Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease

Journal of Experimental Medicine

Volumn 185, Issue 9, 1997, Pages 1585-1594

  Bieganowska, Katarzyna D ^a   Ausubel, Lara J ^a   Modabber, Yalda ^a   Slovik, Elissa ^a   Messersmith, Wells ^a   Hafler, David A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; MYELIN BASIC PROTEIN;

ANALYTIC METHOD; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CELL DEATH; CELL ISOLATION; DEMYELINATION; GENE FREQUENCY; HUMAN; HUMAN CELL; LYMPHOCYTIC INFILTRATION; MOLECULAR CLONING; PRIORITY JOURNAL; STEM CELL; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD95; AUTOANTIGENS; AUTOIMMUNE DISEASES; CELL DEATH; CLONE CELLS; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 0030973104     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.9.1585     Document Type: Article

References (32)

1. Adams, R.D., and R.L. Sidman. 1968. Demyelinative diseases. In Introduction to Neuropathology. McGraw-Hill Inc., New York. 149-170.
2. Prineas, J.W., and C.S. Raine. 1976. Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions. Neurology. 26:29-32.
3. Prineas, J.W., and R.G. Wright. 1978. Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis lesions. Lab. Invest. 38:409-421.
4. Booss, J., M.M. Esiri, and W.W. Tourtellotte. 1983. Immunohistochemical analysis of T-lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. J. Neurol. Sci. 62:19-32.
5. Hafler, D.A., and H.L. Weiner. 1995. Immunologic mechanisms and therapy in multiple sclerosis. Immunol. Rev. 144:75-107.
6. Martin, R., D. Jaraquemada, M. Flerlage, J.R. Richert, J. Whitaker, E.O. Long, D.E. McFarlin, and H.F. McFarland. 1990. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J. Immunol. 145:540-548.
7. Ota, K., M. Matsui, E.L. Milford, G.A. Mackin, H.L. Weiner, and D.A. Hafler. 1990. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature (Lond.). 346:183-187.
8. Pette, M., K. Fujita, D. Wilkinson, D.M. Altmann, J. Trowsdale, G. Giegerich, A. Hinkkanen, J.T. Epplen, L. Kappos, and H. Wekerle. 1990. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors. Proc. Natl. Acad. Sci. USA. 87:7968-7972.
9. Windhagen, A., D.E. Anderson, A. Carrizosa, R.E. Williams, and D.A. Hafler. 1996. IL-12 induces human T cells secreting IL-10 with IFNγ. J. Immunol. 157:1127-1131.
10. Allegretta, M., J.A. Nicklas, J. Sriram, and R.J. Albertini. 1990. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science (Wash. DC). 247:718-721.
11. Zhang, J., S. Markovic-Plese, B. Lacet, J. Raus, H.L. Weiner, and D.A. Hafler. 1994. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179:973-984.
12. Ben-Nun, A., A.C. Liblau, L. Cohen, D. Lehmann, E. Tournier-Lasserve, A. Rosenzweig, J.W. Zhang, J.C. Raus, and M.A. Bach. 1991. Restricted T-cell receptor Vβ gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals. Proc. Natl. Acad. Sci. USA. 88:2466-2470.
13. Wucherpfennig, K.W., J. Zhang, K. Witek, Y. Modabber, K. Ota and D.A. Hafler. 1994. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 152:5581-5592.
14. Wucherpfennig, K.W., A. Sette, S. Southwood, C. Oscroff, M. Matsui, J.L. Strominger, and D.A. Hafler. 1994. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179:279-290.
15. Wesselborg, S., O. Janssen, and D. Kabelitz. 1993. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood cells. J. Immunol. 150:4338-4345.
16. Pelfrey, C.M., L.R. Tranquill, S.A. Boehme, H.F. McFarland and M.J. Lenardo. 1995. Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals. J. Immunol. 154:6191-6202.
17. Alderson, M.R., T.W. Tough, T. Davis-Smith, S. Braddy, B. Falk, K.A. Schooley, R.G. Goodwin, C.A. Smith, F. Ramsdell, and D.H. Lynch. 1995. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181:71-77.
18. Critchfield, J.M., M.K. Racke, J.C. Zuniga-Pflucker, B. Cannella, C.S. Raine, J. Goverman, and M.J. Lenardo. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalitis. Science (Wash. DC). 263:1139-1143.
19. Griffith, T.S., T. Brunner, S.M. Fletcher, D.R. Green, and T.A. Ferguson. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science (Wash. DC). 270: 1189-1192.
20. Zheng, L., G. Fisher, R.E. Miller, J. Peschon, D.H. Lynch, and M.J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumor necrosis factor. Nature (Lond.). 377:348-351.
21. Ju, S.-T., D.J. Panka, H. Cui, R. Ettinger, E.-K. Maan, D.H. Sherr, B.Z. Stanger, and A. Marshak-Rothstein. 1995. Fas (CD95)/FasL interactions required for programmed cell death after T cell activation. Nature (Lond.). 373:444-448.
22. Brunner, T., R.J. Mogil, D. LaFace, N.J. Yoo, A. Mahboubi, F. Echeverri, S.J. Martin, W.R. Force, D.H. Lynch, and C.F. Ware. 1995. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature (Lond.). 373:441-444.
23. Dhein, J., H. Walczak, C. Baumler, K.M. Debatin, and P.H. Krammer. 1995. Autocrine T-cell suicide mediated by Apo-1/(Fas/CD95). Nature (Lond.). 373:438-441.
24. Lenardo, M.J. 1996. Fas and the art of lymphocyte maintenance. J. Exp. Med. 183:721-724.
25. Jacobson, S., S. Hisatoshi, D.E. McFarlin, A.S. Fauci and S. Koenig. 1990. Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-1 pX in patients with HTLV-I associated neurological disease. Nature (Lond.). 348:245-248.
26. Elovaara, I., S. Koenig, A.Y. Brewah, R.M. Woods, T. Lehky, and S. Jacobson. 1993. High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease. J. Exp. Med. 177:1567-1573.
27. Moss, P.A.H., S.L. Rowland-Jones, P.M. Frodsham, S. McAdam, P. Giangrande, A. McMicheal, and J.I. Bell. 1995. Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors. Proc. Natl. Acad. Sci. USA. 92:5773-5777.
28. Altman, J.D., P.A.H. Moss, P.J.R. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMicheal, and M.M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science (Wash. DC). 274:94-96.
29. Cochet, M., C. Pannetier, A. Regnault, S. Darche, C. Leclerc, and P. Kourilsky. 1992. Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. Eur. J. Immunol. 22:2639-2647.
30. McHeyzer-Williams, M.G., and M.M. Davis. 1995. Antigen-specific development of primary and memory T cells in vivo. Science (Wash. DC). 268:106-111.
31. Wucherpfennig, K.W., and J.L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:695-705.
32. Fukaura, H., S.C. Kent, M.J. Pietrusewicz, S.J. Khoury, H.L. Weiner and D.A. Hafler. 1996. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-β1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J. Clin. Invest. 98:70-77.