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Simpson S Jr., Blizzard L, Otahal P, Van Der Mei I, Taylor B. Latitude is significantly associated with the prevalence of multiple sclerosis: A meta-analysis. J. Neurol. Neurosurg. Psychiatry DOI: 10.1136/jnnp.2011.240432 (2011) (Epub ahead of print).
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79955450037
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Relationship of UV exposure to prevalence of multiple sclerosis in England
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By using data on ultraviolet B radiation, multiple sclerosis (MS) and infectious mononucleosis (IM) prevalence, the authors demonstrate that UVB exposure and IM together can explain a substantial proportion of the variance of MS prevalence in England
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Ramagopalan SV, Handel AE, Giovannoni G, Rutherford Siegel S, Ebers GC, Chaplin G. Relationship of UV exposure to prevalence of multiple sclerosis in England. Neurology 76(16), 1410-1414 (2011). . By using data on ultraviolet B radiation, multiple sclerosis (MS) and infectious mononucleosis (IM) prevalence, the authors demonstrate that UVB exposure and IM together can explain a substantial proportion of the variance of MS prevalence in England.
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Neurology
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Ramagopalan, S.V.1
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0345830740
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Vitamin D intake and incidence of multiple sclerosis
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Neurology
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DOI 10.1001/jama.296.23.2832
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Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296(23), 2832-2838 (2006). . In a prospective, nested case-control study among more than 7 million US military personnel, 25-hydroxyvitamin D levels were shown to inversely correlate with the risk of MS later in life. (Pubitemid 44969183)
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The vitamin D connection to pediatric infections and immune function
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Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: Modulation of innate and autoimmunity. J. Mol. Med. 88(5), 441-450 (2010).
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A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution
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Ramagopalan SV, Heger A, Berlanga AJ et al. A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution. Genome Res. 20(10), 1352-1360 (2010).
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Epstein-Barr virus infection and multiple sclerosis: A review
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Role of the HLA system in the association between multiple sclerosis and infectious mononucleosis
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Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: A prospective national cohort study
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Banwell B, Bar-Or A, Arnold Dl et al. Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: A prospective national cohort study. Lancet Neurol. 10(5), 436-445 (2011).
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Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis
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In this study, the authors demonstrate a direct correlation between 25-hydroxyvitamin D levels and functionality of regulatory T cells in MS patients
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Smolders J, Thewissen M, Peelen E et al. Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. PLoS One 4(8), e6635 (2009). . In this study, the authors demonstrate a direct correlation between 25-hydroxyvitamin D levels and functionality of regulatory T cells in MS patients.
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This work provides evidence for a potential role played by regulatory T cells in controlling primary Epstein-Barr virus infection and IM onset
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Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes
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The Epstein-Barr virus protein EBNA3 is able to bind the vitamin D receptor and block the activation of vitamin D-regulated genes against vitamin D-induced growth arrest and/or apoptosis
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Yenamandra SP, Hellman U, Kempkes B et al. Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes. Cell Mol. Life Sci. 67(24), 4249-4256 (2010). . The Epstein-Barr virus protein EBNA3 is able to bind the vitamin D receptor and block the activation of vitamin D-regulated genes against vitamin D-induced growth arrest and/or apoptosis.
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