T regulatory cells in autoimmune diabetes: Past challenges, future prospects

Journal of Clinical Immunology

Volumn 28, Issue 6, 2008, Pages 677-684

  Bluestone, Jeffrey A ^a   Tang, Qizhi ^a   Sedwick, Caitlin E ^a  

^a UCSF Diabetes Center   (United States)

Author keywords

Autoimmunity; Diabetes; Foxp3; Tregs

Indexed keywords

AUTOANTIBODY; CD28 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; PROTEIN BCL 2; RAPAMYCIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE IMMUNOTHERAPY; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL POPULATION; CELL SUBPOPULATION; CELL SURVIVAL; CELL THERAPY; CLINICAL TRIAL; DISEASE MODEL; EFFECTOR CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; KNOCKOUT MOUSE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTE TRANSFER; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; NONOBESE DIABETIC MOUSE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; SPLEEN CELL; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD28; AUTOIMMUNITY; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; SELF TOLERANCE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 56649095905     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-008-9242-z     Document Type: Review

References (46)

1. KD Moudgil EE Sercarz 2000 The self-directed T cell repertoire: its creation and activation Rev Immunogenet. 2 26 37
2. S Makino K Kunimoto Y Muraoka 1980 Breeding of a non-obese, diabetic strain of mice Jikken Dobutsu. 29 1 13
3. S Turley L Poirot M Hattori 2003 Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model J Exp Med. 198 1527 1537
4. L Yu DT Robles N Abiru 2000 Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes Proc Natl Acad Sci U S A 97 1701 1706
5. S Sakaguchi N Sakaguchi M Asano 1995 Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol. 155 1151 1164
6. M Asano M Toda N Sakaguchi 1996 Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation J Exp Med. 184 387 396
7. M Itoh T Takahashi N Sakaguchi 1999 Thymus and autoimmunity: production of CD25 + CD4 + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance J Immunol. 162 5317 5326
8. JD Fontenot MA Gavin AY Rudensky 2003 Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells Nat Immunol. 4 330 336
9. VL Godfrey JE Wilkinson EM Rinchik 1991 Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education Proc Natl Acad Sci U S A. 88 5528 5532
10. RS Wildin S Smyk-Pearson AH Filipovich 2002 Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome J Med Genet. 39 537 545
11. S Hori T Nomura S Sakaguchi 2003 Control of regulatory T cell development by the transcription factor Foxp3 Science. 299 1057 1061
12. JD Fontenot JP Rasmussen LM Williams 2005 Regulatory T cell lineage specification by the forkhead transcription factor foxp3 Immunity. 22 329 341
13. LS Wicker BJ Miller Y Mullen 1986 Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice Diabetes. 35 855 860
14. A Bendelac C Carnaud C Boitard 1987 Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4 + and Lyt-2 + T cells J Exp Med. 166 823 832
15. C Boitard R Yasunami M Dardenne 1989 T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice J Exp Med. 169 1669 1680
16. A Herbelin JM Gombert F Lepault 1998 Mature mainstream TCR alpha beta + CD4 + thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse J Immunol. 161 2620 2628
17. B Salomon DJ Lenschow L Rhee 2000 B7/CD28 costimulation is essential for the homeostasis of the CD4 + CD25 + immunoregulatory T cells that control autoimmune diabetes Immunity. 12 431 440
18. DJ Lenschow KC Herold L Rhee 1996 CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes Immunity. 5 285 293
19. S Sakaguchi 2000 Regulatory T cells: key controllers of immunologic self-tolerance Cell. 101 455 458
20. Q Tang KJ Henriksen EK Boden 2003 Cutting edge: CD28 controls peripheral homeostasis of CD4 + CD25 + regulatory T cells J Immunol. 171 3348 3352
21. JD Fontenot AY Rudensky 2004 Molecular aspects of regulatory T cell development Semin Immunol. 16 73 80
22. A Rabinovitch WL Suarez-Pinzon AM Shapiro 2002 Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice Diabetes. 51 638 645
23. MG Roncarolo M Battaglia 2007 Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans Nat Rev Immunol. 7 585 598
24. Q Tang KJ Henriksen M Bi 2004 In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes J Exp Med. 199 1455 1465
25. EL Masteller MR Warner Q Tang 2005 Expansion of functional endogenous antigen-specific CD4 + CD25 + regulatory T cells from nonobese diabetic mice J Immunol. 175 3053 3059
26. Meagher C. J Immunol In Press: (2008).
27. Q Tang JA Bluestone 2008 The FoxP3 + regulatory T cell: a jack of all trades, master of regulation Nat Immunol. 9 129 134
28. W Chen W Jin N Hardegen 2003 Conversion of peripheral CD4+ CD25-naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 J Exp Med. 198 1875 1886
29. S You B Leforban C Garcia 2007 Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment Proc Natl Acad Sci U S A. 104 6335 6340
30. JA Bluestone AK Abbas 2003 Natural versus adaptive regulatory T cells Nat Rev Immunol. 3 253 257
31. CS Hsieh Y Liang AJ Tyznik 2004 Recognition of the peripheral self by naturally arising CD25 + CD4 + T cell receptors Immunity. 21 267 277
32. CW Lio CS Hsieh 2008 A two-step process for thymic regulatory T cell development Immunity. 28 100 111
33. A Izcue F Powrie 2008 Special regulatory T-cell review: regulatory T cells and the intestinal tract-patrolling the frontier Immunology. 123 6 10
34. Q Tang JY Adams AJ Tooley 2006 Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice Nat Immunol. 7 83 92
35. L Cederbom H Hall F Ivars 2000 CD4 + CD25 + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells Eur J Immunol. 30 1538 1543
36. N Misra J Bayry S Lacroix-Desmazes 2004 Cutting edge: human CD4 + CD25 + T cells restrain the maturation and antigen-presenting function of dendritic cells J Immunol. 172 4676 4680
37. AE Herman GJ Freeman D Mathis 2004 CD4+ CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion J Exp Med. 199 1479 1489
38. S You M Belghith S Cobbold 2005 Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells Diabetes. 54 1415 1422
39. Q Tang JA Bluestone 2006 Regulatory T-cell physiology and application to treat autoimmunity Immunol Rev. 212 217 237
40. KE Earle Q Tang X Zhou 2005 In vitro expanded human CD4 + CD25 + regulatory T cells suppress effector T cell proliferation Clin Immunol. 115 3 9
41. JM Kim A Rudensky 2006 The role of the transcription factor Foxp3 in the development of regulatory T cells Immunol Rev. 212 86 98
42. JA Hill M Feuerer K Tash 2007 Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature Immunity. 27 786 800
43. W Liu AL Putnam Z Xu-Yu 2006 CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 + T reg cells J Exp Med. 203 1701 1711
44. M Lopez MR Clarkson M Albin 2006 A novel mechanism of action for anti-thymocyte globulin: induction of CD4+ CD25+ Foxp3+ regulatory T cells J Am Soc Nephrol. 17 2844 2853
45. KC Herold W Hagopian JA Auger 2002 Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus N Engl J Med. 346 1692 1698
46. KC Herold SE Gitelman U Masharani 2005 A single course of anti-CD3 monoclonal antibody hOKT3gamma1 (Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes Diabetes. 54 1763 1769