Ligation of TLR9 induced on human IL-10-secreting Tregs by 1α,25-dihydroxyvitamin D3 abrogates regulatory function

Journal of Clinical Investigation

Volumn 119, Issue 2, 2009, Pages 387-398

  Urry, Zoë ^a   Xystrakis, Emmanuel ^a   Richards, David F ^a   McDonald, Joanne ^a   Sattar, Zahid ^a   Cousins, David J ^a   Corrigan, Christopher J ^a   Hickman, Emma ^b   Brown, Zarin ^b   Hawrylowicz, Catherine M ^a,c,d  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^d GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CPG OLIGODEOXYNUCLEOTIDE; DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 10; PREDNISOLONE; TOLL LIKE RECEPTOR 9; VITAMIN D; CALCITRIOL RECEPTOR; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; MESSENGER RNA; OLIGODEOXYRIBONUCLEOTIDE; TLR9 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ANTIGEN RECOGNITION; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; GENE INDUCTION; HUMAN; HUMAN CELL; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; ADULT; AGED; BIOSYNTHESIS; DRUG EFFECT; GENETICS; MALE; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGED; CALCITRIOL; DEXAMETHASONE; HUMANS; INTERLEUKIN-10; MALE; MIDDLE AGED; OLIGODEOXYRIBONUCLEOTIDES; RECEPTORS, CALCITRIOL; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTOR 9;

EID: 61749100051     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI32354     Document Type: Article

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