In vivo antihyperlipidemic activity of a new series of N-(Benzoylphenyl) and N-(Acetylphenyl)-1-benzofuran-2-carboxamides in rats

Archiv der Pharmazie

Volumn 345, Issue 5, 2012, Pages 401-406

  Al Qirim, Tariq ^a   Shattat, Ghassan ^a   Sweidan, Kamal ^b   El Huneidi, Waseem ^a   Sheikha, Ghassan Abu ^a   Khalaf, Reema Abu ^a   Hikmat, Suhair ^a  

^a AL ZAYTOONAH UNIVERSITY OF JORDAN   (Jordan)

^b UNIVERSITY OF JORDAN   (Jordan)

Author keywords

High density lipoprotein cholesterol; Hypolipidemic activity; N (Benzoylphenyl) and N (acetylphenyl) 1 benzofuran 2 carboxamides; Triglycerides; Triton induced hyperlipidemia

Indexed keywords

ANTILIPEMIC AGENT; BEZAFIBRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; N (4 ACETYLPHENYL) 1 BENZOFURAN 2 CARBOXAMIDE; N(2 ACETYLPHENYL) 1 BENZOFURAN 2 CARBOXAMIDE; N(2 BENZOYLPHENYL) 1 BENZOFURAN 2 CARBOXAMIDE; N(3 ACETYLPHENYL) 1 BENZOFURAN 2 CARBOXAMIDE; N(3 BENZOYLPHENYL) 1 BENZOFURAN 2 CARBOXAMIDE; N[2 (4' METHYLBENZOYL)PHENYL] 1 BENZOFURAN 2 CARBOXAMIDE; N[2 (5 CHLOROBENZOYL)PHENYL] 1 BENZOFURAN 2 CARBOXAMIDE; TRIACYLGLYCEROL; TYLOXAPOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPERLIPIDEMIA; IN VIVO STUDY; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BENZOFURANS; BEZAFIBRATE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; HYPOLIPIDEMIC AGENTS; MALE; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

EID: 84861313755     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201100225     Document Type: Article

References (25)

1. C. K. Glass, K. L. Witztum, Cell 2001, 104, 503-516.
2. R. Ross, New Engl. J. Med. 1999, 340, 115-126.
3. M. H. Frick, O. Elo, K. Haapa, O. P. Heinonen, P. Heinsalmi, P. Helo, J. K. Huttunen, P. Kaitaniemi, P. Koskinen, V. Manninen, H. Mäenpää, M. Mälkönen, M. Mänttäri, S. Norola, A. Pasternack, J. Pikkarainen, M. Romo, T. Sjöblom, E. A. Nikkilä, New Engl. J. Med. 1987, 317, 1237-1245.
4. W. H. Frishman, Am. J. Med. 1998, 104, 18S-27S.
5. J. L. Goldstein, W. R. Hazzard, H. G. Schrott, E. L. Bierman, A. G. Motulsky, J. Clin. Invest. 1973, 52, 1533-1543.
6. P. Libby, U. Schoenbeck, F. Mach, A. P. Selwyn, P. Ganz, Am. J. Med. 1998, 104, 18S-27S.
7. M. J. Martin, S. B. Hulley, W. S. Browner, L. H. Kuller, D. Wentworth, Lancet 1986, 2, 933-936.
8. K. M. West, M. S. Ahuja, P. H. Bennet, Diab. Care 1983, 6, 361-369.
9. K. Schoonjans, B. Staels, J. Auwerx, J. Lipid Res. 1996, 37, 907-925.
10. H. N. Ginsberg, Am. J. Cardiol. 2001, 87, 1174-1180.
11. T. Kuusi, C. Ehnholm, J. Viikari, R. Harkonen, E. Vartiainen, P. Puska, J. Lipid Res. 1989, 30, 1117-1126.
12. J. R. Patsch, S. Prasad, A. M. Gotto, W. Patsch, J. Clin. Invest. 1987, 80, 341-347.
13. P. E. Schurr, J. R. Schultz, T. M. Parkinson, Lipids 1972, 7, 69-74.
14. H. Hayashi, S. Niinobe, Y. Matsumoto, T. Suga, J. Biochem. 1981, 89, 573-579.
15. B. C. Ross, D. Middlemiss, D. Scopes, T. Jack, K. Cardwell, M. Dowle, D. Judd, S. Watson, U.S. 5498722. 1992.
16. G. Holzemann, K. Schiemann, H. Bottcher, T. Heinrich, C. Seyfried, J. Leibrock, C. Van Amsterdam, G. Bartoszyk, U.S. 7425574. 2008.
17. R. A. Parker, U.S. 4229467. 1980.
18. T. Sohda, H. Odaka, Y. Momose, U.S. 5723479. 1998.
19. G. Shattat, T. Al-Qirim, K. Sweidan, M. Shahwan, W. El-Huneidi, Y. Al-Hiari, J. Enzyme Inhib. Med. Chem. 2010, 25 (6), 751-755.
20. K. Yamamoto, R. Byrne, C. Edelstein, B. Shen, A. M. Scanu, J. Lipid Res. 1984, 25, 770-779.
21. S. Otway, D. S. Robinson, J. Physiol. 1967, 190, 309-319.
22. J. Skorve, A. Al-Shurbaji, D. Asiedu, I. Bjorkhem, L. Berglund, R. Bergel, J. Lipid Res. 1993, 34, 1177-1185.
23. L. Anila, N. R. Vijayalakshmi, J. Ethnopharmacol. 2002, 79, 81-87.
24. B. Staels, J. Dallongville, J. Auwerx, K. Schoonjans, E. Leitersdorf, J. C. Fruchart, Circulation 1998, 98, 2088-2093.
25. G. Abu Sheikha, B. Hussin, Y. Al-Hiari, T. Al-Qirim, G. Shattat, Z. Naturforsch. C 2011, 66c, 93-103.