Multiple sclerosis and regulatory T cells

Journal of Clinical Immunology

Volumn 28, Issue 6, 2008, Pages 697-706

  Costantino, Cristina Maria ^a   Baecher Allan, Clare ^a   Hafler, David A ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Center for Neurologic Diseases   (United States)

Author keywords

Autoimmune disease; Immune system; Lymphocytes; Multiple sclerosis; Regulatory T cells

Indexed keywords

CD4 ANTIGEN; HLA DR ANTIGEN; L SELECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR;

ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BLOOD BRAIN BARRIER; CD4+ CD25+ T LYMPHOCYTE; CELL SURFACE; CENTRAL NERVOUS SYSTEM; EFFECTOR CELL; GENE CONTROL; GENETIC RESISTANCE; GLIOBLASTOMA; HISTOCOMPATIBILITY COMPLEX; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; IMMUNOREGULATION; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MICROGLIA; MULTIPLE SCLEROSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TISSUE INJURY; WHITE MATTER;

ANIMALS; AUTOIMMUNITY; CENTRAL NERVOUS SYSTEM; HUMANS; IMMUNOTHERAPY; MEMBRANE PROTEINS; MULTIPLE SCLEROSIS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTORS;

EID: 56649117451     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-008-9236-x     Document Type: Review

References (79)

1. RP Mackay NC Myrianth 1966 Multiple sclerosis in twins and their relatives-final report Arch Neurol 15 5 449 457
2. DA Hafler A Compston S Sawcer S Lander MJ Daly PL DeJager PIW de Bakker SB Gabriel DB Mirel AJ Ivinson MA Pericak-Vance SG Gregory JD Rioux JL McCauley JL Haines LF Barcellos B Cree JR Oksenberg SL Hauser International Multiple Sclerosis Genetic Consortium 2007 Novel risk alleles for multiple sclerosis identified by a whole genome association study N Engl J Med 357 851 862
3. MI McCarthy 2002 Susceptibility gene discovery for common metabolic and endocrine traits J Mol Endocrin 28 1 17
4. EA Kabat M Glusman V Knaub 1948 Quantitative estimation of the albumin and gamma-globulin in normal and pathologic cerebrospinal fluid by immunochemical methods Am J Med 4 5 653 662
5. TM Rivers DH Sprunt GP Berry 1933 Observations on attempts to produce acute disseminated encephalomyelitis in monkeys J Exp Med 58 1 39 U58
6. J Goverman 1993 Transgenic mice that express a myelin basic protein-specific T-cell receptor develop spontaneous autoimmunity Cell 72 4 551 560
7. DH Miller 2003 A controlled trial of natalizumab for relapsing multiple sclerosis New Eng J Med 348 15 23
8. K Ota 1990 T-cell recognition of an immunodominant myelin basic-protein epitope in multiple-sclerosis Nature 346 6280 183 187
9. M Pette 1990 Myelin basic protein-specific lymphocyte-T lines from MS patients and healthy-individuals Neurology 40 11 1770 1776
10. R Martin 1990 Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T-cell lines from multiple-sclerosis patients and healthy-individuals J Immunol 145 2 540 548
11. M Hahn MJ Nicholson J Pyrdol KW Wucherpfennig 2005 Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor Nat Immunol 6 5 490 496
12. LJ Ausubel 1996 Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones Proc Natl Acad Sci U S A 93 26 15317 15322
13. X Zhang 2008 Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis Euro J Immunol 38 5 1297 1309
14. RS Fujinami MB Oldstone 1985 Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity Science 230 4729 1043 1045
15. KW Wucherpfennig JL Strominger 1995 Molecular mimicry in T-cell-mediated autoimmunity-viral peptides activate human T-cell clones specific for myelin basic-protein Cell 80 5 695 705
16. B Hemmer 1997 Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone J Exp Med 185 9 1651 1659
17. HL Lang 2002 A functional and structural basis for TCR cross-reactivity in multiple sclerosis Nat Immunol 3 10 940 943
18. DC Lenz 2001 A Chlamydia pneumoniae-specific peptide induces experimental autoimmune encephalomyelitis in rats J Immunol 167 3 1803 1808
19. RS Fujinami 1983 Molecular mimicry in virus infection: crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments Proc Natl Acad Sci U S A 80 8 2346 2350
20. JL Croxford HA Anger SD Miller 2005 Viral delifery of an epitope from Haemophilus influenzae induces central nervous system autoimmune disease by molecular mimicry J Immunol 174 2 907 917
21. A Ascherio KL Munger 2007 Environmental risk factors for multiple sclerosis. Part I: the role of infection Ann Neuro 61 4 288 299
22. PL de Jager 2008 Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis Neurology 70 13 part 2 1113 1118
23. PV Lehmann 1992 Spreading of T cell autoimmunity to cryptic determinants of an autoantigen Nature 358 6382 155 157
24. S Ellmerich 2004 Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis Eur J Immunol 34 7 1839 1848
25. BD Trapp 1998 Axonal transection in the lesions of multiple sclerosis New Eng J Med 338 5 278 285
26. CF Lucchinetti 1996 Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis Brain Pathol 6 3 259 274
27. KW Wucherpfennig 1992 T-cell receptor V-alpha-V-beta repertoire and cytokine gene-expression in active multiple-sclerosis lesions J Exp Med 175 4 993 1002
28. U Traugott EL Reinherz CS Raine 1983 Multiple-sclerosis-distribution of T-cell subsets within active chronic lesions Science 219 4582 308 310
29. SL Hauser 1986 Immunohistochemical analysis of the cellular infiltrate in multiple-sclerosis lesions Ann Neurol 19 6 578 587
30. KW Wucherpfennig 1992 Gamma-delta T-cell receptor repertoire in acute multiple-sclerosis lesions Proc Natl Acad Sci U S A 89 10 4588 4592
31. JW Prineas RG Wright 1978 Macrophages, lymphocytes, and plasma-cells in perivascular compartment in chronic multiple-sclerosis Lab Invest 38 4 409 421
32. J Prineas 1975 Pathology of early lesion in multiple-sclerosis Human Pathol 6 5 531 554
33. B Becher 1996 Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro J Clin Invest 98 7 1539 1543
34. AC Anderson DE Anderson L Bregoli WD Hastings N Kassam C Lei R Chandwaskar J Karman EW Su M Hirashima JN Bruce LP Kane VK Kuchroo DA Hafler 2007 TIM-3 is expressed by cells of the innate immune system and promotes tissue inflammation Science 318 5853 1141 1143
35. S Lehnardt 2003 Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway Proc Natl Acad Sci U S A 100 14 8514 8519
36. ML Monje H Toda TD Palmer 2003 Inflammatory blockade restores adult hippocampal neurogenesis Science 302 5651 1760 1765
37. CT Ekdahl 2003 Inflammation is detrimental for neurogenesis in adult brain Proc Natl Acad Sci U S A 100 23 13632 13637
38. SE Baranzini 2000 Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression J Immunol 165 11 6576 6582
39. MP Mycko 2004 Microarray gene expression profiling of chronic active and inactive lesions in multiple sclerosis Clin Neurol Neurosurg 106 3 223 229
40. F Aloisi 1997 IL-12 production by central nervous system microglia is inhibited by astrocytes J Immunol 159 4 1604 1612
41. A Ledeboer 2000 Interleukin-10, interleukin-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells Glia 30 2 134 142
42. I Onuki 2001 Axonal degeneration is an early pathological feature in autoimmune-mediated demyelination in mice Microsc Res Tech 52 6 731 739
43. MM Ayers 2004 Early glial responses in murine models of multiple sclerosis Neurochem Int 45 2-3 409 419
44. V Trajkovic 2004 Astrocyte-induced regulatory T cells mitigate CNS autoimmunity Glia 47 2 168 179
45. MG Roncarolo 2001 Type 1 T regulatory cells Imm Rev 182 68 79
46. AM Pullen P Marrack JW Kappler 1989 Evidence that MLS-2 antigens which delete V-beta-3+ T-cells are controlled by multiple genes J Immunol 142 9 3033 3037
47. S Sakaguchi 2000 Regulatory T cells: key controllers of immunologic self-tolerance Cell 101 5 455 458
48. EM Shevach 2001 Control of T-cell activation by CD4(+) CD25(+) suppressor T cells Immunol Rev 182 58 67
49. S Sakaguchi 1985 Organ-specific autoimmune-diseases induced in mice by elimination of T-cell subset 1. Evidence for the active participation of T-cells in natural self-tolerance-deficit of a T-cell subset as a possible cause of autoimmune-disease J Exp Med 161 1 72 87
50. S Read V Malmstrom F Powrie 2000 Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation J Exp Med 192 2 295 302
51. C Baecher-Allan 2001 CD4+CD25(high) regulatory cells in human peripheral blood J Immunol 167 3 1245 1253
52. D Dieckmann 2001 Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood J Exp Med 193 11 1303 1310
53. J Wang 2007 Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells Eur J Immunol 37 129 138
54. JD Fontenot 2005 Regulatory T cell lineage specification by the forkhead transcription factor foxp3 Immunity 22 329 341
55. W Liu 2006 CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Treg cells J Exp Med 203 1701 1711
56. N Seddiki 2006 Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells J Exp Med 203 1693 1700
57. CR Ruprecht 2005 Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in invlamed synovia J Exp Med 201 1793 1803
58. CM Baecher-Allan E Wolf DA Hafler 2006 MHC class II expression identifies functionally distinct human regulatory T cells J Immunol 176 4622 4631
59. CM Baecher-Allan DA Hafler 2006 Human regulatory T cells and their role in autoimmune disease Imm Rev 212 203 216
60. D Dieckmann 2002 Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing contact-independent type 1-like regulatory T cells J Exp Med 196 247 253
61. H Jonuleit 2002 Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) helper cells J Exp Med 196 255 260
62. C Baecher-Allan V Viglietta DA Hafler 2002 Inhibition of human CD4(+)CD25(+high) regulatory T cell function J Immunol 169 11 6210 6217
63. H Reijonen 2002 Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects Diabetes 51 5 1375 1382
64. V Viglietta 2004 Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis J Exp Med 199 7 971 979
65. J Huan 2005 Decreased FOXP3 levels in multiple sclerosis patients J Neurosci Res 81 1 45 52
66. K Venken 2006 Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression J Neurosci Res 83 8 1432 1446
67. AL Astier 2006 Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis J Clin Invest 116 12 3252 3257
68. D Cao 1998 Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis J Immunol 160 1532 1538
69. H Sugiyama 2005 Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation J Immunol 174 164 173
70. S Lindley 2005 Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes Diabetes 54 92 99
71. A Balandina 2003 Analysis of CD4+CD25+ cell population in the thymus from myasthenia gravis patients Ann NY Acad Sci 998 275 277
72. E Gambineri 2003 Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis Curr Opin Rheum 15 430 435
73. DA Hafler 2007 Risk alleles for multiple sclerosis identified by a genomewide study New Eng J Med 357 851 862
74. The Wellcome Trust Cast Consortium 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 661 678
75. AP Kohm 2002 Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis J Immunol 169 9 4712 4716
76. MJ McGeachy LA Stephens SM Anderton 2005 Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system J Immunol 175 5 3025 3032
77. D Gartner 2006 CD25 regulatory T cells determine secondary but not primary remission in EAE: impact on long-term disease progression J Neuroimmunol 172 1-2 73 84
78. X Zhang 2006 Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells Int Immunol 18 4 495 503
79. T Korn 2007 Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation Nat Med 13 4 423 431