Defective activation-induced cell death in NOD T lymphocytes: 1,25-Dihydroxyvitamin D3 restores defect

Annals of the New York Academy of Sciences

Volumn 1005, Issue , 2003, Pages 176-177

  Decallonne, B ^a   Mathieu, C ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b LEGENDO   (Belgium)

Author keywords

1 ,25 dihydroxyvitamin D 3 1 ,25(OH)2D3 ; Activation induced cell death (AICD); Apoptosis resistance; T lymphocytes

Indexed keywords

CALCITRIOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL DEATH; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; FEMALE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; INSULITIS; MOUSE; NONHUMAN; SPLEEN LYMPHOCYTE; STRAIN DIFFERENCE; T LYMPHOCYTE ACTIVATION;

ANIMALIA;

EID: 1942539123     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1288.021     Document Type: Conference Paper

References (7)

1. COLUCCI, F., C. CILIO, K. LEIJON et al. 1996. Programmed cell death in the pathogenesis of murine IDDM: resistance to apoptosis induced in lymphocytes by cyclophosphamide. J. Autoimmun. 9: 271-276.
2. RADOSEVIC, K., K. CASTEELS, C. MATHIEU et al. 1999. Splenic dendritic cells from the non-obese diabetic mouse induce a prolonged proliferation of syngeneic T cells: a role for an impaired apoptosis of NOD T cells? J. Autoimmun. 13: 373-382.
3. 3 restores defect. Diabetes 47: 1033-1037.
4. VAN PARIJS, L. & A.K. ABBAS. 1998. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 280: 243-248.
5. MATHIEU, C., J. LAUREYS, H. SOBIS et al. 1992. 1,25-Dihydroxyvitamin D3 prevents insulitis in NOD mice. Diabetes 41: 1491-1495.
6. MATHIEU, C., M. WAER, J. LAUREYS et al. 1994. Prevention of autoimmune diabetes in NOD mice by 1,25-dihydroxyvitamin D3. Diabetologia 37: 552-558.
7. KISHIMOTO, H. & J. SPRENT. 2001. A defect in central tolerance in NOD mice. Nat. Immunol. 2: 1025-1031.