Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes

Journal of Immunology

Volumn 179, Issue 9, 2007, Pages 6273-6283

  Gorman, Shelley ^a   Alexandra Kuritzky, L ^a   Judge, Melinda A ^a   Dixon, Katie M ^b   McGlade, Jacqueline P ^a   Mason, Rebecca S ^b   Finlay Jones, John J ^a   Hart, Prue H ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CALCITRIOL; OVALBUMIN; TRANSCRIPTION FACTOR FOXP3; INTERLEUKIN 2 RECEPTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL COUNT; CELLULAR IMMUNITY; CONTROLLED STUDY; DONOR; ENVIRONMENTAL FACTOR; FEMALE; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; LYMPHADENOPATHY; MEDIATOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; SENSITIZATION; SKIN DRAINING LYMPH NODE; ULTRAVIOLET B RADIATION; ANIMAL; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; LYMPH NODE; METABOLISM; PHENOTYPE; RADIATION EXPOSURE; SKIN;

ANIMALS; ANTIGENS; CALCITRIOL; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPH NODES; MICE; PHENOTYPE; SKIN;

EID: 38449101546     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.9.6273     Document Type: Article

References (37)

1. Norman, A. W., M. T. Mizwicki, and D. P. Norman. 2004. Steroid-hormone rapid actions, membrane receptors, and a conformational ensemble model. Nat. Rev. 3: 27-41.
2. Bikle, D. D., M. K. Nemanic, J. O. Whitney, and P. W. Elias. 1986. Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3. Biochemistry 25: 1545-1548.
3. Lehmann, B., W. Sauter, P. Knuschke, S. Dressler, and M. Meurer. 2003. Demonstration of UVB-induced synthesis of 1,25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis. Arch. Dermatol. Res. 295: 24-28.
4. Gupta, R., K. M. Dixon, S. S. Deo, C. J. Holliday, M. Slater, G. M. Halliday, V. E. Reeve, and R. S. Mason. 2007. Photoprotection by 1,25 dihydroxyvitamin D3 is associated with an increase in p53 and a decrease in nitric oxide products. J. Invest. Dermatol. 127: 707-715.
5. Penna, G., S. Amuchastegui, N. Giarratana, K. C. Daniel, M. Vulcano, S. Sozzani, and L. Adorini. 2007. 1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J. Immunol. 178: 145-153.
6. + T cells to enhance the development of Th2 cells. J. Immunol. 167: 4974-4980.
7. + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 Th1- and Th2-inducing cytokines. J. Exp. Med. 195: 603-616.
8. Gregori, S., N. Giarratana, S. Smiroldo, M. Uskokovic, and L. Adorini. 2002. A 1-α,25-dihydroxyvitamin D3 analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 51: 1367-1374.
9. Cantorna, M. T., C. E. Hayes, and H. F. DeLuca. 1996. 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc. Natl. Acad. Sci. USA 93: 7861-7864.
10. Cantorna, M. T., C. E. Hayes, and H. F. DeLuca. 1998. 1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis. J. Nutr. 128: 68-72.
11. Matheu, V., O. Back, E. Mondoc, and S. Issazadeh-Navikas. 2003. Dual effects of vitamin D-induced alteration of Th1/Th2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J. Allergy Clin. Immunol. 112: 585-592.
12. Garrigue, J. L., J. F. Nicolas, A. Demidem, H. Bour, J. Viac, J. Thivolet, and D. Schmitt. 1993. Contact sensitivity in mice: differential effect of vitamin D3 derivative (calcipotriol) and corticosteroids. Clin. Immunol. Immunopathol. 67: 137-142.
13. Tani, M., Y. Murata, S. Harada, T. Takashima, and T. Horikawa. 1989. Increased contact hypersensitivity response in mice by topical application of 1-α,25-dihydroxyvitamin D3 to elicitation site. Arch. Dermatol. Res. 281: 355-361.
14. Guo, Z., H. Okamoto, and S. Imamura. 1992. The effect of 1,25(OH)2-vitamin D3 on Langerhans cells and contact hypersensitivity in mice. Arch. Dermatol. Res. 284: 368-370.
15. Hanneman, K. K., H. M. Scull, K. D. Cooper, and E. D. Baron. 2006. Effect of topical vitamin D analogue on in vivo contact sensitization. Arch. Dermatol. 142: 1332-1334.
16. + T cells in lymph nodes of UVB-irradiated mice suppress immune responses to new antigens both in vitro and in vivo. J. Invest. Dermatol. 127: 915-924.
17. Hart, P. H., M. A. Grimbaldeston, G. J. Swift, A. Jaksic, F. P. Noonan, and J. J. Finlay-Jones. 1998. Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice. J. Exp. Med. 187: 2045-2053.
18. Hart, P. H., A. Jaksic, G. Swift, M. Norval, A. A. el-Ghorr, and J. J. Finlay-Jones. 1997. Histamine involvement in UVB- and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses. Immunology 91: 601-608.
19. Dixon, K. M., S. S. Deo, G. Wong, M. Slater, A. W. Norman, J. E. Bishop, G. H. Posner, S. Ishizuka, G. M. Halliday, V. E. Reeve, and R. S. Mason. 2005. Skin cancer prevention: a possible role of 1,25dihydroxyvitamin D3 and its analogs. J. Steroid Biochem. Mol. Biol. 97: 137-143.
20. Dixon, K. M., S. S. Deo, A. W. Norman, J. E. Bishop, G. M. Halliday, V. E. Reeve, and R. S. Mason. 2007. In vivo relevance for photoprotection by the vitamin D rapid response pathway. J. Steroid Biochem. Mol. Biol. 103: 451-456.
21. Mahon, B. D., A. Wittke, V. Weaver, and M. T. Cantorna. 2003. The targets of vitamin D depend on the differentiation and activation status of CD4-positive T cells. J. Cell. Biochem. 89: 922-932.
22. Penna, G., and L. Adorini. 2000. 1-α,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J. Immunol. 164: 2405-2411.
23. Daniel, C., H. H. Radeke, N. A. Sartory, N. Zahn, U. Zuegal, A. Steinmeyer, and J. Stein. 2006. The new low calcemic vitamin D analog 22-ene-25-oxa-vitamin D prominently ameliorates T helper cell type 1-mediated colitis in mice. J. Pharmacol. Exp. Ther. 319: 622-631.
24. Penna, G., S. Amuchastegui, N. Giarratana, K. C. Daniel, M. Vulcano, S. Sozzani, and L. Adorini. 2006. Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol. J. Immunol. 177: 8504-8511.
25. Schwarz, A., A. Maeda, M. K. Wild, K. Kernebeck, N. Gross, Y. Aragane, S. Beissert, D. Vestweber, and T. Schwarz. 2004. Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity. J. Immunol. 172: 1036-1043.
26. + T regulatory cells and is dependent on host-derived IL-10. J. Immunol. 176: 2635-2644.
27. + regulatory T cells restore normoglycemia in diabetic NOD mice. J. Exp. Med. 204: 191-201.
28. Aubin, F. 2003. Mechanisms involved in ultraviolet light-induced immunosuppression. Eur. J. Dermatol. 13: 515-523.
29. Gorman, S., J. W. Tan, J. A. Thomas, S. L. Townley, P. A. Stumbles, J. J. Finlay-Jones, and P. H. Hart. 2005. Primary defect in UVB-induced systemic immunomodulation does not relate to immature or functionally impaired APCs in regional lymph nodes. J. Immunol. 174: 6677-6685.
30. Byrne, S. N., and G. M. Halliday. 2005. B cells activated in lymph nodes in response to ultraviolet irradiation or by interleukin-10 inhibit dendritic cell induction of immunity. J. Invest. Dermatol. 124: 570-578.
31. Kolgen, W., H. Both, H. van Weelden, K. L. Guikers, C. A. Bruijnzeel-Koomen, E. F. Knol, W. A. van Vloten, and F. R. De Gruijl. 2002. Epidermal Langerhans cell depletion after artificial ultraviolet B irradiation of human skin in vivo: apoptosis versus migration. J. Invest. Dermatol. 118: 812-817.
32. Schwarz, A., A. Maeda, K. Kernebeck, H. van Steeg, S. Beissert, and T. Schwarz. 2006. Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J. Exp. Med. 201: 173-179.
33. 3 on purified mouse Langerhans cells. Cell. Immunol. 245: 70-79.
34. Sigmundsdottir, H., J. Pan, G. F. Debes, C. Alt, A. Habtezion, D. Soler, and E. C. Butcher. 2007. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat. Immunol. 8: 285-293.
35. Loser, K., A. Mehling, S. Loeser, J. Apelt, A. Kuhn, S. Grabbe, T. Schwarz, J. M. Penninger, and S. Beissert. 2006. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat. Med. 12: 1372-1379.
36. Theill, L. E., W. J. Boyle, and J. M. Penninger. 2002. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20: 795-823.
37. + regulatory T cells by 1,25-dihydroxyvitamin D3. Blood 106: 3490-3497.