메뉴 건너뛰기




Volumn 11, Issue 1, 2010, Pages 7-13

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN EXPRESSION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BACTERIAL INFECTION; CD4+ CD25+ T LYMPHOCYTE; GENE MUTATION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTOPOIESIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION; THYMUS; ANIMAL; BIOLOGICAL MODEL; DENDRITIC CELL; IMMUNOLOGY; T LYMPHOCYTE;

EID: 74049164847     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1818     Document Type: Review
Times cited : (922)

References (101)
  • 3
    • 0029936944 scopus 로고    scopus 로고
    • Clonal anergy of B cells: A flexible, reversible, and quantitative concept
    • Nossal, G.J. Clonal anergy of B cells: a flexible, reversible, and quantitative concept. J. Exp. Med. 183, 1953-1956 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 1953-1956
    • Nossal, G.J.1
  • 4
    • 36249024247 scopus 로고    scopus 로고
    • Regulatory T cells-a brief history and perspective
    • Sakaguchi, S., wing, K. & Miyara, M. Regulatory T cells-a brief history and perspective. Eur. J. Immunol. 37 (suppl. 1), S116-S123 (2007).
    • (2007) Eur. J. Immunol. , vol.37 , Issue.SUPPL. 1
    • Sakaguchi, S.1    Wing, K.2    Miyara, M.3
  • 5
    • 0014792798 scopus 로고
    • Cell Interactions in the induction of tolerance: The role of thymic lymphocytes
    • Gershon, R.K. & Kondo, K. Cell Interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology 18, 723-737 (1970).
    • (1970) Immunology , vol.18 , pp. 723-737
    • Gershon, R.K.1    Kondo, K.2
  • 6
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25) Breakdown of a single mechanism of self-tolerance causes various autoImmune diseaseS
    • Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoImmune diseases. J. Immunol. 155, 1151-1164 (1995).
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 7
    • 16844365788 scopus 로고    scopus 로고
    • + Regulatory T cells in immunological tolerance to self and non-self
    • + Regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6, 345-352 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 8
    • 65749103989 scopus 로고    scopus 로고
    • Regulatory lymphocytes and intestinal inflammation
    • Izcue, A., Coombes, J.L. & Powrie, F. Regulatory lymphocytes and intestinal inflammation. Annu. Rev. Immunol. 27, 313-338 (2009).
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 313-338
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 9
    • 0035180067 scopus 로고    scopus 로고
    • Control of intestinal inflammation by Regulatory T cells
    • Singh, B. et al. Control of intestinal inflammation by Regulatory T cells. Immunol. Rev. 182, 190-200 (2001).
    • (2001) Immunol. Rev. , vol.182 , pp. 190-200
    • Singh, B.1
  • 10
    • 0347785480 scopus 로고    scopus 로고
    • Control of Regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. & Sakaguchi, S. Control of Regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 13
    • 0038434099 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPeX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasiS
    • Gambineri, E., Torgerson, T. & Ochs, H. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPeX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr. opin. rheumatol. 15, 430-435 (2003).
    • (2003) Curr. Opin. Rheumatol. , vol.15 , pp. 430-435
    • Gambineri, E.1    Torgerson, T.2    Ochs, H.3
  • 14
    • 0036346861 scopus 로고    scopus 로고
    • Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPeX) syndrome
    • WILdin, R.S., Smyk-Pearson, S. & FILipovich, A.H. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPeX) syndrome. J. Med. Genet. 39, 537-545 (2002).
    • (2002) J. Med. Genet. , vol.39 , pp. 537-545
    • Wildin, R.S.1    Smyk-Pearson, S.2    Filipovich, A.H.3
  • 15
    • 0033136302 scopus 로고    scopus 로고
    • Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • Itoh, M. et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162, 5317-5326 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 5317-5326
    • Itoh, M.1
  • 16
    • 0034055693 scopus 로고    scopus 로고
    • Self-antigen presentation by thymic stromal cells: A subtle division of laboR
    • Klein, L. & Kyewski, B. Self-antigen presentation by thymic stromal cells: a subtle division of labor. Curr. opin. Immunol. 12, 179-186 (2000).
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 179-186
    • Klein, L.1    Kyewski, B.2
  • 17
    • 57249097253 scopus 로고    scopus 로고
    • Clinical and molecular profILe of a new series of patients with Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: Inconsistent correlation between forkhead box protein 3 expression and disease severity
    • Gambineri, E. et al. Clinical and molecular profILe of a new series of patients with Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity. J. allergy Clin. Immunol. 122, 1105-1112.e1 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.122 , pp. 1105-1112
    • Gambineri, E.1
  • 19
    • 0037348923 scopus 로고    scopus 로고
    • CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells
    • Wing, K. et al. CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells. Eur. J. Immunol. 33, 579-587 (2003).
    • (2003) Eur. J. Immunol. , vol.33 , pp. 579-587
    • Wing, K.1
  • 20
    • 0036086232 scopus 로고    scopus 로고
    • + Regulatory T cells
    • + Regulatory T cells. Eur. J. Immunol. 32, 1621-1630 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1621-1630
    • Taams, L.S.1
  • 21
    • 62449213245 scopus 로고    scopus 로고
    • NY-eSO-1 DNA vaccine induces T-cell responses that are suppressed by Regulatory T cells
    • Gnjatic, S. et al. NY-eSO-1 DNA vaccine induces T-cell responses that are suppressed by Regulatory T cells. Clin. cancer res. 15, 2130-2139 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2130-2139
    • Gnjatic, S.1
  • 22
    • 27844518834 scopus 로고    scopus 로고
    • Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects
    • Danke, N.A., Yang, J., Greenbaum, C. & Kwok, W.W. Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects. J. autoimmun. 25, 303-311 (2005).
    • (2005) J. Autoimmun. , vol.25 , pp. 303-311
    • Danke, N.A.1    Yang, J.2    Greenbaum, C.3    Kwok, W.W.4
  • 23
    • 43649105125 scopus 로고    scopus 로고
    • CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope
    • Yang, J. et al. CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope. J. autoimmun. 31, 30-41 (2008).
    • (2008) J. Autoimmun. , vol.31 , pp. 30-41
    • Yang, J.1
  • 24
    • 35549010987 scopus 로고    scopus 로고
    • The origin and application of experimental autoImmune encephalomy-elitiS
    • Baxter, A.G. The origin and application of experimental autoImmune encephalomy-elitis. Nat. Rev. Immunol. 7, 904-912 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 904-912
    • Baxter, A.G.1
  • 25
    • 0036236683 scopus 로고    scopus 로고
    • AutoImmune thyroid disease induced by thyroglobulin and lipopoly-saccharide is inhibited by soluble TNF receptor type i
    • Zaccone, P. et al. AutoImmune thyroid disease induced by thyroglobulin and lipopoly-saccharide is inhibited by soluble TNF receptor type I. Eur. J. Immunol. 32, 1021-1028 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1021-1028
    • Zaccone, P.1
  • 26
    • 10744228908 scopus 로고    scopus 로고
    • Dendritic cell-induced autoImmune heart faILure requires cooperation between adaptive and innate immunity
    • Eriksson, U. et al. Dendritic cell-induced autoImmune heart faILure requires cooperation between adaptive and innate immunity. Nat. Med. 9, 1484-1490 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 1484-1490
    • Eriksson, U.1
  • 27
    • 17944403804 scopus 로고    scopus 로고
    • Experimental autoImmune thyroiditis induced by thyroglobulin-pulsed dendritic cells
    • Watanabe, H. et al. experimental autoImmune thyroiditis induced by thyroglobulin-pulsed dendritic cells. autoimmunity 31, 273-282 (1999).
    • (1999) Autoimmunity , vol.31 , pp. 273-282
    • Watanabe, H.1
  • 28
    • 0042766347 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis 19-kILodalton lipoprotein inhibits gamma Interferon-regulated HLA-Dr and Fc gamma r1 on human macrophages through Toll-like receptor 2
    • Gehring, A.J. et al. The Mycobacterium tuberculosis 19-kILodalton lipoprotein inhibits gamma Interferon-regulated HLA-Dr and Fc gamma r1 on human macrophages through Toll-like receptor 2. Infect. Immun. 71, 4487-4497 (2003).
    • (2003) Infect. Immun. , vol.71 , pp. 4487-4497
    • Gehring, A.J.1
  • 29
    • 0015026039 scopus 로고
    • Murine thyroiditis: Importance of adjuvant and mouse strain for the induction of thyroid lesions
    • Rose, N.R., Twarog, F.J. & Crowle, A.J. Murine thyroiditis: importance of adjuvant and mouse strain for the induction of thyroid lesions. J. Immunol. 106, 698-704 (1971).
    • (1971) J. Immunol. , vol.106 , pp. 698-704
    • Rose, N.R.1    Twarog, F.J.2    Crowle, A.J.3
  • 30
    • 23844478869 scopus 로고    scopus 로고
    • Natural recovery and protection from autoImmune encephalomyelitis: Contribution of CD4+CD25+ Regulatory cells within the central nervous system
    • McGeachy, M.J., Stephens, L.A. & Anderton, S.M. Natural recovery and protection from autoImmune encephalomyelitis: contribution of CD4+CD25+ Regulatory cells within the central nervous system. J. Immunol. 175, 3025-3032 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 3025-3032
    • McGeachy, M.J.1    Stephens, L.A.2    Anderton, S.M.3
  • 31
    • 34147128572 scopus 로고    scopus 로고
    • Myelin-specific Regulatory T cells accumulate in the CNS but faIL to control autoImmune inflammation
    • Korn, T. et al. Myelin-specific Regulatory T cells accumulate in the CNS but faIL to control autoImmune inflammation. Nat. Med. 13, 423-431 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 423-431
    • Korn, T.1
  • 32
    • 0036838536 scopus 로고    scopus 로고
    • + Regulatory T cells suppress antigen-specific autoreactive Immune responses and central nervous system inflammation during active experimental autoImmune encephalo-myelitis
    • + Regulatory T cells suppress antigen-specific autoreactive Immune responses and central nervous system inflammation during active experimental autoImmune encephalo-myelitis. J. Immunol. 169, 4712-4716 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 4712-4716
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 33
    • 14044260593 scopus 로고    scopus 로고
    • H2A-and H2e-derived CD4+CD25+ Regulatory T cells: A potential role in reciprocal Inhibition by class II genes in autoImmune thyroiditis
    • Morris, G.P., Yan, Y., David, C.S. & Kong, Y.M. H2A-and H2e-derived CD4+CD25+ Regulatory T cells: a potential role in reciprocal Inhibition by class II genes in autoImmune thyroiditis. J. Immunol. 174, 3111-3116 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 3111-3116
    • Morris, G.P.1    Yan, Y.2    David, C.S.3    Kong, Y.M.4
  • 34
    • 7444250675 scopus 로고    scopus 로고
    • Myelin proteolipid protein-specific CD4+CD25+ Regulatory cells mediate genetic resistance to experimental autoImmune encephalomyelitiS
    • Reddy, J. et al. Myelin proteolipid protein-specific CD4+CD25+ Regulatory cells mediate genetic resistance to experimental autoImmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 101, 15434-15439 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15434-15439
    • Reddy, J.1
  • 35
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoImmune disease by breaking their anergic/suppressive state
    • Takahashi, T. et al. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoImmune disease by breaking their anergic/suppressive state. Int. Immunol. 10, 1969-1980 (1998).
    • (1998) Int. Immunol. , vol.10 , pp. 1969-1980
    • Takahashi, T.1
  • 36
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim, J.M., Rasmussen, J.P. & Rudensky, A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8, 191-197 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 37
    • 33846423147 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ Regulatory T cells induces a scurfy-like disease
    • Lahl, K. et al. Selective depletion of Foxp3+ Regulatory T cells induces a scurfy-like disease. J. Exp. Med. 204, 57-63 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 57-63
    • Lahl, K.1
  • 38
    • 25844504653 scopus 로고    scopus 로고
    • Developmental regulation of Foxp3 expression during ontogeny
    • Fontenot, J.D., Dooley, J.L., Farr, A.G. & Rudensky, A.Y. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202, 901-906 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 901-906
    • Fontenot, J.D.1    Dooley, J.L.2    Farr, A.G.3    Rudensky, A.Y.4
  • 39
    • 33847153417 scopus 로고    scopus 로고
    • Foxp3-dependent programme of Regulatory T-cell differentiation
    • Gavin, M.A. et al. Foxp3-dependent programme of Regulatory T-cell differentiation. Nature 445, 771-775 (2007).
    • (2007) Nature , vol.445 , pp. 771-775
    • Gavin, M.A.1
  • 40
    • 33947600584 scopus 로고    scopus 로고
    • Regulatory T cell development in the absence of functional Foxp3
    • Lin, W. et al. Regulatory T cell development in the absence of functional Foxp3. Nat. Immunol. 8, 359-368 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 359-368
    • Lin, W.1
  • 41
    • 0035320679 scopus 로고    scopus 로고
    • + Regulatory T cells induced by an agonist self-peptide
    • + Regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301-306 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 301-306
    • Jordan, M.1
  • 42
    • 0036568942 scopus 로고    scopus 로고
    • Generation of CD4+CD25+ Regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonau-toreactive T cells by endogenous TCr expression
    • Kawahata, K. et al. Generation of CD4+CD25+ Regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonau-toreactive T cells by endogenous TCr expression. J. Immunol. 168, 4399-4405 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 4399-4405
    • Kawahata, K.1
  • 43
    • 9244244736 scopus 로고    scopus 로고
    • Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • Van Santen, H.-M., Benoist, C. & Mathis, D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200, 1221-1230 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 1221-1230
    • Van Santen, H.-M.1    Benoist, C.2    Mathis, D.3
  • 44
    • 33845879342 scopus 로고    scopus 로고
    • Early events in the thymus affect the balance of Effector and Regulatory T cells
    • Pennington, D.J. et al. Early events in the thymus affect the balance of Effector and Regulatory T cells. Nature 444, 1073-1077 (2006).
    • (2006) Nature , vol.444 , pp. 1073-1077
    • Pennington, D.J.1
  • 45
    • 4143066714 scopus 로고    scopus 로고
    • + T cell receptors
    • + T cell receptors. Immunity 21, 267-277 (2004).
    • (2004) Immunity , vol.21 , pp. 267-277
    • Hsieh, C.-S.1
  • 46
    • 33747099523 scopus 로고    scopus 로고
    • Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells
    • Pacholczyk, R., Ignatowicz, H., Kraj, P. & Ignatowicz, L. Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. Immunity 25, 249-259 (2006).
    • (2006) Immunity , vol.25 , pp. 249-259
    • Pacholczyk, R.1    Ignatowicz, H.2    Kraj, P.3    Ignatowicz, L.4
  • 47
    • 34548680545 scopus 로고    scopus 로고
    • Nonself-antigens are the cognate specificities of Foxp3+ Regulatory T cells
    • Pacholczyk, R. et al. Nonself-antigens are the cognate specificities of Foxp3+ Regulatory T cells. Immunity 27, 493-504 (2007).
    • (2007) Immunity , vol.27 , pp. 493-504
    • Pacholczyk, R.1
  • 48
    • 34249814016 scopus 로고    scopus 로고
    • Adaptation of TCr repertoires to self-peptides in Regulatory and nonRegulatory CD4+ T cells
    • Wong, J. et al. Adaptation of TCr repertoires to self-peptides in Regulatory and nonRegulatory CD4+ T cells. J. Immunol. 178, 7032-7041 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 7032-7041
    • Wong, J.1
  • 49
    • 65749120321 scopus 로고    scopus 로고
    • Intraclonal competition limits the fate determination of Regulatory T cells in the thymus
    • Bautista, J.L. et al. Intraclonal competition limits the fate determination of Regulatory T cells in the thymus. Nat. Immunol. 10, 610-617 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 610-617
    • Bautista, J.L.1
  • 50
    • 60549084941 scopus 로고    scopus 로고
    • CD4+ T-cell development in a mouse expressing a transgenic TCr derived from a Treg
    • DiPaolo, R.J. & Shevach, E.M. CD4+ T-cell development in a mouse expressing a transgenic TCr derived from a Treg. Eur. J. Immunol. 39, 234-240 (2009).
    • (2009) Eur J. Immunol. , vol.39 , pp. 234-240
    • Dipaolo, R.J.1    Shevach, E.M.2
  • 51
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and Immune tolerance
    • Sakaguchi, S., Yamaguchi, T., Nomura, T. & Ono, M. Regulatory T cells and Immune tolerance. Cell 133, 775-787 (2008).
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 52
    • 16444377660 scopus 로고    scopus 로고
    • Dependence of self-tolerance on TrAF6-directed development of thymic stroma
    • Akiyama, T. et al. Dependence of self-tolerance on TrAF6-directed development of thymic stroma. Science 308, 248-251 (2005).
    • (2005) Science , vol.308 , pp. 248-251
    • Akiyama, T.1
  • 53
    • 10744226628 scopus 로고    scopus 로고
    • NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner
    • Kajiura, F. et al. NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J. Immunol. 172, 2067-2075 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 2067-2075
    • Kajiura, F.1
  • 55
    • 24144480562 scopus 로고    scopus 로고
    • + Regulatory T cells in human thymus
    • + Regulatory T cells in human thymus. Nature 436, 1181-1185 (2005).
    • (2005) Nature , vol.436 , pp. 1181-1185
    • Watanabe, N.1
  • 56
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395-1401 (2002).
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1
  • 57
    • 13544262691 scopus 로고    scopus 로고
    • Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice
    • Kuroda, N. et al. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J. Immunol. 174, 1862-1870 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 1862-1870
    • Kuroda, N.1
  • 58
    • 34248598295 scopus 로고    scopus 로고
    • + medullary thymic epithelial cells
    • + medullary thymic epithelial cells. Nat. Immunol. 8, 351-358 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 351-358
    • Aschenbrenner, K.1
  • 59
    • 33846203837 scopus 로고    scopus 로고
    • A defect of Regulatory T cells in patients with autoImmune polyendocrinopathy-candidiasis-ectodermal dystrophy
    • Kekäläinen, E. et al. A defect of Regulatory T cells in patients with autoImmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J. Immunol. 178, 1208-1215 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 1208-1215
    • Kekäläinen, E.1
  • 60
    • 33745288812 scopus 로고    scopus 로고
    • Emerging possibILities in the development and function of Regulatory T cells
    • Wing, K., Fehervari, Z. & Sakaguchi, S. Emerging possibILities in the development and function of Regulatory T cells. Int. Immunol. 18, 991-1000 (2006).
    • (2006) Int. Immunol. , vol.18 , pp. 991-1000
    • Wing, K.1    Fehervari, Z.2    Sakaguchi, S.3
  • 61
    • 60549115770 scopus 로고    scopus 로고
    • Heterogeneity of natural Foxp3+ T cells: A committed Regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    • Komatsu, N. et al. Heterogeneity of natural Foxp3+ T cells: a committed Regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc. Natl. Acad. Sci. USA 106, 1903-1908 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 1903-1908
    • Komatsu, N.1
  • 62
    • 65449125930 scopus 로고    scopus 로고
    • Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditionS
    • Duarte, J.H., Zelenay, S., Bergman, M., Martins, A.C. & Demengeot, J. Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur. J. Immunol. 39, 948-955 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 948-955
    • Duarte, J.H.1    Zelenay, S.2    Bergman, M.3    Martins, A.C.4    Demengeot, J.5
  • 63
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan, Y.Y. & Flavell, R.A. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445, 766-770 (2007).
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 64
    • 69049107358 scopus 로고    scopus 로고
    • InstabILity of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou, X. et al. InstabILity of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 10, 1000-1007 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 1000-1007
    • Zhou, X.1
  • 65
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T Regulatory cell-mediated suppression
    • Shevach, E.M. Mechanisms of foxp3+ T Regulatory cell-mediated suppression. Immunity 30, 636-645 (2009).
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 67
    • 39449126502 scopus 로고    scopus 로고
    • + Regulatory T cell: A jack of all trades, master of regulation
    • + Regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 9, 239-244 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 239-244
    • Tang, Q.1    Bluestone, J.2
  • 68
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoRegulatory T cells that control autoImmune diabetes
    • Salomon, B. et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoRegulatory T cells that control autoImmune diabetes. Immunity 12, 431-440 (2000).
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 69
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ Regulatory cells that control intestinal inflammation
    • Read, S., Malmstrom, V. & Powrie, F. Cytotoxic T lymphocyte- associated antigen 4 plays an essential role in the function of CD25+CD4+ Regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295-302 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 70
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ Regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi, T. et al. Immunologic self-tolerance maintained by CD25+CD4+ Regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303-310 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 303-310
    • Takahashi, T.1
  • 71
    • 66949171924 scopus 로고    scopus 로고
    • + T cells expressing the FoxP3 transcription factor
    • doi:10.1016/j.immunI.2009.03.019
    • + T cells expressing the FoxP3 transcription factor. Immunity 30, 899-911, doi:10.1016/j.immunI.2009.03.019 (2009).
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1
  • 72
    • 2642655282 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoImmune diabetes
    • Lühder, F., Höglund, P., Allison, J.P., Benoist, C. & Mathis, D. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoImmune diabetes. J. Exp. Med. 187, 427-432 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 427-432
    • Lühder, F.1    Höglund, P.2    Allison, J.P.3    Benoist, C.4    Mathis, D.5
  • 73
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • Marson, A. et al. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 445, 931-935 (2007).
    • (2007) Nature , vol.445 , pp. 931-935
    • Marson, A.1
  • 74
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature Regulatory T cells
    • Zheng, Y. et al. Genome-wide analysis of Foxp3 target genes in developing and mature Regulatory T cells. Nature 445, 936-940 (2007).
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1
  • 75
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls Regulatory T cell function through cooperation with NFAT
    • Wu, Y. et al. FOXP3 controls Regulatory T cell function through cooperation with NFAT. Cell 126, 375-387 (2006).
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1
  • 76
    • 34247215187 scopus 로고    scopus 로고
    • Foxp3 controls Regulatory T-cell function by interacting with AML1/ runx1
    • Ono, M. et al. Foxp3 controls Regulatory T-cell function by interacting with AML1/ runx1. Nature 446, 685-689 (2007).
    • (2007) Nature , vol.446 , pp. 685-689
    • Ono, M.1
  • 77
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ Regulatory T cell function
    • Wing, K. et al. CTLA-4 control over Foxp3+ Regulatory T cell function. Science 322, 271-275 (2008).
    • (2008) Science , vol.322 , pp. 271-275
    • Wing, K.1
  • 78
    • 48249103057 scopus 로고    scopus 로고
    • Foxp3+ natural Regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
    • Onishi, Y., Fehervari, Z., Yamaguchi, T. & Sakaguchi, S. Foxp3+ natural Regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl. Acad. Sci. USA 105, 10113-10118 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 10113-10118
    • Onishi, Y.1    Fehervari, Z.2    Yamaguchi, T.3    Sakaguchi, S.4
  • 79
    • 0036852170 scopus 로고    scopus 로고
    • CTLA-4-Ig regulates tryptophan catabolism in vivo
    • Grohmann, U. et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat. Immunol. 3, 1097-1101 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 1097-1101
    • Grohmann, U.1
  • 80
    • 65249155463 scopus 로고    scopus 로고
    • Transcription factor Foxo3 controls the magnitude of T cell Immune responses by modulating the function of dendritic cells
    • Dejean, A.S. et al. Transcription factor Foxo3 controls the magnitude of T cell Immune responses by modulating the function of dendritic cells. Nat. Immunol. 10, 504-513 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 504-513
    • Dejean, A.S.1
  • 81
    • 29244482759 scopus 로고    scopus 로고
    • Visualizing Regulatory T cell control of autoImmune responses in nonobese diabetic mice
    • Tang, Q. et al. Visualizing Regulatory T cell control of autoImmune responses in nonobese diabetic mice. Nat. Immunol. 7, 83-92 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 83-92
    • Tang, Q.1
  • 82
    • 33645067654 scopus 로고    scopus 로고
    • + T cells and dendritic cells in vivo
    • + T cells and dendritic cells in vivo. J. Exp. Med. 203, 505-511 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 505-511
    • Tadokoro, C.E.1
  • 83
    • 34548131112 scopus 로고    scopus 로고
    • - precursor cells in the absence of interleukin 10
    • - precursor cells in the absence of interleukin 10. Nat. Immunol. 8, 931-941 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 931-941
    • Maynard, C.L.1
  • 84
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Rubtsov, Y.P. et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28, 546-558 (2008).
    • (2008) Immunity , vol.28 , pp. 546-558
    • Rubtsov, Y.P.1
  • 85
    • 35449006679 scopus 로고    scopus 로고
    • Granzyme B and perforin are important for Regulatory T cell-mediated suppression of tumor clearance
    • Cao, X. et al. Granzyme B and perforin are important for Regulatory T cell-mediated suppression of tumor clearance. Immunity 27, 635-646 (2007).
    • (2007) Immunity , vol.27 , pp. 635-646
    • Cao, X.1
  • 86
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls Regulatory T cell homeostasis and function during type 1 inflammation
    • Koch, M.A. et al. The transcription factor T-bet controls Regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595-602 (2009).
    • (2009) Nat.Immunol. , vol.10 , pp. 595-602
    • Koch, M.A.1
  • 87
    • 62649165369 scopus 로고    scopus 로고
    • H2 responseS
    • H2 responses. Nature 458, 351-356 (2009).
    • (2009) Nature , vol.458 , pp. 351-356
    • Zheng, Y.1
  • 88
    • 43449135305 scopus 로고    scopus 로고
    • H17 cell differentiation by antagonizing rOrγt function
    • H17 cell differentiation by antagonizing rOrγt function. Nature 453, 236-240 (2008).
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1
  • 89
    • 34548491824 scopus 로고    scopus 로고
    • Tolerance and autoimmunity: Lessons at the bedside of primary immunodeficiencies
    • DOI 10.1016/S0065-2776(07)95002-6, PII S0065277607950026
    • Carneiro-Sampaio, M. & Coutinho, A. Tolerance and autoimmunity: lessons at the bedside of primary immunodeficiencies. Adv. Immunol. 95, 51-82 (2007). (Pubitemid 47380503)
    • (2007) Advances in Immunology , vol.95 , pp. 51-82
    • Carneiro-Sampaio, M.1    Coutinho, A.2
  • 90
    • 47249124078 scopus 로고    scopus 로고
    • Human Regulatory T cells: Role in autoImmune disease and therapeutic opportunities
    • Brusko, T.M., Putnam, A.L. & Bluestone, J.A. Human Regulatory T cells: role in autoImmune disease and therapeutic opportunities. Immunol. Rev. 223, 371-390 (2008).
    • (2008) Immunol. Rev. , vol.223 , pp. 371-390
    • Brusko, T.M.1    Putnam, A.L.2    Bluestone, J.A.3
  • 91
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlS
    • The wellcome Trust Case Control Consortium
    • The wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
    • (2007) Nature , vol.447 , pp. 661-678
  • 92
    • 57749208427 scopus 로고    scopus 로고
    • Gene-gene Interactions in the NOD mouse model of type 1 diabeteS
    • Ridgway, W.M. et al. Gene-gene Interactions in the NOD mouse model of type 1 diabetes. Adv. Immunol. 100, 151-175 (2008).
    • (2008) Adv. Immunol. , vol.100 , pp. 151-175
    • Ridgway, W.M.1
  • 93
    • 15444374646 scopus 로고    scopus 로고
    • Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ Regulatory T cells by interleukin IL-2 and induction of autoImmune disease by IL-2 neutralization
    • Setoguchi, R., Hori, S., Takahashi, T. & Sakaguchi, S. Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ Regulatory T cells by interleukin IL-2 and induction of autoImmune disease by IL-2 neutralization. J. Exp. Med. 201, 723-735 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 94
    • 63449124912 scopus 로고    scopus 로고
    • Differential control of allo-antigen-specific Regulatory T cells and Effector T cells by anti-CD4 and other agents in establishing transplantation tolerance
    • Nagahama, K. et al. Differential control of allo-antigen-specific Regulatory T cells and Effector T cells by anti-CD4 and other agents in establishing transplantation tolerance. Int. Immunol. 21, 379-391 (2009).
    • (2009) Int. Immunol. , vol.21 , pp. 379-391
    • Nagahama, K.1
  • 95
    • 44449100271 scopus 로고    scopus 로고
    • Cutting edge: Foxp3-mediated induction of Pim 2 allows human T Regulatory cells to preferentially expand in rapamycin
    • Basu, S., Golovina, T., Mikheeva, T., June, C.H. & RIley, J.L. Cutting edge: Foxp3-mediated induction of Pim 2 allows human T Regulatory cells to preferentially expand in rapamycin. J. Immunol. 180, 5794-5798 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 5794-5798
    • Basu, S.1    Golovina, T.2    Mikheeva, T.3    June, C.H.4    Riley, J.L.5
  • 96
    • 33845915103 scopus 로고    scopus 로고
    • Selective survival of naturally ocCurring human CD4+CD25+Foxp3+ Regulatory T cells cultured with rapamycin
    • Strauss, L. et al. Selective survival of naturally ocCurring human CD4+CD25+Foxp3+ Regulatory T cells cultured with rapamycin. J. Immunol. 178, 320-329 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 320-329
    • Strauss, L.1
  • 97
    • 67649185215 scopus 로고    scopus 로고
    • The receptor S1P1 overrides Regulatory T cell-mediated Immune suppression through Akt-mTOR
    • Liu, G. et al. The receptor S1P1 overrides Regulatory T cell-mediated Immune suppression through Akt-mTOR. Nat. Immunol. 10, 769-777 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 769-777
    • Liu, G.1
  • 98
    • 29144514700 scopus 로고    scopus 로고
    • The sphingosine 1-phosphate receptor agonist FTY720 differen-tially affects the sequestration of CD4+/CD25+ T-Regulatory cells and enhances their functional activity
    • Sawicka, E. et al. The sphingosine 1-phosphate receptor agonist FTY720 differen-tially affects the sequestration of CD4+/CD25+ T-Regulatory cells and enhances their functional activity. J. Immunol. 175, 7973-7980 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 7973-7980
    • Sawicka, E.1
  • 99
    • 62849120700 scopus 로고    scopus 로고
    • Using histone deacetylase inhibitors to enhance Foxp3+ Regulatory T-cell function and induce allograft tolerance
    • Wang, L., Tao, R. & Hancock, W.W. Using histone deacetylase inhibitors to enhance Foxp3+ Regulatory T-cell function and induce allograft tolerance. Immunol. Cell Biol. 87, 195-202 (2009).
    • (2009) Immunol. Cell Biol. , vol.87 , pp. 195-202
    • Wang, L.1    Tao, R.2    Hancock, W.W.3
  • 100
    • 65549091509 scopus 로고    scopus 로고
    • In vivo expansion of T reg cells with IL-2-mAb complexes: Induction of resistance to eAe and long-term acceptance of islet allografts without immunosuppression
    • Webster, K.E. et al. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to eAe and long-term acceptance of islet allografts without immunosuppression. J. Exp. Med. 206, 751-760 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 751-760
    • Webster, K.E.1
  • 101
    • 33847301982 scopus 로고    scopus 로고
    • Dendritic cells with TGF-β1 differentiate naive CD4+CD25-T cells into islet-protective Foxp3+ Regulatory T cells
    • Luo, X. et al. Dendritic cells with TGF-β1 differentiate naive CD4+CD25-T cells into islet-protective Foxp3+ Regulatory T cells. Proc. Natl. Acad. Sci. USA 104, 2821-2826 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 2821-2826
    • Luo, X.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.