메뉴 건너뛰기




Volumn 57, Issue 2, 2011, Pages 176-185

Genetics of type 1 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA ANTIGEN CLASS 2; HLA ANTIGEN CLASS 3; INSULIN; INTERFERON; INTERFERON INDUCED WITH HELICASE C DOMAIN 1; INTERLEUKIN 2 RECEPTOR ALPHA; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; UNCLASSIFIED DRUG;

EID: 79551469699     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2010.148221     Document Type: Review
Times cited : (218)

References (76)
  • 1
    • 0029953008 scopus 로고    scopus 로고
    • The role of HLA class II genes in insulin-dependent diabetes mellitus: Molecular analysis of 180 Caucasian, multiplex families
    • Noble JA, Valdes AM, Cook M, Klitz W, Thomson G, Erlich HA. The role of HLA class II genes in insulin-dependent diabetes mellitus: Molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet 1996;59:1134-48.
    • (1996) Am J Hum Genet , vol.59 , pp. 1134-1148
    • Noble, J.A.1    Valdes, A.M.2    Cook, M.3    Klitz, W.4    Thomson, G.5    Erlich, H.A.6
  • 2
    • 0021343570 scopus 로고
    • A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
    • Bell GI, Horita S, Karam JH. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 1984;33:176-83.
    • (1984) Diabetes , vol.33 , pp. 176-183
    • Bell, G.I.1    Horita, S.2    Karam, J.H.3
  • 4
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    • Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 2004;36:337-8.
    • (2004) Nat Genet , vol.36 , pp. 337-338
    • Bottini, N.1    Musumeci, L.2    Alonso, A.3    Rahmouni, S.4    Nika, K.5    Rostamkhani, M.6
  • 5
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genomewide analyses of type 1 diabetes
    • Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, et al. Robust associations of four new chromosome regions from genomewide analyses of type 1 diabetes. Nat Genet 2007;39:857-64.
    • (2007) Nat Genet , vol.39 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3    Smyth, D.J.4    Downes, K.5    Plagnol, V.6
  • 6
    • 42449144715 scopus 로고    scopus 로고
    • HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the type 1 diabetes genetics consortium families
    • Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008;57:1084-92.
    • (2008) Diabetes , vol.57 , pp. 1084-1092
    • Erlich, H.1    Valdes, A.M.2    Noble, J.3    Carlson, J.A.4    Varney, M.5    Concannon, P.6
  • 7
    • 0033429304 scopus 로고    scopus 로고
    • Worldwide increase in incidence of Type I diabetes-the analysis of the data on published incidence trends
    • Onkamo P, Vaananen S, Karvonen M, Tuomilehto J. Worldwide increase in incidence of Type I diabetes-the analysis of the data on published incidence trends. Diabetologia 1999;42:1395-403.
    • (1999) Diabetologia , vol.42 , pp. 1395-1403
    • Onkamo, P.1    Vaananen, S.2    Karvonen, M.3    Tuomilehto, J.4
  • 8
    • 0037386030 scopus 로고    scopus 로고
    • Clinical, autoimmune, and HLA characteristics of children diagnosed with type 1 diabetes before 5 years of age
    • Hathout EH, Hartwick N, Fagoaga OR, Colacino AR, Sharkey J, Racine M, et al. Clinical, autoimmune, and HLA characteristics of children diagnosed with type 1 diabetes before 5 years of age. Pediatrics 2003;111:860-3.
    • (2003) Pediatrics , vol.111 , pp. 860-863
    • Hathout, E.H.1    Hartwick, N.2    Fagoaga, O.R.3    Colacino, A.R.4    Sharkey, J.5    Racine, M.6
  • 9
    • 0345505676 scopus 로고    scopus 로고
    • Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: A nationwide follow-up study
    • Hyttinen V, Kaprio J, Kinnunen L, Koskenvuo M, Tuomilehto J. Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes 2003;52:1052-5.
    • (2003) Diabetes , vol.52 , pp. 1052-1055
    • Hyttinen, V.1    Kaprio, J.2    Kinnunen, L.3    Koskenvuo, M.4    Tuomilehto, J.5
  • 14
  • 15
    • 0033550904 scopus 로고    scopus 로고
    • Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: Prospective twin study
    • Redondo MJ, Rewers M, Yu L, Garg S, Pilcher CC, Elliott RB, Eisenbarth GS. Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: prospective twin study. BMJ 1999;318:698-702.
    • (1999) BMJ , vol.318 , pp. 698-702
    • Redondo, M.J.1    Rewers, M.2    Yu, L.3    Garg, S.4    Pilcher, C.C.5    Elliott, R.B.6    Eisenbarth, G.S.7
  • 16
    • 17344372511 scopus 로고    scopus 로고
    • A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus
    • Concannon P, Gogolin-Ewens KJ, Hinds DA, Wapelhorst B, Morrison VA, Stirling B, et al. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nat Genet 1998;19:292-6.
    • (1998) Nat Genet , vol.19 , pp. 292-296
    • Concannon, P.1    Gogolin-Ewens, K.J.2    Hinds, D.A.3    Wapelhorst, B.4    Morrison, V.A.5    Stirling, B.6
  • 17
    • 25844441709 scopus 로고    scopus 로고
    • Type 1 diabetes: Evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families
    • Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F, et al. Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes 2005;54:2995-3001.
    • (2005) Diabetes , vol.54 , pp. 2995-3001
    • Concannon, P.1    Erlich, H.A.2    Julier, C.3    Morahan, G.4    Nerup, J.5    Pociot, F.6
  • 18
    • 8944258928 scopus 로고    scopus 로고
    • Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY)
    • Rewers M, Bugawan TL, Norris JM, Blair A, Beaty B, Hoffman M, et al. Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia 1996;39:807-12.
    • (1996) Diabetologia , vol.39 , pp. 807-812
    • Rewers, M.1    Bugawan, T.L.2    Norris, J.M.3    Blair, A.4    Beaty, B.5    Hoffman, M.6
  • 19
    • 0026697932 scopus 로고
    • Life table analysis of the risk of type I (insulin-dependent) diabetes mellitus in siblings according to islet cell antibodies and HLA markers: An 8 year prospective study
    • Deschamps I, Boitard C, Hors J, Busson M, Marcelli-Barge A, Mogenet A, Robert JJ. Life table analysis of the risk of type I (insulin-dependent) diabetes mellitus in siblings according to islet cell antibodies and HLA markers: an 8 year prospective study. Diabetologia 1992;35:951-7.
    • (1992) Diabetologia , vol.35 , pp. 951-957
    • Deschamps, I.1    Boitard, C.2    Hors, J.3    Busson, M.4    Marcelli-Barge, A.5    Mogenet, A.6    Robert, J.J.7
  • 20
    • 0027380268 scopus 로고
    • The role of DQ alpha-beta heterodimers in genetic susceptibilty to insulin-dependent diabetes
    • Deschamps I, Khalil I. The role of DQ alpha-beta heterodimers in genetic susceptibilty to insulin-dependent diabetes. Diabetes Metab Rev 1993;9:71-92.
    • (1993) Diabetes Metab Rev , vol.9 , pp. 71-92
    • Deschamps, I.1    Khalil, I.2
  • 21
    • 0028989040 scopus 로고
    • HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM
    • Pugliese A, Gianani R, Moromisato R, Awdeh ZL, Alper CA, Erlich HA, et al. HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes 1995;44:608-13.
    • (1995) Diabetes , vol.44 , pp. 608-613
    • Pugliese, A.1    Gianani, R.2    Moromisato, R.3    Awdeh, Z.L.4    Alper, C.A.5    Erlich, H.A.6
  • 23
  • 26
    • 15444367789 scopus 로고    scopus 로고
    • Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset
    • Valdes AM, Erlich HA, Noble JA. Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset. Hum Immunol 2005;66:301-13.
    • (2005) Hum Immunol , vol.66 , pp. 301-313
    • Valdes, A.M.1    Erlich, H.A.2    Noble, J.A.3
  • 27
    • 36849012027 scopus 로고    scopus 로고
    • Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
    • Nejentsev S, Howson JM, Walker NM, Szeszko J, Field SF, Stevens HE, et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007;450:887-92.
    • (2007) Nature , vol.450 , pp. 887-892
    • Nejentsev, S.1    Howson, J.M.2    Walker, N.M.3    Szeszko, J.4    Field, S.F.5    Stevens, H.E.6
  • 28
    • 43649103659 scopus 로고    scopus 로고
    • Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: Association of DPB1 and HLA class I loci among DR3-and DR4-matched Italian patients and controls
    • Noble JA, Martin A, Valdes AM, Lane JA, Galgani A, Petrone A, et al. Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3-and DR4-matched Italian patients and controls. Hum Immunol 2008;69:291-300.
    • (2008) Hum Immunol , vol.69 , pp. 291-300
    • Noble, J.A.1    Martin, A.2    Valdes, A.M.3    Lane, J.A.4    Galgani, A.5    Petrone, A.6
  • 29
    • 0036020518 scopus 로고    scopus 로고
    • The HLA class I a locus affects susceptibility to type 1 diabetes
    • DOI 10.1016/S0198-8859(02)00421-4, PII S0198885902004214
    • Noble JA, Valdes AM, Bugawan TL, Apple RJ, Thomson G, Erlich HA. The HLA class I A locus affects susceptibility to type 1 diabetes. Hum Immunol 2002;63:657-64. (Pubitemid 34816108)
    • (2002) Human Immunology , vol.63 , Issue.8 , pp. 657-664
    • Noble, J.A.1    Valdes, A.M.2    Bugawan, T.L.3    Apple, R.J.4    Thomson, G.5    Erlich, H.A.6
  • 30
    • 23944503063 scopus 로고    scopus 로고
    • Homozygosity for premature stop codon of the MHC class I chain-related gene a (MIC-A) is associated with early activation of islet autoimmunity of DR3/4-DQ2/8 high risk DAISY relatives
    • Ide A, Babu SR, Robles DT, Wang T, Erlich HA, Bugawan TL, et al. Homozygosity for premature stop codon of the MHC class I chain-related gene A (MIC-A) is associated with early activation of islet autoimmunity of DR3/4-DQ2/8 high risk DAISY relatives. J Clin Immunol 2005;25:303-8.
    • (2005) J Clin Immunol , vol.25 , pp. 303-308
    • Ide, A.1    Babu, S.R.2    Robles, D.T.3    Wang, T.4    Erlich, H.A.5    Bugawan, T.L.6
  • 31
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78.
    • (2007) Nature , vol.447 , pp. 661-678
  • 33
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • Pugliese A, Zeller M, Fernandez A, Jr, Zalcberg LJ, Bartlett RJ, Ricordi C, et al. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 1997;15:293-7.
    • (1997) Nat Genet , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez Jr., A.3    Zalcberg, L.J.4    Bartlett, R.J.5    Ricordi, C.6
  • 34
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 1997;15:289-92.
    • (1997) Nat Genet , vol.15 , pp. 289-292
    • Vafiadis, P.1    Bennett, S.T.2    Todd, J.A.3    Nadeau, J.4    Grabs, R.5    Goodyer, C.G.6
  • 35
    • 0041335584 scopus 로고    scopus 로고
    • Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse
    • Moriyama H, Abiru N, Paronen J, Sikora K, Liu E, Miao D, et al. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc Natl Acad Sci U S A 2003;100:10376-81.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10376-10381
    • Moriyama, H.1    Abiru, N.2    Paronen, J.3    Sikora, K.4    Liu, E.5    Miao, D.6
  • 36
    • 14644445981 scopus 로고    scopus 로고
    • Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes
    • Zheng W, She JX. Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes. Diabetes 2005;54:906-8.
    • (2005) Diabetes , vol.54 , pp. 906-908
    • Zheng, W.1    She, J.X.2
  • 37
    • 64649083362 scopus 로고    scopus 로고
    • Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR, DQ genotypes?
    • Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, et al. Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR, DQ genotypes? Diabetes 2009;58:1028-33.
    • (2009) Diabetes , vol.58 , pp. 1028-1033
    • Steck, A.K.1    Zhang, W.2    Bugawan, T.L.3    Barriga, K.J.4    Blair, A.5    Erlich, H.A.6
  • 38
    • 75649138796 scopus 로고    scopus 로고
    • rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype
    • Steck AK, Baschal EE, Jasinski JM, Boehm BO, Bottini N, Concannon P, et al. rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype. Genes Immun 2009;10(Suppl 1):S21-26.
    • (2009) Genes Immun , vol.10 , Issue.SUPPL. 1
    • Steck, A.K.1    Baschal, E.E.2    Jasinski, J.M.3    Boehm, B.O.4    Bottini, N.5    Concannon, P.6
  • 39
    • 3242713277 scopus 로고    scopus 로고
    • A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    • Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 2004;75:330-7.
    • (2004) Am J Hum Genet , vol.75 , pp. 330-337
    • Begovich, A.B.1    Carlton, V.E.2    Honigberg, L.A.3    Schrodi, S.J.4    Chokkalingam, A.P.5    Alexander, H.C.6
  • 40
    • 28444469783 scopus 로고    scopus 로고
    • Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
    • Vang T, Congia M, Macis MD, Musumeci L, Orru V, Zavattari P, et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 2005;37:1317-9.
    • (2005) Nat Genet , vol.37 , pp. 1317-1319
    • Vang, T.1    Congia, M.2    Macis, M.D.3    Musumeci, L.4    Orru, V.5    Zavattari, P.6
  • 42
    • 7044253358 scopus 로고    scopus 로고
    • Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
    • Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM, et al. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 2004;53:3020-3.
    • (2004) Diabetes , vol.53 , pp. 3020-3023
    • Smyth, D.1    Cooper, J.D.2    Collins, J.E.3    Heward, J.M.4    Franklyn, J.A.5    Howson, J.M.6
  • 43
    • 4143105691 scopus 로고    scopus 로고
    • Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE
    • Kyogoku C, Langefeld CD, Ortmann WA, Lee A, Selby S, Carlton VE, et al. Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet 2004;75:504-7.
    • (2004) Am J Hum Genet , vol.75 , pp. 504-507
    • Kyogoku, C.1    Langefeld, C.D.2    Ortmann, W.A.3    Lee, A.4    Selby, S.5    Carlton, V.E.6
  • 44
    • 21244490890 scopus 로고    scopus 로고
    • CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: A HuGE Review and meta-analysis
    • Kavvoura FK, Ioannidis JP. CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis. Am J Epidemiol 2005;162:3-16.
    • (2005) Am J Epidemiol , vol.162 , pp. 3-16
    • Kavvoura, F.K.1    Ioannidis, J.P.2
  • 45
    • 0034548720 scopus 로고    scopus 로고
    • CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease
    • Kouki T, Sawai Y, Gardine CA, Fisfalen ME, Alegre ML, DeGroot LJ. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease. J Immunol 2000;165:6606-11.
    • (2000) J Immunol , vol.165 , pp. 6606-6611
    • Kouki, T.1    Sawai, Y.2    Gardine, C.A.3    Fisfalen, M.E.4    Alegre, M.L.5    DeGroot, L.J.6
  • 46
    • 3042592443 scopus 로고    scopus 로고
    • Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen
    • Eggena MP, Walker LS, Nagabhushanam V, Barron L, Chodos A, Abbas AK. Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen. J Exp Med 2004;199:1725-30.
    • (2004) J Exp Med , vol.199 , pp. 1725-1730
    • Eggena, M.P.1    Walker, L.S.2    Nagabhushanam, V.3    Barron, L.4    Chodos, A.5    Abbas, A.K.6
  • 48
    • 3242732770 scopus 로고    scopus 로고
    • Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease
    • Blomhoff A, Lie BA, Myhre AG, Kemp EH, Weetman AP, Akselsen HE, et al. Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease. J Clin Endocrinol Metab 2004;89:3474-6.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3474-3476
    • Blomhoff, A.1    Lie, B.A.2    Myhre, A.G.3    Kemp, E.H.4    Weetman, A.P.5    Akselsen, H.E.6
  • 50
    • 33847656517 scopus 로고    scopus 로고
    • A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene
    • Howson JM, Dunger DB, Nutland S, Stevens H, Wicker LS, Todd JA. A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene. Diabetologia 2007;50:741-6.
    • (2007) Diabetologia , vol.50 , pp. 741-746
    • Howson, J.M.1    Dunger, D.B.2    Nutland, S.3    Stevens, H.4    Wicker, L.S.5    Todd, J.A.6
  • 51
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003;423:506-11.
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1    Howson, J.M.2    Esposito, L.3    Heward, J.4    Snook, H.5    Chamberlain, G.6
  • 52
    • 20244373351 scopus 로고    scopus 로고
    • Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
    • Vella A, Cooper JD, Lowe CE, Walker N, Nutland S, Widmer B, et al. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet 2005;76:773-9.
    • (2005) Am J Hum Genet , vol.76 , pp. 773-779
    • Vella, A.1    Cooper, J.D.2    Lowe, C.E.3    Walker, N.4    Nutland, S.5    Widmer, B.6
  • 53
    • 34548367511 scopus 로고    scopus 로고
    • Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    • Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R, et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 2007;39:1074-82.
    • (2007) Nat Genet , vol.39 , pp. 1074-1082
    • Lowe, C.E.1    Cooper, J.D.2    Brusko, T.3    Walker, N.M.4    Smyth, D.J.5    Bailey, R.6
  • 54
    • 3543046736 scopus 로고    scopus 로고
    • A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
    • Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, et al. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet 2004;36:837-41.
    • (2004) Nat Genet , vol.36 , pp. 837-841
    • Guo, D.1    Li, M.2    Zhang, Y.3    Yang, P.4    Eckenrode, S.5    Hopkins, D.6
  • 55
    • 33745240931 scopus 로고    scopus 로고
    • A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    • Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, et al. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 2006;38:617-9.
    • (2006) Nat Genet , vol.38 , pp. 617-619
    • Smyth, D.J.1    Cooper, J.D.2    Bailey, R.3    Field, S.4    Burren, O.5    Smink, L.J.6
  • 56
    • 39049121734 scopus 로고    scopus 로고
    • The association between the IFIH1 locus and type 1 diabetes
    • Qu HQ, Marchand L, Grabs R, Polychronakos C. The association between the IFIH1 locus and type 1 diabetes. Diabetologia 2008;51:473-5.
    • (2008) Diabetologia , vol.51 , pp. 473-475
    • Qu, H.Q.1    Marchand, L.2    Grabs, R.3    Polychronakos, C.4
  • 57
    • 33846190681 scopus 로고    scopus 로고
    • TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat
    • Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA. TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol 2007;178:693-701.
    • (2007) J Immunol , vol.178 , pp. 693-701
    • Zipris, D.1    Lien, E.2    Nair, A.3    Xie, J.X.4    Greiner, D.L.5    Mordes, J.P.6    Rossini, A.A.7
  • 58
    • 35748981184 scopus 로고    scopus 로고
    • Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    • Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007;39:1329-37.
    • (2007) Nat Genet , vol.39 , pp. 1329-1337
    • Burton, P.R.1    Clayton, D.G.2    Cardon, L.R.3    Craddock, N.4    Deloukas, P.5    Duncanson, A.6
  • 59
    • 42449094966 scopus 로고    scopus 로고
    • A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study
    • Hakonarson H, Qu HQ, Bradfield JP, Marchand L, Kim CE, Glessner JT, et al. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. Diabetes 2008;57:1143-6.
    • (2008) Diabetes , vol.57 , pp. 1143-1146
    • Hakonarson, H.1    Qu, H.Q.2    Bradfield, J.P.3    Marchand, L.4    Kim, C.E.5    Glessner, J.T.6
  • 60
    • 56749183605 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    • Cooper JD, Smyth DJ, Smiles AM, Plagnol V, Walker NM, Allen JE, et al. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet 2008;40:1399-401.
    • (2008) Nat Genet , vol.40 , pp. 1399-1401
    • Cooper, J.D.1    Smyth, D.J.2    Smiles, A.M.3    Plagnol, V.4    Walker, N.M.5    Allen, J.E.6
  • 62
    • 32944461406 scopus 로고    scopus 로고
    • Type 1 diabetes and the OAS gene cluster: Association with splicing polymorphism or haplotype?
    • Tessier MC, Qu HQ, Frechette R, Bacot F, Grabs R, Taback SP, et al. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? J Med Genet 2006;43:129-32.
    • (2006) J Med Genet , vol.43 , pp. 129-132
    • Tessier, M.C.1    Qu, H.Q.2    Frechette, R.3    Bacot, F.4    Grabs, R.5    Taback, S.P.6
  • 63
  • 64
    • 36749050449 scopus 로고    scopus 로고
    • CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans
    • Ramos-Lopez E, Bruck P, Jansen T, Herwig J, Badenhoop K. CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev 2007;23:631-6.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 631-636
    • Ramos-Lopez, E.1    Bruck, P.2    Jansen, T.3    Herwig, J.4    Badenhoop, K.5
  • 65
    • 63249115398 scopus 로고    scopus 로고
    • Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes
    • Grant SF, Qu HQ, Bradfield JP, Marchand L, Kim CE, Glessner JT, et al. Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes 2009;58:290-5.
    • (2009) Diabetes , vol.58 , pp. 290-295
    • Grant, S.F.1    Qu, H.Q.2    Bradfield, J.P.3    Marchand, L.4    Kim, C.E.5    Glessner, J.T.6
  • 67
    • 77957012972 scopus 로고    scopus 로고
    • Global gene expression changes in type 1 diabetes: Insights into autoimmune response in the target organ and in the periphery
    • Planas R, Pujol-Borrell R, Vives-Pi M. Global gene expression changes in type 1 diabetes: insights into autoimmune response in the target organ and in the periphery. Immunol Lett 2010;133:55-61.
    • (2010) Immunol Lett , vol.133 , pp. 55-61
    • Planas, R.1    Pujol-Borrell, R.2    Vives-Pi, M.3
  • 69
    • 40749100302 scopus 로고    scopus 로고
    • Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics
    • Wang X, Jia S, Geoffrey R, Alemzadeh R, Ghosh S, Hessner MJ. Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. J Immunol 2008;180:1929-37.
    • (2008) J Immunol , vol.180 , pp. 1929-1937
    • Wang, X.1    Jia, S.2    Geoffrey, R.3    Alemzadeh, R.4    Ghosh, S.5    Hessner, M.J.6
  • 70
    • 2542484935 scopus 로고    scopus 로고
    • Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up
    • Barker JM, Goehrig SH, Barriga K, Hoffman M, Slover R, Eisenbarth GS, et al. Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up. Diabetes Care 2004;27:1399-404.
    • (2004) Diabetes Care , vol.27 , pp. 1399-1404
    • Barker, J.M.1    Goehrig, S.H.2    Barriga, K.3    Hoffman, M.4    Slover, R.5    Eisenbarth, G.S.6
  • 71
    • 10744222979 scopus 로고    scopus 로고
    • IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity
    • Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, et al. IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity. Diabetologia 2003;46:712-20.
    • (2003) Diabetologia , vol.46 , pp. 712-720
    • Walter, M.1    Albert, E.2    Conrad, M.3    Keller, E.4    Hummel, M.5    Ferber, K.6
  • 72
    • 2542505445 scopus 로고    scopus 로고
    • Brief communication: Early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents
    • Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG. Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents. Ann Intern Med 2004;140:882-6.
    • (2004) Ann Intern Med , vol.140 , pp. 882-886
    • Hummel, M.1    Bonifacio, E.2    Schmid, S.3    Walter, M.4    Knopff, A.5    Ziegler, A.G.6
  • 73
    • 7444253875 scopus 로고    scopus 로고
    • IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes
    • Bonifacio E, Hummel M, Walter M, Schmid S, Ziegler AG. IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes. Diabetes Care 2004;27:2695-700.
    • (2004) Diabetes Care , vol.27 , pp. 2695-2700
    • Bonifacio, E.1    Hummel, M.2    Walter, M.3    Schmid, S.4    Ziegler, A.G.5
  • 74
    • 4043091960 scopus 로고    scopus 로고
    • Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    • Barker JM, Barriga KJ, Yu L, Miao D, Erlich HA, Norris JM, et al. Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab 2004;89:3896-902.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3896-3902
    • Barker, J.M.1    Barriga, K.J.2    Yu, L.3    Miao, D.4    Erlich, H.A.5    Norris, J.M.6
  • 75
    • 44849138907 scopus 로고    scopus 로고
    • Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization
    • Achenbach P, Barker J, Bonifacio E. Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization. Curr Diab Rep 2008;8:87-93.
    • (2008) Curr Diab Rep , vol.8 , pp. 87-93
    • Achenbach, P.1    Barker, J.2    Bonifacio, E.3
  • 76
    • 43649106996 scopus 로고    scopus 로고
    • Extreme genetic risk for type 1A diabetes in the post-genome era
    • Baschal EE, Eisenbarth GS. Extreme genetic risk for type 1A diabetes in the post-genome era. J Autoimmun 2008;31:1-6.
    • (2008) J Autoimmun , vol.31 , pp. 1-6
    • Baschal, E.E.1    Eisenbarth, G.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.