European Charcot Foundation Lecture: The natural history of multiple sclerosis and gender

Journal of the Neurological Sciences

Volumn 286, Issue 1-2, 2009, Pages 1-5

  Sadovnick, A D ^a  

^a Faculty of Medicine   (Canada)

Author keywords

Epidemiology; Gender; Genetics; Multiple sclerosis; Sex ratio

Indexed keywords

C TYPE LECTIN DOMAIN FAMILY 16 MEMBER A; CHEMOKINE; IMMUNOGLOBULIN; INTERLEUKIN 2 RECEPTOR ALPHA; LECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; METHYLPREDNISOLONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHROMOSOME 16; EUROPE; FEMALE; GENE CLUSTER; GENETIC LINKAGE; GENETIC RISK; GENOME; GEOGRAPHIC DISTRIBUTION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICROSATELLITE MARKER; MULTIPLE SCLEROSIS; ONSET AGE; PREGNANCY; PRIORITY JOURNAL; PUERPERIUM; RECURRENCE RISK; RELAPSE; REPRODUCTION; RISK FACTOR; SEX DIFFERENCE; SEX RATIO; X CHROMOSOME;

AGE FACTORS; CHROMOSOMES, HUMAN, PAIR 16; FEMALE; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HLA-A ANTIGENS; HUMANS; MALE; MULTIPLE SCLEROSIS; SEX FACTORS;

EID: 70349783663     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2009.09.005     Document Type: Article

References (81)

1. Brain W.R. Critical review: disseminated sclerosis. Q J Med 23 (1930) 343-391
2. Talley C.L. The emergence of multiple sclerosis, 1870-1950: a puzzle of historical epidemiology. Perspect Biol Med 48 (2005) 383-395
3. Wechsler I.S. Statistics of multiple sclerosis. Association for Research in Nervous and Mental Diseases. Multiple sclerosis (1922), Paul B. Hoeber, New York 26-43
4. Fremont-Smith M. On certain diagnostic difficulties in private practice. Med Clin North Am 10 (1927) 1317-1327
5. Reese H.F. Diagnosis and treatment of multiple sclerosis. Postgrad. Med. 6 (1949) 127-131
6. Limburg C.C. The geographic distribution of multiple sclerosis and its estimated prevalence in the United States. Res Publ Assoc Res Nerv Ment Dis 28 (1950) 15-24
7. Buckley O.E. The status of multiple sclerosis. Ann NY Acad Sci 58 (1954) 541-720
8. Kurland L.T. Epidemiologic characteristics of multiple sclerosis. Am J Med 12 (1952) 561-571
9. Schumacher G.A. Multiple sclerosis. Postgrad Med 27 (1960) 569-580
10. Acheson E.D. Epidemiology of multiple sclerosis. Br Med Bull 33 (1977) 9-14
11. Confavreux C., Aimard G., and Devic M. Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients. Brain 103 (1980) 281-300
12. Steinman L. Autoimmune disease. Sci Am 269 (1993) 106-114
13. Ness J.N., Chabas D., Sadovnick A.D., Pohl D., Banwell B., and Weinstock-Guttman B. Clinical features of children and adolescents with multiple sclerosis. Neurology 68 Suppl 2 (2007) S37-S45
14. Banwell B., Kennedy J., Sadovnick A.D., Arnold D.L., Magalhaes S., Wambera K., et al. The incidence of acquired demyelination of the central nervous system in Canadian children. Neurology 72 (2009) 232-239
15. Sadovnick A.D., Risch N.J., and the Canadian Collaborative Study Group. Canadian Collaborative Project on Genetic Susceptibility to MS, phase 2: rationale and method. Can J Neurol Sci 25 (1998) 216-221
16. Willer C.J., Dyment D.A., Risch N.J., Sadovnick A.D., and Ebers G.C. Twin concordance and sibling recurrence rates in multiple sclerosis. PNAS 100 (2003) 12877-12882
17. Ebers G.C., Sadovnick A.D., Dyment D.A., Yee I.M.L., Willer C.J., and Risch N. Parent of origin effect in multiple sclerosis: observations in half siblings. Lancet 363 (2004) 1773-1774
18. Poser C.M., Paty D.W., Scheinberg L., McDonald W.I., Davis F.A., Ebers G.C., et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13 (1983) 227-231
19. Polman C.H., Reingold S.C., Edan G., Filippi M., Hartung H.P., Kappos L., et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol 58 (2005) 840-846
20. Larsen J.P., Kvaale G., Riise T., Nyland H., and Aarli J.A. An increase in the incidence of multiple sclerosis in western Norway. Acta Neurol Scand 70 (1984) 96-103
21. McLeod J.G., Hammond S.R., and Hallpike J.F. Epidemiology of multiple sclerosis in Australia. With NSW and SA survey results. Med J Aust 160 (1994) 117-122
22. Granieri E., Casetta I., Govoni V., Tola M.R., Marchi D., Murgia S.B., et al. The increasing incidence and prevalence of MS in a Sardinian province. Neurology 55 (2000) 842-848
23. Pugliatti M., Sotgiu S., Solinas G., Castiglia P., Pirastru M.I., Murgia B., et al. Multiple sclerosis epidemiology in Sardinia: evidence for a true increasing risk. Acta Neurol Scand 103 (2001) 20-26
24. Barnett M.H., Williams D.B., Day S., Macaskill P., and McLeod J.G. Progressive increase in incidence and prevalence of multiple sclerosis in Newcastle, Australia: a 35-year study. J Neurol Sci 213 (2003) 1-6
25. Phadke J.G., and Downie A.W. Epidemiology of multiple sclerosis in the north-east (Grampian region) of Scotland: an update. J Epidemiol Community Health 41 (1987) 5-13
26. Svenningsson A., Runmarker B., Lycke J., and Andersen O. Incidence of MS during two fifteen-year periods in the Gothenburg region of Sweden. Acta Neurol Scand 82 (1990) 161-168
27. Orton S.M., Herrrera B.M., Yee I.M., Valdar W., Ramagopalan S.V., Sadovnick A.D., et al. Sex ratio of multiple sclerosis in Canada: a longitudinal study. Lancet Neurology 5 (2006) 932-936
28. Alonso A., and Hernan M.A. Temporal trends in the incidence of multiple sclerosis: a systematic review. Neurol 71 (2008) 129-135
29. Grytten N., Glad S.B., Aarseth J.H., Nyland H., Midgard R., and Myhr K.M. A 50-year follow-up of the incidence of multiple sclerosis in Hordaland County, Norway. Neurol 66 (2006) 182-186
30. Paty D.W., Noseworthy J.H., and Ebers G.C. Diagnosis of multiple sclerosis. In: Paty D.W., and Ebers G.C. (Eds). Multiple sclerosis (1997), FA Davis Company, Philadelphia, PA 48-51
31. Fogdell A., Hillert J., Sachs C., and Olerup O. The multiple sclerosis- and narcolepsy-associated HLA class II haplotype includes the DRB5*0101 allele. Tissue Antigens 46 (1995) 333-336
32. Dyment D.A., Sadovnick A.D., Willer C.J., Armstrong H., Cader Z.M., Wiltshire S., et al. An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study Group. Hum Mol Genet 13 (2004) 1005-1015
33. Sawcer S., Ban M., Maranian M., Yeo T.W., Compston A., Kirby A., et al. International Multiple Sclerosis Genetics Consortium. A high-density screen for linkage in multiple sclerosis. Am J Hum Genet 77 (2005) 454-467
34. Lincoln M.R., Montpetit A., Cader M.Z., Saarela J., Dyment D.A., Tiislar M., et al. A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet 37 (2005) 1108-1112
35. Hermanowski J., Bouzigon E., Forabosco P., Ng M.Y., Fisher S.A., and Lewis C.M. Meta-analysis of genome-wide linkage studies for multiple sclerosis, using an extended GSMA method. Eur J Hum Genet 6 (2007) 703-710
36. Aulchenko Y.S., Hoppenbrouwers I.A., Ramagopalan S.V., Broer L., Jafari N., Hillert J., et al. Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nat Genet. 40 (2008) 1402-1403
37. Baranzini S.E., Wang J., Gibson R.A., Galwey N., Naegelin Y., Barkhof F., et al. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 18 (2009) 767-778
38. Herrera B.M., Ramagopalan S.V., Lincoln M.R., Orton S.M., Chao M.J., Sadovnick A.D., et al. Parent-of-origin effects in MS: observations from avuncular pairs. Neurology 71 (2008) 799-803
39. Ramagopalan S.V., Yee I.M., Dyment D.A., Orton S.M., Marrie R.A., Sadovnick A.D., et al. Parent-of-origin effect in multiple sclerosis. Observations from interracial matings. Neurology 73 8 (2009) 602-605
40. Hoppenbrouwers I.A., Liu F., Aulchenko Y.S., Ebers G.C., Oostra B.A., van Duijn C.M., et al. Maternal transmission of multiple sclerosis in a Dutch population. Arch Neurol 65 (2008) 345-348
41. Chao M.J., Barnardo M.C., Bu G.Z., Lincoln M.R., Ramagopalan S.V., Herrera B.M., et al. Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium. Hum Mol Genet 16 (2007) 1951-1958
42. Chao M.J., Ramagopalan S.V., Herrera B.M., Lincoln M.R., Dyment D.A., Sadovnick A.D., et al. Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex. Hum Mol Genet 18 (2009) 261-266
43. Chao M.J., Barnardo M.C., Lincoln M.R., Ramagopalan S.V., Herrera B.M., Dyment D.A., et al. HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility. PNAS 105 (2008) 13069-13074
44. Dyment D.A., Herrera B.M., Cader M.Z., Willer C.J., Lincoln M.R., Sadovnick A.D., et al. Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance. Hum Mol Genet 14 (2005) 2019-2026
45. Ramagopalan S.V., and Ebers G.C. Epistasis: multiple sclerosis and the major histocompatibility complex. Neurology 72 (2009) 566-567
46. Ramagopalan S.V., Maugeri N.J., Handunnetthi L., Lincoln M.R., Orton S.M., Dyment D.A., et al. Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet 5 (2009) e1000369
47. Ebers G.C., Yee I.M., Sadovnick A.D., Duquette P., and the Canadian Collaborative Study Group. Conjugal multiple sclerosis: population-based prevalence and recurrence risks in offspring. Ann Neurol 48 (2000) 927-931
48. Sadovnick A.D., Yee I.M.L., Ebers G.C., and the Canadian Collaborative Study Group. Recurrence risks to sibs of MS index cases: impact of consanguineous mating. Neurology 56 (2001) 784-785
49. Kantarci O.H., Barcellos L.F., Atkinson E.J., Ramsay P.P., Lincoln R., Achenbach S.J., et al. Men transmit MS more often to their children vs women: the Carter effect. Neurology 67 (2006) 305-310
50. Carter C.O. Inheritance of Congenital Pyloric Stenosis. Br Med Bull 17 (1961) 251-254
51. Herrera M., Ramagopalan S.V., Orton S., Chao M.J., Yee I.M., Sadovnick A.D., et al. Parental transmission of MS in a population-based Canadian cohort. Neurology 69 (2007) 1208-1212
52. Sawcer S., Jones H.B., Feakes R., Gray J., Smaldon N., Chataway J., et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet 13 (1996) 464-468
53. Ebers G.C., Kukay K., Bulman D.E., Sadovnick A.D., Rice G., Anderson C., et al. A full genome search in multiple sclerosis. Nat Genet 13 (1996) 472-476
54. Haines J.L., Ter-Minassian M., Bazyk A., Gusella J.F., Kim D.J., Terwedow H., et al. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group. Nat Genet 13 (1996) 469-471
55. Kuokkanen S., Gschwend M., Rioux J.D., Daly M.J., Terwilliger J.D., Tienari P.J., et al. Genomewide scan of multiple sclerosis in Finnish multiplex families. Am J Hum Genet 61 (1997) 1379-1387
56. Hafler D.A., Compston A., Sawcer S., Lander E.S., Daly M.J., De Jager P.L., et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 357 (2007) 851-862
57. Zhang Z., Duvefelt K., Svensson F., Masterman T., Jonasdottir G., Salter H., et al. Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis. Genes Immun 6 (2005) 145-152
58. Booth D.R., Arthur A.T., Teutsch S.M., Bye C., Rubio J., Armati P.J., et al. Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. J Mol Med 83 (2005) 822-830
59. Colhoun H.M., McKeigue P.M., and Davey Smith G. Problems of reporting genetic associations with complex outcomes. Lancet 361 (2003) 865-872
60. Herrera B.M., Cader M.Z., Dyment D.A., Bell J.T., DeLuca G.C., Willer C.J., et al. Multiple sclerosis susceptibility and the X chromosome. Mult Scler 13 (2007) 856-858
61. Jersild C., Svejgaard A., and Fog T. HL-A antigens and multiple sclerosis. Lancet 1 (1972) 1240-1241
62. Naito S., Namerow N., Mickey M.R., and Terasaki P.I. Multiple sclerosis: association with HL-A3. Tissue Antigens 2 (1972) 1-4
63. Compston D.A., Batchelor J.R., and McDonald W.I. B-lymphocyte alloantigens associated with multiple sclerosis. Lancet 2 (1976) 1261-1265
64. Jersild C., Fog T., Hansen G.S., Thomsen M., Svejgaard A., and Dupont B. Histocompatibility determinants in multiple sclerosis, with special reference to clinical course. Lancet 2 (1973) 1221-1225
65. Winchester R., Ebers G., Fu S.M., Espinosa L., Zabriskie J., and Kunkel H.G. B-cell alloantigen Ag 7a in multiple sclerosis. Lancet 2 (1975) 814
66. Terasaki P.I., Park M.S., Opelz G., and Ting A. Multiple sclerosis and high incidence of a B lymphocyte antigen. Science 193 (1976) 1245-1247
67. Fogdell A., Hillert J., Sachs C., and Olerup O. The multiple sclerosis- and narcolepsy-associated HLA class II haplotype includes the DRB5*0101 allele. Tissue Antigens 46 (1995) 333-336
68. Dyment D.A., Ebers G.C., and Sadovnick A.D. Genetics of multiple sclerosis. Lancet Neurol 3 (2004) 104-110
69. Van Lambalgen R., Sanders E.A., and D'Amaro J. Sex distribution, age of onset and HLA profiles in two types of multiple sclerosis. A role for sex hormones and microbial infections in the development of autoimmunity?. J Neurol Sci 76 (1986) 13-21
70. Hensiek A.E., Sawcer S.J., Feakes R., Deans J., Mander A., Akesson E., et al. HLA=DR15 is associated with female sex and younger age of onset at diagnosis in multiple sclerosis. J Neurol Neurosurg Psychiatry 72 (2002) 184-187
71. Chao M.J., Ramagopalan S.V., Herrera B.M., Lincoln M.R., Dyment D.A., Sadovnick A.D., et al. Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex. Hum Mol Genet 18 (2009) 261-266
72. Galimberti D., Scalabrini D., Fenoglio C., De Riz M., Comi C., Venturelli E., et al. Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to multiple sclerosis. J Neurol Sci 267 (2008) 86-90
73. Ramagopalan S.V., Valdar W., Dyment D.A., DeLuca G.C., Yee I.M., Giovannoni G., et al. Asssociation of Infectious Mononucleosis with multiple sclerosis: a population-based study. Neuroepidemiology, Neuroepidemiology 32 (2009) 257-262
74. Rapagopalan S.V., Valdar W., Dyment D.A., DeLuca G.C., Orton S.M., Yee I.M., et al. No effect of preterm birth on the risk of multiple sclerosis: a population based study. BMC Med Genet 8 (2008) 30
75. Ramagopalan S.V., Herrera B.M., Valder W., Dyment D.A., Orton S.M., Yee I.M., et al. No effect of birth weight on the risk of multiple sclerosis: a population based study. Neuroepidemiology 31 (2008) 181-184
76. Ramagopalan S.V., Dyment D.A., Herrera B.M., Criscuoli M., Yee I.M., Sadovnick A.D., et al. Clustering of autoimmune disease in families at high risk for multiple sclerosis?. Lancet Neurol 6 (2007) 206-207
77. Confavreux C., Hutchinson M., Hours M.M., Cortinovis-Tourniaire P., and Moreau T. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group. N Engl J Med 339 (1998) 285-291
78. Vukusic S., and Confavreux C. Pregnancy and multiple sclerosis: the children of PRIMS. Cl Clin Neurol Neurosurg 108 (2006) 266-270
79. Devonshire V., Duquette P., Dwosh E., Guimond C., and Sadovnick A.D. The immune system and hormones: review and relevance to pregnancy and contraception in women with MS. Int MS J 10 (2003) 44-50
80. Dwosh E., Guimond C.G., and Sadovnick A.D. Reproductive counselling for MS: rationale. Int MS J 10 (2003) 52-59
81. Dwosh E., Guimond C.G., and Sadovnick A.D. Reproductive counselling in MS: a guide for healthcare professionals. Int MS J 10 (2003) 67