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Volumn 2, Issue 3, 2003, Pages 205-213

Tamoxifen: A most unlikely pioneering medicine

Author keywords

[No Author keywords available]

Indexed keywords

1,1,2 TRIPHENYLETHYLENE DERIVATIVE; ANDROGEN; ANTIESTROGEN; ANTINEOPLASTIC AGENT; AROMATASE INHIBITOR; CHLOROTRIANISENE; CLOMIFENE; CLOMIFENE CITRATE; DROLOXIFENE; ESTROGEN RECEPTOR; ETHAMOXYTRIPHETOL; FULVESTRANT; GLUCOCORTICOID; N BUTYL 11 (3,17BETA DIHYDROXYESTRA 1,3,5(10) TRIEN 7ALPHA YL) N METHYLUNDECANAMIDE; NAFOXIDENE; ORAL CONTRACEPTIVE AGENT; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TAMOXIFEN CITRATE; TRIPARANOL; UNCLASSIFIED DRUG; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS;

EID: 0037364074     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd1031     Document Type: Review
Times cited : (642)

References (96)
  • 1
    • 0003720744 scopus 로고
    • Paul Ehrlich: Scientist for Life
    • (Holmes & Meier, New York)
    • Baumler, E. Paul Ehrlich: Scientist for Life (Holmes & Meier, New York, 1984).
    • (1984)
    • Baumler, E.1
  • 2
    • 36949059277 scopus 로고
    • Contrasting endocrine activities of cis and trans isomers in a series of substituted triphenylethylenes
    • Harper, M. J. & Walpole, A. L. Contrasting endocrine activities of cis and trans isomers in a series of substituted triphenylethylenes. Nature 212, 87 (1966).
    • (1966) Nature , vol.212 , pp. 87
    • Harper, M.J.1    Walpole, A.L.2
  • 3
    • 0014053604 scopus 로고
    • A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
    • Harper, M. J. & Walpole, A. L. A new derivative of triphenylethylene: effect on implantation and mode of action in rats. J. Reprod. Fertil. 13, 101-119 (1967).
    • (1967) J. Reprod. Fertil. , vol.13 , pp. 101-119
    • Harper, M.J.1    Walpole, A.L.2
  • 4
    • 0014039539 scopus 로고
    • Mode of action of I. C. I. 46,474 in preventing implantation in rats
    • Harper, M. J. & Walpole, A. L. Mode of action of I. C. I. 46,474 in preventing implantation in rats. J. Endocrinol. 37, 83-92 (1967).
    • (1967) J. Endocrinol. , vol.37 , pp. 83-92
    • Harper, M.J.1    Walpole, A.L.2
  • 5
    • 0015069359 scopus 로고
    • A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474
    • Cole, M. P., Jones, C. T. & Todd, I. D. A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474. Br. J. Cancer 25, 270-275 (1971).
    • (1971) Br. J. Cancer , vol.25 , pp. 270-275
    • Cole, M.P.1    Jones, C.T.2    Todd, I.D.3
  • 6
    • 0015915672 scopus 로고
    • Anti-oestrogen therapy for breast cancer: A trial of tamoxifen at two dose levels
    • Ward, H. W. Anti-oestrogen therapy for breast cancer: a trial of tamoxifen at two dose levels. Br. Med. J. 1, 13-14 (1973).
    • (1973) Br. Med. J. , vol.1 , pp. 13-14
    • Ward, H.W.1
  • 7
    • 0019382847 scopus 로고
    • Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer
    • Ingle, J. N. et al. Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer N. Engl. J. Med. 304, 16-21 (1981).
    • (1981) N. Engl. J. Med. , vol.304 , pp. 16-21
    • Ingle, J.N.1
  • 8
    • 50549123220 scopus 로고
    • On the treatment of inoperable cases of carcinoma of the mamma: Suggestions for a new method of treatment with illustrative cases
    • Beatson, G. T. On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases. Lancet 2, 104-107 (1896).
    • (1896) Lancet , vol.2 , pp. 104-107
    • Beatson, G.T.1
  • 9
    • 0001733527 scopus 로고
    • On oophorectomy in cancer of the breast
    • Boyd, S. On oophorectomy in cancer of the breast. BMJ 2, 1161-1167 (1900).
    • (1900) BMJ , vol.2 , pp. 1161-1167
    • Boyd, S.1
  • 10
    • 84965819865 scopus 로고
    • Further investigations on the origins of tumors in mice III on the part played by internal secretions in the spontaneous development of tumors
    • Lathrop, A. E. & Loeb, L. Further investigations on the origins of tumors in mice III on the part played by internal secretions in the spontaneous development of tumors. J. Cancer Res. 1, 1-19 (1916).
    • (1916) J. Cancer Res. , vol.1 , pp. 1-19
    • Lathrop, A.E.1    Loeb, L.2
  • 11
    • 84965826780 scopus 로고
    • Hormonal pathogenesis of adenocarcinoma of the breast
    • Lacassagne, A. Hormonal pathogenesis of adenocarcinoma of the breast. Am. J. Cancer 27, 217-225 (1936).
    • (1936) Am. J. Cancer , vol.27 , pp. 217-225
    • Lacassagne, A.1
  • 13
    • 70449221678 scopus 로고
    • A non-steroidal estrogen antagonist 1-(p-2-diethylamino-ethoxyphenyl)-1-phenyl-2-p-methoxyphenylethanol
    • Lerner, L. J., Holthaus, J. F. & Thompson, C. R. A non-steroidal estrogen antagonist 1-(p-2-diethylamino-ethoxyphenyl)-1-phenyl-2-p-methoxyphenylethanol. Endocrinology 63, 295-318 (1958).
    • (1958) Endocrinology , vol.63 , pp. 295-318
    • Lerner, L.J.1    Holthaus, J.F.2    Thompson, C.R.3
  • 14
  • 15
    • 0017166858 scopus 로고
    • Nafoxidine - An antiestrogen for the treatment of breast cancer
    • Legha, S. S., Slavik, M. & Carter, S. K. Nafoxidine - an antiestrogen for the treatment of breast cancer. Cancer 38, 1535-1541 (1976).
    • (1976) Cancer , vol.38 , pp. 1535-1541
    • Legha, S.S.1    Slavik, M.2    Carter, S.K.3
  • 17
    • 78651125476 scopus 로고
    • Induction of ovulation with MRL-41 - Preliminary Report
    • Greenblatt, R. B., Barfield, W. E., Jungck, E. C. & Ray, A. W. Induction of ovulation with MRL-41 - Preliminary Report. JAMA 178, 101-104 (1961).
    • (1961) JAMA , vol.178 , pp. 101-104
    • Greenblatt, R.B.1    Barfield, W.E.2    Jungck, E.C.3    Ray, A.W.4
  • 19
    • 0013953902 scopus 로고
    • Clomiphene citrate experience with 217 patients
    • Whitelaw, M. J. Clomiphene citrate experience with 217 patients. Fertil. Steril. 17, 584-604 (1966).
    • (1966) Fertil. Steril. , vol.17 , pp. 584-604
    • Whitelaw, M.J.1
  • 20
    • 0003110545 scopus 로고
    • Clomiphene citrate (NSC-35770) in disseminated mammary carcinoma
    • Herbst, A. L., Griffiths, C. T. & Kistner, R. W. Clomiphene citrate (NSC-35770) in disseminated mammary carcinoma. Cancer Chemother. Rep. 43, 39-41 (1964).
    • (1964) Cancer Chemother. Rep. , vol.43 , pp. 39-41
    • Herbst, A.L.1    Griffiths, C.T.2    Kistner, R.W.3
  • 21
    • 0015964856 scopus 로고
    • Antioestrogens in treatment of breast cancer: Value of nafoxidine in 52 advanced cases
    • Bloom, H. J. G. & Boesch, E. Antioestrogens in treatment of breast cancer: value of nafoxidine in 52 advanced cases. Br. Med. J. 2, 7-12 (1974).
    • (1974) Br. Med. J. , vol.2 , pp. 7-12
    • Bloom, H.J.G.1    Boesch, E.2
  • 22
    • 0007780424 scopus 로고
    • Merrel Company. Official Literature on New Drugs: Clomiphene citrate (Clomid)
    • William S. Merrel Company. Official Literature on New Drugs: Clomiphene citrate (Clomid). Clin. Pharmacol. Ther. 8, 891-897 (1967).
    • (1967) Clin. Pharmacol. Ther. , vol.8 , pp. 891-897
    • William, S.1
  • 23
    • 0242325370 scopus 로고
    • The effects of triparanol (MER-29) in subjects with and without coronary artery disease
    • Hollander, W., Chobanian, A. V. & Wilkins, R. W. The effects of triparanol (MER-29) in subjects with and without coronary artery disease. JAMA 174, 87-94 (1960).
    • (1960) JAMA , vol.174 , pp. 87-94
    • Hollander, W.1    Chobanian, A.V.2    Wilkins, R.W.3
  • 24
    • 0000902977 scopus 로고
    • Cataracts in patients treated with triparanol
    • Laughlin, R. C. & Carey, T. F. Cataracts in patients treated with triparanol. JAMA 181, 369-370 (1962).
    • (1962) JAMA , vol.181 , pp. 369-370
    • Laughlin, R.C.1    Carey, T.F.2
  • 25
    • 0038217674 scopus 로고
    • Studies of cholesterol biosynthesis. The identification of desmosterol in serum and tissues of animals and man treated with MER29
    • Avigan, J., Steinberg, D., Vroman H. E., Thompson, M. J. & Mosettig, E. Studies of cholesterol biosynthesis. The identification of desmosterol in serum and tissues of animals and man treated with MER29. J. Biol. Chem. 235, 3123-3126 (1960).
    • (1960) J. Biol. Chem. , vol.235 , pp. 3123-3126
    • Avigan, J.1    Steinberg, D.2    Vroman, H.E.3    Thompson, M.J.4    Mosettig, E.5
  • 26
    • 0242356764 scopus 로고
    • Triparanol in the treatment of disseminated mammary carcinoma
    • Kraft, R. O. Triparanol in the treatment of disseminated mammary carcinoma. Cancer Chemother. Rep. 25, 113-115 (1962).
    • (1962) Cancer Chemother. Rep. , vol.25 , pp. 113-115
    • Kraft, R.O.1
  • 27
    • 84965250913 scopus 로고
    • Influence of synthetic oestrogens upon advanced malignant disease
    • Haddow, A., Watkinson, J. M. & Paterson, E. Influence of synthetic oestrogens upon advanced malignant disease. BMJ 2, 393-398 (1944).
    • (1944) BMJ , vol.2 , pp. 393-398
    • Haddow, A.1    Watkinson, J.M.2    Paterson, E.3
  • 28
    • 0001528477 scopus 로고
    • Synthetic oestrogens in mammary cancer
    • Walpole, A. L. & Paterson, E. Synthetic oestrogens in mammary cancer. Lancet 2, 783-789 (1949).
    • (1949) Lancet , vol.2 , pp. 783-789
    • Walpole, A.L.1    Paterson, E.2
  • 29
    • 0001761072 scopus 로고
    • Preparation and identification of cis and trans isomers of a substituted triphenylethylene
    • Bedford, G. & Richardson, D. N. Preparation and identification of cis and trans isomers of a substituted triphenylethylene. Nature 212, 733-734 (1966).
    • (1966) Nature , vol.212 , pp. 733-734
    • Bedford, G.1    Richardson, D.N.2
  • 30
    • 0012848878 scopus 로고
    • Identification of isomers of a substituted triphenylethylene: The crystal structure of 1-p-(2-dimethylaminoethoxyphenyl)1,2 cis diphenyl but1-ene hydrobromide
    • Kilbourn, B., Mais, R. H. B. & Owston, P. G. Identification of isomers of a substituted triphenylethylene: the crystal structure of 1-p-(2-dimethylaminoethoxyphenyl)1,2 cis diphenyl but1-ene hydrobromide. Chem. Commun. 1, 291 (1968).
    • (1968) Chem. Commun. , vol.1 , pp. 291
    • Kilbourn, B.1    Mais, R.H.B.2    Owston, P.G.3
  • 31
    • 0014930647 scopus 로고
    • Role of oestrogen in spontaneous ovulation demonstrated by use of an antagonist of oestrogen ICI46,474
    • Labhsetwar, A. P. Role of oestrogen in spontaneous ovulation demonstrated by use of an antagonist of oestrogen ICI46,474. Nature 225, 80-81 (1970).
    • (1970) Nature , vol.225 , pp. 80-81
    • Labhsetwar, A.P.1
  • 32
    • 0014847041 scopus 로고
    • Role of estrogen in ovulation a study using estrogen antagonist ICI46,474
    • Labhsetwar, A. P. Role of estrogen in ovulation a study using estrogen antagonist ICI46,474. Endocrinology 87, 542-551 (1970).
    • (1970) Endocrinology , vol.87 , pp. 542-551
    • Labhsetwar, A.P.1
  • 33
    • 0015064011 scopus 로고
    • Effects of antioestrogen on the corpus luteum of rabbits and rats
    • Labhsetwar, A. P. Effects of antioestrogen on the corpus luteum of rabbits and rats. J. Reprod. Fertil. 25, 295-297 (1971).
    • (1971) J. Reprod. Fertil. , vol.25 , pp. 295-297
    • Labhsetwar, A.P.1
  • 34
    • 0015320879 scopus 로고
    • Role of estrogen in spontaneous ovulation: Evidence for positive feedback in hamsters
    • Labhsetwar, A. P. Role of estrogen in spontaneous ovulation: evidence for positive feedback in hamsters. Endocrinology 90, 941-946 (1972).
    • (1972) Endocrinology , vol.90 , pp. 941-946
    • Labhsetwar, A.P.1
  • 35
    • 0023773272 scopus 로고
    • The development of tamoxifen for breast cancer therapy: A tribute to the late Arthur L. Walpole
    • Jordan, V. C. The development of tamoxifen for breast cancer therapy: a tribute to the late Arthur L. Walpole. Breast Cancer Res. Treat. 11, 197-209 (1988).
    • (1988) Breast Cancer Res. Treat. , vol.11 , pp. 197-209
    • Jordan, V.C.1
  • 36
    • 0015228433 scopus 로고
    • New synthetic agent for the induction of ovulation. Preliminary trial in women
    • Klopper, A. & Hall, M. New synthetic agent for the induction of ovulation. Preliminary trial in women. Br. Med. J. 1, 152-154 (1971).
    • (1971) Br. Med. J. , vol.1 , pp. 152-154
    • Klopper, A.1    Hall, M.2
  • 38
    • 0015364812 scopus 로고
    • Treatment of menometrorrhagia with an anti-oestrogen
    • El-Sheikha, Z., Klopper, A. & Beck, J. S. Treatment of menometrorrhagia with an anti-oestrogen. Clin. Endocrinology 1, 275-282 (1972).
    • (1972) Clin. Endocrinology , vol.1 , pp. 275-282
    • El-Sheikha, Z.1    Klopper, A.2    Beck, J.S.3
  • 40
    • 0017231499 scopus 로고
    • Stereochemistry of geometric isomers of clomiphene: A correction of structure-activity relationships
    • Ernst, S., Hite, G., Cantrell, J. S., Richardson Jr, A. & Benson, H. D. Stereochemistry of geometric isomers of clomiphene: a correction of structure-activity relationships. J. Pharm. Sci. 65, 148-150 (1976).
    • (1976) J. Pharm. Sci. , vol.65 , pp. 148-150
    • Ernst, S.1    Hite, G.2    Cantrell, J.S.3    Richardson Jr., A.4    Benson, H.D.5
  • 41
    • 0014710806 scopus 로고
    • Postcoital contraception
    • Emmens, C. W. Postcoital contraception. Br. Med. Bull. 26, 45-51 (1970).
    • (1970) Br. Med. Bull. , vol.26 , pp. 45-51
    • Emmens, C.W.1
  • 43
    • 0000468691 scopus 로고
    • Mammary cancer induced by a single feeding of polynuclear hydrocarbons and their suppression
    • Huggins, C., Grand, L. C. & Brillantes, F. P. Mammary cancer induced by a single feeding of polynuclear hydrocarbons and their suppression. Nature 189, 204 (1961).
    • (1961) Nature , vol.189 , pp. 204
    • Huggins, C.1    Grand, L.C.2    Brillantes, F.P.3
  • 44
    • 0001464486 scopus 로고
    • Basic guides to the mechanism of estrogen action
    • Jensen, E. V. & Jacobson, H. I. Basic guides to the mechanism of estrogen action. Recent Prog. Horm. Res. 18, 387-414 (1962).
    • (1962) Recent Prog. Horm. Res. , vol.18 , pp. 387-414
    • Jensen, E.V.1    Jacobson, H.I.2
  • 46
    • 0015294754 scopus 로고
    • Effect of some triphenylethylenes on oestradiol binding in vitro to macromolecules from uterus and anterior pituitary
    • Skidmore, J. R., Walpole, A. L. & Woodburn, J. Effect of some triphenylethylenes on oestradiol binding in vitro to macromolecules from uterus and anterior pituitary. J. Endocrinol. 52, 289-298 (1972).
    • (1972) J. Endocrinol. , vol.52 , pp. 289-298
    • Skidmore, J.R.1    Walpole, A.L.2    Woodburn, J.3
  • 47
    • 0017665570 scopus 로고
    • A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
    • Jordan, V. C., Collins, M. M., Rowsby, L. & Prestwich, G. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J. Endocrinol. 75, 305-316 (1977).
    • (1977) J. Endocrinol. , vol.75 , pp. 305-316
    • Jordan, V.C.1    Collins, M.M.2    Rowsby, L.3    Prestwich, G.4
  • 48
    • 0019132163 scopus 로고
    • Evidence for the metabolic activation of non-steroidal antioestrogens: A study of structure-activity relationships
    • Allen, K. E., Clark, E. R. & Jordan, V. C. Evidence for the metabolic activation of non-steroidal antioestrogens: a study of structure-activity relationships. Br. J. Pharmacol. 71, 83-91 (1980).
    • (1980) Br. J. Pharmacol. , vol.71 , pp. 83-91
    • Allen, K.E.1    Clark, E.R.2    Jordan, V.C.3
  • 49
    • 0016638259 scopus 로고
    • Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor
    • Jordan, V. C. & Koerner, S. Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor. Eur. J. Cancer. 11, 205-206 (1975).
    • (1975) Eur. J. Cancer. , vol.11 , pp. 205-206
    • Jordan, V.C.1    Koerner, S.2
  • 50
    • 0016736721 scopus 로고
    • The effect of synthetic antioestrogens on the growth and biochemistry of rat mammary tumours
    • Nicholson, R. I. & Golder, M. P. The effect of synthetic antioestrogens on the growth and biochemistry of rat mammary tumours. Eur. J. Cancer 11, 571-579 (1975).
    • (1975) Eur. J. Cancer , vol.11 , pp. 571-579
    • Nicholson, R.I.1    Golder, M.P.2
  • 51
    • 0017152984 scopus 로고
    • Tamoxifen as an antitumour agent: Effect on oestrogen binding
    • Jordan, V. C. & Dowse, L. J. Tamoxifen as an antitumour agent: effect on oestrogen binding. J. Endocrinol. 68, 297-303 (1976).
    • (1976) J. Endocrinol. , vol.68 , pp. 297-303
    • Jordan, V.C.1    Dowse, L.J.2
  • 52
    • 0017078344 scopus 로고
    • Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata
    • Jordan, V. C. Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata. Eur. J. Cancer 12, 419-424 (1976).
    • (1976) Eur. J. Cancer , vol.12 , pp. 419-424
    • Jordan, V.C.1
  • 53
    • 0017098034 scopus 로고
    • Tamoxifen as an antitumour agent: Oestrogen binding as a predictive test for tumour response
    • Jordan, V. C. & Jaspan, T. Tamoxifen as an antitumour agent: oestrogen binding as a predictive test for tumour response. J. Endocrinol. 68, 453-460 (1976).
    • (1976) J. Endocrinol. , vol.68 , pp. 453-460
    • Jordan, V.C.1    Jaspan, T.2
  • 54
    • 0017565317 scopus 로고
    • Tamoxifen (antiestrogen) therapy in advanced breast cancer
    • Kiang, D. T. & Kennedy, B. J. Tamoxifen (antiestrogen) therapy in advanced breast cancer. Ann. Intern. Med. 87, 687-690 (1977).
    • (1977) Ann. Intern. Med. , vol.87 , pp. 687-690
    • Kiang, D.T.1    Kennedy, B.J.2
  • 55
    • 77956028902 scopus 로고
    • Controlled trial of tamoxifen as adjuvant agent in management of early breast cancer. Interim analysis at four years by Nolvadex Adjuvant Trial Organisation
    • NATO
    • NATO. Controlled trial of tamoxifen as adjuvant agent in management of early breast cancer. Interim analysis at four years by Nolvadex Adjuvant Trial Organisation. Lancet 1, 257-261 (1983).
    • (1983) Lancet , vol.1 , pp. 257-261
  • 56
    • 0023888245 scopus 로고
    • Controlled trial of tamoxifen as a single adjuvant agent in the management of early breast cancer
    • NATO. 'Nolvadex' Adjuvant Trial Organisation
    • NATO. Controlled trial of tamoxifen as a single adjuvant agent in the management of early breast cancer. 'Nolvadex' Adjuvant Trial Organisation. Br. J. Cancer 57, 608-611 (1987).
    • (1987) Br. J. Cancer , vol.57 , pp. 608-611
  • 57
    • 0032537396 scopus 로고    scopus 로고
    • Tamoxifen for early breast cancer: An overview of the randomised trials
    • EBCTCG
    • EBCTCG. Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 351, 1451-1467 (1998).
    • (1998) Lancet , vol.351 , pp. 1451-1467
  • 59
    • 0016740410 scopus 로고
    • Oestrogen-responsive human breast cancer in long term tissue culture
    • Lippman, M. E. & Bolan, G. Oestrogen-responsive human breast cancer in long term tissue culture. Nature 256, 592-593 (1975).
    • (1975) Nature , vol.256 , pp. 592-593
    • Lippman, M.E.1    Bolan, G.2
  • 60
    • 0018906517 scopus 로고
    • Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model
    • Jordan, V. C. & Allen, K. E. Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model. Eur. J. Cancer 16, 239-251 (1980).
    • (1980) Eur. J. Cancer , vol.16 , pp. 239-251
    • Jordan, V.C.1    Allen, K.E.2
  • 61
    • 0002487846 scopus 로고
    • (eds Salmon, S. E. & Jones, S. E.) (Grune & Stratton, Inc., New York)
    • Jordan, V. C., Dix, C. J. & Allen, K. E. in Adjuvant Therapy of Cancer (eds Salmon, S. E. & Jones, S. E.) 19-26 (Grune & Stratton, Inc., New York, 1979).
    • (1979) Adjuvant Therapy of Cancer , pp. 19-26
    • Jordan, V.C.1    Dix, C.J.2    Allen, K.E.3
  • 63
    • 0019122379 scopus 로고
    • Pharmacology at tamoxifen in laboratory animals
    • Jordan, V. C., Allen, K. E. & Dix, C. J. Pharmacology at tamoxifen in laboratory animals. Cancer Treat. Rep. 64, 745-759 (1980).
    • (1980) Cancer Treat. Rep. , vol.64 , pp. 745-759
    • Jordan, V.C.1    Allen, K.E.2    Dix, C.J.3
  • 64
    • 0020608412 scopus 로고
    • Improved survival among patients treated with adjuvant tamoxifen after mastectomy for early breast cancer
    • Baum, M. et al. Improved survival among patients treated with adjuvant tamoxifen after mastectomy for early breast cancer. Lancet 2, 450 (1983).
    • (1983) Lancet , vol.2 , pp. 450
    • Baum, M.1
  • 65
    • 0035795683 scopus 로고    scopus 로고
    • Five versus more than five years of tamoxifen for lymph node-negative breast cancer: Updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial
    • Fisher, B., Dignam, J., Bryant, J. & Wolmark, N. Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial. J. Natl Cancer Inst. 93, 684-690 (2001).
    • (2001) J. Natl Cancer Inst. , vol.93 , pp. 684-690
    • Fisher, B.1    Dignam, J.2    Bryant, J.3    Wolmark, N.4
  • 66
    • 0023235522 scopus 로고
    • Human breast cancer in the athymic nude mouse: Cytostatic effects of long-term antiestrogen therapy
    • Osborne, C. K., Coronado, E. B. & Robinson, J. P. Human breast cancer in the athymic nude mouse: cytostatic effects of long-term antiestrogen therapy. Eur. J. Cancer Clin. Oncol. 23, 1189-1196 (1987).
    • (1987) Eur. J. Cancer Clin. Oncol. , vol.23 , pp. 1189-1196
    • Osborne, C.K.1    Coronado, E.B.2    Robinson, J.P.3
  • 67
    • 0023760993 scopus 로고
    • Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration
    • Gottardis, M. M. & Jordan, V. C. Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Res. 48, 5183-5187 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 5183-5187
    • Gottardis, M.M.1    Jordan, V.C.2
  • 68
    • 0023547257 scopus 로고
    • Effects of antiestrogens on bone in castrated and intact female rats
    • Jordan, V. C., Phelps, E. & Lindgren, J. U. Effects of antiestrogens on bone in castrated and intact female rats. Breast Cancer Res. Treat. 10, 31-35 (1987).
    • (1987) Breast Cancer Res. Treat. , vol.10 , pp. 31-35
    • Jordan, V.C.1    Phelps, E.2    Lindgren, J.U.3
  • 69
    • 0023263237 scopus 로고
    • Species-specific pharmacology of antiestrogens: Role of metabolism
    • Jordan, V. C. & Robinson, S. P. Species-specific pharmacology of antiestrogens: role of metabolism. Fed. Proc. 46, 1870-1874 (1987).
    • (1987) Fed. Proc. , vol.46 , pp. 1870-1874
    • Jordan, V.C.1    Robinson, S.P.2
  • 70
    • 0035421182 scopus 로고    scopus 로고
    • Selective estrogen receptor modulation: A personal perspective
    • Jordan, V. C. Selective estrogen receptor modulation: a personal perspective. Cancer Res. 61, 5683-5687 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 5683-5687
    • Jordan, V.C.1
  • 71
    • 0025931791 scopus 로고
    • Effects of tamoxifen on cardiovascular risk factors in postmenopausal women
    • Love, R. R. et al. Effects of tamoxifen on cardiovascular risk factors in postmenopausal women. Ann. Intern. Med. 115, 860-864 (1991).
    • (1991) Ann. Intern. Med. , vol.115 , pp. 860-864
    • Love, R.R.1
  • 72
    • 0026585852 scopus 로고
    • Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer
    • Love, R. R. et al. Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. N. Engl J. Med. 326, 852-856 (1992).
    • (1992) N. Engl J. Med. , vol.326 , pp. 852-856
    • Love, R.R.1
  • 73
    • 0023229345 scopus 로고
    • Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model
    • Gottardis, M. M. & Jordan, V. C. Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model. Cancer Res. 47, 4020-4024 (1987).
    • (1987) Cancer Res. , vol.47 , pp. 4020-4024
    • Gottardis, M.M.1    Jordan, V.C.2
  • 74
    • 0025859907 scopus 로고
    • Suppression of mouse mammary tumorigenesis by long-term tamoxifen therapy
    • Jordan, V. C., Lababidi, M. K. & Langan-Fahey, S. Suppression of mouse mammary tumorigenesis by long-term tamoxifen therapy. J. Natl Cancer Inst. 83, 492-496 (1991).
    • (1991) J. Natl Cancer Inst. , vol.83 , pp. 492-496
    • Jordan, V.C.1    Lababidi, M.K.2    Langan-Fahey, S.3
  • 75
    • 0347450835 scopus 로고
    • Tamoxifen and contralateral breast cancer
    • CUzick, J. & Baum, M. Tamoxifen and contralateral breast cancer. Lancet 2, 282 (1985).
    • (1985) Lancet , vol.2 , pp. 282
    • CUzick, J.1    Baum, M.2
  • 76
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Fisher, B. et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J. Natl Cancer Inst. 90, 1371-1388 (1998).
    • (1998) J. Natl Cancer Inst. , vol.90 , pp. 1371-1388
    • Fisher, B.1
  • 77
    • 80052059849 scopus 로고    scopus 로고
    • First results from the International Breast Study: A randomized prevention trial
    • IBIS Investigators
    • IBIS Investigators. First results from the International Breast Study: a randomized prevention trial. Lancet 360, 817-824 (2002).
    • (2002) Lancet , vol.360 , pp. 817-824
  • 78
    • 0024353118 scopus 로고
    • A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer
    • Powles, T. J. et al. A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer. Br. J. Cancer 60, 126-131 (1989).
    • (1989) Br. J. Cancer , vol.60 , pp. 126-131
    • Powles, T.J.1
  • 79
    • 0032508294 scopus 로고    scopus 로고
    • Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial
    • Powles, T. et al. Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial. Lancet 352, 98-101 (1998).
    • (1998) Lancet , vol.352 , pp. 98-101
    • Powles, T.1
  • 80
    • 0024801278 scopus 로고
    • Projecting individualized probabilities of developing breast cancer for white females who are being examined annually
    • Gail, M. H. et al. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J. Natl Cancer Inst. 81, 1879-1886 (1989).
    • (1989) J. Natl Cancer Inst. , vol.81 , pp. 1879-1886
    • Gail, M.H.1
  • 81
    • 0021129120 scopus 로고
    • Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice
    • Satyaswaroop, P. G., Zaino, R. J. & Mortel, R. Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice. Cancer Res. 44, 4006-4010 (1984).
    • (1984) Cancer Res. , vol.44 , pp. 4006-4010
    • Satyaswaroop, P.G.1    Zaino, R.J.2    Mortel, R.3
  • 82
    • 0023915865 scopus 로고
    • Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse
    • Gottardis, M. M., Robinson, S. P., Satyaswaroop, P. G. & Jordan, V. C. Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse. Cancer Res. 48, 812-815 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 812-815
    • Gottardis, M.M.1    Robinson, S.P.2    Satyaswaroop, P.G.3    Jordan, V.C.4
  • 83
    • 0024546736 scopus 로고
    • Adjuvant tamoxifen in early breast cancer: Occurrence of new primary cancers
    • Fornander, T. et al. Adjuvant tamoxifen in early breast cancer: occurrence of new primary cancers. Lancet 1, 117-120 (1989).
    • (1989) Lancet , vol.1 , pp. 117-120
    • Fornander, T.1
  • 84
    • 0028208456 scopus 로고
    • Endometrial cancer in tamoxifen-treated breast cancer patients: Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14
    • Fisher, B. et al. Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. J. Natl Cancer Inst. 86, 527-537 (1994).
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 527-537
    • Fisher, B.1
  • 85
    • 0027201501 scopus 로고
    • Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
    • Greaves, P., Goonetilleke, R., Nunn, G., Topham, J. & Orton, T. Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res. 53, 3919-3924 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 3919-3924
    • Greaves, P.1    Goonetilleke, R.2    Nunn, G.3    Topham, J.4    Orton, T.5
  • 86
    • 0028796491 scopus 로고
    • What if tamoxifen (ICI 46,474) had been found to produce rat liver tumors in 1973? A personal perspective
    • Jordan, V. C. What if tamoxifen (ICI 46,474) had been found to produce rat liver tumors in 1973? A personal perspective. Ann. Oncol. 6, 29-34 (1995).
    • (1995) Ann. Oncol. , vol.6 , pp. 29-34
    • Jordan, V.C.1
  • 87
    • 0033581212 scopus 로고    scopus 로고
    • Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trial
    • Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators
    • Ettinger, B. et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA 282, 637-645 (1999).
    • (1999) JAMA , vol.282 , pp. 637-645
    • Ettinger, B.1
  • 88
    • 0033575083 scopus 로고    scopus 로고
    • The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the MORE randomized trial. Multiple Outcomes at Raloxifene Evaluation
    • Cummings, S. R. et al. The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes at Raloxifene Evaluation. JAMA 281, 2189-2197 (1999).
    • (1999) JAMA , vol.281 , pp. 2189-2197
    • Cummings, S.R.1
  • 89
    • 0023683229 scopus 로고
    • Phase II evaluation of Ly156758 in metastatic breast cancer
    • Buzdar, A. U., Marcus, C., Holmes, F., Hug, V. & Hortobagyi, G. Phase II evaluation of Ly156758 in metastatic breast cancer. Oncology 45, 344-345 (1988).
    • (1988) Oncology , vol.45 , pp. 344-345
    • Buzdar, A.U.1    Marcus, C.2    Holmes, F.3    Hug, V.4    Hortobagyi, G.5
  • 90
    • 0032187509 scopus 로고    scopus 로고
    • Designer estrogens
    • Jordan, V. C. Designer estrogens. Sci. Am. 279, 60-67 (1998).
    • (1998) Sci. Am. , vol.279 , pp. 60-67
    • Jordan, V.C.1
  • 91
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women principal results from the women's health initiative randomized controlled trial
    • Writing Group for the Women's Health Initiative Investigators
    • Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women principal results from the women's health initiative randomized controlled trial. JAMA 288, 321-333 (2002).
    • (2002) JAMA , vol.288 , pp. 321-333
  • 92
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • Wakeling, A. E., Dukes, M. & Bowler, J. A potent specific pure antiestrogen with clinical potential. Cancer Res. 51, 3867-3873 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 3867-3873
    • Wakeling, A.E.1    Dukes, M.2    Bowler, J.3
  • 93
    • 0037157603 scopus 로고    scopus 로고
    • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomized trial
    • The ATAC Trialist Group
    • The ATAC Trialist Group. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomized trial. Lancet 359, 2131-2139 (2002).
    • (2002) Lancet , vol.359 , pp. 2131-2139
  • 94
    • 0037102126 scopus 로고    scopus 로고
    • Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: Results at a North American trial
    • Osborne, C. K. et al. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results at a North American trial. J. Clin. Oncol. 20, 3386-3395 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3386-3395
    • Osborne, C.K.1
  • 95
    • 0037102121 scopus 로고    scopus 로고
    • Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
    • Howell, A. et al. Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J. Clin. Oncol. 20, 3396-3403 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3396-3403
    • Howell, A.1


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