DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology

Journal of Autoimmunity

Volumn 50, Issue , 2014, Pages 33-37

  Stefan, Mihaela ^a,b   Zhang, Weijia ^a   Concepcion, Erlinda ^a   Yi, Zhengzi ^a   Tomer, Yaron ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

DNA methylation; Monozygotic twins; Transcriptional regulation; Type 1 diabetes

Indexed keywords

CD226 ANTIGEN; HLA ANTIGEN; INTERLEUKIN 2 RECEPTOR BETA; T LYMPHOCYTE ANTIGEN;

ADOLESCENT; CHILD; CPG ISLAND; DNA METHYLATION; DNA MICROARRAY; FEMALE; GENE EXPRESSION PROFILING; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MONOZYGOTIC TWINS; PRESCHOOL CHILD; PROMOTER REGION;

ADOLESCENT; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CHILD; CHILD, PRESCHOOL; CPG ISLANDS; DIABETES MELLITUS, TYPE 1; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION TO DISEASE; HLA ANTIGENS; HUMANS; INFANT; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC; TWINS, MONOZYGOTIC;

EID: 84898787481     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2013.10.001     Document Type: Article

References (22)

1. LaPorte R.E., Fishbein H.A., Drash A.L., Kuller L.H., Schneider B.B., Orchard T.J., et al. The Pittsburgh insulin-dependent diabetes mellitus (IDDM) registry. The incidence of insulin-dependent diabetes mellitus in Allegheny County, Pennsylvania (1965-1976). Diabetes 1981, 30:279-284.
2. Falorni A., Kockum C.B., Sanjeevi C.B., Lernmark A. The pathogenesis of insulin-dependent diabetes mellitus. Baillière's Clin Endocrinol Metab 1995, 9:25-46.
3. The Diabetes Control and Complications Trial Research Group The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. NEngl J Med 1993, 329:977-986.
4. Jahromi M.M., Eisenbarth G.S. Genetic determinants of type 1 diabetes across populations. Ann N Y Acad Sci 2006, 1079:289-299.
5. Huber A., Menconi F., Corathers S., Jacobson E.M., Tomer Y. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev 2008, 29:697-725.
6. Hasham A., Tomer Y. The recent rise in the frequency of type 1 diabetes: who pulled the trigger?. JAutoimmun 2011, 37:1-2.
7. Macfarlane A.J., Strom A., Scott F.W. Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes. Mamm Genome 2009, 20:624-632.
8. Bell J.T., Spector T.D. Atwin approach to unraveling epigenetics. Trends Genet 2011, 27:116-125.
9. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997, 20:1183-1197.
10. Li X.N., Herrington J., Petrov A., Ge L., Eiermann G., Xiong Y., et al. The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. JPharmacol Exp Ther 2013, 344:407-416.
11. Jensen M.V., Haldeman J.M., Zhang H., Lu D., Huising M.O., Vale W.W., et al. Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. JBiol Chem 2013, 288:23128-23140.
12. Polychronakos C., Li Q. Understanding type 1 diabetes through genetics: advances and prospects. Nat Rev Genet 2011, 12:781-792.
13. Karouzakis E., Gay R.E., Michel B.A., Gay S., Neidhart M. DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2009, 60:3613-3622.
14. Nile C.J., Read R.C., Akil M., Duff G.W., Wilson A.G. Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum 2008, 58:2686-2693.
15. Takami N., Osawa K., Miura Y., Komai K., Taniguchi M., Shiraishi M., et al. Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells. Arthritis Rheum 2006, 54:779-787.
16. Javierre B.M., Fernandez A.F., Richter J., Al-Shahrour F., Martin-Subero J.I., Rodriguez-Ubreva J., et al. Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res 2010, 20:170-179.
17. Rakyan V.K., Beyan H., Down T.A., Hawa M.I., Maslau S., Aden D., et al. Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet 2011, 7:e1002300.
18. Disanto G., Vcelakova J., Pakpoor J., Elangovan R.I., Sumnik Z., Ulmannova T., et al. DNA methylation in monozygotic quadruplets affected by type 1 diabetes. Diabetologia 2013, 56:2093-2095.
19. Bell C.G., Teschendorff A.E., Rakyan V.K., Maxwell A.P., Beck S., Savage D.A. Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus. BMC Med Genomics 2010, 3:33.
20. Fradin D., Le F.S., Mille C., Naoui N., Groves C., Zelenika D., et al. Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes. PLoS One 2012, 7:e36278.
21. Gale E.A., Gillespie K.M. Diabetes and gender. Diabetologia 2001, 44:3-15.
22. Karvonen M., Pitkaniemi M., Pitkaniemi J., Kohtamaki K., Tajima N., Tuomilehto J. Sex difference in the incidence of insulin-dependent diabetes mellitus: an analysis of the recent epidemiological data. World Health Organization DIAMOND Project Group. Diabetes Metab Rev 1997, 13:275-291.