ANTINEOPLASTIC ACTIVITY;
ARTICLE;
CANCER CELL CULTURE;
CONTROLLED STUDY;
CYTOTOXICITY;
DRUG SYNTHESIS;
HEAD AND NECK SQUAMOUS CELL CARCINOMA;
HUMAN;
HUMAN CELL;
SIGNAL TRANSDUCTION;
WESTERN BLOTTING;
ANTAGONISTS AND INHIBITORS;
CELL PROLIFERATION;
CELL SURVIVAL;
CHEMICAL STRUCTURE;
CHEMISTRY;
DOSE RESPONSE;
DRUG EFFECTS;
DRUG SCREENING;
HCT116 CELL LINE;
HT 29 CELL LINE;
METABOLISM;
STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
TUMOR CELL LINE;
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells
T.R. Kau, F. Schroeder, S. Ramaswamy, C.L. Wojciechowski, J.J. Zhao, T.M. Roberts, J. Clardy, W.R. Sellers, and P.A. Silver A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells Cancer Cell 4 2003 463 476
Benzofuran derivatives as a novel class of inhibitors of mTOR signaling
C. Salomé, V. Narbonne, N. Ribeiro, F. Thuaud, M. Serova, A. de Gramont, S. Faivre, E. Raymond, and L. Désaubry Benzofuran derivatives as a novel class of inhibitors of mTOR signaling Eur. J. Med. Chem. 74 2014 41 49
Study on nitro derivatives of biological interest. XXXIII. Synthesis of 5-nitrofuryl and 5-nitrothienyl derivatives of benzofuran and their effect on microorganisms
J. Guillaumel, R. Royer, C.M. Le, A. Hercouet, and R. Cavier Study on nitro derivatives of biological interest. XXXIII. Synthesis of 5-nitrofuryl and 5-nitrothienyl derivatives of benzofuran and their effect on microorganisms Eur. J. Med. Chem. Chim. Ther. 18 1983 431 436
Facile synthesis of 2-arylbenzo[b]furans through unusual acid catalyzed 1,2-elimination
A.K. Jha, P.C. Sharma, P.R. Maulik, U. Yadav, and K. Hajela Facile synthesis of 2-arylbenzo[b]furans through unusual acid catalyzed 1,2-elimination Indian J. Chem. Sect. B Org. Chem. Incl. Med. Chem. 43B 6 2004 1341 1344
2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: A new class of protein tyrosine phosphatase 1B inhibitors
D.R. Adams, A. Abraham, J. Asano, C. Breslin, C.A.J. Dick, U. Ixkes, B.F. Johnston, D. Johnston, J. Kewnay, S.P. Mackay, S.J. MacKenzie, M. McFarlane, L. Mitchell, D. Spinks, and Y. Takano 2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors Bioorg. Med. Chem. Lett. 17 2007 6579 6583
Palladium-catalyzed direct arylation of (hetero)arenes with aryl boronic acids
S.-D. Yang, C.-L. Sun, Z. Fang, B.-J. Li, Y.-Z. Li, and Z.-J. Shi Palladium-catalyzed direct arylation of (hetero)arenes with aryl boronic acids Angew. Chem. Int. Ed 47 8 2008 1473 1476
Efficient synthesis of 3-acyl-5-hydroxybenzofurans via copper(II) triflate-catalyzed cycloaddition of unactivated 1,4-benzoquinones with 1,3-dicarbonyl compounds
S.R. Mothe, D. Susanti, and P.W.H. Chan Efficient synthesis of 3-acyl-5-hydroxybenzofurans via copper(II) triflate-catalyzed cycloaddition of unactivated 1,4-benzoquinones with 1,3-dicarbonyl compounds Tetrahedron Lett. 51 2010 2136 2140
An efficient system for the Pd-catalyzed cross-coupling of amides and aryl chlorides
B.P. Fors, K. Dooleweerdt, Q. Zeng, and S.L. Buchwald An efficient system for the Pd-catalyzed cross-coupling of amides and aryl chlorides Tetrahedron 65 2009 6576 6583
S. Raeppel, O. Saavedra, S. Claridge, A. Vaisburg, F. Gaudette, L. Isakovic, R. Deziel, Heterocycles, Processes for Preparing Them, Pharmaceutical Compositions Containing them, and Their Use as Kinase Inhibitors, PCT Int. Appl., WO 2008046216 A1 20080424, 2008.
C-H bond functionalization via hydride transfer: Synthesis of dihydrobenzopyrans from ortho-vinylaryl akyl ethers
K.M. McQuaid, J.Z. Long, and D. Sames C-H bond functionalization via hydride transfer: synthesis of dihydrobenzopyrans from ortho-vinylaryl akyl ethers Org. Lett. 11 2009 2972 2975
G.M. Wynne, S.P. Wren, P.D. Johnson, D. Price, M.O. De, G. Nugent, J.M. Tinsley, R. Storer, A. Mulvaney, R.J. Pye, C.R. Dorgan, Preparation of Benzimidazoles, Benzoxazoles, Benzothiazoles, Indoles and Their Analogs for the Treatment of Muscular Dystrophy and Cachexia, PCT Int. Appl., WO 2007091106 A2 20070816, 2007.
Palladium-catalyzed reaction of 2-hydroxyaryl and hydroxyheteroaryl halides with 1-alkynes: An improved route to the benzo[b]furan ring system
A. Arcadi, F. Marinelli, and S. Cacchi Palladium-catalyzed reaction of 2-hydroxyaryl and hydroxyheteroaryl halides with 1-alkynes: an improved route to the benzo[b]furan ring system Synthesis 1986 749 751
Air-stable trialkylphosphonium salts: Simple, practical, and versatile replacements for air-sensitive trialkylphosphines. Applications in stoichiometric and catalytic processes
M.R. Netherton, and G.C. Fu Air-stable trialkylphosphonium salts: simple, practical, and versatile replacements for air-sensitive trialkylphosphines. Applications in stoichiometric and catalytic processes Org. Lett. 3 2001 4295 4298
Regioselectivity of fluorine substitution by alkoxides on unsymmetrical difluoroarenes
R. Dirr, C. Anthaume, and L. Désaubry Regioselectivity of fluorine substitution by alkoxides on unsymmetrical difluoroarenes Tetrahedron Lett. 49 2008 4588 4590
K.E. O'Reilly, F. Rojo, Q.-B. She, D. Solit, G.B. Mills, D. Smith, H. Lane, F. Hofmann, D.J. Hicklin, D.L. Ludwig, J. Baselga, and N. Rosen mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates akt Cancer Res. 66 2006 1500 1508
