G. David, H. Ralph, G. Keith, G. Iwan, A.N. James, K. Mira, S. Uresh, and A.H. David J. Med. Chem. 39 1996 237 245
18. S. Takashi, M. Katsutoshi, M. Yu, I. Hitoshi, F. Takeshi, and M. Kanji J. Med. Chem. 35 1992 2617 2626
19. V.D. Pratik, C. Sean, J. Yoon, F.C. Qu, and C.N. Shao J. Med. Chem. 48 2005 2248 2250
20. X.F. Duan, J. Zeng, Z.B. Zhang, and G.F. Zi J. Org. Chem. 72 2007 10283 10286
21. S. Ducki, D. Rennison, M.K. Woo, A. Kendall, D.C. Fournier, M.G. Jeremie, T.L. Alan, and J. Nicholas Bioorg. Med. Chem. 17 2009 7698 7710
22. D. Biswanath, B. Joydeep, R. Ramu, P. Rammohan, N. Ravindranath, and C. Ramesh Tetrahedron. Lett. 44 2003 5465 5468
23. K.D. Kaufman, D.J. Erb, T.M. Blok, R.W. Carlson, D.J. Knoechel, L. McBride, and T. Zeitlow J. Heterocyclic. Chem. 19 1982 1051 1056
24. National Committee for Clinical Laboratory Standard Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Approved Standard, M7eA6 fifth ed. 2003 National Committee for Clinical Laboratory Standards Wayne, PA
25. National Committee for Clinical Laboratory Standard Reference Method for Broth Dilution Antifungal Susceptibility Testing of Conidium-forming Filamentous Fungi Proposed Standard M38eP 1998 National Committee for Clinical Laboratory Standards Wayne, PA