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Volumn 6, Issue MAR, 2015, Pages

Vitamin D actions on CD4+ T cells in autoimmune disease

Author keywords

Autoimmune diseases; CD4 positive T lymphocytes; Multiple sclerosis; Type 1 diabetes; Vitamin D

Indexed keywords

CALCITRIOL; CUTANEOUS T CELL ATTRACTING CHEMOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; ECALECTIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 9; MEMBRANE COFACTOR PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHOLIPASE C GAMMA1; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

EID: 84926643679     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00100     Document Type: Review
Times cited : (99)

References (330)
  • 1
    • 84855561973 scopus 로고    scopus 로고
    • Unraveling the autoimmune translational research process layer by layer
    • Blumberg RS, Dittel B, Hafler D, von Herrath M, Nestle FO. Unraveling the autoimmune translational research process layer by layer. Nat Med (2012) 18:35-41. doi:10.1038/nm.2632
    • (2012) Nat Med , vol.18 , pp. 35-41
    • Blumberg, R.S.1    Dittel, B.2    Hafler, D.3    von Herrath, M.4    Nestle, F.O.5
  • 2
    • 84884581173 scopus 로고    scopus 로고
    • Incidence and prevalence of multiple sclerosis in Europe: a systematic review
    • Kingwell E, Marriott JJ, Jette N, Pringsheim T, Makhani N, Morrow SA, et al. Incidence and prevalence of multiple sclerosis in Europe: a systematic review. BMC Neurol (2013) 13:128. doi:10.1186/1471-2377-13-128
    • (2013) BMC Neurol , vol.13 , pp. 128
    • Kingwell, E.1    Marriott, J.J.2    Jette, N.3    Pringsheim, T.4    Makhani, N.5    Morrow, S.A.6
  • 3
    • 84873051205 scopus 로고    scopus 로고
    • Incidence and prevalence of multiple sclerosis in the Americas: a systematic review
    • Evans C, Beland SG, Kulaga S, Wolfson C, Kingwell E, Marriott J, et al. Incidence and prevalence of multiple sclerosis in the Americas: a systematic review. Neuroepidemiology (2013) 40:195-210. doi:10.1159/000342779
    • (2013) Neuroepidemiology , vol.40 , pp. 195-210
    • Evans, C.1    Beland, S.G.2    Kulaga, S.3    Wolfson, C.4    Kingwell, E.5    Marriott, J.6
  • 4
    • 84895780170 scopus 로고    scopus 로고
    • Diabetes in the young-a global view and worldwide estimates of numbers of children with type 1 diabetes
    • Patterson C, Guariguata L, Dahlquist G, Soltesz G, Ogle G, Silink M. Diabetes in the young-a global view and worldwide estimates of numbers of children with type 1 diabetes. Diabetes Res Clin Pract (2014) 103:161-75. doi:10.1016/j.diabres.2013.11.005
    • (2014) Diabetes Res Clin Pract , vol.103 , pp. 161-175
    • Patterson, C.1    Guariguata, L.2    Dahlquist, G.3    Soltesz, G.4    Ogle, G.5    Silink, M.6
  • 5
    • 84893049118 scopus 로고    scopus 로고
    • Genetics. A unified process for neurological disease
    • Singleton AB. Genetics. A unified process for neurological disease. Science (2014) 343:497-8. doi:10.1126/science.1250172
    • (2014) Science , vol.343 , pp. 497-498
    • Singleton, A.B.1
  • 6
    • 84979784763 scopus 로고    scopus 로고
    • Vitamin D and autoimmunity
    • Gombart AF, editor. Boca Raton: Taylor & Francis Group, CRC Press
    • Hayes CE, Nelson CD, Spanier JA. Vitamin D and autoimmunity. In: Gombart AF, editor. Vitamin D: Oxidation, Immunity, and Aging. Boca Raton: Taylor & Francis Group, CRC Press (2012). p. 239-306.
    • (2012) Vitamin D: Oxidation, Immunity, and Aging , pp. 239-306
    • Hayes, C.E.1    Nelson, C.D.2    Spanier, J.A.3
  • 7
    • 84870244915 scopus 로고    scopus 로고
    • Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature
    • Antico A, Tampoia M, Tozzoli R, Bizzaro N. Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmun Rev (2012) 12:127-36. doi:10.1016/j.autrev.2012.07.007
    • (2012) Autoimmun Rev , vol.12 , pp. 127-136
    • Antico, A.1    Tampoia, M.2    Tozzoli, R.3    Bizzaro, N.4
  • 8
    • 84898017077 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis
    • Friese MA, Schattling B, Fugger L. Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis. Nat Rev Neurol (2014) 10:225-38. doi:10.1038/nrneurol.2014.37
    • (2014) Nat Rev Neurol , vol.10 , pp. 225-238
    • Friese, M.A.1    Schattling, B.2    Fugger, L.3
  • 10
    • 84875432419 scopus 로고    scopus 로고
    • Type 1 diabetes: translating mechanistic observations into effective clinical outcomes
    • Herold KC, Vignali DA, Cooke A, Bluestone JA. Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol (2013) 13:243-56. doi:10.1038/nri3422
    • (2013) Nat Rev Immunol , vol.13 , pp. 243-256
    • Herold, K.C.1    Vignali, D.A.2    Cooke, A.3    Bluestone, J.A.4
  • 13
    • 79551469699 scopus 로고    scopus 로고
    • Genetics of type 1 diabetes
    • Steck AK, Rewers MJ. Genetics of type 1 diabetes. Clin Chem (2011) 57:176-85. doi:10.1373/clinchem.2010.148221
    • (2011) Clin Chem , vol.57 , pp. 176-185
    • Steck, A.K.1    Rewers, M.J.2
  • 14
    • 77951836633 scopus 로고    scopus 로고
    • Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis
    • Baranzini SE, Mudge J, van Velkinburgh JC, Khankhanian P, Khrebtukova I, Miller NA, et al. Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 464:1351-6. doi:10.1038/nature08990
    • (2010) Nature , vol.464 , pp. 1351-1356
    • Baranzini, S.E.1    Mudge, J.2    van Velkinburgh, J.C.3    Khankhanian, P.4    Khrebtukova, I.5    Miller, N.A.6
  • 15
    • 84898787481 scopus 로고    scopus 로고
    • DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology
    • Stefan M, Zhang W, Concepcion E, Yi Z, Tomer Y. DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology. J Autoimmun (2014) 50:33-7. doi:10.1016/j.jaut.2013.10.001
    • (2014) J Autoimmun , vol.50 , pp. 33-37
    • Stefan, M.1    Zhang, W.2    Concepcion, E.3    Yi, Z.4    Tomer, Y.5
  • 16
    • 78650097770 scopus 로고    scopus 로고
    • Genetics in twins with Crohn's disease: less pronounced than previously believed?
    • Halfvarson J. Genetics in twins with Crohn's disease: less pronounced than previously believed? Inflamm Bowel Dis (2011) 17:6-12. doi:10.1002/ibd.21295
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 6-12
    • Halfvarson, J.1
  • 17
    • 84926657627 scopus 로고    scopus 로고
    • Whole genome and exome sequencing of monozygotic twins discordant for Crohn's disease
    • Petersen BS, Spehlmann ME, Raedler A, Stade B, Thomsen I, Rabionet R, et al. Whole genome and exome sequencing of monozygotic twins discordant for Crohn's disease. BMC Genomics (2014) 15:564. doi:10.1186/1471-2164-15-564
    • (2014) BMC Genomics , vol.15 , pp. 564
    • Petersen, B.S.1    Spehlmann, M.E.2    Raedler, A.3    Stade, B.4    Thomsen, I.5    Rabionet, R.6
  • 18
    • 84872616388 scopus 로고    scopus 로고
    • Genome, epigenome and transcriptome analyses of a pair of monozygotic twins discordant for systemic lupus erythematosus
    • Furukawa H, Oka S, Matsui T, Hashimoto A, Arinuma Y, Komiya A, et al. Genome, epigenome and transcriptome analyses of a pair of monozygotic twins discordant for systemic lupus erythematosus. Hum Immunol (2013) 74:170-5. doi:10.1016/j.humimm.2012.11.007
    • (2013) Hum Immunol , vol.74 , pp. 170-175
    • Furukawa, H.1    Oka, S.2    Matsui, T.3    Hashimoto, A.4    Arinuma, Y.5    Komiya, A.6
  • 19
    • 77949424680 scopus 로고    scopus 로고
    • Environmental factors and their timing in adult-onset multiple sclerosis
    • Handel AE, Giovannoni G, Ebers GC, Ramagopalan SV. Environmental factors and their timing in adult-onset multiple sclerosis. Nat Rev Neurol (2010) 6:156-66. doi:10.1038/nrneurol.2010.1
    • (2010) Nat Rev Neurol , vol.6 , pp. 156-166
    • Handel, A.E.1    Giovannoni, G.2    Ebers, G.C.3    Ramagopalan, S.V.4
  • 20
    • 84887493093 scopus 로고    scopus 로고
    • Interactions of environment and genes in multiple sclerosis
    • Ebers G. Interactions of environment and genes in multiple sclerosis. J Neurol Sci (2013) 334:161-3. doi:10.1016/j.jns.2013.08.018
    • (2013) J Neurol Sci , vol.334 , pp. 161-163
    • Ebers, G.1
  • 21
    • 0000241517 scopus 로고
    • Some comments on the relationship of the distribution of multiple sclerosis to latitude, solar radiation and other variables
    • Acheson ED, Bachrach CA, Wright FM. Some comments on the relationship of the distribution of multiple sclerosis to latitude, solar radiation and other variables. Acta Psychiatr Scand Suppl (1960) 35(Suppl 147):132-47. doi:10.1111/j.1600-0447.1960.tb08674.x
    • (1960) Acta Psychiatr Scand Suppl , vol.35 , pp. 132-147
    • Acheson, E.D.1    Bachrach, C.A.2    Wright, F.M.3
  • 22
    • 80052610245 scopus 로고    scopus 로고
    • Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis
    • Simpson S Jr, Blizzard L, Otahal P, Van der Mei I, Taylor B. Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis. J Neurol Neurosurg Psychiatry (2011) 82:1132-41. doi:10.1136/jnnp.2011.240432
    • (2011) J Neurol Neurosurg Psychiatry , vol.82 , pp. 1132-1141
    • Simpson, S.1    Blizzard, L.2    Otahal, P.3    Van der Mei, I.4    Taylor, B.5
  • 23
    • 38949107656 scopus 로고    scopus 로고
    • Environmental factors and multiple sclerosis
    • Ebers GC. Environmental factors and multiple sclerosis. Lancet Neurol (2008) 7:268-77. doi:10.1016/S1474-4422(08)70042-5
    • (2008) Lancet Neurol , vol.7 , pp. 268-277
    • Ebers, G.C.1
  • 24
    • 32344446192 scopus 로고    scopus 로고
    • Canadian Collaborative Study. Multiple sclerosis in stepsiblings: recurrence risk and ascertainment
    • Dyment DA, Yee IM, Ebers GC, Sadovnick AD, G. Canadian Collaborative Study. Multiple sclerosis in stepsiblings: recurrence risk and ascertainment. J Neurol Neurosurg Psychiatry (2006) 77:258-9. doi:10.1136/jnnp.2005.063008
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 258-259
    • Dyment, D.A.1    Yee, I.M.2    Ebers, G.C.3    Sadovnick, A.D.4
  • 27
    • 70349783663 scopus 로고    scopus 로고
    • European Charcot foundation lecture: the natural history of multiple sclerosis and gender
    • Sadovnick AD. European Charcot foundation lecture: the natural history of multiple sclerosis and gender. J Neurol Sci (2009) 286:1-5. doi:10.1016/j.jns.2009.09.005
    • (2009) J Neurol Sci , vol.286 , pp. 1-5
    • Sadovnick, A.D.1
  • 28
    • 58349117349 scopus 로고    scopus 로고
    • UV radiation: balancing risks and benefits
    • McKenzie RL, Liley JB, Bjorn LO. UV radiation: balancing risks and benefits. Photochem Photobiol (2009) 85:88-98. doi:10.1111/j.1751-1097.2008.00400.x
    • (2009) Photochem Photobiol , vol.85 , pp. 88-98
    • McKenzie, R.L.1    Liley, J.B.2    Bjorn, L.O.3
  • 29
    • 0033856680 scopus 로고    scopus 로고
    • Vitamin D and seasonal fluctuations of gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis
    • Embry AF, Snowdon LR, Vieth R. Vitamin D and seasonal fluctuations of gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis. Ann Neurol (2000) 48:271-2. doi:10.1002/1531-8249(200008)48:2<271::AID-ANA28>3.3.CO;2-F
    • (2000) Ann Neurol , vol.48 , pp. 271-272
    • Embry, A.F.1    Snowdon, L.R.2    Vieth, R.3
  • 30
    • 38849171242 scopus 로고    scopus 로고
    • A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis
    • Soilu-Hanninen M, Laaksonen M, Laitinen I, Eralinna JP, Lilius EM, Mononen I. A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis. J Neurol Neurosurg Psychiatry (2008) 79:152-7. doi:10.1136/jnnp.2006.105320
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 152-157
    • Soilu-Hanninen, M.1    Laaksonen, M.2    Laitinen, I.3    Eralinna, J.P.4    Lilius, E.M.5    Mononen, I.6
  • 32
    • 0042634407 scopus 로고    scopus 로고
    • Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study
    • van der Mei IA, Ponsonby AL, Dwyer T, Blizzard L, Simmons R, Taylor BV, et al. Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. BMJ (2003) 327:316. doi:10.1136/bmj.327.7410.316
    • (2003) BMJ , vol.327 , pp. 316
    • van der Mei, I.A.1    Ponsonby, A.L.2    Dwyer, T.3    Blizzard, L.4    Simmons, R.5    Taylor, B.V.6
  • 33
    • 33947601619 scopus 로고    scopus 로고
    • Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic circle
    • Kampman MT, Wilsgaard T, Mellgren SI. Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic circle. J Neurol (2007) 254:471-7. doi:10.1007/s00415-006-0395-5
    • (2007) J Neurol , vol.254 , pp. 471-477
    • Kampman, M.T.1    Wilsgaard, T.2    Mellgren, S.I.3
  • 34
    • 34547616817 scopus 로고    scopus 로고
    • Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins
    • Islam T, Gauderman WJ, Cozen W, Mack TM. Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins. Neurology (2007) 69:381-8. doi:10.1212/01.wnl.0000268266.50850.48
    • (2007) Neurology , vol.69 , pp. 381-388
    • Islam, T.1    Gauderman, W.J.2    Cozen, W.3    Mack, T.M.4
  • 35
  • 37
    • 48149085565 scopus 로고    scopus 로고
    • The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide
    • Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia (2008) 51:1391-8. doi:10.1007/s00125-008-1061-5
    • (2008) Diabetologia , vol.51 , pp. 1391-1398
    • Mohr, S.B.1    Garland, C.F.2    Gorham, E.D.3    Garland, F.C.4
  • 38
    • 67649756856 scopus 로고    scopus 로고
    • Seasonal variation of diagnosis of Type 1 diabetes mellitus in children worldwide
    • Moltchanova EV, Schreier N, Lammi N, Karvonen M. Seasonal variation of diagnosis of Type 1 diabetes mellitus in children worldwide. Diabet Med (2009) 26:673-8. doi:10.1111/j.1464-5491.2009.02743.x
    • (2009) Diabet Med , vol.26 , pp. 673-678
    • Moltchanova, E.V.1    Schreier, N.2    Lammi, N.3    Karvonen, M.4
  • 39
    • 0038070245 scopus 로고    scopus 로고
    • Ecologic analysis of some immune-related disorders, including type 1 diabetes, in Australia: latitude, regional ultraviolet radiation, and disease prevalence
    • Staples JA, Ponsonby AL, Lim LL, McMichael AJ. Ecologic analysis of some immune-related disorders, including type 1 diabetes, in Australia: latitude, regional ultraviolet radiation, and disease prevalence. Environ Health Perspect (2003) 111:518-23. doi:10.1289/ehp.5941
    • (2003) Environ Health Perspect , vol.111 , pp. 518-523
    • Staples, J.A.1    Ponsonby, A.L.2    Lim, L.L.3    McMichael, A.J.4
  • 40
    • 24644452957 scopus 로고    scopus 로고
    • UV doses worldwide
    • Godar DE. UV doses worldwide. Photochem Photobiol (2005) 81:736-49. doi:10.1111/j.1751-1097.2005.tb01438.x
    • (2005) Photochem Photobiol , vol.81 , pp. 736-749
    • Godar, D.E.1
  • 41
    • 42449116593 scopus 로고    scopus 로고
    • Time series analysis of ultraviolet B radiation and type 1 diabetes in Newfoundland
    • Sloka S, Grant M, Newhook LA. Time series analysis of ultraviolet B radiation and type 1 diabetes in Newfoundland. Pediatr Diabetes (2008) 9:81-6. doi:10.1111/j.1399-5448.2007.00310.x
    • (2008) Pediatr Diabetes , vol.9 , pp. 81-86
    • Sloka, S.1    Grant, M.2    Newhook, L.A.3
  • 42
    • 84890084194 scopus 로고    scopus 로고
    • Environmental factors in multiple sclerosis
    • Ascherio A. Environmental factors in multiple sclerosis. Expert Rev Neurother (2013) 13:3-9. doi:10.1586/14737175.2013.865866
    • (2013) Expert Rev Neurother , vol.13 , pp. 3-9
    • Ascherio, A.1
  • 43
    • 84899054811 scopus 로고    scopus 로고
    • Season of infectious mononucleosis and risk of multiple sclerosis at different latitudes; the EnvIMS Study
    • Lossius A, Riise T, Pugliatti M, Bjornevik K, Casetta I, Drulovic J, et al. Season of infectious mononucleosis and risk of multiple sclerosis at different latitudes; the EnvIMS Study. Mult Scler (2014) 20:669-74. doi:10.1177/1352458513505693
    • (2014) Mult Scler , vol.20 , pp. 669-674
    • Lossius, A.1    Riise, T.2    Pugliatti, M.3    Bjornevik, K.4    Casetta, I.5    Drulovic, J.6
  • 44
    • 77955982402 scopus 로고    scopus 로고
    • Epstein-Barr virus infection and multiple sclerosis: a review
    • Ascherio A, Munger KL. Epstein-Barr virus infection and multiple sclerosis: a review. J Neuroimmune Pharmacol (2010) 5:271-7. doi:10.1007/s11481-010-9201-3
    • (2010) J Neuroimmune Pharmacol , vol.5 , pp. 271-277
    • Ascherio, A.1    Munger, K.L.2
  • 45
    • 80052218628 scopus 로고    scopus 로고
    • Vitamin D: a link between Epstein-Barr virus and multiple sclerosis development?
    • Disanto G, Meier U, Giovannoni G, Ramagopalan SV. Vitamin D: a link between Epstein-Barr virus and multiple sclerosis development? Expert Rev Neurother (2011) 11:1221-4. doi:10.1586/ern.11.97
    • (2011) Expert Rev Neurother , vol.11 , pp. 1221-1224
    • Disanto, G.1    Meier, U.2    Giovannoni, G.3    Ramagopalan, S.V.4
  • 47
    • 79952661796 scopus 로고    scopus 로고
    • Vitamin D as a T-cell modulator in multiple sclerosis
    • Smolders J, Damoiseaux J. Vitamin D as a T-cell modulator in multiple sclerosis. Vitam Horm (2011) 86:401-28. doi:10.1016/B978-0-12-386960-9.00018-6
    • (2011) Vitam Horm , vol.86 , pp. 401-428
    • Smolders, J.1    Damoiseaux, J.2
  • 48
    • 84925174564 scopus 로고    scopus 로고
    • Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases?
    • D'Aurizio F, Villalta D, Metus P, Doretto P, Tozzoli R. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun Rev (2014). doi:10.1016/j.autrev.2014.10.008
    • (2014) Autoimmun Rev
    • D'Aurizio, F.1    Villalta, D.2    Metus, P.3    Doretto, P.4    Tozzoli, R.5
  • 50
    • 34948901373 scopus 로고    scopus 로고
    • Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes
    • Bailey R, Cooper JD, Zeitels L, Smyth DJ, Yang JH, Walker NM, et al. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes (2007) 56:2616-21. doi:10.2337/db07-0652
    • (2007) Diabetes , vol.56 , pp. 2616-2621
    • Bailey, R.1    Cooper, J.D.2    Zeitels, L.3    Smyth, D.J.4    Yang, J.H.5    Walker, N.M.6
  • 51
    • 36749050449 scopus 로고    scopus 로고
    • CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans
    • Ramos-Lopez E, Bruck P, Jansen T, Herwig J, Badenhoop K. CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev (2007) 23:631-6. doi:10.1002/dmrr.719
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 631-636
    • Ramos-Lopez, E.1    Bruck, P.2    Jansen, T.3    Herwig, J.4    Badenhoop, K.5
  • 52
    • 79958822945 scopus 로고    scopus 로고
    • Inherited variation in vitamin d genes is associated with predisposition to autoimmune disease type 1 diabetes
    • Cooper JD, Smyth DJ, Walker NM, Stevens H, Burren OS, Wallace C, et al. Inherited variation in vitamin d genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes (2011) 60:1624-31. doi:10.2337/db10-1656
    • (2011) Diabetes , vol.60 , pp. 1624-1631
    • Cooper, J.D.1    Smyth, D.J.2    Walker, N.M.3    Stevens, H.4    Burren, O.S.5    Wallace, C.6
  • 53
    • 84871653536 scopus 로고    scopus 로고
    • Synergism of CYP2R1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Egyptian children
    • Hussein AG, Mohamed RH, Alghobashy AA. Synergism of CYP2R1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Egyptian children. Cell Immunol (2012) 279:42-5. doi:10.1016/j.cellimm.2012.08.006
    • (2012) Cell Immunol , vol.279 , pp. 42-45
    • Hussein, A.G.1    Mohamed, R.H.2    Alghobashy, A.A.3
  • 54
    • 84887436408 scopus 로고    scopus 로고
    • Association between vitamin D metabolism gene polymorphisms and risk of islet autoimmunity and progression to type 1 diabetes: the diabetes autoimmunity study in the young (DAISY)
    • Frederiksen BN, Kroehl M, Fingerlin TE, Wong R, Steck AK, Rewers M, et al. Association between vitamin D metabolism gene polymorphisms and risk of islet autoimmunity and progression to type 1 diabetes: the diabetes autoimmunity study in the young (DAISY). J Clin Endocrinol Metab (2013) 98:E1845-51. doi:10.1210/jc.2013-2256
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E1845-E1851
    • Frederiksen, B.N.1    Kroehl, M.2    Fingerlin, T.E.3    Wong, R.4    Steck, A.K.5    Rewers, M.6
  • 56
    • 4444254102 scopus 로고    scopus 로고
    • A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans
    • Lopez ER, Zwermann O, Segni M, Meyer G, Reincke M, Seissler J, et al. A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans. Eur J Endocrinol (2004) 151:193-7. doi:10.1530/eje.0.1510193
    • (2004) Eur J Endocrinol , vol.151 , pp. 193-197
    • Lopez, E.R.1    Zwermann, O.2    Segni, M.3    Meyer, G.4    Reincke, M.5    Seissler, J.6
  • 57
    • 45149115037 scopus 로고    scopus 로고
    • Vitamin D-dependent rickets as a possible risk factor for multiple sclerosis
    • Torkildsen O, Knappskog PM, Nyland HI, Myhr KM. Vitamin D-dependent rickets as a possible risk factor for multiple sclerosis. Arch Neurol (2008) 65:809-11. doi:10.1001/archneur.65.6.809
    • (2008) Arch Neurol , vol.65 , pp. 809-811
    • Torkildsen, O.1    Knappskog, P.M.2    Nyland, H.I.3    Myhr, K.M.4
  • 59
    • 84872140226 scopus 로고    scopus 로고
    • Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis
    • Alcina A, Fedetz M, Fernandez O, Saiz A, Izquierdo G, Lucas M, et al. Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis. J Med Genet (2013) 50:25-33. doi:10.1136/jmedgenet-2012-101085
    • (2013) J Med Genet , vol.50 , pp. 25-33
    • Alcina, A.1    Fedetz, M.2    Fernandez, O.3    Saiz, A.4    Izquierdo, G.5    Lucas, M.6
  • 61
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 476:214-9. doi:10.1038/nature10251
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3    Spencer, C.C.4    Patsopoulos, N.A.5    Moutsianas, L.6
  • 63
    • 84876492894 scopus 로고    scopus 로고
    • No evidence for a role of rare CYP27B1 functional variations in multiple sclerosis
    • Barizzone N, Pauwels I, Luciano B, Franckaert D, Guerini FR, Cosemans L, et al. No evidence for a role of rare CYP27B1 functional variations in multiple sclerosis. Ann Neurol (2013) 73:433-7. doi:10.1002/ana.23834
    • (2013) Ann Neurol , vol.73 , pp. 433-437
    • Barizzone, N.1    Pauwels, I.2    Luciano, B.3    Franckaert, D.4    Guerini, F.R.5    Cosemans, L.6
  • 64
    • 84876483525 scopus 로고    scopus 로고
    • No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis
    • Ban M, Caillier S I, Mero L, Myhr KM, Celius EG, Aarseth J, et al. No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis. Ann Neurol (2013) 73:430-2. doi:10.1002/ana.23833
    • (2013) Ann Neurol , vol.73 , pp. 430-432
    • Ban, M.1    Caillier, S.I.2    Mero, L.3    Myhr, K.M.4    Celius, E.G.5    Aarseth, J.6
  • 65
    • 84895758148 scopus 로고    scopus 로고
    • No evidence for a role of rare CYP27B1 variants in Austrian multiple sclerosis patients
    • Reinthaler E, Machetanz G, Hotzy C, Reindl M, Fazekas F, Kristoferitsch W, et al. No evidence for a role of rare CYP27B1 variants in Austrian multiple sclerosis patients. Mult Scler (2014) 20:391-2. doi:10.1177/1352458513498130
    • (2014) Mult Scler , vol.20 , pp. 391-392
    • Reinthaler, E.1    Machetanz, G.2    Hotzy, C.3    Reindl, M.4    Fazekas, F.5    Kristoferitsch, W.6
  • 66
    • 67349275439 scopus 로고    scopus 로고
    • The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis
    • Smolders J, Peelen E, Thewissen M, Menheere P, Cohen Tervaert JW, Hupperts R, et al. The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis. Autoimmun Rev (2009) 8:621-6. doi:10.1016/j.autrev.2009.02.009
    • (2009) Autoimmun Rev , vol.8 , pp. 621-626
    • Smolders, J.1    Peelen, E.2    Thewissen, M.3    Menheere, P.4    Cohen Tervaert, J.W.5    Hupperts, R.6
  • 68
    • 84855584954 scopus 로고    scopus 로고
    • Polymorphisms in the vitamin D receptor gene and multiple sclerosis risk: a meta-analysis of case-control studies
    • Huang J, Xie ZF. Polymorphisms in the vitamin D receptor gene and multiple sclerosis risk: a meta-analysis of case-control studies. J Neurol Sci (2012) 313:79-85. doi:10.1016/j.jns.2011.09.024
    • (2012) J Neurol Sci , vol.313 , pp. 79-85
    • Huang, J.1    Xie, Z.F.2
  • 69
    • 0034253941 scopus 로고    scopus 로고
    • Vitamin D receptor gene polymorphism in multiple sclerosis and the association with HLA class II alleles
    • Niino M, Fukazawa T, Yabe I, Kikuchi S, Sasaki H, Tashiro K. Vitamin D receptor gene polymorphism in multiple sclerosis and the association with HLA class II alleles. J Neurol Sci (2000) 177:65-71. doi:10.1016/S0022-510X(00)00336-1
    • (2000) J Neurol Sci , vol.177 , pp. 65-71
    • Niino, M.1    Fukazawa, T.2    Yabe, I.3    Kikuchi, S.4    Sasaki, H.5    Tashiro, K.6
  • 70
    • 61449102631 scopus 로고    scopus 로고
    • Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D
    • Ramagopalan SV, Maugeri NJ, Handunnetthi L, Lincoln MR, Orton SM, Dyment DA, et al. Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet (2009) 5:e1000369. doi:10.1371/journal.pgen.1000369
    • (2009) PLoS Genet , vol.5
    • Ramagopalan, S.V.1    Maugeri, N.J.2    Handunnetthi, L.3    Lincoln, M.R.4    Orton, S.M.5    Dyment, D.A.6
  • 71
    • 0031751215 scopus 로고    scopus 로고
    • The vitamin D receptor gene start codon polymorphism: a functional analysis of FokI variants
    • Gross C, Krishnan AV, Malloy PJ, Eccleshall TR, Zhao XY, Feldman D. The vitamin D receptor gene start codon polymorphism: a functional analysis of FokI variants. J Bone Miner Res (1998) 13:1691-9. doi:10.1359/jbmr.1998.13.11.1691
    • (1998) J Bone Miner Res , vol.13 , pp. 1691-1699
    • Gross, C.1    Krishnan, A.V.2    Malloy, P.J.3    Eccleshall, T.R.4    Zhao, X.Y.5    Feldman, D.6
  • 72
    • 17744385120 scopus 로고    scopus 로고
    • The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB
    • Jurutka PW, Remus LS, Whitfield GK, Thompson PD, Hsieh JC, Zitzer H, et al. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinol (2000) 14:401-20. doi:10.1210/mend.14.3.0435
    • (2000) Mol Endocrinol , vol.14 , pp. 401-420
    • Jurutka, P.W.1    Remus, L.S.2    Whitfield, G.K.3    Thompson, P.D.4    Hsieh, J.C.5    Zitzer, H.6
  • 73
    • 2942711624 scopus 로고    scopus 로고
    • Susceptibility and outcome in MS: associations with polymorphisms in pigmentation-related genes
    • Partridge JM, Weatherby SJ, Woolmore JA, Highland DJ, Fryer AA, Mann CL, et al. Susceptibility and outcome in MS: associations with polymorphisms in pigmentation-related genes. Neurology (2004) 62:2323-5. doi:10.1212/WNL.62.12.2323
    • (2004) Neurology , vol.62 , pp. 2323-2325
    • Partridge, J.M.1    Weatherby, S.J.2    Woolmore, J.A.3    Highland, D.J.4    Fryer, A.A.5    Mann, C.L.6
  • 75
    • 59249107698 scopus 로고    scopus 로고
    • Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis
    • Mamutse G, Woolmore J, Pye E, Partridge J, Boggild M, Young C, et al. Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis. Mult Scler (2008) 14:1280-3. doi:10.1177/1352458508094643
    • (2008) Mult Scler , vol.14 , pp. 1280-1283
    • Mamutse, G.1    Woolmore, J.2    Pye, E.3    Partridge, J.4    Boggild, M.5    Young, C.6
  • 76
    • 60149088668 scopus 로고    scopus 로고
    • Fok-I vitamin D receptor gene polymorphism (rs10735810) and vitamin D metabolism in multiple sclerosis
    • Smolders J, Damoiseaux J, Menheere P, Tervaert JW, Hupperts R. Fok-I vitamin D receptor gene polymorphism (rs10735810) and vitamin D metabolism in multiple sclerosis. J Neuroimmunol (2009) 207:117-21. doi:10.1016/j.jneuroim.2008.12.011
    • (2009) J Neuroimmunol , vol.207 , pp. 117-121
    • Smolders, J.1    Damoiseaux, J.2    Menheere, P.3    Tervaert, J.W.4    Hupperts, R.5
  • 77
    • 0030922601 scopus 로고    scopus 로고
    • A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women
    • Arai H, Miyamoto K, Taketani Y, Yamamoto H, Iemori Y, Morita K, et al. A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res (1997) 12:915-21. doi:10.1359/jbmr.1997.12.6.915
    • (1997) J Bone Miner Res , vol.12 , pp. 915-921
    • Arai, H.1    Miyamoto, K.2    Taketani, Y.3    Yamamoto, H.4    Iemori, Y.5    Morita, K.6
  • 78
    • 65349086727 scopus 로고    scopus 로고
    • Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction
    • Dickinson J, Perera D, van der Mei A, Ponsonby AL, Polanowski A, Thomson R, et al. Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction. Mult Scler (2009) 15:563-70. doi:10.1177/1352458509102459
    • (2009) Mult Scler , vol.15 , pp. 563-570
    • Dickinson, J.1    Perera, D.2    van der Mei, A.3    Ponsonby, A.L.4    Polanowski, A.5    Thomson, R.6
  • 79
    • 49449099724 scopus 로고    scopus 로고
    • Variation in associations between allelic variants of the vitamin D receptor gene and onset of type 1 diabetes mellitus by ambient winter ultraviolet radiation levels: a meta-regression analysis
    • Ponsonby AL, Pezic A, Ellis J, Morley R, Cameron F, Carlin J, et al. Variation in associations between allelic variants of the vitamin D receptor gene and onset of type 1 diabetes mellitus by ambient winter ultraviolet radiation levels: a meta-regression analysis. Am J Epidemiol (2008) 168:358-65. doi:10.1093/aje/kwn142
    • (2008) Am J Epidemiol , vol.168 , pp. 358-365
    • Ponsonby, A.L.1    Pezic, A.2    Ellis, J.3    Morley, R.4    Cameron, F.5    Carlin, J.6
  • 80
    • 67349199566 scopus 로고    scopus 로고
    • Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    • Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 41:703-7. doi:10.1038/ng.381
    • (2009) Nat Genet , vol.41 , pp. 703-707
    • Barrett, J.C.1    Clayton, D.G.2    Concannon, P.3    Akolkar, B.4    Cooper, J.D.5    Erlich, H.A.6
  • 81
    • 77949510627 scopus 로고    scopus 로고
    • Interaction of vitamin D receptor with HLA DRB1 0301 in type 1 diabetes patients from North India
    • Israni N, Goswami R, Kumar A, Rani R. Interaction of vitamin D receptor with HLA DRB1 0301 in type 1 diabetes patients from North India. PLoS One (2009) 4:e8023. doi:10.1371/journal.pone.0008023
    • (2009) PLoS One , vol.4
    • Israni, N.1    Goswami, R.2    Kumar, A.3    Rani, R.4
  • 82
    • 79960843735 scopus 로고
    • The action of vitamin D in preventing the spread and promoting the arrest of caries in children
    • Mellanby M, Pattison CL. The action of vitamin D in preventing the spread and promoting the arrest of caries in children. Br Med J (1928) 2:1079-82. doi:10.1136/bmj.2.3545.1079
    • (1928) Br Med J , vol.2 , pp. 1079-1082
    • Mellanby, M.1    Pattison, C.L.2
  • 83
    • 0018130651 scopus 로고
    • Comparative epidemiology of multiple sclerosis and dental caries
    • Craelius W. Comparative epidemiology of multiple sclerosis and dental caries. J Epidemiol Community Health (1978) 32:155-65. doi:10.1136/jech.32.3.155
    • (1978) J Epidemiol Community Health , vol.32 , pp. 155-165
    • Craelius, W.1
  • 84
    • 24744443699 scopus 로고    scopus 로고
    • Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice
    • Spach KM, Hayes CE. Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice. J Immunol (2005) 175:4119-26. doi:10.4049/jimmunol.175.6.4119
    • (2005) J Immunol , vol.175 , pp. 4119-4126
    • Spach, K.M.1    Hayes, C.E.2
  • 86
    • 33845720114 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    • Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA (2006) 296:2832-8. doi:10.1001/jama.296.23.2832
    • (2006) JAMA , vol.296 , pp. 2832-2838
    • Munger, K.L.1    Levin, L.I.2    Hollis, B.W.3    Howard, N.S.4    Ascherio, A.5
  • 88
    • 77955291052 scopus 로고    scopus 로고
    • Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis
    • Simpson S Jr, Taylor B, Blizzard L, Ponsonby AL, Pittas F, Tremlett H, et al. Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Ann Neurol (2010) 68:193-203. doi:10.1002/ana.22043
    • (2010) Ann Neurol , vol.68 , pp. 193-203
    • Simpson, S.1    Taylor, B.2    Blizzard, L.3    Ponsonby, A.L.4    Pittas, F.5    Tremlett, H.6
  • 90
    • 77951713604 scopus 로고    scopus 로고
    • Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis
    • Mowry EM, Krupp LB, Milazzo M, Chabas D, Strober JB, Belman AL, et al. Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Ann Neurol (2010) 67:618-24. doi:10.1002/ana.21972
    • (2010) Ann Neurol , vol.67 , pp. 618-624
    • Mowry, E.M.1    Krupp, L.B.2    Milazzo, M.3    Chabas, D.4    Strober, J.B.5    Belman, A.L.6
  • 91
    • 79954652299 scopus 로고    scopus 로고
    • Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study
    • Banwell B, Bar-Or A, Arnold DL, Sadovnick D, Narayanan S, McGowan M, et al. Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study. Lancet Neurol (2011) 10:436-45. doi:10.1016/S1474-4422(11)70045-X
    • (2011) Lancet Neurol , vol.10 , pp. 436-445
    • Banwell, B.1    Bar-Or, A.2    Arnold, D.L.3    Sadovnick, D.4    Narayanan, S.5    McGowan, M.6
  • 92
    • 84866126261 scopus 로고    scopus 로고
    • Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis
    • Runia TF, Hop WC, de Rijke YB, Buljevac D, Hintzen RQ. Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis. Neurology (2012) 79:261-6. doi:10.1212/WNL.0b013e31825fdec7
    • (2012) Neurology , vol.79 , pp. 261-266
    • Runia, T.F.1    Hop, W.C.2    de Rijke, Y.B.3    Buljevac, D.4    Hintzen, R.Q.5
  • 93
    • 84866117980 scopus 로고    scopus 로고
    • Vitamin D and disease activity in multiple sclerosis before and during interferon-beta treatment
    • Loken-Amsrud KI, Holmoy T, Bakke SJ, Beiske AG, Bjerve KS, Bjornara BT, et al. Vitamin D and disease activity in multiple sclerosis before and during interferon-beta treatment. Neurology (2012) 79:267-73. doi:10.1212/WNL.0b013e31825fdf01
    • (2012) Neurology , vol.79 , pp. 267-273
    • Loken-Amsrud, K.I.1    Holmoy, T.2    Bakke, S.J.3    Beiske, A.G.4    Bjerve, K.S.5    Bjornara, B.T.6
  • 94
    • 84896765960 scopus 로고    scopus 로고
    • Vitamin D as an early predictor of multiple sclerosis activity and progression
    • Ascherio A, Munger KL, White R, Kochert K, Simon KC, Polman CH, et al. Vitamin D as an early predictor of multiple sclerosis activity and progression. JAMA Neurol (2014) 71:306-14. doi:10.1001/jamaneurol.2013.5993
    • (2014) JAMA Neurol , vol.71 , pp. 306-314
    • Ascherio, A.1    Munger, K.L.2    White, R.3    Kochert, K.4    Simon, K.C.5    Polman, C.H.6
  • 95
    • 77950910418 scopus 로고    scopus 로고
    • UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production
    • Becklund BR, Severson KS, Vang SV, DeLuca HF. UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production. Proc Natl Acad Sci U S A (2010) 107:6418-23. doi:10.1073/pnas.1001119107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 6418-6423
    • Becklund, B.R.1    Severson, K.S.2    Vang, S.V.3    DeLuca, H.F.4
  • 96
    • 77953328331 scopus 로고    scopus 로고
    • A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis
    • Burton JM, Kimball S, Vieth R, Bar-Or A, Dosch HM, Cheung R, et al. A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis. Neurology (2010) 74:1852-9. doi:10.1212/WNL.0b013e3181e1cec2
    • (2010) Neurology , vol.74 , pp. 1852-1859
    • Burton, J.M.1    Kimball, S.2    Vieth, R.3    Bar-Or, A.4    Dosch, H.M.5    Cheung, R.6
  • 97
    • 84883343453 scopus 로고    scopus 로고
    • Preventive effect of vitamin D3 supplementation on conversion of optic neuritis to clinically definite multiple sclerosis: a double blind, randomized, placebo-controlled pilot clinical trial
    • Derakhshandi H, Etemadifar M, Feizi A, Abtahi SH, Minagar A, Abtahi MA, et al. Preventive effect of vitamin D3 supplementation on conversion of optic neuritis to clinically definite multiple sclerosis: a double blind, randomized, placebo-controlled pilot clinical trial. Acta Neurol Belg (2013) 113:257-63. doi:10.1007/s13760-012-0166-2
    • (2013) Acta Neurol Belg , vol.113 , pp. 257-263
    • Derakhshandi, H.1    Etemadifar, M.2    Feizi, A.3    Abtahi, S.H.4    Minagar, A.5    Abtahi, M.A.6
  • 98
    • 82955236170 scopus 로고    scopus 로고
    • A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis
    • Stein MS, Liu Y, Gray OM, Baker JE, Kolbe SC, Ditchfield MR, et al. A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology (2011) 77:1611-8. doi:10.1212/WNL.0b013e3182343274
    • (2011) Neurology , vol.77 , pp. 1611-1618
    • Stein, M.S.1    Liu, Y.2    Gray, O.M.3    Baker, J.E.4    Kolbe, S.C.5    Ditchfield, M.R.6
  • 99
    • 84859928429 scopus 로고    scopus 로고
    • A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis
    • Grimaldi L, Barkhof F, Beelke M, Burton J, Holmoy T, Hupperts R, et al. A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology (2012) 78:841. doi:10.1212/01.wnl.0000413180.13413.ce
    • (2012) Neurology , vol.78 , pp. 841
    • Grimaldi, L.1    Barkhof, F.2    Beelke, M.3    Burton, J.4    Holmoy, T.5    Hupperts, R.6
  • 100
    • 34247890248 scopus 로고    scopus 로고
    • DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
    • Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, et al. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat Immunol (2007) 8:285-93. doi:10.1038/ni1433
    • (2007) Nat Immunol , vol.8 , pp. 285-293
    • Sigmundsdottir, H.1    Pan, J.2    Debes, G.F.3    Alt, C.4    Habtezion, A.5    Soler, D.6
  • 102
    • 84861551708 scopus 로고    scopus 로고
    • Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis
    • Tripkovic L, Lambert H, Hart K, Smith CP, Bucca G, Penson S, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr (2012) 95:1357-64. doi:10.3945/ajcn.111.031070
    • (2012) Am J Clin Nutr , vol.95 , pp. 1357-1364
    • Tripkovic, L.1    Lambert, H.2    Hart, K.3    Smith, C.P.4    Bucca, G.5    Penson, S.6
  • 103
    • 81255152070 scopus 로고    scopus 로고
    • Efficacy of vitamin D3 as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon beta-1a: a phase II, multicenter, double-blind, randomized, placebo-controlled trial
    • Smolders J, Hupperts R, Barkhof F, Grimaldi LM, Holmoy T, Killestein J, et al. Efficacy of vitamin D3 as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon beta-1a: a phase II, multicenter, double-blind, randomized, placebo-controlled trial. J Neurol Sci (2011) 311:44-9. doi:10.1016/j.jns.2011.04.013
    • (2011) J Neurol Sci , vol.311 , pp. 44-49
    • Smolders, J.1    Hupperts, R.2    Barkhof, F.3    Grimaldi, L.M.4    Holmoy, T.5    Killestein, J.6
  • 104
    • 77955041026 scopus 로고    scopus 로고
    • Vitamin D and increasing incidence of type 1 diabetes-evidence for an association?
    • Hypponen E. Vitamin D and increasing incidence of type 1 diabetes-evidence for an association? Diabetes Obes Metab (2010) 12:737-43. doi:10.1111/j.1463-1326.2010.01211.x
    • (2010) Diabetes Obes Metab , vol.12 , pp. 737-743
    • Hypponen, E.1
  • 105
    • 77955512222 scopus 로고    scopus 로고
    • Vitamin D and diabetes: the devil is in the D-tails
    • Mathieu C. Vitamin D and diabetes: the devil is in the D-tails. Diabetologia (2010) 53:1545-8. doi:10.1007/s00125-010-1791-z
    • (2010) Diabetologia , vol.53 , pp. 1545-1548
    • Mathieu, C.1
  • 106
    • 0032939358 scopus 로고    scopus 로고
    • Vitamin D supplement in early childhood and risk for type I (insulin-dependent) diabetes mellitus. The EURODIAB substudy 2 study group
    • Vitamin D supplement in early childhood and risk for type I (insulin-dependent) diabetes mellitus. The EURODIAB substudy 2 study group. Diabetologia (1999) 42:51-4.
    • (1999) Diabetologia , vol.42 , pp. 51-54
  • 107
    • 44149111801 scopus 로고    scopus 로고
    • Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis
    • Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child (2008) 93:512-7. doi:10.1136/adc.2007.128579
    • (2008) Arch Dis Child , vol.93 , pp. 512-517
    • Zipitis, C.S.1    Akobeng, A.K.2
  • 108
    • 0028898668 scopus 로고
    • Environmental factors that influence the cutaneous production of vitamin D
    • Holick MF. Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr (1995) 61:638S-45S.
    • (1995) Am J Clin Nutr , vol.61 , pp. 638S-645S
    • Holick, M.F.1
  • 109
    • 77955299793 scopus 로고    scopus 로고
    • Is there a role of vitamin D deficiency in type 1 diabetes of children?
    • Mohr SB, Garland FC, Garland CF, Gorham ED, Ricordi C. Is there a role of vitamin D deficiency in type 1 diabetes of children? Am J Prev Med (2010) 39:189-90. doi:10.1016/j.amepre.2010.03.023
    • (2010) Am J Prev Med , vol.39 , pp. 189-190
    • Mohr, S.B.1    Garland, F.C.2    Garland, C.F.3    Gorham, E.D.4    Ricordi, C.5
  • 110
    • 0035802695 scopus 로고    scopus 로고
    • Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
    • Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet (2001) 358:1500-3. doi:10.1016/S0140-6736(01)06580-1
    • (2001) Lancet , vol.358 , pp. 1500-1503
    • Hypponen, E.1    Laara, E.2    Reunanen, A.3    Jarvelin, M.R.4    Virtanen, S.M.5
  • 111
    • 84901323711 scopus 로고    scopus 로고
    • Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term
    • Takiishi T, Ding L, Baeke F, Spagnuolo I, Sebastiani G, Laureys J, et al. Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term. Diabetes (2014) 63:2026-36. doi:10.2337/db13-1559
    • (2014) Diabetes , vol.63 , pp. 2026-2036
    • Takiishi, T.1    Ding, L.2    Baeke, F.3    Spagnuolo, I.4    Sebastiani, G.5    Laureys, J.6
  • 112
    • 0022640891 scopus 로고
    • Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man
    • Gedik O, Akalin S. Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia (1986) 29:142-5. doi:10.1007/BF02427083
    • (1986) Diabetologia , vol.29 , pp. 142-145
    • Gedik, O.1    Akalin, S.2
  • 113
    • 78649392064 scopus 로고    scopus 로고
    • Glycemic changes after vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency
    • Aljabri KS, Bokhari SA, Khan MJ. Glycemic changes after vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency. Ann Saudi Med (2010) 30:454-8. doi:10.4103/0256-4947.72265
    • (2010) Ann Saudi Med , vol.30 , pp. 454-458
    • Aljabri, K.S.1    Bokhari, S.A.2    Khan, M.J.3
  • 114
    • 84903398617 scopus 로고    scopus 로고
    • The effects of vitamin D supplementation on hepatic dysfunction, vitamin D status, and glycemic control in children and adolescents with vitamin D deficiency and either type 1 or type 2 diabetes mellitus
    • Nwosu BU, Maranda L. The effects of vitamin D supplementation on hepatic dysfunction, vitamin D status, and glycemic control in children and adolescents with vitamin D deficiency and either type 1 or type 2 diabetes mellitus. PLoS One (2014) 9:e99646. doi:10.1371/journal.pone.0099646
    • (2014) PLoS One , vol.9
    • Nwosu, B.U.1    Maranda, L.2
  • 115
    • 31844443695 scopus 로고
    • The environment and disease: association or causation?
    • Hill AB. The environment and disease: association or causation? Proc R Soc Med (1965) 58:295-300.
    • (1965) Proc R Soc Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 116
    • 79953162407 scopus 로고    scopus 로고
    • T cell receptor recognition of self and foreign antigens in the induction of autoimmunity
    • Wucherpfennig KW, Sethi D. T cell receptor recognition of self and foreign antigens in the induction of autoimmunity. Semin Immunol (2011) 23:84-91. doi:10.1016/j.smim.2011.01.007
    • (2011) Semin Immunol , vol.23 , pp. 84-91
    • Wucherpfennig, K.W.1    Sethi, D.2
  • 117
    • 35549010987 scopus 로고    scopus 로고
    • The origin and application of experimental autoimmune encephalomyelitis
    • Baxter AG. The origin and application of experimental autoimmune encephalomyelitis. Nat Rev Immunol (2007) 7:904-12. doi:10.1038/nri2190
    • (2007) Nat Rev Immunol , vol.7 , pp. 904-912
    • Baxter, A.G.1
  • 118
    • 0021873134 scopus 로고
    • Recurrent diabetes mellitus in the pancreas iso-and allograft. A light and electron microscopic and immunohistochemical analysis of four cases
    • Sibley RK, Sutherland DE, Goetz F, Michael AF. Recurrent diabetes mellitus in the pancreas iso-and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest (1985) 53:132-44.
    • (1985) Lab Invest , vol.53 , pp. 132-144
    • Sibley, R.K.1    Sutherland, D.E.2    Goetz, F.3    Michael, A.F.4
  • 119
    • 84887627529 scopus 로고    scopus 로고
    • T-lymphocyte recognition of beta cells in type 1 diabetes: clinical perspectives
    • Boitard C. T-lymphocyte recognition of beta cells in type 1 diabetes: clinical perspectives. Diabetes Metab (2013) 39:459-66. doi:10.1016/j.diabet.2013.08.001
    • (2013) Diabetes Metab , vol.39 , pp. 459-466
    • Boitard, C.1
  • 120
    • 0023522632 scopus 로고
    • T cells in multiple sclerosis and inflammatory central nervous system diseases
    • Hafler DA, Weiner HL. T cells in multiple sclerosis and inflammatory central nervous system diseases. Immunol Rev (1987) 100:307-32. doi:10.1111/j.1600-065X.1987.tb00537.x
    • (1987) Immunol Rev , vol.100 , pp. 307-332
    • Hafler, D.A.1    Weiner, H.L.2
  • 121
    • 0029079836 scopus 로고
    • A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide
    • Wucherpfennig KW, Hafler DA. A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. Ann N Y Acad Sci (1995) 756:241-58. doi:10.1111/j.1749-6632.1995.tb44522.x
    • (1995) Ann N Y Acad Sci , vol.756 , pp. 241-258
    • Wucherpfennig, K.W.1    Hafler, D.A.2
  • 123
    • 77953524192 scopus 로고    scopus 로고
    • The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis
    • Gandhi KS, McKay FC, Cox M, Riveros C, Armstrong N, Heard RN, et al. The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Hum Mol Genet (2010) 19:2134-43. doi:10.1093/hmg/ddq090
    • (2010) Hum Mol Genet , vol.19 , pp. 2134-2143
    • Gandhi, K.S.1    McKay, F.C.2    Cox, M.3    Riveros, C.4    Armstrong, N.5    Heard, R.N.6
  • 124
    • 84866871850 scopus 로고    scopus 로고
    • An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity
    • Ottoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, et al. An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity. Sci Transl Med (2012) 4:153ra131. doi:10.1126/scitranslmed.3004186
    • (2012) Sci Transl Med , vol.4
    • Ottoboni, L.1    Keenan, B.T.2    Tamayo, P.3    Kuchroo, M.4    Mesirov, J.P.5    Buckle, G.J.6
  • 125
    • 84900338300 scopus 로고    scopus 로고
    • Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
    • Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (2014) 344:519-23. doi:10.1126/science.1249547
    • (2014) Science , vol.344 , pp. 519-523
    • Raj, T.1    Rothamel, K.2    Mostafavi, S.3    Ye, C.4    Lee, M.N.5    Replogle, J.M.6
  • 126
    • 84907202723 scopus 로고    scopus 로고
    • Intersection of population variation and autoimmunity genetics in human T cell activation
    • Ye CJ, Feng T, Kwon HK, Raj T, Wilson MT, Asinovski N, et al. Intersection of population variation and autoimmunity genetics in human T cell activation. Science (2014) 345:1254665. doi:10.1126/science.1254665
    • (2014) Science , vol.345 , pp. 1254665
    • Ye, C.J.1    Feng, T.2    Kwon, H.K.3    Raj, T.4    Wilson, M.T.5    Asinovski, N.6
  • 128
    • 0037302906 scopus 로고    scopus 로고
    • Vitamin D: a millennium perspective
    • Holick MF. Vitamin D: a millennium perspective. J Cell Biochem (2003) 88:296-307. doi:10.1002/jcb.10338
    • (2003) J Cell Biochem , vol.88 , pp. 296-307
    • Holick, M.F.1
  • 129
    • 0037508549 scopus 로고    scopus 로고
    • Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teeth
    • Whitfield GK, Dang HT, Schluter SF, Bernstein RM, Bunag T, Manzon LA, et al. Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teeth. Endocrinology (2003) 144:2704-16. doi:10.1210/en.2002-221101
    • (2003) Endocrinology , vol.144 , pp. 2704-2716
    • Whitfield, G.K.1    Dang, H.T.2    Schluter, S.F.3    Bernstein, R.M.4    Bunag, T.5    Manzon, L.A.6
  • 130
    • 84922480716 scopus 로고    scopus 로고
    • Effect of high-dose 1.25 dihydroxyvitamin D on remyelination in the cuprizone model
    • Nystad AE, Wergeland S, Aksnes L, Myhr KM, Bo L, Torkildsen O. Effect of high-dose 1.25 dihydroxyvitamin D on remyelination in the cuprizone model. APMIS (2014) 122(12):1178-86. doi:10.1111/apm.12281
    • (2014) APMIS , vol.122 , Issue.12 , pp. 1178-1186
    • Nystad, A.E.1    Wergeland, S.2    Aksnes, L.3    Myhr, K.M.4    Bo, L.5    Torkildsen, O.6
  • 132
    • 77449119375 scopus 로고    scopus 로고
    • Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease
    • Wang TT, Dabbas B, Laperriere D, Bitton AJ, Soualhine H, Tavera-Mendoza LE, et al. Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease. J Biol Chem (2010) 285:2227-31. doi:10.1074/jbc.C109.071225
    • (2010) J Biol Chem , vol.285 , pp. 2227-2231
    • Wang, T.T.1    Dabbas, B.2    Laperriere, D.3    Bitton, A.J.4    Soualhine, H.5    Tavera-Mendoza, L.E.6
  • 133
    • 8544284075 scopus 로고    scopus 로고
    • Enzymes involved in the activation and inactivation of vitamin D
    • Prosser DE, Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci (2004) 29:664-73. doi:10.1016/j.tibs.2004.10.005
    • (2004) Trends Biochem Sci , vol.29 , pp. 664-673
    • Prosser, D.E.1    Jones, G.2
  • 134
    • 84861577327 scopus 로고    scopus 로고
    • 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D
    • Jones G, Prosser DE, Kaufmann M. 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D. Arch Biochem Biophys (2012) 523:9-18. doi:10.1016/j.abb.2011.11.003
    • (2012) Arch Biochem Biophys , vol.523 , pp. 9-18
    • Jones, G.1    Prosser, D.E.2    Kaufmann, M.3
  • 135
    • 84889867812 scopus 로고    scopus 로고
    • The role of the parent compound vitamin D with respect to metabolism and function: why clinical dose intervals can affect clinical outcomes
    • Hollis BW, Wagner CL. The role of the parent compound vitamin D with respect to metabolism and function: why clinical dose intervals can affect clinical outcomes. J Clin Endocrinol Metab (2013) 98(12):4619-28. doi:10.1210/jc.2013-2653
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.12 , pp. 4619-4628
    • Hollis, B.W.1    Wagner, C.L.2
  • 137
    • 0027957364 scopus 로고
    • Seasonal variation in serum 25-hydroxy vitamin D3 does not affect 1,25-dihydroxy vitamin D
    • Hine TJ, Roberts NB. Seasonal variation in serum 25-hydroxy vitamin D3 does not affect 1,25-dihydroxy vitamin D. Ann Clin Biochem (1994) 31(Pt 1):31-4. doi:10.1177/000456329403100105
    • (1994) Ann Clin Biochem , vol.31 , pp. 31-34
    • Hine, T.J.1    Roberts, N.B.2
  • 138
    • 0023741187 scopus 로고
    • Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin
    • Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab (1988) 67:373-78. doi:10.1210/jcem-67-2-373
    • (1988) J Clin Endocrinol Metab , vol.67 , pp. 373-378
    • Webb, A.R.1    Kline, L.2    Holick, M.F.3
  • 139
    • 39749113142 scopus 로고    scopus 로고
    • Vitamin D and skin physiology: a D-lightful story
    • Holick MF, Chen TC, Lu Z, Sauter E. Vitamin D and skin physiology: a D-lightful story. J Bone Miner Res (2007) 22(Suppl 2):V28-33. doi:10.1359/jbmr.07s211
    • (2007) J Bone Miner Res , vol.22 , pp. V28-33
    • Holick, M.F.1    Chen, T.C.2    Lu, Z.3    Sauter, E.4
  • 140
    • 84880200953 scopus 로고    scopus 로고
    • Vitamin D for health: a global perspective
    • Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc (2013) 88:720-55. doi:10.1016/j.mayocp.2013.05.011
    • (2013) Mayo Clin Proc , vol.88 , pp. 720-755
    • Hossein-nezhad, A.1    Holick, M.F.2
  • 141
    • 66549093502 scopus 로고    scopus 로고
    • High prevalence of vitamin D deficiency in young children in a highly sunny humid country: a global health problem
    • Bener A, Al-Ali M, Hoffmann GF. High prevalence of vitamin D deficiency in young children in a highly sunny humid country: a global health problem. Minerva Pediatr (2009) 61:15-22.
    • (2009) Minerva Pediatr , vol.61 , pp. 15-22
    • Bener, A.1    Al-Ali, M.2    Hoffmann, G.F.3
  • 143
    • 77958452526 scopus 로고    scopus 로고
    • Possible role of serum 25-hydroxyvitamin D in black-white health disparities in the United States
    • Grant WB, Peiris AN. Possible role of serum 25-hydroxyvitamin D in black-white health disparities in the United States. J Am Med Dir Assoc (2010) 11:617-28. doi:10.1016/j.jamda.2010.03.013
    • (2010) J Am Med Dir Assoc , vol.11 , pp. 617-628
    • Grant, W.B.1    Peiris, A.N.2
  • 145
    • 77955052903 scopus 로고    scopus 로고
    • Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    • Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 376:180-8. doi:10.1016/S0140-6736(10)60588-0
    • (2010) Lancet , vol.376 , pp. 180-188
    • Wang, T.J.1    Zhang, F.2    Richards, J.B.3    Kestenbaum, B.4    van Meurs, J.B.5    Berry, D.6
  • 146
    • 84889813182 scopus 로고    scopus 로고
    • Vitamin D-binding protein and vitamin D status of black Americans and white Americans
    • Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med (2013) 369:1991-2000. doi:10.1056/NEJMoa1306357
    • (2013) N Engl J Med , vol.369 , pp. 1991-2000
    • Powe, C.E.1    Evans, M.K.2    Wenger, J.3    Zonderman, A.B.4    Berg, A.H.5    Nalls, M.6
  • 147
    • 33747854680 scopus 로고    scopus 로고
    • Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism
    • Speeckaert M, Huang G, Delanghe JR, Taes YE. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta (2006) 372:33-42. doi:10.1016/j.cca.2006.03.011
    • (2006) Clin Chim Acta , vol.372 , pp. 33-42
    • Speeckaert, M.1    Huang, G.2    Delanghe, J.R.3    Taes, Y.E.4
  • 148
    • 84919413313 scopus 로고    scopus 로고
    • Common vitamin D pathway gene variants reveal contrasting effects on serum vitamin D levels in African Americans and European Americans
    • Batai K, Murphy AB, Shah E, Ruden M, Newsome J, Agate S, et al. Common vitamin D pathway gene variants reveal contrasting effects on serum vitamin D levels in African Americans and European Americans. Hum Genet (2014) 133:1395-405. doi:10.1007/s00439-014-1472-y
    • (2014) Hum Genet , vol.133 , pp. 1395-1405
    • Batai, K.1    Murphy, A.B.2    Shah, E.3    Ruden, M.4    Newsome, J.5    Agate, S.6
  • 149
    • 84866753709 scopus 로고    scopus 로고
    • Predictors of serum vitamin D levels in African American and European American men in Chicago
    • Murphy AB, Kelley B, Nyame YA, Martin IK, Smith DJ, Castaneda L, et al. Predictors of serum vitamin D levels in African American and European American men in Chicago. Am J Mens Health (2012) 6:420-6. doi:10.1177/1557988312437240
    • (2012) Am J Mens Health , vol.6 , pp. 420-426
    • Murphy, A.B.1    Kelley, B.2    Nyame, Y.A.I.3    Martin, I.K.4    Smith, D.J.5    Castaneda, L.6
  • 150
    • 0033624656 scopus 로고    scopus 로고
    • 1alpha-Hydroxylase and the action of vitamin D
    • Hewison M, Zehnder D, Bland R, Stewart PM. 1alpha-Hydroxylase and the action of vitamin D. J Mol Endocrinol (2000) 25:141-8. doi:10.1677/jme.0.0250141
    • (2000) J Mol Endocrinol , vol.25 , pp. 141-148
    • Hewison, M.1    Zehnder, D.2    Bland, R.3    Stewart, P.M.4
  • 151
    • 0021847794 scopus 로고
    • Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis
    • Adams JS, Gacad MA. Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis. J Exp Med (1985) 161:755-65. doi:10.1084/jem.161.4.755
    • (1985) J Exp Med , vol.161 , pp. 755-765
    • Adams, J.S.1    Gacad, M.A.2
  • 152
    • 0021089040 scopus 로고
    • Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation
    • Bhalla AK, Amento EP, Clemens TL, Holick MF, Krane SM. Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab (1983) 57:1308-10. doi:10.1210/jcem-57-6-1308
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 1308-1310
    • Bhalla, A.K.1    Amento, E.P.2    Clemens, T.L.3    Holick, M.F.4    Krane, S.M.5
  • 153
    • 0020517536 scopus 로고
    • 1,25-dihydroxyvitamin D3 receptors in human leukocytes
    • Provvedini DM, Tsoukas CD, Deftos LJ, Manolagas SC. 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science (1983) 221:1181-3. doi:10.1126/science.6310748
    • (1983) Science , vol.221 , pp. 1181-1183
    • Provvedini, D.M.1    Tsoukas, C.D.2    Deftos, L.J.3    Manolagas, S.C.4
  • 154
    • 84869815306 scopus 로고    scopus 로고
    • Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses
    • Jeffery LE, Wood AM, Qureshi OS, Hou TZ, Gardner D, Briggs Z, et al. Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses. J Immunol (2012) 189:5155-64. doi:10.4049/jimmunol.1200786
    • (2012) J Immunol , vol.189 , pp. 5155-5164
    • Jeffery, L.E.1    Wood, A.M.2    Qureshi, O.S.3    Hou, T.Z.4    Gardner, D.5    Briggs, Z.6
  • 156
    • 58149182886 scopus 로고    scopus 로고
    • IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway
    • Krutzik SR, Hewison M, Liu PT, Robles JA, Stenger S, Adams JS, et al. IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J Immunol (2008) 181:7115-20. doi:10.4049/jimmunol.181.10.7115
    • (2008) J Immunol , vol.181 , pp. 7115-7120
    • Krutzik, S.R.1    Hewison, M.2    Liu, P.T.3    Robles, J.A.4    Stenger, S.5    Adams, J.S.6
  • 157
    • 85055774872 scopus 로고    scopus 로고
    • Extrarenal CYP27B1 and vitamin D physiology
    • Gombart AF, editor. Oxidative Stress, Immunity, and Aging. Boca Raton, FL: CRC Press, Taylor & Francis Group
    • Hewison M. Extrarenal CYP27B1 and vitamin D physiology. In: Gombart AF, editor. Vitamin D. Oxidative Stress, Immunity, and Aging. Boca Raton, FL: CRC Press, Taylor & Francis Group (2013). p. 99-127.
    • (2013) Vitamin D , pp. 99-127
    • Hewison, M.1
  • 158
    • 0030782757 scopus 로고    scopus 로고
    • Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1
    • Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, et al. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol (1997) 11:1961-70. doi:10.1210/mend.11.13.0035
    • (1997) Mol Endocrinol , vol.11 , pp. 1961-1970
    • Fu, G.K.1    Lin, D.2    Zhang, M.Y.3    Bikle, D.D.4    Shackleton, C.H.5    Miller, W.L.6
  • 159
    • 0022495288 scopus 로고
    • 1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation
    • Bikle DD, Nemanic MK, Gee E, Elias P. 1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation. J Clin Invest (1986) 78:557-66. doi:10.1172/JCI112609
    • (1986) J Clin Invest , vol.78 , pp. 557-566
    • Bikle, D.D.1    Nemanic, M.K.2    Gee, E.3    Elias, P.4
  • 160
    • 58149189055 scopus 로고    scopus 로고
    • Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense
    • Hansdottir S, Monick MM, Hinde SL, Lovan N, Look DC, Hunninghake GW. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol (2008) 181:7090-9. doi:10.4049/jimmunol.181.10.7090
    • (2008) J Immunol , vol.181 , pp. 7090-7099
    • Hansdottir, S.1    Monick, M.M.2    Hinde, S.L.3    Lovan, N.4    Look, D.C.5    Hunninghake, G.W.6
  • 161
    • 53249123179 scopus 로고    scopus 로고
    • Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation
    • Liu N, Nguyen L, Chun RF, Lagishetty V, Ren S, Wu S, et al. Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology (2008) 149:4799-808. doi:10.1210/en.2008-0060
    • (2008) Endocrinology , vol.149 , pp. 4799-4808
    • Liu, N.1    Nguyen, L.2    Chun, R.F.3    Lagishetty, V.4    Ren, S.5    Wu, S.6
  • 162
    • 82455199205 scopus 로고    scopus 로고
    • Colonic vitamin D metabolism: implications for the pathogenesis of inflammatory bowel disease and colorectal cancer
    • Cross HS, Nittke T, Kallay E. Colonic vitamin D metabolism: implications for the pathogenesis of inflammatory bowel disease and colorectal cancer. Mol Cell Endocrinol (2011) 347(1-2):70-9. doi:10.1016/j.mce.2011.07.022
    • (2011) Mol Cell Endocrinol , vol.347 , Issue.1-2 , pp. 70-79
    • Cross, H.S.1    Nittke, T.2    Kallay, E.3
  • 163
    • 39849102476 scopus 로고    scopus 로고
    • Co-expression of C'YP27B1 enzyme with the 1.5 kb CYP27B1 promoter-luciferase transgene in the mouse
    • Anderson PH, Hendrix I, Sawyer RK, Zarrinkalam R, Manvis J, Sarvestani GT, et al. Co-expression of C'YP27B1 enzyme with the 1.5 kb CYP27B1 promoter-luciferase transgene in the mouse. Mol Cell Endocrinol (2008) 285:1-9. doi:10.1016/j.mce.2007.12.018
    • (2008) Mol Cell Endocrinol , vol.285 , pp. 1-9
    • Anderson, P.H.1    Hendrix, I.2    Sawyer, R.K.3    Zarrinkalam, R.4    Manvis, J.5    Sarvestani, G.T.6
  • 164
    • 84898421154 scopus 로고    scopus 로고
    • Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calciotropic hormones
    • O'Brien KO, Li S, Cao C, Kent T, Young BV, Queenan RA, et al. Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calciotropic hormones. J Clin Endocrinol Metab (2014) 99:1348-56. doi:10.1210/jc.2013-1366
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. 1348-1356
    • O'Brien, K.O.1    Li, S.2    Cao, C.3    Kent, T.4    Young, B.V.5    Queenan, R.A.6
  • 165
    • 0034028664 scopus 로고    scopus 로고
    • Identification and immune regulation of 25-hydroxyvitamin D-1-alpha-hydroxylase in murine macrophages
    • Overbergh L, Decallonne B, Valckx D, Verstuyf A, Depovere J, Laureys J, et al. Identification and immune regulation of 25-hydroxyvitamin D-1-alpha-hydroxylase in murine macrophages. Clin Exp Immunol (2000) 120:139-46. doi:10.1046/j.1365-2249.2000.01204.x
    • (2000) Clin Exp Immunol , vol.120 , pp. 139-146
    • Overbergh, L.1    Decallonne, B.2    Valckx, D.3    Verstuyf, A.4    Depovere, J.5    Laureys, J.6
  • 166
    • 0018765156 scopus 로고
    • Evidence that increased circulating 1 alpha, 25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis
    • Bell NH, Stern PH, Pantzer E, Sinha TK, DeLuca HF. Evidence that increased circulating 1 alpha, 25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. J Clin Invest (1979) 64:218-25. doi:10.1172/JCI109442
    • (1979) J Clin Invest , vol.64 , pp. 218-225
    • Bell, N.H.1    Stern, P.H.2    Pantzer, E.3    Sinha, T.K.4    DeLuca, H.F.5
  • 167
    • 0018965165 scopus 로고
    • Pathogenetic role of 1 alpha,25-dihydroxyvitamin D in sarcoidosis and absorptive hypercalciuria: different response to prednisolone therapy
    • Zerwekh JE, Pak CY, Kaplan RA, McGuire JL, Upchurch K, Breslau N, et al. Pathogenetic role of 1 alpha,25-dihydroxyvitamin D in sarcoidosis and absorptive hypercalciuria: different response to prednisolone therapy. J Clin Endocrinol Metab (1980) 51:381-6. doi:10.1210/jcem-51-2-381
    • (1980) J Clin Endocrinol Metab , vol.51 , pp. 381-386
    • Zerwekh, J.E.1    Pak, C.Y.2    Kaplan, R.A.3    McGuire, J.L.4    Upchurch, K.5    Breslau, N.6
  • 168
    • 84901643353 scopus 로고    scopus 로고
    • Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial
    • Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA (2014) 311:2083-91. doi:10.1001/jama.2014.5052
    • (2014) JAMA , vol.311 , pp. 2083-2091
    • Castro, M.1    King, T.S.2    Kunselman, S.J.3    Cabana, M.D.4    Denlinger, L.5    Holguin, F.6
  • 169
    • 67649344487 scopus 로고    scopus 로고
    • Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface
    • Novakovic B, Sibson M, Ng HK, Manuelpillai U, Rakyan V, Down T, et al. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J Biol Chem (2009) 284:14838-48. doi:10.1074/jbc.M809542200
    • (2009) J Biol Chem , vol.284 , pp. 14838-14848
    • Novakovic, B.1    Sibson, M.2    Ng, H.K.3    Manuelpillai, U.4    Rakyan, V.5    Down, T.6
  • 170
    • 77955037065 scopus 로고    scopus 로고
    • Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer
    • Luo W, Karpf AR, Deeb KK, Muindi JR, Morrison CD, Johnson CS, et al. Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer. Cancer Res (2010) 70:5953-62. doi:10.1158/0008-5472.CAN-10-0617
    • (2010) Cancer Res , vol.70 , pp. 5953-5962
    • Luo, W.1    Karpf, A.R.2    Deeb, K.K.3    Muindi, J.R.4    Morrison, C.D.5    Johnson, C.S.6
  • 171
    • 84866175699 scopus 로고    scopus 로고
    • The ifng gene is essential for vdr gene expression and vitamin d3-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model
    • Spanier JA, Nashold FE, Olson JK, Hayes CE. The ifng gene is essential for vdr gene expression and vitamin d3-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model. J Immunol (2012) 189:3188-97. doi:10.4049/jimmunol.1102925
    • (2012) J Immunol , vol.189 , pp. 3188-3197
    • Spanier, J.A.1    Nashold, F.E.2    Olson, J.K.3    Hayes, C.E.4
  • 172
    • 78049509828 scopus 로고    scopus 로고
    • Gender differences in 1,25 dihydroxyvitamin D3 immunomodulatory effects in multiple sclerosis patients and healthy subjects
    • Correale J, Ysrraelit MC, Gaitan MI. Gender differences in 1,25 dihydroxyvitamin D3 immunomodulatory effects in multiple sclerosis patients and healthy subjects. J Immunol (2010) 185:4948-58. doi:10.4049/jimmunol.1000588
    • (2010) J Immunol , vol.185 , pp. 4948-4958
    • Correale, J.1    Ysrraelit, M.C.2    Gaitan, M.I.3
  • 173
    • 79951480055 scopus 로고    scopus 로고
    • Association of UV radiation with multiple sclerosis prevalence and sex ratio in France
    • Orton SM, Wald L, Confavreux C, Vukusic S, Krohn JP, Ramagopalan SV, et al. Association of UV radiation with multiple sclerosis prevalence and sex ratio in France. Neurology (2011) 76:425-31. doi:10.1212/WNL.0b013e31820a0a9f
    • (2011) Neurology , vol.76 , pp. 425-431
    • Orton, S.M.1    Wald, L.2    Confavreux, C.3    Vukusic, S.4    Krohn, J.P.5    Ramagopalan, S.V.6
  • 174
    • 84901048634 scopus 로고    scopus 로고
    • Genome-wide (over)view on the actions of vitamin D
    • Carlberg C. Genome-wide (over)view on the actions of vitamin D. Front Physiol (2014) 5:167. doi:10.3389/fphys.2014.00167
    • (2014) Front Physiol , vol.5 , pp. 167
    • Carlberg, C.1
  • 175
    • 84871431768 scopus 로고    scopus 로고
    • Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor
    • Carlberg C, Campbell MJ. Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor. Steroids (2013) 78:127-36. doi:10.1016/j.steroids.2012.10.019
    • (2013) Steroids , vol.78 , pp. 127-136
    • Carlberg, C.1    Campbell, M.J.2
  • 176
    • 75549087005 scopus 로고    scopus 로고
    • Identification of a highly specific and versatile vitamin D receptor antibody
    • Wang Y, Becklund BR, DeLuca HF. Identification of a highly specific and versatile vitamin D receptor antibody. Arch Biochem Biophys (2010) 494:166-77. doi:10.1016/j.abb.2009.11.029
    • (2010) Arch Biochem Biophys , vol.494 , pp. 166-177
    • Wang, Y.1    Becklund, B.R.2    DeLuca, H.F.3
  • 177
    • 84861577440 scopus 로고    scopus 로고
    • Where is the vitamin D receptor?
    • Wang Y, Zhu J, DeLuca HF. Where is the vitamin D receptor? Arch Biochem Biophys (2012) 523:123-33. doi:10.1016/j.abb.2012.04.001
    • (2012) Arch Biochem Biophys , vol.523 , pp. 123-133
    • Wang, Y.1    Zhu, J.2    DeLuca, H.F.3
  • 178
    • 0023256844 scopus 로고
    • Dendritic cells from human tissues express receptors for the immunoregulatory vitamin D3 metabolite, dihydroxycholecalciferol
    • Brennan A, Katz DR, Nunn JD, Barker S, Hewison M, Fraher LJ, et al. Dendritic cells from human tissues express receptors for the immunoregulatory vitamin D3 metabolite, dihydroxycholecalciferol. Immunology (1987) 61:457-61.
    • (1987) Immunology , vol.61 , pp. 457-461
    • Brennan, A.1    Katz, D.R.2    Nunn, J.D.3    Barker, S.4    Hewison, M.5    Fraher, L.J.6
  • 179
    • 77954763264 scopus 로고    scopus 로고
    • Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system
    • Baeke F, Korf H, Overbergh L, van Etten E, Verstuyf A, Gysemans C, et al. Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system. J Steroid Biochem Mol Biol (2010) 121:221-7. doi:10.1016/j.jsbmb.2010.03.037
    • (2010) J Steroid Biochem Mol Biol , vol.121 , pp. 221-227
    • Baeke, F.1    Korf, H.2    Overbergh, L.3    van Etten, E.4    Verstuyf, A.5    Gysemans, C.6
  • 180
    • 0034652314 scopus 로고    scopus 로고
    • Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system
    • Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys (2000) 374:334-8. doi:10.1006/abbi.1999.1605
    • (2000) Arch Biochem Biophys , vol.374 , pp. 334-338
    • Veldman, C.M.1    Cantorna, M.T.2    DeLuca, H.F.3
  • 181
    • 77949873898 scopus 로고    scopus 로고
    • Vitamin D controls T cell antigen receptor signaling and activation of human T cells
    • von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol (2010) 11:344-9. doi:10.1038/ni.1851
    • (2010) Nat Immunol , vol.11 , pp. 344-349
    • von Essen, M.R.1    Kongsbak, M.2    Schjerling, P.3    Olgaard, K.4    Odum, N.5    Geisler, C.6
  • 182
    • 0035801791 scopus 로고    scopus 로고
    • Rag-1-dependent cells are necessary for 1,25-dihydroxyvitamin D(3) prevention of experimental autoimmune encephalomyelitis
    • Nashold FE, Hoag KA, Goverman J, Hayes CE. Rag-1-dependent cells are necessary for 1,25-dihydroxyvitamin D(3) prevention of experimental autoimmune encephalomyelitis. J Neuroimmunol (2001) 119:16-29. doi:10.1016/S0165-5728(01)00360-5
    • (2001) J Neuroimmunol , vol.119 , pp. 16-29
    • Nashold, F.E.1    Hoag, K.A.2    Goverman, J.3    Hayes, C.E.4
  • 183
    • 78649816415 scopus 로고    scopus 로고
    • Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression
    • Chang SH, Chung Y, Dong C. Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression. J Biol Chem (2010) 285:38751-5. doi:10.1074/jbc.C110.185777
    • (2010) J Biol Chem , vol.285 , pp. 38751-38755
    • Chang, S.H.1    Chung, Y.2    Dong, C.3
  • 184
    • 79951782445 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis
    • Mayne CG, Spanier JA, Relland LM, Williams CB, Hayes CE. 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur J Immunol (2011) 41:822-32. doi:10.1002/eji.201040632
    • (2011) Eur J Immunol , vol.41 , pp. 822-832
    • Mayne, C.G.1    Spanier, J.A.2    Relland, L.M.3    Williams, C.B.4    Hayes, C.E.5
  • 185
    • 80052387833 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A
    • Joshi S, Pantalena LC, Liu XK, Gaffen SL, Liu H, Rohowsky-Kochan C, et al. 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol (2011) 31:3653-69. doi:10.1128/MCB.05020-11
    • (2011) Mol Cell Biol , vol.31 , pp. 3653-3669
    • Joshi, S.1    Pantalena, L.C.2    Liu, X.K.3    Gaffen, S.L.4    Liu, H.5    Rohowsky-Kochan, C.6
  • 186
    • 70349336167 scopus 로고    scopus 로고
    • Estrogen controls vitamin D3-mediated resistance to experimental autoimmune encephalomyelitis by controlling vitamin D3 metabolism and receptor expression
    • Nashold FE, Spach KM, Spanier JA, Hayes CE. Estrogen controls vitamin D3-mediated resistance to experimental autoimmune encephalomyelitis by controlling vitamin D3 metabolism and receptor expression. J Immunol (2009) 183:3672-81. doi:10.4049/jimmunol.0901351
    • (2009) J Immunol , vol.183 , pp. 3672-3681
    • Nashold, F.E.1    Spach, K.M.2    Spanier, J.A.3    Hayes, C.E.4
  • 187
    • 77958605267 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitis
    • Chang JH, Cha HR, Lee DS, Seo KY, Kweon MN. 1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitis. PLoS One (2010) 5:e12925. doi:10.1371/journal.pone.0012925
    • (2010) PLoS One , vol.5
    • Chang, J.H.1    Cha, H.R.2    Lee, D.S.3    Seo, K.Y.4    Kweon, M.N.5
  • 189
    • 84876279910 scopus 로고    scopus 로고
    • The role of vitamin D receptor in innate and adaptive immunity: a study in hereditary vitamin D-resistant rickets patients
    • Tiosano D, Wildbaum G, Gepstein V, Verbitsky O, Weisman Y, Karin N, et al. The role of vitamin D receptor in innate and adaptive immunity: a study in hereditary vitamin D-resistant rickets patients. J Clin Endocrinol Metab (2013) 98:1685-93. doi:10.1210/jc.2012-3858
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 1685-1693
    • Tiosano, D.1    Wildbaum, G.2    Gepstein, V.3    Verbitsky, O.4    Weisman, Y.5    Karin, N.6
  • 190
    • 84901487911 scopus 로고    scopus 로고
    • Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
    • Klein L, Kyewski B, Allen PM, Hogquist KA. Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat Rev Immunol (2014) 14:377-91. doi:10.1038/nri3667
    • (2014) Nat Rev Immunol , vol.14 , pp. 377-391
    • Klein, L.1    Kyewski, B.2    Allen, P.M.3    Hogquist, K.A.4
  • 191
    • 70449470318 scopus 로고    scopus 로고
    • Structural alterations in peptide-MHC recognition by self-reactive T cell receptors
    • Wucherpfennig KW, Call MJ, Deng L, Mariuzza R. Structural alterations in peptide-MHC recognition by self-reactive T cell receptors. Curr Opin Immunol (2009) 21:590-5. doi:10.1016/j.coi.2009.07.008
    • (2009) Curr Opin Immunol , vol.21 , pp. 590-595
    • Wucherpfennig, K.W.1    Call, M.J.2    Deng, L.3    Mariuzza, R.4
  • 192
    • 0036793245 scopus 로고    scopus 로고
    • A functional and structural basis for TCR cross-reactivity in multiple sclerosis
    • Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, et al. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol (2002) 3:940-3. doi:10.1038/ni835
    • (2002) Nat Immunol , vol.3 , pp. 940-943
    • Lang, H.L.1    Jacobsen, H.2    Ikemizu, S.3    Andersson, C.4    Harlos, K.5    Madsen, L.6
  • 194
    • 84866419166 scopus 로고    scopus 로고
    • Why must T cells be cross-reactive?
    • Sewell AK. Why must T cells be cross-reactive? Nat Rev Immunol (2012) 12:669-77. doi:10.1038/nri3279
    • (2012) Nat Rev Immunol , vol.12 , pp. 669-677
    • Sewell, A.K.1
  • 195
    • 84901295133 scopus 로고    scopus 로고
    • Deconstructing the peptide-MHC specificity of T cell recognition
    • Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, et al. Deconstructing the peptide-MHC specificity of T cell recognition. Cell (2014) 157:1073-87. doi:10.1016/j.cell.2014.03.047
    • (2014) Cell , vol.157 , pp. 1073-1087
    • Birnbaum, M.E.1    Mendoza, J.L.2    Sethi, D.K.3    Dong, S.4    Glanville, J.5    Dobbins, J.6
  • 196
    • 77953803192 scopus 로고    scopus 로고
    • Terminating the immune response
    • Marrack P, Scott-Browne J, MacLeod MK. Terminating the immune response. Immunol Rev (2010) 236:5-10. doi:10.1111/j.1600-065X.2010.00928.x
    • (2010) Immunol Rev , vol.236 , pp. 5-10
    • Marrack, P.1    Scott-Browne, J.2    MacLeod, M.K.3
  • 198
    • 84893454390 scopus 로고    scopus 로고
    • The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment
    • Robinson AP, Harp CT, Noronha A, Miller SD. The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment. Handbook Clin Neurol (2014) 122:173-89. doi:10.1016/B978-0-444-52001-2.00008-X
    • (2014) Handbook Clin Neurol , vol.122 , pp. 173-189
    • Robinson, A.P.1    Harp, C.T.2    Noronha, A.3    Miller, S.D.4
  • 199
    • 84908365143 scopus 로고    scopus 로고
    • From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development
    • Ben-Nun A, Kaushansky N, Kawakami N, Krishnamoorthy G, Berer K, Liblau R, et al. From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development. J Autoimmun (2014) 54:33-50. doi:10.1016/j.jaut.2014.06.004
    • (2014) J Autoimmun , vol.54 , pp. 33-50
    • Ben-Nun, A.1    Kaushansky, N.2    Kawakami, N.3    Krishnamoorthy, G.4    Berer, K.5    Liblau, R.6
  • 200
    • 79251621206 scopus 로고    scopus 로고
    • Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease
    • Driver JP, Serreze DV, Chen YG. Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol (2011) 33:67-87. doi:10.1007/s00281-010-0204-1
    • (2011) Semin Immunopathol , vol.33 , pp. 67-87
    • Driver, J.P.1    Serreze, D.V.2    Chen, Y.G.3
  • 201
    • 0028357305 scopus 로고
    • Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3
    • Mathieu C, Waer M, Laureys J, Rutgeerts O, Bouillon R. Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia (1994) 37:552-8. doi:10.1007/BF00403372
    • (1994) Diabetologia , vol.37 , pp. 552-558
    • Mathieu, C.1    Waer, M.2    Laureys, J.3    Rutgeerts, O.4    Bouillon, R.5
  • 202
    • 0028812632 scopus 로고
    • Prevention of murine experimental allergic encephalomyelitis: cooperative effects of cyclosporine and 1 alpha, 25-(OH)2D3
    • Branisteanu DD, Waer M, Sobis H, Marcelis S, Vandeputte M, Bouillon R. Prevention of murine experimental allergic encephalomyelitis: cooperative effects of cyclosporine and 1 alpha, 25-(OH)2D3. J Neuroimmunol (1995) 61:151-60. doi:10.1016/0165-5728(95)00076-E
    • (1995) J Neuroimmunol , vol.61 , pp. 151-160
    • Branisteanu, D.D.1    Waer, M.2    Sobis, H.3    Marcelis, S.4    Vandeputte, M.5    Bouillon, R.6
  • 203
    • 0029821239 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
    • Cantorna MT, Hayes CE, DeLuca HF. 1,25-dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci U S A (1996) 93:7861-4. doi:10.1073/pnas.93.15.7861
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 7861-7864
    • Cantorna, M.T.1    Hayes, C.E.2    DeLuca, H.F.3
  • 204
    • 0032103001 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4
    • Cantorna MT, Woodward WD, Hayes CE, DeLuca HF. 1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4. J Immunol (1998) 160:5314-9.
    • (1998) J Immunol , vol.160 , pp. 5314-5319
    • Cantorna, M.T.1    Woodward, W.D.2    Hayes, C.E.3    DeLuca, H.F.4
  • 205
    • 33750314525 scopus 로고    scopus 로고
    • IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis
    • Spach KM, Nashold FE, Dittel BN, Hayes CE. IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J Immunol (2006) 177:6030-7. doi:10.4049/jimmunol.177.9.6030
    • (2006) J Immunol , vol.177 , pp. 6030-6037
    • Spach, K.M.1    Nashold, F.E.2    Dittel, B.N.3    Hayes, C.E.4
  • 206
    • 0033975024 scopus 로고    scopus 로고
    • Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3)
    • Mattner F, Smiroldo S, Galbiati F, Muller M, Di Lucia P, Poliani PL, et al. Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3). Eur J Immunol (2000) 30:498-508. doi:10.1002/1521-4141(200002)30:2<498::AID-IMMU498>3.3.CO;2-H
    • (2000) Eur J Immunol , vol.30 , pp. 498-508
    • Mattner, F.1    Smiroldo, S.2    Galbiati, F.3    Muller, M.4    Di Lucia, P.5    Poliani, P.L.6
  • 207
    • 0029822324 scopus 로고    scopus 로고
    • 1,25 Dihydroxyvitamin D3 exerts regional effects in the central nervous system during experimental allergic encephalomyelitis
    • Nataf S, Garcion E, Darcy F, Chabannes D, Muller JY, Brachet P. 1,25 Dihydroxyvitamin D3 exerts regional effects in the central nervous system during experimental allergic encephalomyelitis. J Neuropathol Exp Neurol (1996) 55:904-14. doi:10.1097/00005072-199608000-00006
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 904-914
    • Nataf, S.1    Garcion, E.2    Darcy, F.3    Chabannes, D.4    Muller, J.Y.5    Brachet, P.6
  • 208
    • 0033965231 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D3 treatment decreases macrophage accumulation in the CNS of mice with experimental autoimmune encephalomyelitis
    • Nashold FE, Miller DJ, Hayes CE. 1,25-dihydroxyvitamin D3 treatment decreases macrophage accumulation in the CNS of mice with experimental autoimmune encephalomyelitis. J Neuroimmunol (2000) 103:171-9. doi:10.1016/S0165-5728(99)00247-7
    • (2000) J Neuroimmunol , vol.103 , pp. 171-179
    • Nashold, F.E.1    Miller, D.J.2    Hayes, C.E.3
  • 209
    • 4844224867 scopus 로고    scopus 로고
    • Gene expression analysis suggests that 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by stimulating inflammatory cell apoptosis
    • Spach KM, Pedersen LB, Nashold FE, Kayo T, Yandell BS, Prolla TA, et al. Gene expression analysis suggests that 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by stimulating inflammatory cell apoptosis. Physiol Genomics (2004) 18:141-51. doi:10.1152/physiolgenomics.00003.2004
    • (2004) Physiol Genomics , vol.18 , pp. 141-151
    • Spach, K.M.1    Pedersen, L.B.2    Nashold, F.E.3    Kayo, T.4    Yandell, B.S.5    Prolla, T.A.6
  • 210
    • 34547630883 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by inhibiting chemokine synthesis and monocyte trafficking
    • Pedersen LB, Nashold FE, Spach KM, Hayes CE. 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by inhibiting chemokine synthesis and monocyte trafficking. J Neurosci Res (2007) 85:2480-90. doi:10.1002/jnr.21382
    • (2007) J Neurosci Res , vol.85 , pp. 2480-2490
    • Pedersen, L.B.1    Nashold, F.E.2    Spach, K.M.3    Hayes, C.E.4
  • 211
    • 0025826684 scopus 로고
    • Down-regulation of monocyte functions by treatment of healthy adults with 1 alpha,25 dihydroxyvitamin D3
    • Muller K, Gram J, Bollerslev J, Diamant M, Barington T, Hansen MB, et al. Down-regulation of monocyte functions by treatment of healthy adults with 1 alpha,25 dihydroxyvitamin D3. Int J Immunopharmacol (1991) 13:525-30. doi:10.1016/0192-0561(91)90072-F
    • (1991) Int J Immunopharmacol , vol.13 , pp. 525-530
    • Muller, K.1    Gram, J.2    Bollerslev, J.3    Diamant, M.4    Barington, T.5    Hansen, M.B.6
  • 212
    • 0037223587 scopus 로고    scopus 로고
    • Cytokine profile in patients with multiple sclerosis following vitamin D supplementation
    • Mahon BD, Gordon SA, Cruz J, Cosman F, Cantorna MT. Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. J Neuroimmunol (2003) 134:128-32. doi:10.1016/S0165-5728(02)00396-X
    • (2003) J Neuroimmunol , vol.134 , pp. 128-132
    • Mahon, B.D.1    Gordon, S.A.2    Cruz, J.3    Cosman, F.4    Cantorna, M.T.5
  • 213
    • 84893161668 scopus 로고    scopus 로고
    • Oral vitamin D increases the frequencies of CD38+ human B cells and ameliorates IL-17-producing T cells
    • Drozdenko G, Heine G, Worm M. Oral vitamin D increases the frequencies of CD38+ human B cells and ameliorates IL-17-producing T cells. Exp Dermatol (2014) 23:107-12. doi:10.1111/exd.12300
    • (2014) Exp Dermatol , vol.23 , pp. 107-112
    • Drozdenko, G.1    Heine, G.2    Worm, M.3
  • 214
    • 65249120937 scopus 로고    scopus 로고
    • Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response
    • Tang J, Zhou R, Luger D, Zhu W, Silver PB, Grajewski RS, et al. Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol (2009) 182:4624-32. doi:10.4049/jimmunol.0801543
    • (2009) J Immunol , vol.182 , pp. 4624-4632
    • Tang, J.1    Zhou, R.2    Luger, D.3    Zhu, W.4    Silver, P.B.5    Grajewski, R.S.6
  • 215
    • 79960719546 scopus 로고    scopus 로고
    • Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling
    • Bruce D, Yu S, Ooi JH, Cantorna MT. Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling. Int Immunol (2011) 23:519-28. doi:10.1093/intimm/dxr045
    • (2011) Int Immunol , vol.23 , pp. 519-528
    • Bruce, D.1    Yu, S.2    Ooi, J.H.3    Cantorna, M.T.4
  • 216
    • 84884815731 scopus 로고    scopus 로고
    • One calcitriol dose transiently increases Helios+FoxP3+ T cells and ameliorates autoimmune demyelinating disease
    • Nashold FE, Nelson CD, Brown LM, Hayes CE. One calcitriol dose transiently increases Helios+FoxP3+ T cells and ameliorates autoimmune demyelinating disease. J Neuroimmunol (2013) 263:64-74. doi:10.1016/j.jneuroim.2013.07.016
    • (2013) J Neuroimmunol , vol.263 , pp. 64-74
    • Nashold, F.E.1    Nelson, C.D.2    Brown, L.M.3    Hayes, C.E.4
  • 217
    • 84862093116 scopus 로고    scopus 로고
    • 1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region
    • Kang SW, Kim SH, Lee N, Lee WW, Hwang KA, Shin MS, et al. 1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region. J Immunol (2012) 188:5276-82. doi:10.4049/jimmunol.1101211
    • (2012) J Immunol , vol.188 , pp. 5276-5282
    • Kang, S.W.1    Kim, S.H.2    Lee, N.3    Lee, W.W.4    Hwang, K.A.5    Shin, M.S.6
  • 218
    • 77951253745 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3
    • Jeffery LE, Burke F, Mura M, Zheng Y, Qureshi OS, Hewison M, et al. 1,25-dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol (2009) 183:5458-67. doi:10.4049/jimmunol.0803217
    • (2009) J Immunol , vol.183 , pp. 5458-5467
    • Jeffery, L.E.1    Burke, F.2    Mura, M.3    Zheng, Y.4    Qureshi, O.S.5    Hewison, M.6
  • 220
    • 84926621134 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients
    • Van Belle TL, Vanherwegen AS, Feyaerts D, De Clercq P, Verstuyf A, Korf H, et al. 1,25-dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients. PLoS One (2014) 9:e109194. doi:10.1371/journal.pone.0109194
    • (2014) PLoS One , vol.9
    • Van Belle, T.L.1    Vanherwegen, A.S.2    Feyaerts, D.3    De Clercq, P.4    Verstuyf, A.5    Korf, H.6
  • 221
    • 66549129834 scopus 로고    scopus 로고
    • Immunomodulatory effects of Vitamin D in multiple sclerosis
    • Correale J, Ysrraelit MC, Gaitan MI. Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain (2009) 132:1146-60. doi:10.1093/brain/awp033
    • (2009) Brain , vol.132 , pp. 1146-1160
    • Correale, J.1    Ysrraelit, M.C.2    Gaitan, M.I.3
  • 222
    • 68949140898 scopus 로고    scopus 로고
    • Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis
    • Smolders J, Thewissen M, Peelen E, Menheere P, Cohen Tervaert JW, Damoiseaux J, et al. Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. PLoS One (2009) 4:e6635. doi:10.1371/journal.pone.0006635
    • (2009) PLoS One , vol.4
    • Smolders, J.1    Thewissen, M.2    Peelen, E.3    Menheere, P.4    Cohen Tervaert, J.W.5    Damoiseaux, J.6
  • 223
    • 78650790685 scopus 로고    scopus 로고
    • Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis
    • Smolders J, Peelen E, Thewissen M, Cohen Tervaert JW, Menheere P, Hupperts R, et al. Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis. PLoS One (2010) 5:e15235. doi:10.1371/journal.pone.0015235
    • (2010) PLoS One , vol.5
    • Smolders, J.1    Peelen, E.2    Thewissen, M.3    Cohen Tervaert, J.W.4    Menheere, P.5    Hupperts, R.6
  • 224
    • 0034193477 scopus 로고    scopus 로고
    • In vivo upregulation of interleukin-4 is one mechanism underlying the immunoregulatory effects of 1,25-dihydroxyvitamin D(3)
    • Cantorna MT, Humpal-Winter J, DeLuca HF. In vivo upregulation of interleukin-4 is one mechanism underlying the immunoregulatory effects of 1,25-dihydroxyvitamin D(3). Arch Biochem Biophys (2000) 377:135-8. doi:10.1006/abbi.2000.1765
    • (2000) Arch Biochem Biophys , vol.377 , pp. 135-138
    • Cantorna, M.T.1    Humpal-Winter, J.2    DeLuca, H.F.3
  • 225
    • 84893092211 scopus 로고    scopus 로고
    • Effect of vitamin D on T-helper type 9 polarized human memory cells in chronic persistent asthma
    • Keating P, Munim A, Hartmann JX. Effect of vitamin D on T-helper type 9 polarized human memory cells in chronic persistent asthma. Ann Allergy Asthma Immunol (2014) 112:154-62. doi:10.1016/j.anai.2013.11.015
    • (2014) Ann Allergy Asthma Immunol , vol.112 , pp. 154-162
    • Keating, P.1    Munim, A.2    Hartmann, J.X.3
  • 226
    • 64049088217 scopus 로고    scopus 로고
    • Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells
    • Wang F, Wan L, Zhang C, Zheng X, Li J, Chen ZK. Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells. Immunobiology (2009) 214:342-9. doi:10.1016/j.imbio.2008.10.007
    • (2009) Immunobiology , vol.214 , pp. 342-349
    • Wang, F.1    Wan, L.2    Zhang, C.3    Zheng, X.4    Li, J.5    Chen, Z.K.6
  • 227
    • 0343496952 scopus 로고    scopus 로고
    • Neuronal FasL induces cell death of encephalitogenic T lymphocytes
    • Flugel A, Schwaiger FW, Neumann H, Medana I, Willem M, Wekerle H, et al. Neuronal FasL induces cell death of encephalitogenic T lymphocytes. Brain Pathol (2000) 10:353-64. doi:10.1111/j.1750-3639.2000.tb00267.x
    • (2000) Brain Pathol , vol.10 , pp. 353-364
    • Flugel, A.1    Schwaiger, F.W.2    Neumann, H.3    Medana, I.4    Willem, M.5    Wekerle, H.6
  • 228
    • 0034237154 scopus 로고    scopus 로고
    • Coexpression of Fas/FasL and Bax on brain and infiltrating T cells in the central nervous system is closely associated with apoptotic cell death during autoimmune encephalomyelitis
    • Kohji T, Matsumoto Y. Coexpression of Fas/FasL and Bax on brain and infiltrating T cells in the central nervous system is closely associated with apoptotic cell death during autoimmune encephalomyelitis. J Neuroimmunol (2000) 106:165-71. doi:10.1016/S0165-5728(00)00238-1
    • (2000) J Neuroimmunol , vol.106 , pp. 165-171
    • Kohji, T.1    Matsumoto, Y.2
  • 229
    • 0030873325 scopus 로고    scopus 로고
    • Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region
    • Colucci F, Bergman ML, Penha-Goncalves C, Cilio CM, Holmberg D. Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region. Proc Natl Acad Sci U S A (1997) 94:8670-4. doi:10.1073/pnas.94.16.8670
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 8670-8674
    • Colucci, F.1    Bergman, M.L.2    Penha-Goncalves, C.3    Cilio, C.M.4    Holmberg, D.5
  • 230
    • 84870253612 scopus 로고    scopus 로고
    • The role of T cell apoptosis in nervous system autoimmunity
    • Comi C, Fleetwood T, Dianzani U. The role of T cell apoptosis in nervous system autoimmunity. Autoimmun Rev (2012) 12:150-6. doi:10.1016/j.autrev.2011.08.011
    • (2012) Autoimmun Rev , vol.12 , pp. 150-156
    • Comi, C.1    Fleetwood, T.2    Dianzani, U.3
  • 231
    • 0030973104 scopus 로고    scopus 로고
    • Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease
    • Bieganowska KD, Ausubel LJ, Modabber Y, Slovik E, Messersmith W, Hafler DA. Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease. J Exp Med (1997) 185:1585-94. doi:10.1084/jem.185.9.1585
    • (1997) J Exp Med , vol.185 , pp. 1585-1594
    • Bieganowska, K.D.1    Ausubel, L.J.2    Modabber, Y.3    Slovik, E.4    Messersmith, W.5    Hafler, D.A.6
  • 232
    • 23044506228 scopus 로고    scopus 로고
    • Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis
    • Saresella M, Marventano I, Speciale L, Ruzzante S, Trabattoni D, Della Bella S, et al. Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis. J Neuroimmunol (2005) 166:173-9. doi:10.1016/j.jneuroim.2005.05.010
    • (2005) J Neuroimmunol , vol.166 , pp. 173-179
    • Saresella, M.1    Marventano, I.2    Speciale, L.3    Ruzzante, S.4    Trabattoni, D.5    Della Bella, S.6
  • 233
    • 0031917693 scopus 로고    scopus 로고
    • Interaction between apoptotic cells and reactive brain cells in the central nervous system of rats with autoimmune encephalomyelitis
    • Kohji T, Tanuma N, Aikawa Y, Kawazoe Y, Suzuki Y, Kohyama K, et al. Interaction between apoptotic cells and reactive brain cells in the central nervous system of rats with autoimmune encephalomyelitis. J Neuroimmunol (1998) 82:168-74. doi:10.1016/S0165-5728(97)00198-7
    • (1998) J Neuroimmunol , vol.82 , pp. 168-174
    • Kohji, T.1    Tanuma, N.2    Aikawa, Y.3    Kawazoe, Y.4    Suzuki, Y.5    Kohyama, K.6
  • 234
    • 0033168749 scopus 로고    scopus 로고
    • FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier
    • Bechmann I, Mor G, Nilsen J, Eliza M, Nitsch R, Naftolin F. FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier. Glia (1999) 27:62-74. doi:10.1002/(SICI)1098-1136(199907)27:1<62::AID-GLIA7>3.0.CO;2-S
    • (1999) Glia , vol.27 , pp. 62-74
    • Bechmann, I.1    Mor, G.2    Nilsen, J.3    Eliza, M.4    Nitsch, R.5    Naftolin, F.6
  • 235
    • 0036848115 scopus 로고    scopus 로고
    • Astrocyte-induced T cell elimination is CD95 ligand dependent
    • Bechmann I, Steiner B, Gimsa U, Mor G, Wolf S, Beyer M, et al. Astrocyte-induced T cell elimination is CD95 ligand dependent. J Neuroimmunol (2002) 132:60-5. doi:10.1016/S0165-5728(02)00311-9
    • (2002) J Neuroimmunol , vol.132 , pp. 60-65
    • Bechmann, I.1    Steiner, B.2    Gimsa, U.3    Mor, G.4    Wolf, S.5    Beyer, M.6
  • 236
    • 1942539123 scopus 로고    scopus 로고
    • Defective activation-induced cell death in NOD T lymphocytes: 1,25-dihydroxyvitamin D3 restores defect
    • Decallonne B, Mathieu C. Defective activation-induced cell death in NOD T lymphocytes: 1,25-dihydroxyvitamin D3 restores defect. Ann N Y Acad Sci (2003) 1005:176-7. doi:10.1196/annals.1288.021
    • (2003) Ann N Y Acad Sci , vol.1005 , pp. 176-177
    • Decallonne, B.1    Mathieu, C.2
  • 237
    • 0038062649 scopus 로고    scopus 로고
    • Defect in activation-induced cell death in non-obese diabetic (NOD) T lymphocytes
    • Decallonne B, van Etten E, Giulietti A, Casteels K, Overbergh L, Bouillon R, et al. Defect in activation-induced cell death in non-obese diabetic (NOD) T lymphocytes. J Autoimmun (2003) 20:219-26. doi:10.1016/S0896-8411(03)00025-8
    • (2003) J Autoimmun , vol.20 , pp. 219-226
    • Decallonne, B.1    van Etten, E.2    Giulietti, A.3    Casteels, K.4    Overbergh, L.5    Bouillon, R.6
  • 238
    • 20144369107 scopus 로고    scopus 로고
    • 1Alpha,25-dihydroxyvitamin D3 restores thymocyte apoptosis sensitivity in non-obese diabetic (NOD) mice through dendritic cells
    • Decallonne B, van Etten E, Overbergh L, Valckx D, Bouillon R, Mathieu C. 1Alpha,25-dihydroxyvitamin D3 restores thymocyte apoptosis sensitivity in non-obese diabetic (NOD) mice through dendritic cells. J Autoimmun (2005) 24:281-9. doi:10.1016/j.jaut.2005.03.007
    • (2005) J Autoimmun , vol.24 , pp. 281-289
    • Decallonne, B.1    van Etten, E.2    Overbergh, L.3    Valckx, D.4    Bouillon, R.5    Mathieu, C.6
  • 239
    • 30044434075 scopus 로고    scopus 로고
    • The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    • Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, et al. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol (2005) 6:1245-52. doi:10.1038/ni1271
    • (2005) Nat Immunol , vol.6 , pp. 1245-1252
    • Zhu, C.1    Anderson, A.C.2    Schubart, A.3    Xiong, H.4    Imitola, J.5    Khoury, S.J.6
  • 240
    • 34547099820 scopus 로고    scopus 로고
    • Differential glycosylation of T(H)1, T(H)2 and T(H)-17 effector cells selectively regulates susceptibility to cell death
    • Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, et al. Differential glycosylation of T(H)1, T(H)2 and T(H)-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol (2007) 8(8):825-34. doi:10.1038/ni1482
    • (2007) Nat Immunol , vol.8 , Issue.8 , pp. 825-834
    • Toscano, M.A.1    Bianco, G.A.2    Ilarregui, J.M.3    Croci, D.O.4    Correale, J.5    Hernandez, J.D.6
  • 241
    • 79958728985 scopus 로고    scopus 로고
    • Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis
    • Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, et al. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun (2011) 2:334. doi:10.1038/ncomms1333
    • (2011) Nat Commun , vol.2 , pp. 334
    • Mkhikian, H.1    Grigorian, A.2    Li, C.F.3    Chen, H.L.4    Newton, B.5    Zhou, R.W.6
  • 242
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol (2010) 11:7-13. doi:10.1038/ni.1818
    • (2010) Nat Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 243
    • 0016818290 scopus 로고
    • Suppressor cell control of unresponsiveness to experimental allergic encephalomyelitis
    • Swierkosz JE, Swanborg RH. Suppressor cell control of unresponsiveness to experimental allergic encephalomyelitis. J Immunol (1975) 115:631-3.
    • (1975) J Immunol , vol.115 , pp. 631-633
    • Swierkosz, J.E.1    Swanborg, R.H.2
  • 244
    • 0024341132 scopus 로고
    • CD4+ suppressor cells differentially affect the production of IFN-gamma by effector cells of experimental autoimmune encephalomyelitis
    • Karpus WJ, Swanborg RH. CD4+ suppressor cells differentially affect the production of IFN-gamma by effector cells of experimental autoimmune encephalomyelitis. J Immunol (1989) 143:3492-7.
    • (1989) J Immunol , vol.143 , pp. 3492-3497
    • Karpus, W.J.1    Swanborg, R.H.2
  • 245
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 155:1151-64.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 246
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet (2001) 27:68-73. doi:10.1038/83784
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3    Paeper, B.4    Clark, L.B.5    Yasayko, S.A.6
  • 247
    • 35348876040 scopus 로고    scopus 로고
    • IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity
    • Ochs HD, Gambineri E, Torgerson TR. IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol Res (2007) 38:112-21. doi:10.1007/s12026-007-0022-2
    • (2007) Immunol Res , vol.38 , pp. 112-121
    • Ochs, H.D.1    Gambineri, E.2    Torgerson, T.R.3
  • 248
    • 84875498856 scopus 로고    scopus 로고
    • Development and maintenance of regulatory T cells
    • Ohkura N, Kitagawa Y, Sakaguchi S. Development and maintenance of regulatory T cells. Immunity (2013) 38:414-23. doi:10.1016/j.immuni.2013.03.002
    • (2013) Immunity , vol.38 , pp. 414-423
    • Ohkura, N.1    Kitagawa, Y.2    Sakaguchi, S.3
  • 250
    • 84958548312 scopus 로고    scopus 로고
    • Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications
    • Roncarolo MG, Gregori S, Bacchetta R, Battaglia M. Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications. Curr Top Microbiol Immunol (2014) 380:39-68. doi:10.1007/978-3-662-43492-5_3
    • (2014) Curr Top Microbiol Immunol , vol.380 , pp. 39-68
    • Roncarolo, M.G.1    Gregori, S.2    Bacchetta, R.3    Battaglia, M.4
  • 251
    • 2442450433 scopus 로고    scopus 로고
    • IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    • Vieira PL, Christensen JR, Minaee S, O'Neill EJ, Barrat FJ, Boonstra A, et al. IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J Immunol (2004) 172:5986-93. doi:10.4049/jimmunol.172.10.5986
    • (2004) J Immunol , vol.172 , pp. 5986-5993
    • Vieira, P.L.1    Christensen, J.R.2    Minaee, S.3    O'Neill, E.J.4    Barrat, F.J.5    Boonstra, A.6
  • 252
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    • Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med (2013) 19:739-46. doi:10.1038/nm.3179
    • (2013) Nat Med , vol.19 , pp. 739-746
    • Gagliani, N.1    Magnani, C.F.2    Huber, S.3    Gianolini, M.E.4    Pala, M.5    Licona-Limon, P.6
  • 253
    • 0347895101 scopus 로고    scopus 로고
    • Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
    • Kemper C, Chan AC, Green JM, Brett KA, Murphy KM, Atkinson JP. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature (2003) 421:388-92. doi:10.1038/nature01315
    • (2003) Nature , vol.421 , pp. 388-392
    • Kemper, C.1    Chan, A.C.2    Green, J.M.3    Brett, K.A.4    Murphy, K.M.5    Atkinson, J.P.6
  • 254
    • 78649526238 scopus 로고    scopus 로고
    • Mechanisms of impaired regulation by CD4(+)CD25(+) FOXP3(+) regulatory T cells in human autoimmune diseases
    • Buckner JH. Mechanisms of impaired regulation by CD4(+)CD25(+) FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol (2010) 10:849-59. doi:10.1038/nri2889
    • (2010) Nat Rev Immunol , vol.10 , pp. 849-859
    • Buckner, J.H.1
  • 255
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med (2004) 199:971-9. doi:10.1084/jem.20031579
    • (2004) J Exp Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 256
    • 27944499757 scopus 로고    scopus 로고
    • Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
    • Haas J, Hug A, Viehover A, Fritzsching B, Falk CS, Filser A, et al. Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol (2005) 35:3343-52. doi:10.1002/eji.200526065
    • (2005) Eur J Immunol , vol.35 , pp. 3343-3352
    • Haas, J.1    Hug, A.2    Viehover, A.3    Fritzsching, B.4    Falk, C.S.5    Filser, A.6
  • 257
    • 34548721641 scopus 로고    scopus 로고
    • Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis
    • Haas J, Fritzsching B, Trubswetter P, Korporal M, Milkova L, Fritz B, et al. Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J Immunol (2007) 179:1322-30. doi:10.4049/jimmunol.179.2.1322
    • (2007) J Immunol , vol.179 , pp. 1322-1330
    • Haas, J.1    Fritzsching, B.2    Trubswetter, P.3    Korporal, M.4    Milkova, L.5    Fritz, B.6
  • 258
    • 44449171488 scopus 로고    scopus 로고
    • Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression
    • Venken K, Hellings N, Broekmans T, Hensen K, Rummens JL, Stinissen P. Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J Immunol (2008) 180:6411-20. doi:10.4049/jimmunol.180.9.6411
    • (2008) J Immunol , vol.180 , pp. 6411-6420
    • Venken, K.1    Hellings, N.2    Broekmans, T.3    Hensen, K.4    Rummens, J.L.5    Stinissen, P.6
  • 260
    • 37149003363 scopus 로고    scopus 로고
    • Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level
    • Venken K, Hellings N, Thewissen M, Somers V, Hensen K, Rummens JL, et al. Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level. Immunology (2008) 123:79-89. doi:10.1111/j.1365-2567.2007.02690.x
    • (2008) Immunology , vol.123 , pp. 79-89
    • Venken, K.1    Hellings, N.2    Thewissen, M.3    Somers, V.4    Hensen, K.5    Rummens, J.L.6
  • 261
  • 262
    • 76249094369 scopus 로고    scopus 로고
    • Disturbed regulatory T cell homeostasis in multiple sclerosis
    • Venken K, Hellings N, Liblau R, Stinissen P. Disturbed regulatory T cell homeostasis in multiple sclerosis. Trends Mol Med (2010) 16:58-68. doi:10.1016/j.molmed.2009.12.003
    • (2010) Trends Mol Med , vol.16 , pp. 58-68
    • Venken, K.1    Hellings, N.2    Liblau, R.3    Stinissen, P.4
  • 263
    • 56649095905 scopus 로고    scopus 로고
    • T regulatory cells in autoimmune diabetes: past challenges, future prospects
    • Bluestone JA, Tang Q, Sedwick CE. T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol (2008) 28:677-84. doi:10.1007/s10875-008-9242-z
    • (2008) J Clin Immunol , vol.28 , pp. 677-684
    • Bluestone, J.A.1    Tang, Q.2    Sedwick, C.E.3
  • 264
    • 85047690395 scopus 로고    scopus 로고
    • Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
    • Arif S, Tree TI, Astill TP, Tremble JM, Bishop AJ, Dayan CM, et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest (2004) 113:451-63. doi:10.1172/JCI19585
    • (2004) J Clin Invest , vol.113 , pp. 451-463
    • Arif, S.1    Tree, T.I.2    Astill, T.P.3    Tremble, J.M.4    Bishop, A.J.5    Dayan, C.M.6
  • 265
    • 33845302957 scopus 로고    scopus 로고
    • Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis
    • Astier AL, Meiffren G, Freeman S, Hafler DA. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J Clin Invest (2006) 116:3252-7. doi:10.1172/JCI29251
    • (2006) J Clin Invest , vol.116 , pp. 3252-3257
    • Astier, A.L.1    Meiffren, G.2    Freeman, S.3    Hafler, D.A.4
  • 266
    • 43749095839 scopus 로고    scopus 로고
    • T-cell regulation by CD46 and its relevance in multiple sclerosis
    • Astier AL. T-cell regulation by CD46 and its relevance in multiple sclerosis. Immunology (2008) 124:149-54. doi:10.1111/j.1365-2567.2008.02821.x
    • (2008) Immunology , vol.124 , pp. 149-154
    • Astier, A.L.1
  • 268
    • 63549119572 scopus 로고    scopus 로고
    • Dysfunction of IL-10-producing type 1 regulatory T cells and CD4(+)CD25(+) regulatory T cells in a mimic model of human multiple sclerosis in Cynomolgus monkeys
    • Ma A, Xiong Z, Hu Y, Qi S, Song L, Dun H, et al. Dysfunction of IL-10-producing type 1 regulatory T cells and CD4(+)CD25(+) regulatory T cells in a mimic model of human multiple sclerosis in Cynomolgus monkeys. Int Immunopharmacol (2009) 9:599-608. doi:10.1016/j.intimp.2009.01.034
    • (2009) Int Immunopharmacol , vol.9 , pp. 599-608
    • Ma, A.1    Xiong, Z.2    Hu, Y.3    Qi, S.4    Song, L.5    Dun, H.6
  • 269
    • 84855263699 scopus 로고    scopus 로고
    • CD46 processing: a means of expression
    • Ni Choileain S, Astier AL. CD46 processing: a means of expression. Immunobiology (2012) 217:169-75. doi:10.1016/j.imbio.2011.06.003
    • (2012) Immunobiology , vol.217 , pp. 169-175
    • Ni Choileain, S.1    Astier, A.L.2
  • 270
    • 84861999693 scopus 로고    scopus 로고
    • From patient to discoverer-Niels Ryberg Finsen (1860-1904)-the founder of phototherapy in dermatology
    • Grzybowski A, Pietrzak K. From patient to discoverer-Niels Ryberg Finsen (1860-1904)-the founder of phototherapy in dermatology. Clin Dermatol (2012) 30:451-5. doi:10.1016/j.clindermatol.2011.11.019
    • (2012) Clin Dermatol , vol.30 , pp. 451-455
    • Grzybowski, A.1    Pietrzak, K.2
  • 271
    • 84856865635 scopus 로고    scopus 로고
    • Regulatory T cells: banned cells for decades
    • Loser K, Beissert S. Regulatory T cells: banned cells for decades. J Invest Dermatol (2012) 132:864-71. doi:10.1038/jid.2011.375
    • (2012) J Invest Dermatol , vol.132 , pp. 864-871
    • Loser, K.1    Beissert, S.2
  • 272
    • 33845543666 scopus 로고    scopus 로고
    • Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
    • Loser K, Mehling A, Loeser S, Apelt J, Kuhn A, Grabbe S, et al. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med (2006) 12:1372-9. doi:10.1038/nm1518
    • (2006) Nat Med , vol.12 , pp. 1372-1379
    • Loser, K.1    Mehling, A.2    Loeser, S.3    Apelt, J.4    Kuhn, A.5    Grabbe, S.6
  • 273
    • 63549107572 scopus 로고    scopus 로고
    • Regulation of cutaneous immunity by the environment: an important role for UV irradiation and vitamin D
    • Loser K, Beissert S. Regulation of cutaneous immunity by the environment: an important role for UV irradiation and vitamin D. Int Immunopharmacol (2009) 9:587-9. doi:10.1016/j.intimp.2009.01.024
    • (2009) Int Immunopharmacol , vol.9 , pp. 587-589
    • Loser, K.1    Beissert, S.2
  • 274
    • 0037615170 scopus 로고    scopus 로고
    • Demonstration of UVB-induced synthesis of 1 alpha,25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis
    • Lehmann B, Sauter W, Knuschke P, Dressler S, Meurer M. Demonstration of UVB-induced synthesis of 1 alpha,25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis. Arch Dermatol Res (2003) 295:24-8. doi:10.1007/s00403-003-0387-6
    • (2003) Arch Dermatol Res , vol.295 , pp. 24-28
    • Lehmann, B.1    Sauter, W.2    Knuschke, P.3    Dressler, S.4    Meurer, M.5
  • 275
    • 0034748888 scopus 로고    scopus 로고
    • IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times
    • Elenkov IJ, Wilder RL, Bakalov VK, Link AA, Dimitrov MA, Fisher S, et al. IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times. J Clin Endocrinol Metab (2001) 86:4933-8. doi:10.1210/jcem.86.10.7905
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4933-4938
    • Elenkov, I.J.1    Wilder, R.L.2    Bakalov, V.K.3    Link, A.A.4    Dimitrov, M.A.5    Fisher, S.6
  • 276
    • 0036289336 scopus 로고    scopus 로고
    • Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter
    • Kitazawa R, Kitazawa S. Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter. Biochem Biophys Res Commun (2002) 290:650-5. doi:10.1006/bbrc.2001.6251
    • (2002) Biochem Biophys Res Commun , vol.290 , pp. 650-655
    • Kitazawa, R.1    Kitazawa, S.2
  • 277
    • 0037636046 scopus 로고    scopus 로고
    • Vitamin D3 supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter
    • Kitazawa S, Kajimoto K, Kondo T, Kitazawa R. Vitamin D3 supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter. J Cell Biochem (2003) 89:771-7. doi:10.1002/jcb.10567
    • (2003) J Cell Biochem , vol.89 , pp. 771-777
    • Kitazawa, S.1    Kajimoto, K.2    Kondo, T.3    Kitazawa, R.4
  • 278
    • 33947149145 scopus 로고    scopus 로고
    • Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3
    • Kim S, Yamazaki M, Zella LA, Meyer MB, Fretz JA, Shevde NK, et al. Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol (2007) 103:430-4. doi:10.1016/j.jsbmb.2006.12.020
    • (2007) J Steroid Biochem Mol Biol , vol.103 , pp. 430-434
    • Kim, S.1    Yamazaki, M.2    Zella, L.A.3    Meyer, M.B.4    Fretz, J.A.5    Shevde, N.K.6
  • 279
    • 79958016522 scopus 로고    scopus 로고
    • Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region
    • Bishop KA, Coy HM, Nerenz RD, Meyer MB, Pike JW. Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region. J Biol Chem (2011) 286:20880-91. doi:10.1074/jbc.M111.231548
    • (2011) J Biol Chem , vol.286 , pp. 20880-20891
    • Bishop, K.A.1    Coy, H.M.2    Nerenz, R.D.3    Meyer, M.B.4    Pike, J.W.5
  • 280
    • 84916608044 scopus 로고    scopus 로고
    • Transcriptional regulation of the human TNFSF11 gene in t cells via a cell type-selective set of distal enhancers
    • Bishop KA, Wang X, Coy HM, Meyer MB, Gumperz JE, Pike JW. Transcriptional regulation of the human TNFSF11 gene in t cells via a cell type-selective set of distal enhancers. J Cell Biochem (2014) 116(2):320-30. doi:10.1002/jcb.24974
    • (2014) J Cell Biochem , vol.116 , Issue.2 , pp. 320-330
    • Bishop, K.A.1    Wang, X.2    Coy, H.M.3    Meyer, M.B.4    Gumperz, J.E.5    Pike, J.W.6
  • 281
    • 38449101546 scopus 로고    scopus 로고
    • Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes
    • Gorman S, Kuritzky LA, Judge MA, Dixon KM, McGlade JP, Mason RS, et al. Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes. J Immunol (2007) 179:6273-83. doi:10.4049/jimmunol.179.9.6273
    • (2007) J Immunol , vol.179 , pp. 6273-6283
    • Gorman, S.1    Kuritzky, L.A.2    Judge, M.A.3    Dixon, K.M.4    McGlade, J.P.5    Mason, R.S.6
  • 282
    • 73849123602 scopus 로고    scopus 로고
    • Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol
    • Ghoreishi M, Bach P, Obst J, Komba M, Fleet JC, Dutz JP. Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol. J Immunol (2009) 182:6071-8. doi:10.4049/jimmunol.0804064
    • (2009) J Immunol , vol.182 , pp. 6071-6078
    • Ghoreishi, M.1    Bach, P.2    Obst, J.3    Komba, M.4    Fleet, J.C.5    Dutz, J.P.6
  • 283
    • 77949747054 scopus 로고    scopus 로고
    • Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice
    • Tomura M, Honda T, Tanizaki H, Otsuka A, Egawa G, Tokura Y, et al. Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest (2010) 120:883-93. doi:10.1172/JCI40926
    • (2010) J Clin Invest , vol.120 , pp. 883-893
    • Tomura, M.1    Honda, T.2    Tanizaki, H.3    Otsuka, A.4    Egawa, G.5    Tokura, Y.6
  • 284
    • 84861666390 scopus 로고    scopus 로고
    • Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function
    • Milliken SV, Wassall H, Lewis BJ, Logie J, Barker RN, Macdonald H, et al. Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function. J Allergy Clin Immunol (2012) 129:1554-61. doi:10.1016/j.jaci.2012.03.001
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 1554-1561
    • Milliken, S.V.1    Wassall, H.2    Lewis, B.J.3    Logie, J.4    Barker, R.N.5    Macdonald, H.6
  • 285
    • 84912535463 scopus 로고    scopus 로고
    • Homeostasis of thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin
    • Yamazaki S, Nishioka A, Kasuya S, Ohkura N, Hemmi H, Kaisho T, et al. Homeostasis of thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin. J Immunol (2014) 193(11):5488-97. doi:10.4049/jimmunol.1400985
    • (2014) J Immunol , vol.193 , Issue.11 , pp. 5488-5497
    • Yamazaki, S.1    Nishioka, A.2    Kasuya, S.3    Ohkura, N.4    Hemmi, H.5    Kaisho, T.6
  • 287
    • 53849116091 scopus 로고    scopus 로고
    • Role of IL-10 in the resolution of airway inflammation
    • Ogawa Y, Duru EA, Ameredes BT. Role of IL-10 in the resolution of airway inflammation. Curr Mol Med (2008) 8:437-45. doi:10.2174/156652408785160907
    • (2008) Curr Mol Med , vol.8 , pp. 437-445
    • Ogawa, Y.1    Duru, E.A.2    Ameredes, B.T.3
  • 288
    • 84958539762 scopus 로고    scopus 로고
    • IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms
    • Engelhardt KR, Grimbacher B. IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms. Curr Top Microbiol Immunol (2014) 380:1-18. doi:10.1007/978-3-662-43492-5_1
    • (2014) Curr Top Microbiol Immunol , vol.380 , pp. 1-18
    • Engelhardt, K.R.1    Grimbacher, B.2
  • 289
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 28:546-58. doi:10.1016/j.immuni.2008.02.017
    • (2008) Immunity , vol.28 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3    Fontenot, J.4    Castelli, L.5    Ye, X.6
  • 291
    • 84958527320 scopus 로고    scopus 로고
    • The molecular basis of IL-10 function: from receptor structure to the onset of signaling
    • Walter MR. The molecular basis of IL-10 function: from receptor structure to the onset of signaling. Curr Top Microbiol Immunol (2014) 380:191-212. doi:10.1007/978-3-662-43492-5_9
    • (2014) Curr Top Microbiol Immunol , vol.380 , pp. 191-212
    • Walter, M.R.1
  • 292
    • 0033485424 scopus 로고    scopus 로고
    • Activation of regulatory cells suppresses experimental allergic encephalomyelitis via secretion of IL-10
    • Stohlman SA, Pei L, Cua DJ, Li Z, Hinton DR. Activation of regulatory cells suppresses experimental allergic encephalomyelitis via secretion of IL-10. J Immunol (1999) 163:6338-44.
    • (1999) J Immunol , vol.163 , pp. 6338-6344
    • Stohlman, S.A.1    Pei, L.2    Cua, D.J.3    Li, Z.4    Hinton, D.R.5
  • 293
    • 0032821774 scopus 로고    scopus 로고
    • Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10
    • Burkhart C, Liu GY, Anderton SM, Metzler B, Wraith DC. Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10. Int Immunol (1999) 11:1625-34. doi:10.1093/intimm/11.10.1625
    • (1999) Int Immunol , vol.11 , pp. 1625-1634
    • Burkhart, C.1    Liu, G.Y.2    Anderton, S.M.3    Metzler, B.4    Wraith, D.C.5
  • 294
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines
    • Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines. J Exp Med (2002) 195:603-16. doi:10.1084/jem.20011629
    • (2002) J Exp Med , vol.195 , pp. 603-616
    • Barrat, F.J.1    Cua, D.J.2    Boonstra, A.3    Richards, D.F.4    Crain, C.5    Savelkoul, H.F.6
  • 295
    • 0036020679 scopus 로고    scopus 로고
    • A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice
    • Gregori S, Giarratana N, Smiroldo S, Uskokovic M, Adorini L. A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes (2002) 51:1367-74. doi:10.2337/diabetes.51.5.1367
    • (2002) Diabetes , vol.51 , pp. 1367-1374
    • Gregori, S.1    Giarratana, N.2    Smiroldo, S.3    Uskokovic, M.4    Adorini, L.5
  • 296
    • 38449087569 scopus 로고    scopus 로고
    • Unaltered diabetes presentation in NOD mice lacking the vitamin D receptor
    • Gysemans C, van Etten E, Overbergh L, Giulietti A, Eelen G, Waer M, et al. Unaltered diabetes presentation in NOD mice lacking the vitamin D receptor. Diabetes (2008) 57:269-75. doi:10.2337/db07-1095
    • (2008) Diabetes , vol.57 , pp. 269-275
    • Gysemans, C.1    van Etten, E.2    Overbergh, L.3    Giulietti, A.4    Eelen, G.5    Waer, M.6
  • 297
    • 78651407519 scopus 로고    scopus 로고
    • Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells
    • Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, et al. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J Biol Chem (2011) 286:997-1004. doi:10.1074/jbc.M110.163790
    • (2011) J Biol Chem , vol.286 , pp. 997-1004
    • Palmer, M.T.1    Lee, Y.K.2    Maynard, C.L.3    Oliver, J.R.4    Bikle, D.D.5    Jetten, A.M.6
  • 298
    • 3142666845 scopus 로고    scopus 로고
    • Low vitamin D status is associated with low cord blood levels of the immunosuppressive cytokine interleukin-10
    • Zittermann A, Dembinski J, Stehle P. Low vitamin D status is associated with low cord blood levels of the immunosuppressive cytokine interleukin-10. Pediatr Allergy Immunol (2004) 15:242-6. doi:10.1111/j.1399-3038.2004.00140.x
    • (2004) Pediatr Allergy Immunol , vol.15 , pp. 242-246
    • Zittermann, A.1    Dembinski, J.2    Stehle, P.3
  • 299
    • 84901503979 scopus 로고    scopus 로고
    • Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma
    • Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM. Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Ann N Y Acad Sci (2014) 1317:57-69. doi:10.1111/nyas.12410
    • (2014) Ann N Y Acad Sci , vol.1317 , pp. 57-69
    • Mann, E.H.1    Chambers, E.S.2    Pfeffer, P.E.3    Hawrylowicz, C.M.4
  • 300
    • 61749100051 scopus 로고    scopus 로고
    • Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function
    • Urry Z, Xystrakis E, Richards DF, McDonald J, Sattar Z, Cousins DJ, et al. Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. J Clin Invest (2009) 119:387-98. doi:10.1172/JCI32354
    • (2009) J Clin Invest , vol.119 , pp. 387-398
    • Urry, Z.1    Xystrakis, E.2    Richards, D.F.3    McDonald, J.4    Sattar, Z.5    Cousins, D.J.6
  • 301
    • 84863416318 scopus 로고    scopus 로고
    • 1alpha,25-dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells
    • Dimeloe S, Richards DF, Urry ZL, Gupta A, Stratigou V, Farooque S, et al. 1alpha,25-dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells. Thorax (2012) 67:574-81. doi:10.1136/thoraxjnl-2011-200651
    • (2012) Thorax , vol.67 , pp. 574-581
    • Dimeloe, S.1    Richards, D.F.2    Urry, Z.L.3    Gupta, A.4    Stratigou, V.5    Farooque, S.6
  • 302
    • 84867202982 scopus 로고    scopus 로고
    • The role of 1alpha,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells
    • Urry Z, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabrysova L, et al. The role of 1alpha,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells. Eur J Immunol (2012) 42:2697-708. doi:10.1002/eji.201242370
    • (2012) Eur J Immunol , vol.42 , pp. 2697-2708
    • Urry, Z.1    Chambers, E.S.2    Xystrakis, E.3    Dimeloe, S.4    Richards, D.F.5    Gabrysova, L.6
  • 303
    • 84901026697 scopus 로고    scopus 로고
    • Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma
    • Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, et al. Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Thorax (2014) 69:508-15. doi:10.1136/thoraxjnl-2013-203421
    • (2014) Thorax , vol.69 , pp. 508-515
    • Gupta, A.1    Dimeloe, S.2    Richards, D.F.3    Chambers, E.S.4    Black, C.5    Urry, Z.6
  • 304
    • 84904865500 scopus 로고    scopus 로고
    • 1alpha,25-dihydroxyvitamin D3 in combination with transforming growth factor-beta increases the frequency of Foxp3(+) regulatory T cells through preferential expansion and usage of interleukin-2
    • Chambers ES, Suwannasaen D, Mann EH, Urry Z, Richards DF, Lertmemongkolchai G, et al. 1alpha,25-dihydroxyvitamin D3 in combination with transforming growth factor-beta increases the frequency of Foxp3(+) regulatory T cells through preferential expansion and usage of interleukin-2. Immunology (2014) 143:52-60. doi:10.1111/imm.12289
    • (2014) Immunology , vol.143 , pp. 52-60
    • Chambers, E.S.1    Suwannasaen, D.2    Mann, E.H.3    Urry, Z.4    Richards, D.F.5    Lertmemongkolchai, G.6
  • 305
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol (2010) 184:3433-41. doi:10.4049/jimmunol.0904028
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6
  • 306
    • 77950628840 scopus 로고    scopus 로고
    • A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells
    • Getnet D, Grosso JF, Goldberg MV, Harris TJ, Yen HR, Bruno TC, et al. A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells. Mol Immunol (2010) 47:1595-600. doi:10.1016/j.molimm.2010.02.001
    • (2010) Mol Immunol , vol.47 , pp. 1595-1600
    • Getnet, D.1    Grosso, J.F.2    Goldberg, M.V.3    Harris, T.J.4    Yen, H.R.5    Bruno, T.C.6
  • 308
    • 68049101203 scopus 로고    scopus 로고
    • Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosis
    • Royal W III, Mia Y, Li H, Naunton K. Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosis. J Neuroimmunol (2009) 213:135-41. doi:10.1016/j.jneuroim.2009.05.012
    • (2009) J Neuroimmunol , vol.213 , pp. 135-141
    • Royal, W.1    Mia, Y.2    Li, H.3    Naunton, K.4
  • 309
    • 77954357437 scopus 로고    scopus 로고
    • Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis
    • Smolders J, Menheere P, Thewissen M, Peelen E, Cohen Tervaert JW, Hupperts R, et al. Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis. J Steroid Biochem Mol Biol (2010) 121:243-6. doi:10.1016/j.jsbmb.2010.03.001
    • (2010) J Steroid Biochem Mol Biol , vol.121 , pp. 243-246
    • Smolders, J.1    Menheere, P.2    Thewissen, M.3    Peelen, E.4    Cohen Tervaert, J.W.5    Hupperts, R.6
  • 310
    • 84855338089 scopus 로고    scopus 로고
    • Seasonal variation in vitamin D(3) levels is paralleled by changes in the peripheral blood human T cell compartment
    • Khoo AL, Koenen HJ, Chai LY, Sweep FC, Netea MG, van der Ven AJ, et al. Seasonal variation in vitamin D(3) levels is paralleled by changes in the peripheral blood human T cell compartment. PLoS One (2012) 7:e29250. doi:10.1371/journal.pone.0029250
    • (2012) PLoS One , vol.7
    • Khoo, A.L.1    Koenen, H.J.2    Chai, L.Y.3    Sweep, F.C.4    Netea, M.G.5    van der Ven, A.J.6
  • 311
    • 84866020743 scopus 로고    scopus 로고
    • Correlation between the cord vitamin D levels and regulatory T cells in newborn infants
    • Guven A, Ecevit A, Sozer O, Tarcan A, Tarcan A, Ozbek N. Correlation between the cord vitamin D levels and regulatory T cells in newborn infants. Eur J Pediatr (2012) 171:1161-6. doi:10.1007/s00431-012-1688-6
    • (2012) Eur J Pediatr , vol.171 , pp. 1161-1166
    • Guven, A.1    Ecevit, A.2    Sozer, O.3    Tarcan, A.4    Tarcan, A.5    Ozbek, N.6
  • 312
    • 79251567975 scopus 로고    scopus 로고
    • The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation
    • Baeke F, Korf H, Overbergh L, Verstuyf A, Thorrez L, Van Lommel L, et al. The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation. J Immunol (2011) 186:132-42. doi:10.4049/jimmunol.1000695
    • (2011) J Immunol , vol.186 , pp. 132-142
    • Baeke, F.1    Korf, H.2    Overbergh, L.3    Verstuyf, A.4    Thorrez, L.5    Van Lommel, L.6
  • 313
    • 84938070889 scopus 로고    scopus 로고
    • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations
    • Schubert D, Bode C, Kenefeck R, Hou TZ, Wing JB, Kennedy A, et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med (2014) 20(12):1410-6. doi:10.1038/nm.3746
    • (2014) Nat Med , vol.20 , Issue.12 , pp. 1410-1416
    • Schubert, D.1    Bode, C.2    Kenefeck, R.3    Hou, T.Z.4    Wing, J.B.5    Kennedy, A.6
  • 314
    • 84907909000 scopus 로고    scopus 로고
    • Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
    • Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, et al. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science (2014) 345:1623-7. doi:10.1126/science.1255904
    • (2014) Science , vol.345 , pp. 1623-1627
    • Kuehn, H.S.1    Ouyang, W.2    Lo, B.3    Deenick, E.K.4    Niemela, J.E.5    Avery, D.T.6
  • 315
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (2011) 332:600-3. doi:10.1126/science.1202947
    • (2011) Science , vol.332 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3    Attridge, K.4    Manzotti, C.5    Schmidt, E.M.6
  • 316
  • 317
    • 79960982822 scopus 로고    scopus 로고
    • The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation
    • Ni Choileain S, Weyand NJ, Neumann C, Thomas J, So M, Astier AL. The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation. PLoS One (2011) 6:e16287. doi:10.1371/journal.pone.0016287
    • (2011) PLoS One , vol.6
    • Ni Choileain, S.1    Weyand, N.J.2    Neumann, C.3    Thomas, J.4    So, M.5    Astier, A.L.6
  • 318
    • 77955876612 scopus 로고    scopus 로고
    • Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells
    • Cardone J, Le Friec G, Vantourout P, Roberts A, Fuchs A, Jackson I, et al. Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat Immunol (2010) 11:862-71. doi:10.1038/ni.1917
    • (2010) Nat Immunol , vol.11 , pp. 862-871
    • Cardone, J.1    Le Friec, G.2    Vantourout, P.3    Roberts, A.4    Fuchs, A.5    Jackson, I.6
  • 319
    • 77953339908 scopus 로고    scopus 로고
    • A defect of CD4+CD25+ regulatory T cells in inducing interleukin-10 production from CD4+ T cells under CD46 costimulation in asthma patients
    • Xu YQ, Gao YD, Yang J, Guo W. A defect of CD4+CD25+ regulatory T cells in inducing interleukin-10 production from CD4+ T cells under CD46 costimulation in asthma patients. J Asthma (2010) 47:367-73. doi:10.3109/02770903.2010.481340
    • (2010) J Asthma , vol.47 , pp. 367-373
    • Xu, Y.Q.1    Gao, Y.D.2    Yang, J.3    Guo, W.4
  • 320
    • 84907424958 scopus 로고    scopus 로고
    • Multistable switches and their role in cellular differentiation networks
    • Ghaffarizadeh A, Flann NS, Podgorski GJ. Multistable switches and their role in cellular differentiation networks. BMC Bioinformatics (2014) 15(Suppl 7):S7. doi:10.1186/1471-2105-15-S7-S7
    • (2014) BMC Bioinformatics , vol.15 , pp. S7
    • Ghaffarizadeh, A.1    Flann, N.S.2    Podgorski, G.J.3
  • 321
    • 84904400215 scopus 로고    scopus 로고
    • Helios defines T cells being driven to tolerance in the periphery and thymus
    • Ross EM, Bourges D, Hogan TV, Gleeson PA, van Driel IR. Helios defines T cells being driven to tolerance in the periphery and thymus. Eur J Immunol (2014) 44:2048-58. doi:10.1002/eji.201343999
    • (2014) Eur J Immunol , vol.44 , pp. 2048-2058
    • Ross, E.M.1    Bourges, D.2    Hogan, T.V.3    Gleeson, P.A.4    van Driel, I.R.5
  • 322
    • 84872740201 scopus 로고    scopus 로고
    • Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells
    • Baine I, Basu S, Ames R, Sellers RS, Macian F. Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells. J Immunol (2013) 190:1008-16. doi:10.4049/jimmunol.1200792
    • (2013) J Immunol , vol.190 , pp. 1008-1016
    • Baine, I.1    Basu, S.2    Ames, R.3    Sellers, R.S.4    Macian, F.5
  • 323
    • 84873839294 scopus 로고    scopus 로고
    • Features of human herpesvirus-6A and-6B entry
    • 384069
    • Maeki T, Mori Y. Features of human herpesvirus-6A and-6B entry. Adv Virol (2012) 2012:384069. doi:10.1155/2012/384069
    • (2012) Adv Virol , vol.2012
    • Maeki, T.1    Mori, Y.2
  • 324
    • 0033797692 scopus 로고    scopus 로고
    • Innate production of interleukin-10 and tumor necrosis factor affects the risk of multiple sclerosis
    • de Jong BA, Schrijver HM, Huizinga TW, Bollen EL, Polman CH, Uitdehaag BM, et al. Innate production of interleukin-10 and tumor necrosis factor affects the risk of multiple sclerosis. Ann Neurol (2000) 48:641-6. doi:10.1002/1531-8249(200010)48:4<641::AID-ANA11>3.0.CO;2-Z
    • (2000) Ann Neurol , vol.48 , pp. 641-646
    • de Jong, B.A.1    Schrijver, H.M.2    Huizinga, T.W.3    Bollen, E.L.4    Polman, C.H.5    Uitdehaag, B.M.6
  • 326
    • 0035991493 scopus 로고    scopus 로고
    • Interleukin-10 promoter polymorphism in multiple sclerosis: association with disease progression
    • Almeras L, Meresse B, Seze J, De Lefranc D, Dubucquoi S, Fajardy I, et al. Interleukin-10 promoter polymorphism in multiple sclerosis: association with disease progression. Eur Cytokine Netw (2002) 13:200-6.
    • (2002) Eur Cytokine Netw , vol.13 , pp. 200-206
    • Almeras, L.1    Meresse, B.2    Seze, J.3    De Lefranc, D.4    Dubucquoi, S.5    Fajardy, I.6
  • 327
  • 329
    • 84866053994 scopus 로고    scopus 로고
    • Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene
    • Dyment DA, Cader MZ, Chao MJ, Lincoln MR, Morrison KM, Disanto G, et al. Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene. Neurology (2012) 79:406-11. doi:10.1212/WNL.0b013e3182616fc4
    • (2012) Neurology , vol.79 , pp. 406-411
    • Dyment, D.A.1    Cader, M.Z.2    Chao, M.J.3    Lincoln, M.R.4    Morrison, K.M.5    Disanto, G.6


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