Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases?

Autoimmunity Reviews

Volumn 14, Issue 5, 2015, Pages 363-369

  D'Aurizio, Federica ^a   Villalta, Danilo ^a   Metus, Paolo ^a   Doretto, Paolo ^a   Tozzoli, Renato ^a  

^a S MARIA DEGLI ANGELI HOSPITAL   (Italy)

Author keywords

1,25 Dihydroxyvitamin D; Autoimmune diseases; Autoimmune thyroid diseases; Thyroid specific autoantibodies; Vitamin D deficiency; Vitamin D receptor polymorphism

Indexed keywords

1 ALPHA HYDROXYLASE; 25 HYDROXYLASE; CALCITRIOL; CYTOCHROME P450 27B1; CYTOCHROME P450 2R1; CYTOCHROME P450 ISOENZYME; GAMMA INTERFERON; OXYGENASE; RETINOID X RECEPTOR; THYROGLOBULIN; THYROID ANTIBODY; THYROID PEROXIDASE; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D BINDING PROTEIN; VITAMIN D RECEPTOR; VITAMIN;

ADAPTIVE IMMUNITY; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BLOOD SAMPLING; CASE CONTROL STUDY; DENDRITIC CELL; DNA POLYMORPHISM; GASTRITIS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; HYPOTHYROIDISM; IMMUNOPATHOGENESIS; INFLAMMATORY BOWEL DISEASE; INSULIN DEPENDENT DIABETES MELLITUS; MACROPHAGE; MULTIPLE SCLEROSIS; PATHOPHYSIOLOGY; PEDIGREE; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; SUBCLINICAL HYPOTHYROIDISM; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; T LYMPHOCYTE; THYROID FUNCTION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; ANIMAL; AUTOIMMUNE DISEASE; CROSS-SECTIONAL STUDY; IMMUNOLOGY; PHYSIOLOGY; THYROID DISEASE; VITAMIN D DEFICIENCY;

ANIMALS; AUTOIMMUNE DISEASES; CROSS-SECTIONAL STUDIES; HUMANS; THYROID DISEASES; VITAMIN D; VITAMIN D DEFICIENCY; VITAMINS;

EID: 84925174564     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2014.10.008     Document Type: Review

References (52)

1. Wacker M., Holick F.M. Sunlight and vitamin D. A global perspective for health. Dermatoendocrinology 2013, 5:51-108.
2. Zhang R., Naughton D.P. Vitamin D in health and disease: current perspectives. Nutr J 2010, 9:65.
3. Cappelletti P., Tozzoli R. Laboratory and hypercalcemia. Hypercalcemia, pathophysiology and treatment 2009, 45-61. Bentham Science, Sharjah. F. Lumachi, S.M.M. Basso (Eds.).
4. Holick M.F., Binkley N.C., Bischof-Ferrari H.A., Gordon C., Hanley D.A., Heaney R.P. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011, 96:1911-1930.
5. Grober U., Spitz J., Reichrath J., Kisters K., Holick M.F. Vitamin D: uptake 2013. From ricket prophylaxis to general preventive healthcare. Dermatoendocrinology 2013, 5:331-347.
6. Prietl B., Treiber G., Pieber T.R., Amrein K. Vitamin D and immune function. Nutrients 2013, 5:2502-2521.
7. Antico A., Tampoia M., Tozzoli R., Bizzaro N. Can supplementation with vitamin D reduce the risk or modify the course of autoimmune disease? A systematic review of the literature. Autoimmun Rev 2012, 12:127-136.
8. Arnson Y., Amital H., Shoenfeld Y. Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis 2007, 66:1137-1142.
9. Hewison M. An update on vitamin D and autoimmunity. Clin Endocrinol 2012, 76:315-325.
10. Carlberg C., Campbell M.J. Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor. Steroids 2013, 78:127-136.
11. Yang C.-Y., Leoung P.S.C., Adamopoulos I.E., Gershwin M.E. The implication of vitamin D and autoimmunity: a comprehensive review. Clin Rev Allergy Immunol 2013, 45:217-226.
12. Antico A., Tozzoli R., Giavarina D., Tonutti E., Bizzaro N. Hypovitaminosis D as predisposing factor for atrophic type A gastritis: a case-control study and review of the literature on the interaction of vitamin D with the immune system. Clin Rev Allergy Immunol 2012, 42:355-364.
13. Kriegel M.A., Manson J.E., Costenbader K.H. Does vitamin D affect risk of developing autoimmune disease?: A systematic review. Semin Arthritis Rheum 2011, 40:512-531.
14. Schwalfenberg G.K. Solar radiation and vitamin D: mitigating environmental factors in autoimmune disease. J Environ Public Health 2012, 2012:619381.
15. Agmon-Levin N., Theodor E., Segal R.M., Shoenfeld Y. Vitamin D in systemic and organ-specific autoimmune diseases. Clin Rev Allergy Immunol 2013, 45:256-266.
16. Caturegli P., De Remigis A., Rose N.R. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev 2014, 13:391-397.
17. Menconi F., Marcocci C., Marinò M. Diagnosis and classification of Graves' disease. Autoimmun Rev 2014, 13:398-402.
18. McLeod D.S.A., Cooper D.S. The incidence and prevalence of thyroid autoimmunity. Endocrine 2012, 42:252-265.
19. Effraimidis G., Wiersinga W.M. Autoimmune thyroid disease: old and new players. Eur J Endocrinol 2014, 170:R241-R252.
20. Hasham A., Tomer Y. Genetic and epigenetic mechanisms in thyroid autoimmunity. Immunol Res 2012, 54:204-213.
21. Tomer Y. Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics. Annu Rev Pathol 2014, 9:147-156.
22. Mazokopakis E.E., Kotsiris D.A. Hashimoto's autoimmune thyroiditis and vitamin D deficiency. Current aspects. Hell J Nucl Med 2014, 17:37-40.
23. Lacka K., Maciejewski A. Vitamin D in the pathogenesis of autoimmune thyroiditis. Pol Merkur Lekarski 2013, 34:281-285.
24. Muscogiuri G., Mitri J., Mathieu C., Badenhoop K., Tamer G., Oria F., et al. Vitamin D as a potential contributor in endocrine health and disease. Eur J Endocrinol 2014, 17:R101-R110.
25. Feng M., Li H., Chen S.F., Li W.F., Zhang F.B. Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Endocrine 2013, 43:318-326.
26. Lin W.Y., Wan L., Tsai C.H., Chen R.H., Lee C.C., Tsai F.J. Vitamin D gene polymorphisms are associated with risk of Hashimotos thyroiditis in Chinese patients in Taiwan. J Clin Lab Anal 2006, 20:109-112.
27. Stefanic M., Papic S., Suver M., Glavas-Obrovac L., Karner I. Association of vitamin D receptor gene 3'-variants with Hashimoto's thyroiditis in the Croatian population. Int J Immunogenet 2008, 35:125-131.
28. Yazici D., Yavuz D., Tarcin O., Sancak S., Deyneli O., Akalin S. Vitamin D receptor gene ApaI, TaqI, FokI and BsmI polymorphisms in a group of Turkish patients with Hashimoto's thyroiditis. Minerva Endocrinol 2013, 38:195-201.
29. Ban Y., Taniyama M., Ban Y. Vitamin D receptor gene polymorphisms is associated with Graves' disease in the Japanese population. J Clin Endocrinol Metab 2000, 85:4639-4643.
30. Collins J.E., Heward J.M., Nithiyananthan R., Nejentsev S., Todd J.A., Franklyn J.A., et al. Lack of association of the vitamin D receptor gene with Graves' disease in UK Caucasians. Clin Endocrinol (Oxf) 2004, 60:618-624.
31. Stefanic M., Karner I., Glavas-Obrovac L., Papic S., Vrdoliak D., Levak G., et al. Association of vitamin D receptor gene polymorphisms with susceptibility to Graves' disease in Eastern Croatian population: case-control study. Croat Med J 2005, 46:639-646.
32. Horst-Sikorska W., Ignaszak-Sczepaniak M., Marcinkowska M., Kaczmarek M., Stajgis M., Slomski R. Association analysis of vitamin D receptor gene polymorphisms with bone mineral density in young women with Graves' disease. Acta Biochim Pol 2008, 55:371-380.
33. Maalej A., Petit-Teixeira E., Chabchoub G., Hamad M.B., Rebai A., Farid N.R., et al. Lack of association of VDR gene polymorphisms with thyroid autoimmune disorders: familial and case/control studies. J Clin Immunol 2008, 28:21-25.
34. Inoue N., Watanabe M., Ishido N., Katsumata Y., Kagawa T., Hidaka Y., et al. The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases. Clin Exp Immunol 2014, 178:262-269.
35. Pani M.A., Regulla K., Segni M., Hofmann S., Hufner M., Pasquino A.M., et al. A polymorphism within the vitamin D-binding protein gene is associated with Graves' disease but not with Hashimoto's thyroiditis. J Clin Endocrinol Metab 2002, 87:2564-2567.
36. Kurylowicz A., Ramos-Lopez E., Bednarczuk T., Badenhoop K. Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study. Exp Clin Endocrinol Diabetes 2006, 114:329-335.
37. Pani M.A., Regulla K., Segni M., Krause M., Hofmann S., Hufner S., et al. Vitamin D 1a-hydroxylase (CYP1a) polymorphism in Graves' disease, Hashimoto's thyroiditis and type 1 diabetes mellitus. Eur J Endocrinol 2002, 146:777-781.
38. Chen W., Lin H., Wang M. Immune intervention effects on the induction of experimental autoimmune thyroiditis. J Huazhong Univ Sci Technol Med Sci 2002, 22:343-345.
39. Misharin A., Hewison M., Chen C.R., Lagishetty V., Aliesky H.A., Mizutori Y., et al. Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization. Endocrinology 2009, 150:1051-1060.
40. Orbach H., Shoenfeld Y. Vaccination, infection and autoimmunity: myth and reality VIAMR 2005-10-26-28, Beau-Rivage Palace Hotel, Lausanne, Switzerland. Autoimmun Rev 2007, 6:261-266.
41. Goswami R., Marwaha R.K., Gupta N., Tandon N., Sreenivas V., Tomar N., et al. Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey. Br J Nutr 2009, 102:382-386.
42. Kivity S., Agmon-Levin N., Zisappi M., Shapira Y., Nagy E.V., Danko K., et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol 2011, 8:243-247.
43. Tamer G., Arik S., Tamer I., Coksert D. Relative vitamin D insufficiency in Hashimoto's thyroiditis. Thyroid 2011, 21:891-896.
44. Bozkurt N.C., Karbek B., Ucan B., Sahin M., Cakal E., Ozbek M., et al. The association between severity of vitamin D deficiency and Hashimoto's thyroiditis. Endocr Pract 2013, 19:479-484.
45. Mackawy A.M., Al-Ayed B.M., Al-Rashidi B.M. Vitamin D deficiency and its association with thyroid disease. Int J Health Sci (Qassim) 2013, 7:267-275.
46. Shin D.Y., Kim K.J., Kim D., Hwang S., Lee E.J. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med J 2014, 55:476-481.
47. Choi Y.M., Kim W.G., Kim T.Y., Bae S.J., Kim H.K., Jang E.K., et al. Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women. Thyroid 2014, 24:655-661.
48. Camurdan O.M., Döğer E., Bideci A., Celik N., Cinaz P. Vitamin D status in children with Hashimoto thyroiditis. J Pediatr Endocrinol Metab 2012, 25:467-470.
49. Effraimidis G., Badenhoop K., Tijssen J.G.P., Wiersinga W.M. Vitamin D deficiency is not associated with early stages of thyroid autoimmunity. Eur J Endocrinol 2012, 167:43-48.
50. Yasuda T., Okamoto Y., Hamada N., Miyashita K., Takahara M., Sakamoto F., et al. Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves' disease. Endocrine 2012, 42:739-741.
51. Yasuda T., Okamoto Y., Hamada N., Miyashita K., Takahara M., Sakamoto F., et al. Serum vitamin D levels are decreased in patients without remission of Graves' disease. Endocrine 2013, 43:230-232.
52. Holmes E.W., Garbincius J., McKenna K.M. Analytical variability among methods for the measurement of 25-hydroxyvitamin D: still adding to the noise. Am J Clin Pathol 2013, 140:550-560.