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Volumn 182, Issue 8, 2009, Pages 4624-4632

Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 6; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; GAMMA INTERFERON;

EID: 65249120937     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0801543     Document Type: Article
Times cited : (303)

References (43)
  • 1
    • 0035204814 scopus 로고    scopus 로고
    • Vitamin D: Its role and uses in immunology
    • Deluca, H. F., and M. T. Cantorna. 2001. Vitamin D: its role and uses in immunology. FASEB J. 15: 2579-2585.
    • (2001) FASEB J. , vol.15 , pp. 2579-2585
    • Deluca, H.F.1    Cantorna, M.T.2
  • 2
    • 48749085956 scopus 로고    scopus 로고
    • Control of autoimmune diseases by the vitamin D endocrine system
    • Adorini, L., and G. Penna. 2008. Control of autoimmune diseases by the vitamin D endocrine system. Nat. Clin. Pract. Rheumatol. 4: 404-412.
    • (2008) Nat. Clin. Pract. Rheumatol. , vol.4 , pp. 404-412
    • Adorini, L.1    Penna, G.2
  • 3
    • 0030027490 scopus 로고    scopus 로고
    • Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo
    • Lemon, B. D., and L. P. Freedman. 1996. Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo. Mol. Cell. Biol. 16: 1006-1016.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1006-1016
    • Lemon, B.D.1    Freedman, L.P.2
  • 4
    • 0034603725 scopus 로고    scopus 로고
    • 3 receptor: A network of coactivator interactions
    • 3 receptor: a network of coactivator interactions. Gene 246: 9-21.
    • (2000) Gene , vol.246 , pp. 9-21
    • Rachez, C.1    Freedman, L.P.2
  • 6
    • 0034784578 scopus 로고    scopus 로고
    • Lineage commitment in lymphocytes: Controlling the immune response
    • Glimcher, L. H. 2001. Lineage commitment in lymphocytes: controlling the immune response. J. Clin. Invest. 108: s25-s30.
    • (2001) J. Clin. Invest. , vol.108
    • Glimcher, L.H.1
  • 7
    • 39449101603 scopus 로고    scopus 로고
    • Transcriptional regulation of Th17 cell differentiation
    • DOI 10.1016/j.smim.2007.10.011, PII S1044532307000887
    • Ivanov, I. I., L. Zhou, and D. R. Littman. 2007. Transcriptional regulation of Th17 cell differentiation. Semin. Immunol. 19: 409-417. (Pubitemid 351274050)
    • (2007) Seminars in Immunology , vol.19 , Issue.6 , pp. 409-417
    • Ivanov, I.I.1    Zhou, L.2    Littman, D.R.3
  • 8
    • 33845384182 scopus 로고    scopus 로고
    • Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol
    • Penna, G., S. Amuchastegui, C. Cossetti, F. Aquilano, R. Mariani, F. Sanvito, C. Doglioni, and L. Adorini. 2006. Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol. J. Immunol. 177: 8504-8511. (Pubitemid 44895295)
    • (2006) Journal of Immunology , vol.177 , Issue.12 , pp. 8504-8511
    • Penna, G.1    Amuchastegui, S.2    Cossetti, C.3    Aquilano, F.4    Mariani, R.5    Sanvito, F.6    Doglioni, C.7    Adorini, L.8
  • 11
    • 0043270561 scopus 로고    scopus 로고
    • The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells
    • Mahon, B. D., A. Wittke, V. Weaver, and M. T. Cantorna. 2003. The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J. Cell. Biochem. 89: 922-932.
    • (2003) J. Cell. Biochem. , vol.89 , pp. 922-932
    • Mahon, B.D.1    Wittke, A.2    Weaver, V.3    Cantorna, M.T.4
  • 14
    • 4344655342 scopus 로고    scopus 로고
    • Vitamin D receptor-deficient mice fail to develop experimental allergic asthma
    • Wittke, A., V. Weaver, B. D. Mahon, A. August, and M. T. Cantorna. 2004. Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. J. Immunol. 173: 3432-3436. (Pubitemid 39142054)
    • (2004) Journal of Immunology , vol.173 , Issue.5 , pp. 3432-3436
    • Wittke, A.1    Weaver, V.2    Mahon, B.D.3    August, A.4    Cantorna, M.T.5
  • 15
    • 0029821239 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
    • Cantorna, M. T., C. E. Hayes, and H. F. DeLuca. 1996. 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc. Natl. Acad. Sci. USA 93: 7861-7864.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7861-7864
    • Cantorna, M.T.1    Hayes, C.E.2    DeLuca, H.F.3
  • 16
    • 37349104972 scopus 로고    scopus 로고
    • Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile
    • DOI 10.1124/jpet.107.127209
    • Daniel, C., N. A. Sartory, N. Zahn, H. H. Radeke, and J. M. Stein. 2008. Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J. Pharmacol. Exp. Ther. 324: 23-33. (Pubitemid 350294165)
    • (2008) Journal of Pharmacology and Experimental Therapeutics , vol.324 , Issue.1 , pp. 23-33
    • Daniel, C.1    Sartory, N.A.2    Zahn, N.3    Radeke, H.H.4    Stein, J.M.5
  • 17
    • 33749627353 scopus 로고    scopus 로고
    • 3: Therapeutic implications in hemodialysis and renal transplantation
    • Mathieu, C., and M. Jafari. 2006. Immunomodulation by 1,25-dihydroxyvitamin D3: therapeutic implications in hemodialysis and renal transplantation. Clin. Nephrol. 66: 275-283. (Pubitemid 44541215)
    • (2006) Clinical Nephrology , vol.66 , Issue.4 , pp. 275-283
    • Mathieu, C.1    Jafari, M.2
  • 18
    • 22144433724 scopus 로고    scopus 로고
    • A two-compound product containing calcipotriol and β methasone dipropionate provides rapid, effective treatment of psoriasis vulgaris regardless of baseline disease severity
    • Van de Kerkhof, P. C., N. Wasel, K. Kragballe, F. Cambazard, and S. Murray. 2005. A two-compound product containing calcipotriol and β methasone dipropionate provides rapid, effective treatment of psoriasis vulgaris regardless of baseline disease severity. Dermatology 210: 294-299.
    • (2005) Dermatology , vol.210 , pp. 294-299
    • Van De Kerkhof, P.C.1    Wasel, N.2    Kragballe, K.3    Cambazard, F.4    Murray, S.5
  • 19
    • 16644374531 scopus 로고    scopus 로고
    • Rodent models of experimental autoimmune uveitis
    • Agarwal, R. K., and R. R. Caspi. 2004. Rodent models of experimental autoimmune uveitis. Methods Mol. Med. 102: 395-419.
    • (2004) Methods Mol. Med. , vol.102 , pp. 395-419
    • Agarwal, R.K.1    Caspi, R.R.2
  • 20
    • 0023912944 scopus 로고
    • A new model of autoimmune disease: Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens
    • Caspi, R. R., F. G. Roberge, C. C. Chan, B. Wiggert, G. J. Chader, L. A. Rozenszajn, Z. Lando, and R. B. Nussenblatt. 1988. A new model of autoimmune disease: experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol. 140: 1490-1495.
    • (1988) J. Immunol. , vol.140 , pp. 1490-1495
    • Caspi, R.R.1    Roberge, F.G.2    Chan, C.C.3    Wiggert, B.4    Chader, G.J.5    Rozenszajn, L.A.6    Lando, Z.7    Nussenblatt, R.B.8
  • 21
    • 0025105886 scopus 로고
    • The mouse as a model of experimental autoimmune uveoretinitis (EAU)
    • Caspi, R. R., C. C. Chan, B. Wiggert, and G. J. Chader. 1990. The mouse as a model of experimental autoimmune uveoretinitis (EAU). Curr. Eye Res. 9(Suppl.): 169-174. (Pubitemid 20295619)
    • (1990) Current Eye Research , vol.9 , Issue.SUPPL. , pp. 169-174
    • Caspi, R.R.1    Chan, C.-C.2    Wiggert, B.3    Chader, G.J.4
  • 24
    • 34247586615 scopus 로고    scopus 로고
    • Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: Initial encounter with autoantigen defines disease phenotype
    • Tang, J., W. Zhu, P. B. Silver, S. B. Su, C. C. Chan, and R. R. Caspi. 2007. Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype. J. Immunol. 178: 5578-5587. (Pubitemid 46674353)
    • (2007) Journal of Immunology , vol.178 , Issue.9 , pp. 5578-5587
    • Tang, J.1    Zhu, W.2    Silver, P.B.3    Su, S.-B.4    Chan, C.-C.5    Caspi, R.R.6
  • 25
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • DOI 10.1038/ni1263, PII N1263
    • Fontenot, J. D., J. P. Rasmussen, M. A. Gavin, and A. Y. Rudensky. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6: 1142-1151. (Pubitemid 41541792)
    • (2005) Nature Immunology , vol.6 , Issue.11 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 27
    • 0034948029 scopus 로고    scopus 로고
    • Array-based ELISAs for high-throughput analysis of human cytokines
    • 192-194
    • Moody, M. D., S. W. Van Arsdell, K. P. Murphy, S. F. Orencole, and C. Burns. 2001. Array-based ELISAs for high-throughput analysis of human cytokines. BioTechniques 31: 186-190, 192-194.
    • (2001) BioTechniques , vol.31 , pp. 186-190
    • Moody, M.D.1    Van Arsdell, S.W.2    Murphy, K.P.3    Orencole, S.F.4    Burns, C.5
  • 29
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • DOI 10.1084/jem.20060285
    • Sutton, C., C. Brereton, B. Keogh, K. H. Mills, and E. C. Lavelle. 2006. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203: 1685-1691. (Pubitemid 44036274)
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.7 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.G.4    Lavelle, E.C.5
  • 30
    • 39449110445 scopus 로고    scopus 로고
    • The link between IL-23 and Th17 cell-mediated immune pathologies
    • McGeachy, M. J., and D. J. Cua. 2007. The link between IL-23 and Th17 cell-mediated immune pathologies. Semin. Immunol. 19: 372-376.
    • (2007) Semin. Immunol. , vol.19 , pp. 372-376
    • McGeachy, M.J.1    Cua, D.J.2
  • 33
    • 34250005444 scopus 로고    scopus 로고
    • H17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    • DOI 10.1038/nm1585, PII NM1585
    • Amadi-Obi, A., C. R. Yu, X. Liu, R. M. Mahdi, G. L. Clarke, R. B. Nussenblatt, I. Gery, Y. S. Lee, and C. E. Egwuagu. 2007. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat. Med. 13: 711-718. (Pubitemid 46889754)
    • (2007) Nature Medicine , vol.13 , Issue.6 , pp. 711-718
    • Amadi-Obi, A.1    Yu, C.-R.2    Liu, X.3    Mahdi, R.M.4    Clarke, G.L.5    Nussenblatt, R.B.6    Gery, I.7    Lee, Y.S.8    Egwuagu, C.E.9
  • 35
    • 0034161714 scopus 로고    scopus 로고
    • 3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation
    • Penna, G., and L. Adorini. 2000. 1α,25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J. Immunol. 164: 2405-2411. (Pubitemid 30115468)
    • (2000) Journal of Immunology , vol.164 , Issue.5 , pp. 2405-2411
    • Penna, G.1    Adorini, L.2
  • 36
    • 0141567438 scopus 로고    scopus 로고
    • The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches
    • DOI 10.1034/j.1600-065X.2003.00074.x
    • Eberl, G., and D. R. Littman. 2003. The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches. Immunol. Rev. 195: 81-90. (Pubitemid 37153455)
    • (2003) Immunological Reviews , vol.195 , pp. 81-90
    • Eberl, G.1    Littman, D.R.2
  • 37
    • 0032217092 scopus 로고    scopus 로고
    • RORγt, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells
    • He, Y. W., M. L. Deftos, E. W. Ojala, and M. J. Bevan. 1998. RORγt, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity 9: 797-806.
    • (1998) Immunity , vol.9 , pp. 797-806
    • He, Y.W.1    Deftos, M.L.2    Ojala, E.W.3    Bevan, M.J.4
  • 38
    • 39549091298 scopus 로고    scopus 로고
    • Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation
    • Chen, Z., A. Laurence, and J. J. O'Shea. 2007. Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin. Immunol. 19: 400-408.
    • (2007) Semin. Immunol. , vol.19 , pp. 400-408
    • Chen, Z.1    Laurence, A.2    O'Shea, J.J.3
  • 40
    • 34247156267 scopus 로고    scopus 로고
    • Vitamin D receptor-mediated suppression of RelB in antigen presenting cells: A paradigm for ligand-augmented negative transcriptional regulation
    • Griffin, M. D., X. Dong, and R. Kumar. 2007. Vitamin D receptor-mediated suppression of RelB in antigen presenting cells: a paradigm for ligand-augmented negative transcriptional regulation. Arch. Biochem. Biophys. 460: 218-226.
    • (2007) Arch. Biochem. Biophys. , vol.460 , pp. 218-226
    • Griffin, M.D.1    Dong, X.2    Kumar, R.3
  • 41
    • 0037302966 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases
    • DOI 10.1002/jcb.10340
    • Adorini, L., G. Penna, N. Giarratana, and M. Uskokovic. 2003. Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases. J. Cell. Biochem. 88: 227-233. (Pubitemid 36119891)
    • (2003) Journal of Cellular Biochemistry , vol.88 , Issue.2 , pp. 227-233
    • Adorini, L.1    Penna, G.2    Giarratana, N.3    Uskokovic, M.4
  • 42
    • 33845949937 scopus 로고    scopus 로고
    • 3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells
    • Penna, G., S. Amuchastegui, N. Giarratana, K. C. Daniel, M. Vulcano, S. Sozzani, and L. Adorini. 2007. 1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J. Immunol. 178: 145-153. (Pubitemid 46033595)
    • (2007) Journal of Immunology , vol.178 , Issue.1 , pp. 145-153
    • Penna, G.1    Amuchastegui, S.2    Giarratana, N.3    Daniel, K.C.4    Vulcano, M.5    Sozzani, S.6    Adorini, L.7
  • 43
    • 22144431544 scopus 로고    scopus 로고
    • Inhibition of acute and chronic allograft rejection in mouse models by BXL-628, a nonhypercalcemic vitamin D receptor agonist
    • DOI 10.1097/01.TP.0000164619.49828.7A
    • Amuchastegui, S., K. C. Daniel, and L. Adorini. 2005. Inhibition of acute and chronic allograft rejection in mouse models by BXL-628, a nonhypercalcemic vitamin D receptor agonist. Transplantation 80: 81-87. (Pubitemid 40980899)
    • (2005) Transplantation , vol.80 , Issue.1 , pp. 81-87
    • Amuchastegui, S.1    Daniel, K.C.2    Adorini, L.3


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