Immune regulation of 25-hydroxyvitamin-D3-1α-hydroxylase in human monocytes

Journal of Bone and Mineral Research

Volumn 21, Issue 1, 2006, Pages 37-47

  Stoffels, Katinka ^a   Overbergh, Lut ^a   Giulietti, Annapaula ^a   Verlinden, Lieve ^a   Bouillon, Roger ^a   Mathieu, Chantal ^a,b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b LEGENDO   (Belgium)

Author keywords

Cytokines; Molecular pathways; Monocytes; Transcription factors; Vitamin D

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIDIOL 1 MONOOXYGENASE; CCAAT ENHANCER BINDING PROTEIN BETA; CD14 ANTIGEN; CELL NUCLEUS RECEPTOR; COLECALCIFEROL; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; JANUS KINASE INHIBITOR; LIPOPOLYSACCHARIDE; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; SALAZOSULFAPYRIDINE; STAT PROTEIN; STAT1 PROTEIN; STAT1ALPHA PROTEIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BONE DENSITY; CELL ISOLATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HOMEOSTASIS; HUMAN; HUMAN CELL; HYDROXYLATION; IMMUNOREGULATION; IMMUNOSTIMULATION; MACROPHAGE; MOLECULAR CLONING; MOLECULAR RECOGNITION; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMID; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANTIGENS, CD14; BONE DENSITY CONSERVATION AGENTS; CALCIFEDIOL; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELLS, CULTURED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERFERON TYPE II; MONOCYTES; NF-KAPPA B; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 29644442100     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.050908     Document Type: Article

References (47)

1. Mathieu C, Adorini L 2002 The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents. Trends Mol Med 8:174-179.
2. Overbergh L, Decallonne B, Valckx D, Verstuyf A, Depovere J. Laureys J, Rutgeerts O, Saint-Arnaud R, Bouillon R, Mathieu C 2000 Identification and immune regulation of 25-hydroxyvitamin D-1-alpha-hydroxylase in murine macrophages. Clin Exp Immunol 120:139-146.
3. Gao XH, Dwivedi PP, Choe S, Alba F, Morris HA, Omdahl JL, May BK 2002 Basal and parathyroid hormone induced expression of the human 25-hydroxyvitamin D 1alpha-hydroxylase gene promoter in kidney AOK-B50 cells: Role of Sp1, Ets and CCAAT box protein binding sites. Int J Biochem Cell Biol 34:921-930.
4. Brenza HL, DeLuca HF 2000 Regulation of 25-hydroxy-vitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3. Arch Biochem Biophys 381:143-152.
5. Jones G, Strugnell SA, DeLuca HF 1998 Current understanding of the molecular actions of vitamin D. Physiol Rev 78:1193-1231.
6. Barbour GL, Coburn JW, Slatopolsky E, Norman AW, Horst RL 1981 Hypercalcemia in an anephric patient with sarcoidosis: Evidence for extrarenal generation of 1,25-dihydroxy-vitamin D. N Engl J Med 305:440-443.
7. Reichel H, Koeffler HP, Barbers R, Norman AW 1987 Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis. J Clin Endocrinol Metab 65:1201-1209.
8. Sharma OP 2002 Sarcoidosis and other autoimmune disorders. Curr Opin Pulm Med 8:452-456.
9. Sharma OP 2000 Hypercalcemia in granulomatous disorders: A clinical review. Curr Opin Pulm Med 6:442-447.
10. Monkawa T, Yoshida T, Hayashi M, Saruta T 2000 Identification of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression in macrophages. Kidney Int 58:559-568.
11. Yamada S, Shiono S, Joo A, Yoshimura A 2003 Control mechanism of JAK/STAT signal transduction pathway. FEBS Lett 534:190-196.
12. Ramana CV, Gil MP, Schreiber RD, Stark GR 2002 Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling. Trends Immunol 23:96-101.
13. Subramaniam PS, Torres BA, Johnson HM 2001 So many ligands, so few transcription factors: A new paradigm for signaling through the STAT transcription factors. Cytokine 15:175-187.
14. Mirlashari MR, Lyberg T 2003 Expression and involvement of Toll-like receptors (TLR)2, TLR4, and CD14 in monocyte TNF-alpha production induced by lipopolysaccharides from Neisseria meningitidis. Med Sci Monit 9:BR316-BR324.
15. Perera PY, Mayadas TN, Takeuchi O, Akira S, Zaks-Zilberman M, Goyert SM, Vogel SN 2001 CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J Immunol 166:574-581.
16. Hu J, Roy SK, Shapiro PS, Rodig SR, Reddy SP, Platanias LC, Schreiber RD, Kalvakolanu DV 2001 ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma. J Biol Chem 276:287-297.
17. Overbergh L, Giulietti A, Valckx D, Decallonne R, Bouillon R, Mathieu C 2003 The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J Biomol Tech 14:33-43.
18. Giulietti A, Overbergh L, Valckx D, Decallonne B, Bouillon R, Mathieu C 2001 An overview of real-time quantitative PCR: Applications to quantify cytokine gene expression. Methods 25:386-401.
19. Kong XF, Zhu XH, Pei YL, Jackson DM, Holick MF 1999 Molecular cloning, characterization, and promoter analysis of the human 25-hydroxyvitamin D3-1alpha-hydroxylase gene. Proc Natl Acad Sci USA 96:6988-6993.
20. Andrews NC, Faller DV 1991 A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 19:2499.
21. Dusso AS, Kamimura S, Gallieni M, Zhong M, Negrea L, Shapiro S, Slatopolsky E 1997 Gamma-interferon-induced resistance to 1,25-(OH)2 D3 in human monocytes and macrophages: A mechanism for the hypercalcemia of various granulomatoses. J Clin Endocrinol Metab 82:2222-2232.
22. Brenza HL, Kimmel-Jehan C, Jehan F, Shinki T, Wakino S, Anazawa H, Suda T, DeLuca HF 1998 Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter. Proc Natl Acad Sci USA 95:1387-1391.
23. Murayama A, Takeyama K, Kitanaka S, Kodera Y, Hosoya T, Kato S 1998 The promoter of the human 25-hydroxyvitamin D3 1 alpha-hydroxylase gene confers positive and negative responsiveness to PTH, calcitonin, and 1 alpha,25(OH)2D3. Biochem Biophys Res Commun 249:11-16.
24. Bland R, Zehnder D, Hughes SV, Ronco PM, Stewart PM, Hewison M 2001 Regulation of vitamin D-1alpha-hydroxylase in a human cortical collecting duct cell line. Kidney Int 60:1277-1286.
25. Roy SK, Hu J, Meng Q, Xia Y, Shapiro PS, Reddy SP, Platanias LC, Lindner DJ, Johnson PF, Pritchard C, Pages G. Pouyssegur J, Kalvakolanu DV 2002 MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proc Natl Acad Sci USA 99:7945-7950.
26. Chen LF, Greene WC 2004 Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 5:392-401.
27. Yamamoto Y, Gaynor RB 2004 IkappaB kinases: Key regulators of the NF-kappaB pathway. Trends Biochem Sci 29:72-79.
28. Xiao W, Hodge DR, Wang L, Yang X, Zhang X, Farrar WL 2004 NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells. Cancer Biol Ther 3:1007-1017.
29. Xiao W, Hodge DR, Wang L, Yang X, Zhang X, Farrar WL 2004 Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells. Prostate 61:354-370.
30. Papin S, Cazeneuve C, Duquesnoy P, Jeru I, Sahali D, Amselem S 2003 The tumor necrosis factor alpha-dependent activation of the human mediterranean fever (MEFV) promoter is mediated by a synergistic interaction between C/EBP beta and NF kappaB p65. J Biol Chem 278:48839-48847.
31. Roy SK, Wachira SJ, Weihua X, Hu J, Kalvakolanu DV 2000 CCAAT/enhancer-binding protein-beta regulates interferon-induced transcription through a novel element. J Biol Chem 275:12626-12632.
32. Ledstrom-Himes J, Xanthopoulos KG 1998 Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J Biol Chem 273:28545-28548.
33. Chano F, Descoteaux A 2002 Modulation of lipopolysaccharide-induced NF-IL6 activation by protein kinase C-alpha in a mouse macrophage cell line. Eur J Immunol 32:2897-2904.
34. St Denis A, Chano F, Tremblay P, St Pierre Y, Descoteaux A 1998 Protein kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line. J Biol Chem 273:32787-32792.
35. Wegner M, Cao Z, Rosenfeld MG 1992 Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta. Science 256:370-373.
36. Schrem H, Klempnauer J, Borlak J 2004 Liver-enriched transcription factors in liver function and development. Part II: The C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. Pharmacol Rev 56:291-330.
37. Buck M, Poli V, van der GP, Chojkier M, Hunter T 1999 Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. Mol Cell 4:1087-1092.
38. Ramji DP, Foka P 2002 CCAAT/enhancer-binding proteins: Structure, function and regulation. Biochem J 365:561-575.
39. Trautwein C, van der GP, Karin M, Hunter T, Chojkier M 1994 Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. J Clin Invest 93:2554-2561.
40. Piwien-Pilipuk G, MacDougald O, Schwartz J 2002 Dual regulation of phosphorylation and dephosphorylation of C/EBP-beta modulate its transcriptional activation and DNA binding in response to growth hormone. J Biol Chem 277:44557-44565.
41. Esteban L, Vidal M, Dusso A 2004 1alpha-Hydroxylase transactivation by gamma-interferon in murine macrophages requires enhanced C/EBPbeta expression and activation. J Steroid Biochem Mol Biol 89-90:131-137.
42. Maehara K, Hasegawa T, Xiao H, Takeuchi A, Abe R, Isobe K 1999 Cooperative interaction of NF-kappaB and C/EBP binding sites is necessary for manganese superoxide dismutase gene transcription mediated by lipopolysaccharide and interferon-gamma. FEBS Lett 449:115-119.
43. Vidal M, Ramana CV, Dusso AS 2002 Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription. Mol Cell Biol 22:2777-2787.
44. Plevy SE, Gemberling JH, Hsu S, Dorner AJ, Smale ST 1997 Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: Evidence of functional synergy between C/EBP and Rel proteins. Mol Cell Biol 17:4572-4588.
45. Xiong H, Zhu C, Li H, Chen F, Mayer L, Ozato K, Unkeless JC, Plevy SE 2003 Complex formation of the interferon (IFN) consensus sequence-binding protein with IRF-1 is essential for murine macrophage IFN-gamma-induced iNOS gene expression. J Biol Chem 278:2271-2277.
46. Ebert R, Jovanovic M, Ulmer M, Schneider D, Meissner-Weigl J. Adamski J, Jakob F 2004 Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter. Mol Endocrinol 18:2440-2450.
47. Mathieu C, Waer M, Laureys J, Rutgeerts O, Bouillon R 1994 Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia 37:552-558.