-
1
-
-
33845709704
-
The Type 1 Diabetes Genetics Consortium
-
Rich SS, Concannon P, Erlich H, Julier C, Morahan G, Nerup J, Pociot F, Todd JA. The Type 1 Diabetes Genetics Consortium. Ann N Y Acad Sci 2006;1079:1-8
-
(2006)
Ann N Y Acad Sci
, vol.1079
, pp. 1-8
-
-
Rich, S.S.1
Concannon, P.2
Erlich, H.3
Julier, C.4
Morahan, G.5
Nerup, J.6
Pociot, F.7
Todd, J.A.8
-
2
-
-
0038049458
-
Genetic epidemiology of type 1 diabetes
-
Hirschhorn JN. Genetic epidemiology of type 1 diabetes. Pediatr Diabetes 2003;4:87-100
-
(2003)
Pediatr Diabetes
, vol.4
, pp. 87-100
-
-
Hirschhorn, J.N.1
-
3
-
-
0345505676
-
Genetic liability of type 1 diabetes and the onset age among 22, 650 young Finnish twin pairs: A nationwide follow-up study
-
DOI 10.2337/diabetes.52.4.1052
-
Hyttinen V, Kaprio J, Kinnunen L, Koskenvuo M, Tuomilehto J. Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes 2003;52:1052-1055 (Pubitemid 36384278)
-
(2003)
Diabetes
, vol.52
, Issue.4
, pp. 1052-1055
-
-
Hyttinen, V.1
Kaprio, J.2
Kinnunen, L.3
Koskenvuo, M.4
Tuomilehto, J.5
-
4
-
-
25844441709
-
Type 1 diabetes: Evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families
-
Type 1 Diabetes Genetics Consortium
-
Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F, Todd JA, Rich SS, Type 1 Diabetes Genetics Consortium. Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes 2005;54:2995-3001
-
(2005)
Diabetes
, vol.54
, pp. 2995-3001
-
-
Concannon, P.1
Erlich, H.A.2
Julier, C.3
Morahan, G.4
Nerup, J.5
Pociot, F.6
Todd, J.A.7
Rich, S.S.8
-
5
-
-
0025094344
-
Mapping genes in diabetes. Genetic epidemiological perspective
-
Rich SS. Mapping genes in diabetes: genetic epidemiological perspective. Diabetes 1990;39:1315-1319 (Pubitemid 20372217)
-
(1990)
Diabetes
, vol.39
, Issue.11
, pp. 1315-1319
-
-
Rich, S.S.1
-
6
-
-
9444295337
-
Gene map of the extended human MHC
-
Horton R, Wilming L, Rand V, Lovering RC, Bruford EA, Khodiyar VK, Lush MJ, Povey S, Talbot CC, Jr, Wright MW, Wain HM, Trowsdale J, Ziegler A, Beck S. Gene map of the extended human MHC. Nat Rev Genet 2004;5:889-899
-
(2004)
Nat Rev Genet
, vol.5
, pp. 889-899
-
-
Horton, R.1
Wilming, L.2
Rand, V.3
Lovering, R.C.4
Bruford, E.A.5
Khodiyar, V.K.6
Lush, M.J.7
Povey, S.8
Talbot Jr., C.C.9
Wright, M.W.10
Wain, H.M.11
Trowsdale, J.12
Ziegler, A.13
Beck, S.14
-
7
-
-
0344721480
-
Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium
-
The MHC sequencing consortium
-
The MHC sequencing consortium. Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium. Nature 1999;401:921-923
-
(1999)
Nature
, vol.401
, pp. 921-923
-
-
-
8
-
-
34548783929
-
The Environmental Determinants of Diabetes in the Young (TEDDY) study: Study design
-
TEDDY Study Group
-
TEDDY Study Group. The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Pediatr Diabetes 2007;8:286-298
-
(2007)
Pediatr Diabetes
, vol.8
, pp. 286-298
-
-
-
9
-
-
0029616384
-
The Diabetes Prevention Trial-Type 1 diabetes (DPT-1): Implementation of screening and staging of relatives
-
DPT-1 Study Group
-
The Diabetes Prevention Trial-Type 1 diabetes (DPT-1): implementation of screening and staging of relatives. DPT-1 Study Group. Transplant Proc 1995;27:3377
-
(1995)
Transplant Proc
, vol.27
, pp. 3377
-
-
-
10
-
-
58549112413
-
Overview of the MHC fine mapping data
-
Brown WM, Pierce J, Hilner JE, Perdue LH, Lohman K, Li L, Venkatesh RB, Hunt S, Mychaleckyj JC, Deloukas P. Overview of the MHC fine mapping data. Diabetes Obes Metab 2009;11(Suppl. 1):2-7
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.SUPPL. 1
, pp. 2-7
-
-
Brown, W.M.1
Pierce, J.2
Hilner, J.E.3
Perdue, L.H.4
Lohman, K.5
Li, L.6
Venkatesh, R.B.7
Hunt, S.8
Mychaleckyj, J.C.9
Deloukas, P.10
-
11
-
-
42449144715
-
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the type 1 diabetes genetics consortium families
-
Type 1 Diabetes Genetics Consortium
-
Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, Mychaleckyj JC, Todd JA, Bonella P, Fear AL, Lavant E, Louey A, Moonsamy P, Type 1 Diabetes Genetics Consortium. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008;57:1084-1092
-
(2008)
Diabetes
, vol.57
, pp. 1084-1092
-
-
Erlich, H.1
Valdes, A.M.2
Noble, J.3
Carlson, J.A.4
Varney, M.5
Concannon, P.6
Mychaleckyj, J.C.7
Todd, J.A.8
Bonella, P.9
Fear, A.L.10
Lavant, E.11
Louey, A.12
Moonsamy, P.13
-
12
-
-
33749012255
-
Extreme genetic risk for type 1A diabetes
-
Aly TA, Ide A, Jahromi MM, Barker JM, Fernando MS, Babu SR, Yu L, Miao D, Erlich HA, Fain PR, Barriga KJ, Norris JM, Rewers MJ, Eisenbarth GS. Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci U S A 2006;103:14074-14079
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 14074-14079
-
-
Aly, T.A.1
Ide, A.2
Jahromi, M.M.3
Barker, J.M.4
Fernando, M.S.5
Babu, S.R.6
Yu, L.7
Miao, D.8
Erlich, H.A.9
Fain, P.R.10
Barriga, K.J.11
Norris, J.M.12
Rewers, M.J.13
Eisenbarth, G.S.14
-
13
-
-
58549090910
-
Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A
-
Howson JM, Walker NM, Clayton D, Todd JA. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab 2009;11(Suppl. 1):31-45
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.SUPPL. 1
, pp. 31-45
-
-
Howson, J.M.1
Walker, N.M.2
Clayton, D.3
Todd, J.A.4
-
14
-
-
36849012027
-
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
-
Wellcome Trust Case Control Consortium
-
Nejentsev S, Howson JM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA, Wellcome Trust Case Control Consortium. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007;450:887-892
-
(2007)
Nature
, vol.450
, pp. 887-892
-
-
Nejentsev, S.1
Howson, J.M.2
Walker, N.M.3
Szeszko, J.4
Field, S.F.5
Stevens, H.E.6
Reynolds, P.7
Hardy, M.8
King, E.9
Masters, J.10
Hulme, J.11
Maier, L.M.12
Smyth, D.13
Bailey, R.14
Cooper, J.D.15
Ribas, G.16
Campbell, R.D.17
Clayton, D.G.18
Todd, J.A.19
-
15
-
-
58549097473
-
MHC-environment interactions leading to type 1 diabetes: Feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth
-
Badenhoop K, Kahles H, Seidl C, Kordonouri O, Lopez ER, Walter M, Rosinger S, Ziegler A, Bohm BO. MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth. Diabetes Obes Metab 2009; 11(Suppl. 1):88-91
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.SUPPL. 1
, pp. 88-91
-
-
Badenhoop, K.1
Kahles, H.2
Seidl, C.3
Kordonouri, O.4
Lopez, E.R.5
Walter, M.6
Rosinger, S.7
Ziegler, A.8
Bohm, B.O.9
-
16
-
-
58549090344
-
Analysis of maternaloffspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes
-
Bronson PG, Ramsay PP, Thomson G, Barcellos LF. Analysis of maternaloffspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes. Diabetes Obes Metab 2009;11(Suppl. 1):74-83
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.SUPPL. 1
, pp. 74-83
-
-
Bronson, P.G.1
Ramsay, P.P.2
Thomson, G.3
Barcellos, L.F.4
-
17
-
-
58549102519
-
Mating in parents of type 1 diabetes families as a function of the HLA DR-DQ haplotype
-
Kahles H, Kordonouri O, Ramos Lopez E, Walter M, Rosinger S, Boehm BO, Badenhoop K, Seidl C, Ziegler A. Mating in parents of type 1 diabetes families as a function of the HLA DR-DQ haplotype. Diabetes Obes Metab 2009;11(Suppl. 1):84-87
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.SUPPL. 1
, pp. 84-87
-
-
Kahles, H.1
Kordonouri, O.2
Ramos Lopez, E.3
Walter, M.4
Rosinger, S.5
Boehm, B.O.6
Badenhoop, K.7
Seidl, C.8
Ziegler, A.9
-
18
-
-
58549091324
-
Association of MHC SNP genotype with susceptibility to type 1 diabetes: A modified survival approach
-
McKinnon E, Morahan G, Nolan D, James I. Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach. Diabetes Obes Metab 2009;11(Suppl. 1):92-100
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.SUPPL. 1
, pp. 92-100
-
-
McKinnon, E.1
Morahan, G.2
Nolan, D.3
James, I.4
-
19
-
-
0035380479
-
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes
-
Lee KH, Wucherpfennig KW, Wiley DC. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol 2001;2:501-507
-
(2001)
Nat Immunol
, vol.2
, pp. 501-507
-
-
Lee, K.H.1
Wucherpfennig, K.W.2
Wiley, D.C.3
-
20
-
-
55849116389
-
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
-
Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger WW, Unger W, Drijfhout JW, Ossendorp F, Roep BO, Peakman M. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest 2008;118:3390-3402
-
(2008)
J Clin Invest
, vol.118
, pp. 3390-3402
-
-
Skowera, A.1
Ellis, R.J.2
Varela-Calviño, R.3
Arif, S.4
Huang, G.C.5
Van-Krinks, C.6
Zaremba, A.7
Rackham, C.8
Allen, J.S.9
Tree, T.I.10
Zhao, M.11
Dayan, C.M.12
Sewell, A.K.13
Unger, W.W.14
Unger, W.15
Drijfhout, J.W.16
Ossendorp, F.17
Roep, B.O.18
Peakman, M.19
-
21
-
-
49649104814
-
The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes
-
Fourlanos S, Varney MD, Tait BD, Morahan G, Honeyman MC, Colman PG, Harrison LC. The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. Diabetes Care 2008;31:1546-1549
-
(2008)
Diabetes Care
, vol.31
, pp. 1546-1549
-
-
Fourlanos, S.1
Varney, M.D.2
Tait, B.D.3
Morahan, G.4
Honeyman, M.C.5
Colman, P.G.6
Harrison, L.C.7
-
22
-
-
7644230152
-
The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes
-
Gillespie KM, Bain SC, Barnett AH, Bingley PJ, Christie MR, Gill GV, Gale EA. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet 2004;364:1699-1700
-
(2004)
Lancet
, vol.364
, pp. 1699-1700
-
-
Gillespie, K.M.1
Bain, S.C.2
Barnett, A.H.3
Bingley, P.J.4
Christie, M.R.5
Gill, G.V.6
Gale, E.A.7
-
23
-
-
0038222568
-
Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes: Indication of an increased environmental pressure?
-
FinnDiane Study Group
-
Hermann R, Knip M, Veijola R, Simell O, Laine AP, Akerblom HK, Groop PH, Forsblom C, Pettersson-Fernholm K, Ilonen J, FinnDiane Study Group. Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes: indication of an increased environmental pressure? Diabetologia 2003;46:420-425
-
(2003)
Diabetologia
, vol.46
, pp. 420-425
-
-
Hermann, R.1
Knip, M.2
Veijola, R.3
Simell, O.4
Laine, A.P.5
Akerblom, H.K.6
Groop, P.H.7
Forsblom, C.8
Pettersson-Fernholm, K.9
Ilonen, J.10
-
24
-
-
0021343570
-
A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
-
Bell GI, Horita S, Karam JH. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 1984;33:176-183
-
(1984)
Diabetes
, vol.33
, pp. 176-183
-
-
Bell, G.I.1
Horita, S.2
Karam, J.H.3
-
25
-
-
18244421874
-
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
-
Pugliese A, Zeller M, Fernandez A, Jr, Zalcberg LJ, Bartlett RJ, Ricordi C, Pietropaolo M, Eisenbarth GS, Bennett ST, Patel DD. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 1997;15:293-297
-
(1997)
Nat Genet
, vol.15
, pp. 293-297
-
-
Pugliese, A.1
Zeller, M.2
Fernandez Jr., A.3
Zalcberg, L.J.4
Bartlett, R.J.5
Ricordi, C.6
Pietropaolo, M.7
Eisenbarth, G.S.8
Bennett, S.T.9
Patel, D.D.10
-
26
-
-
0031018819
-
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
-
Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, Wickramasinghe S, Colle E, Polychronakos C. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 1997;15:289-292
-
(1997)
Nat Genet
, vol.15
, pp. 289-292
-
-
Vafiadis, P.1
Bennett, S.T.2
Todd, J.A.3
Nadeau, J.4
Grabs, R.5
Goodyer, C.G.6
Wickramasinghe, S.7
Colle, E.8
Polychronakos, C.9
-
27
-
-
18744385526
-
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
-
DOI 10.1038/nature03625
-
Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005;435:224-228 (Pubitemid 40685950)
-
(2005)
Nature
, vol.435
, Issue.7039
, pp. 224-228
-
-
Kent, S.C.1
Chen, Y.2
Bregoli, L.3
Clemmings, S.M.4
Kenyon, N.S.5
Ricordi, C.6
Hering, B.J.7
Hafler, D.A.8
-
29
-
-
0034139830
-
CTLA-4 in autoimmune diseases: A general susceptibility gene to autoimmunity?
-
Kristiansen OP, Larsen ZM, Pociot F. CTLA-4 in autoimmune diseases: a general susceptibility gene to autoimmunity? Genes Immun 2000;1:170-184
-
(2000)
Genes Immun
, vol.1
, pp. 170-184
-
-
Kristiansen, O.P.1
Larsen, Z.M.2
Pociot, F.3
-
30
-
-
8944259914
-
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes
-
Belgian Diabetes Registry
-
Nisticò L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, Bosi E, Larrad MT, Rios MS, Chow CC, Cockram CS, Jacobs K, Mijovic C, Bain SC, Barnett AH, Vandewalle CL, Schuit F, Gorus FK, Tosi R, Pozzilli P, Todd JA. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Hum Mol Genet 1996;5:1075-1080
-
(1996)
Hum Mol Genet
, vol.5
, pp. 1075-1080
-
-
Nisticò, L.1
Buzzetti, R.2
Pritchard, L.E.3
Van Der Auwera, B.4
Giovannini, C.5
Bosi, E.6
Larrad, M.T.7
Rios, M.S.8
Chow, C.C.9
Cockram, C.S.10
Jacobs, K.11
Mijovic, C.12
Bain, S.C.13
Barnett, A.H.14
Vandewalle, C.L.15
Schuit, F.16
Gorus, F.K.17
Tosi, R.18
Pozzilli, P.19
Todd, J.A.20
more..
-
31
-
-
0037648405
-
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
-
DOI 10.1038/nature01621
-
Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003;423:506-511 (Pubitemid 36648570)
-
(2003)
Nature
, vol.423
, Issue.6939
, pp. 506-511
-
-
Ueda, H.1
Howson, J.M.M.2
Esposito, L.3
Heward, J.4
Snook, H.5
Chamberlain, G.6
Rainbow, D.B.7
Hunter, K.M.D.8
Smith, A.N.9
Di Genova, G.10
Herr, M.H.11
Dahlman, I.12
Payne, F.13
Smyth, D.14
Lowe, C.15
Twells, R.C.J.16
Howlett, S.17
Healy, B.18
Nutland, S.19
Rance, H.E.20
Everett, V.21
Smink, L.J.22
Lam, A.C.23
Cordell, H.J.24
Walker, N.M.25
Bordin, C.26
Hulme, J.27
Motzo, C.28
Cucca, F.29
Hess, J.F.30
Metzker, M.L.31
Rogers, J.32
Gregory, S.33
Allahabadia, A.34
Nithiyananthan, R.35
Tuomilehto-Wolf, E.36
Tuomilehto, J.37
Bingley, P.38
Gillespie, K.M.39
Undlien, D.E.40
Ronningen, K.S.41
Guja, C.42
Ionescu-Tirgoviste, C.43
Savage, D.A.44
Maxwell, A.P.45
Carson, D.J.46
Patterson, C.C.47
Franklyn, J.A.48
Clayton, D.G.49
Peterson, L.B.50
Wicker, L.S.51
Todd, J.A.52
Gough, S.C.L.53
more..
-
32
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008;322:271-275
-
(2008)
Science
, vol.322
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
Yamaguchi, T.4
Miyara, M.5
Fehervari, Z.6
Nomura, T.7
Sakaguchi, S.8
-
33
-
-
40049109288
-
Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes
-
Hunter K, Rainbow D, Plagnol V, Todd JA, Peterson LB, Wicker LS. Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes. J Immunol 2007;179:8341-8349
-
(2007)
J Immunol
, vol.179
, pp. 8341-8349
-
-
Hunter, K.1
Rainbow, D.2
Plagnol, V.3
Todd, J.A.4
Peterson, L.B.5
Wicker, L.S.6
-
34
-
-
12144291502
-
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
-
Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 2004;36:337-338
-
(2004)
Nat Genet
, vol.36
, pp. 337-338
-
-
Bottini, N.1
Musumeci, L.2
Alonso, A.3
Rahmouni, S.4
Nika, K.5
Rostamkhani, M.6
MacMurray, J.7
Meloni, G.F.8
Lucarelli, P.9
Pellecchia, M.10
Eisenbarth, G.S.11
Comings, D.12
Mustelin, T.13
-
35
-
-
3242713277
-
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
-
Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, Ardlie KG, Huang Q, Smith AM, Spoerke JM, Conn MT, Chang M, Chang SY, Saiki RK, Catanese JJ, Leong DU, Garcia VE, McAllister LB, Jeffery DA, Lee AT, Batliwalla F, Remmers E, Criswell LA, Seldin MF, Kastner DL, Amos CI, Sninsky JJ, Gregersen PK. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 2004;75:330-337
-
(2004)
Am J Hum Genet
, vol.75
, pp. 330-337
-
-
Begovich, A.B.1
Carlton, V.E.2
Honigberg, L.A.3
Schrodi, S.J.4
Chokkalingam, A.P.5
Alexander, H.C.6
Ardlie, K.G.7
Huang, Q.8
Smith, A.M.9
Spoerke, J.M.10
Conn, M.T.11
Chang, M.12
Chang, S.Y.13
Saiki, R.K.14
Catanese, J.J.15
Leong, D.U.16
Garcia, V.E.17
McAllister, L.B.18
Jeffery, D.A.19
Lee, A.T.20
Batliwalla, F.21
Remmers, E.22
Criswell, L.A.23
Seldin, M.F.24
Kastner, D.L.25
Amos, C.I.26
Sninsky, J.J.27
Gregersen, P.K.28
more..
-
36
-
-
20244373351
-
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
-
Vella A, Cooper JD, Lowe CE, Walker N, Nutland S, Widmer B, Jones R, Ring SM, McArdle W, Pembrey ME, Strachan DP, Dunger DB, Twells RC, Clayton DG, Todd JA. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet 2005;76:773-779
-
(2005)
Am J Hum Genet
, vol.76
, pp. 773-779
-
-
Vella, A.1
Cooper, J.D.2
Lowe, C.E.3
Walker, N.4
Nutland, S.5
Widmer, B.6
Jones, R.7
Ring, S.M.8
McArdle, W.9
Pembrey, M.E.10
Strachan, D.P.11
Dunger, D.B.12
Twells, R.C.13
Clayton, D.G.14
Todd, J.A.15
-
37
-
-
70049095101
-
How do regulatory T cells work?
-
Corthay A. How do regulatory T cells work? Scand J Immunol 2009;70: 326-336
-
(2009)
Scand J Immunol
, vol.70
, pp. 326-336
-
-
Corthay, A.1
-
38
-
-
4544241811
-
Tolerance, not immunity, crucially depends on IL-2
-
Malek TR, Bayer AL. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 2004;4:665-674
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 665-674
-
-
Malek, T.R.1
Bayer, A.L.2
-
39
-
-
0033682056
-
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
-
Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000;12:431-440
-
(2000)
Immunity
, vol.12
, pp. 431-440
-
-
Salomon, B.1
Lenschow, D.J.2
Rhee, L.3
Ashourian, N.4
Singh, B.5
Sharpe, A.6
Bluestone, J.A.7
-
40
-
-
1842732224
-
+ Regulatory T Cells in Patients with Multiple Sclerosis
-
DOI 10.1084/jem.20031579
-
Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004;199:971-979 (Pubitemid 38481088)
-
(2004)
Journal of Experimental Medicine
, vol.199
, Issue.7
, pp. 971-979
-
-
Viglietta, V.1
Baecher-Allan, C.2
Weiner, H.L.3
Hafler, D.A.4
-
41
-
-
58949100205
-
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
-
Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, De Jager PL, Wicker LS, Todd JA, Hafler DA. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet 2009;5:e1000322
-
(2009)
PLoS Genet
, vol.5
-
-
Maier, L.M.1
Lowe, C.E.2
Cooper, J.3
Downes, K.4
Anderson, D.E.5
Severson, C.6
Clark, P.M.7
Healy, B.8
Walker, N.9
Aubin, C.10
Oksenberg, J.R.11
Hauser, S.L.12
Compston, A.13
Sawcer, S.14
De Jager, P.L.15
Wicker, L.S.16
Todd, J.A.17
Hafler, D.A.18
-
42
-
-
69349102624
-
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
-
Dendrou CA, Plagnol V, Fung E, Yang JH, Downes K, Cooper JD, Nutland S, Coleman G, Himsworth M, Hardy M, Burren O, Healy B, Walker NM, Koch K, Ouwehand WH, Bradley JR, Wareham NJ, Todd JA, Wicker LS. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet 2009;41:1011-1015
-
(2009)
Nat Genet
, vol.41
, pp. 1011-1015
-
-
Dendrou, C.A.1
Plagnol, V.2
Fung, E.3
Yang, J.H.4
Downes, K.5
Cooper, J.D.6
Nutland, S.7
Coleman, G.8
Himsworth, M.9
Hardy, M.10
Burren, O.11
Healy, B.12
Walker, N.M.13
Koch, K.14
Ouwehand, W.H.15
Bradley, J.R.16
Wareham, N.J.17
Todd, J.A.18
Wicker, L.S.19
-
43
-
-
33847246293
-
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
-
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 2007;39:329-337
-
(2007)
Nat Genet
, vol.39
, pp. 329-337
-
-
Yamanouchi, J.1
Rainbow, D.2
Serra, P.3
Howlett, S.4
Hunter, K.5
Garner, V.E.6
Gonzalez-Munoz, A.7
Clark, J.8
Veijola, R.9
Cubbon, R.10
Chen, S.L.11
Rosa, R.12
Cumiskey, A.M.13
Serreze, D.V.14
Gregory, S.15
Rogers, J.16
Lyons, P.A.17
Healy, B.18
Smink, L.J.19
Todd, J.A.20
Peterson, L.B.21
Wicker, L.S.22
Santamaria, P.23
more..
-
44
-
-
0036688819
-
Genetics of type 1 diabetes mellitus
-
Pociot F, McDermott MF. Genetics of type 1 diabetes mellitus. Genes Immun 2002;3:235-249
-
(2002)
Genes Immun
, vol.3
, pp. 235-249
-
-
Pociot, F.1
McDermott, M.F.2
-
45
-
-
75649122271
-
Analysis of 55 autoimmune disease and type II diabetes loci: Further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1
-
Type I Diabetes Genetics Consortium
-
Cooper JD, Walker NM, Healy BC, Smyth DJ, Downes K, Todd JA, Type I Diabetes Genetics Consortium. Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1. Genes Immun 2009;10:S95-S120
-
(2009)
Genes Immun
, vol.10
-
-
Cooper, J.D.1
Walker, N.M.2
Healy, B.C.3
Smyth, D.J.4
Downes, K.5
Todd, J.A.6
-
46
-
-
75649103221
-
Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families
-
Type I Diabetes Genetics Consortium
-
Cooper JD, Walker NM, Smyth DJ, Downes K, Healy BC, Todd JA, Type I Diabetes Genetics Consortium. Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families. Genes Immun 2009;10:S85-S94
-
(2009)
Genes Immun
, vol.10
-
-
Cooper, J.D.1
Walker, N.M.2
Smyth, D.J.3
Downes, K.4
Healy, B.C.5
Todd, J.A.6
-
47
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009;41:703-707
-
(2009)
Nat Genet
, vol.41
, pp. 703-707
-
-
Barrett, J.C.1
Clayton, D.G.2
Concannon, P.3
Akolkar, B.4
Cooper, J.D.5
Erlich, H.A.6
Julier, C.7
Morahan, G.8
Nerup, J.9
Nierras, C.10
Plagnol, V.11
Pociot, F.12
Schuilenburg, H.13
Smyth, D.J.14
Stevens, H.15
Todd, J.A.16
Walker, N.M.17
Rich, S.S.18
-
48
-
-
56749183605
-
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
-
Cooper JD, Smyth DJ, Smiles AM, Plagnol V, Walker NM, Allen JE, Downes K, Barrett JC, Healy BC, Mychaleckyj JC, Warram JH, Todd JA. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet 2008;40:1399-1401
-
(2008)
Nat Genet
, vol.40
, pp. 1399-1401
-
-
Cooper, J.D.1
Smyth, D.J.2
Smiles, A.M.3
Plagnol, V.4
Walker, N.M.5
Allen, J.E.6
Downes, K.7
Barrett, J.C.8
Healy, B.C.9
Mychaleckyj, J.C.10
Warram, J.H.11
Todd, J.A.12
-
49
-
-
75749086085
-
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
-
DIAGRAM Consortium, GIANT Consortium, Global BPgen Consortium, on behalf of Procardis Consortium, MAGIC investigators
-
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, Thorleifsson G, Steinthorsdottir V, Henneman P, Grallert H, Dehghan A, Hottenga JJ, Franklin CS, Navarro P, Song K, Goel A, Perry JR, Egan JM, Lajunen T, Grarup N, Sparsø T, Doney A, Voight BF, Stringham HM, Li M, Kanoni S, Shrader P, Cavalcanti-Proença C, Kumari M, Qi L, Timpson NJ, Gieger C, Zabena C, Rocheleau G, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Payne F, Roccasecca RM, Pattou F, Sethupathy P, Ardlie K, Ariyurek Y, Balkau B, Barter P, Beilby JP, Ben-Shlomo Y, Benediktsson R, Bennett AJ, Bergmann S, Bochud M, Boerwinkle E, Bonnefond A, Bonnycastle LL, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Charpentier G, Chen YD, Chines P, Clarke R, Coin LJ, Cooper MN, Cornelis M, Crawford G, Crisponi L, Day IN, de Geus EJ, Delplanque J, Dina C, Erdos MR, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Fox CS, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Groves CJ, Grundy S, Gwilliam R, Gyllensten U, Hadjadj S, Hallmans G, Hammond N, Han X, Hartikainen AL, Hassanali N, Hayward C, Heath SC, Hercberg S, Herder C, Hicks AA, Hillman DR, Hingorani AD, Hofman A, Hui J, Hung J, Isomaa B, Johnson PR, Jørgensen T, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Lyssenko V, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McCulloch LJ, Mc- Pherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Morken MA, Mukherjee S, Naitza S, Narisu N, Neville MJ, Oostra BA, Orrù M, Pakyz R, Palmer CN, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AF, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rathmann W, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Roden M, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Scott LJ, Seedorf U, Sharp SJ, Shields B, Sigurethsson G, Sijbrands EJ, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tanaka T, Thorand B, Tichet J, Tönjes A, Tuomi T, Uitterlinden AG, van Dijk KW, van Hoek M, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Walters GB, Ward KL, Watkins H, Weedon MN, Wild SH, Willemsen G, Witteman JC, Yarnell JW, Zeggini E, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, DIAGRAM Consortium, GIANT Consortium, Global BPgen Consortium, Borecki IB, Loos RJ, Meneton P, Magnusson PK, Nathan DM, Williams GH, Hattersley AT, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Morris AD, Lind L, Palmer LJ, Hu FB, Franks PW, Ebrahim S, Marmot M, Kao WH, Pankow JS, Sampson MJ, Kuusisto J, Laakso M, Hansen T, Pedersen O, Pramstaller PP, Wichmann HE, Illig T, Rudan I, Wright AF, Stumvoll M, Campbell H, Wilson JF, Anders Hamsten on behalf of Procardis Consortium, MAGIC investigators, Bergman RN, Buchanan TA, Collins FS, Mohlke KL, Tuomilehto J, Valle TT, Altshuler D, Rotter JI, Siscovick DS, Penninx BW, Boomsma DI, Deloukas P, Spector TD, Frayling TM, Ferrucci L, Kong A, Thorsteinsdottir U, Stefansson K, van Duijn CM, Aulchenko YS, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin MR, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Abecasis GR, Wareham NJ, Sladek R, Froguel P, Watanabe RM, Meigs JB, Groop L, Boehnke M, McCarthy MI, Florez JC, Barroso I. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010;42:105-116
-
(2010)
Nat Genet
, vol.42
, pp. 105-116
-
-
Dupuis, J.1
Langenberg, C.2
Prokopenko, I.3
Saxena, R.4
Soranzo, N.5
Jackson, A.U.6
Wheeler, E.7
Glazer, N.L.8
Bouatia-Naji, N.9
Gloyn, A.L.10
Lindgren, C.M.11
Mägi, R.12
Morris, A.P.13
Randall, J.14
Johnson, T.15
Elliott, P.16
Rybin, D.17
Thorleifsson, G.18
Steinthorsdottir, V.19
Henneman, P.20
Grallert, H.21
Dehghan, A.22
Hottenga, J.J.23
Franklin, C.S.24
Navarro, P.25
Song, K.26
Goel, A.27
Perry, J.R.28
Egan, J.M.29
Lajunen, T.30
Grarup, N.31
Sparsø, T.32
Doney, A.33
Voight, B.F.34
Stringham, H.M.35
Li, M.36
Kanoni, S.37
Shrader, P.38
Cavalcanti-Proença, C.39
Kumari, M.40
Qi, L.41
Timpson, N.J.42
Gieger, C.43
Zabena, C.44
Rocheleau, G.45
Ingelsson, E.46
An, P.47
O'Connell, J.48
Luan, J.49
Elliott, A.50
McCarroll, S.A.51
Payne, F.52
Roccasecca, R.M.53
Pattou, F.54
Sethupathy, P.55
Ardlie, K.56
Ariyurek, Y.57
Balkau, B.58
Barter, P.59
Beilby, J.P.60
Ben-Shlomo, Y.61
Benediktsson, R.62
Bennett, A.J.63
Bergmann, S.64
Bochud, M.65
Boerwinkle, E.66
Bonnefond, A.67
Bonnycastle, L.L.68
Borch-Johnsen, K.69
Böttcher, Y.70
Brunner, E.71
Bumpstead, S.J.72
Charpentier, G.73
Chen, Y.D.74
Chines, P.75
Clarke, R.76
Coin, L.J.77
Cooper, M.N.78
Cornelis, M.79
Crawford, G.80
Crisponi, L.81
Day, I.N.82
De Geus, E.J.83
Delplanque, J.84
Dina, C.85
Erdos, M.R.86
Fedson, A.C.87
Fischer-Rosinsky, A.88
Forouhi, N.G.89
Fox, C.S.90
Frants, R.91
Franzosi, M.G.92
Galan, P.93
Goodarzi, M.O.94
Graessler, J.95
Groves, C.J.96
Grundy, S.97
Gwilliam, R.98
Gyllensten, U.99
more..
-
50
-
-
69949171150
-
No association of multiple type 2 diabetes loci with type 1 diabetes
-
Raj SM, Howson JM, Walker NM, Cooper JD, Smyth DJ, Field SF, Stevens HE, Todd JA. No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia 2009;52:2109-2116
-
(2009)
Diabetologia
, vol.52
, pp. 2109-2116
-
-
Raj, S.M.1
Howson, J.M.2
Walker, N.M.3
Cooper, J.D.4
Smyth, D.J.5
Field, S.F.6
Stevens, H.E.7
Todd, J.A.8
-
51
-
-
0034821661
-
Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families
-
DOI 10.1086/323501
-
Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, Spielman RS, Todd JA, Concannon P. Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families. Am J Hum Genet 2001;69:820-830 (Pubitemid 32868526)
-
(2001)
American Journal of Human Genetics
, vol.69
, Issue.4
, pp. 820-830
-
-
Cox, N.J.1
Wapelhorst, B.2
Morrison, V.A.3
Johnson, L.4
Pinchuk, L.5
Spielman, R.S.6
Todd, J.A.7
Concannon, P.8
-
52
-
-
0027933734
-
A genome-wide search for human type 1 diabetes susceptibility genes
-
Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SC, Jenkins SC, Palmer SM. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994;371:130-136
-
(1994)
Nature
, vol.371
, pp. 130-136
-
-
Davies, J.L.1
Kawaguchi, Y.2
Bennett, S.T.3
Copeman, J.B.4
Cordell, H.J.5
Pritchard, L.E.6
Reed, P.W.7
Gough, S.C.8
Jenkins, S.C.9
Palmer, S.M.10
-
53
-
-
0028070552
-
Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q
-
Hashimoto L, Habita C, Beressi JP, Delepine M, Besse C, Cambon-Thomsen A, Deschamps I, Rotter JI, Djoulah S, James MR. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 1994;371:161-164
-
(1994)
Nature
, vol.371
, pp. 161-164
-
-
Hashimoto, L.1
Habita, C.2
Beressi, J.P.3
Delepine, M.4
Besse, C.5
Cambon-Thomsen, A.6
Deschamps, I.7
Rotter, J.I.8
Djoulah, S.9
James, M.R.10
-
54
-
-
17144452354
-
A search for type 1 diabetes susceptibility genes in families from the United Kingdom
-
Mein CA, Esposito L, Dunn MG, Johnson GC, Timms AE, Goy JV, Smith AN, Sebag-Montefiore L, Merriman ME, Wilson AJ, Pritchard LE, Cucca F, Barnett AH, Bain SC, Todd JA. A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Nat Genet 1998;19:297-300
-
(1998)
Nat Genet
, vol.19
, pp. 297-300
-
-
Mein, C.A.1
Esposito, L.2
Dunn, M.G.3
Johnson, G.C.4
Timms, A.E.5
Goy, J.V.6
Smith, A.N.7
Sebag-Montefiore, L.8
Merriman, M.E.9
Wilson, A.J.10
Pritchard, L.E.11
Cucca, F.12
Barnett, A.H.13
Bain, S.C.14
Todd, J.A.15
-
55
-
-
0035212224
-
A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: Identification of new loci with evidence of interactions
-
European Consortium for IDDM Studies
-
Nerup J, Pociot F, European Consortium for IDDM Studies. A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions. Am J Hum Genet 2001;69:1301-1313
-
(2001)
Am J Hum Genet
, vol.69
, pp. 1301-1313
-
-
Nerup, J.1
Pociot, F.2
-
56
-
-
64649096894
-
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium
-
Type 1 Diabetes Genetics Consortium
-
Concannon P, Chen WM, Julier C, Morahan G, Akolkar B, Erlich HA, Hilner JE, Nerup J, Nierras C, Pociot F, Todd JA, Rich SS, Type 1 Diabetes Genetics Consortium. Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes 2009;58:1018-1022
-
(2009)
Diabetes
, vol.58
, pp. 1018-1022
-
-
Concannon, P.1
Chen, W.M.2
Julier, C.3
Morahan, G.4
Akolkar, B.5
Erlich, H.A.6
Hilner, J.E.7
Nerup, J.8
Nierras, C.9
Pociot, F.10
Todd, J.A.11
Rich, S.S.12
-
57
-
-
58149090841
-
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3
-
Type 1 Diabetes Genetics Consortium
-
Concannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, Bergholdt R, Akolkar B, Erlich HA, Hilner JE, Julier C, Morahan G, Nerup J, Nierras CR, Chen WM, Rich SS, Type 1 Diabetes Genetics Consortium. A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes 2008;57:2858-2861
-
(2008)
Diabetes
, vol.57
, pp. 2858-2861
-
-
Concannon, P.1
Onengut-Gumuscu, S.2
Todd, J.A.3
Smyth, D.J.4
Pociot, F.5
Bergholdt, R.6
Akolkar, B.7
Erlich, H.A.8
Hilner, J.E.9
Julier, C.10
Morahan, G.11
Nerup, J.12
Nierras, C.R.13
Chen, W.M.14
Rich, S.S.15
-
58
-
-
65249131713
-
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
-
Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009;324:387-389
-
(2009)
Science
, vol.324
, pp. 387-389
-
-
Nejentsev, S.1
Walker, N.2
Riches, D.3
Egholm, M.4
Todd, J.A.5
-
59
-
-
34347335667
-
Guilt beyond a reasonable doubt
-
Altshuler D, Daly M. Guilt beyond a reasonable doubt. Nat Genet 2007;39:813-815
-
(2007)
Nat Genet
, vol.39
, pp. 813-815
-
-
Altshuler, D.1
Daly, M.2
-
60
-
-
65249164859
-
Validating, augmenting and refining genome-wide association signals
-
Ioannidis JP, Thomas G, Daly MJ. Validating, augmenting and refining genome-wide association signals. Nat Rev Genet 2009;10:318-329
-
(2009)
Nat Rev Genet
, vol.10
, pp. 318-329
-
-
Ioannidis, J.P.1
Thomas, G.2
Daly, M.J.3
-
61
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature 2009;461:747-753
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
Collins, F.S.2
Cox, N.J.3
Goldstein, D.B.4
Hindorff, L.A.5
Hunter, D.J.6
McCarthy, M.I.7
Ramos, E.M.8
Cardon, L.R.9
Chakravarti, A.10
Cho, J.H.11
Guttmacher, A.E.12
Kong, A.13
Kruglyak, L.14
Mardis, E.15
Rotimi, C.N.16
Slatkin, M.17
Valle, D.18
Whittemore, A.S.19
Boehnke, M.20
Clark, A.G.21
Eichler, E.E.22
Gibson, G.23
Haines, J.L.24
Mackay, T.F.25
McCarroll, S.A.26
Visscher, P.M.27
more..
-
62
-
-
42349112088
-
Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
-
McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008;9:356-369
-
(2008)
Nat Rev Genet
, vol.9
, pp. 356-369
-
-
McCarthy, M.I.1
Abecasis, G.R.2
Cardon, L.R.3
Goldstein, D.B.4
Little, J.5
Ioannidis, J.P.6
Hirschhorn, J.N.7
-
63
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-678
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
64
-
-
75649147430
-
Evidence for association of the TCF7 locus with type I diabetes
-
Type I Diabetes Genetics Consortium
-
Erlich HA, Valdes AM, Julier C, Mirel D, Noble JA, Type I Diabetes Genetics Consortium. Evidence for association of the TCF7 locus with type I diabetes. Genes Immun 2009;10:S54-S59
-
(2009)
Genes Immun
, vol.10
-
-
Erlich, H.A.1
Valdes, A.M.2
Julier, C.3
Mirel, D.4
Noble, J.A.5
-
65
-
-
68249108329
-
Prediction and interaction in complex disease genetics: Experience in type 1 diabetes
-
Clayton DG. Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet 2009;5:e1000540
-
(2009)
PLoS Genet
, vol.5
-
-
Clayton, D.G.1
-
66
-
-
29444452159
-
Defining a genomic radius for long-range enhancer action: Duplicated conserved non-coding elements hold the key
-
Vavouri T, McEwen GK, Woolfe A, Gilks WR, Elgar G. Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key. Trends Genet 2006;22:5-10
-
(2006)
Trends Genet
, vol.22
, pp. 5-10
-
-
Vavouri, T.1
McEwen, G.K.2
Woolfe, A.3
Gilks, W.R.4
Elgar, G.5
-
67
-
-
77950461601
-
Origins and functional impact of copy number variation in the human genome
-
Wellcome Trust Case Control Consortium
-
Conrad DF, Pinto D, Redon R, Feuk L, Gokcumen O, Zhang Y, Aerts J, Andrews TD, Barnes C, Campbell P, Fitzgerald T, Hu M, Ihm CH, Kristiansson K, Macarthur DG, Macdonald JR, Onyiah I, Pang AW, Robson S, Stirrups K, Valsesia A, Walter K, Wei J, Wellcome Trust Case Control Consortium, Tyler-Smith C, Carter NP, Lee C, Scherer SW, Hurles ME. Origins and functional impact of copy number variation in the human genome. Nature 2010;464:704-712
-
(2010)
Nature
, vol.464
, pp. 704-712
-
-
Conrad, D.F.1
Pinto, D.2
Redon, R.3
Feuk, L.4
Gokcumen, O.5
Zhang, Y.6
Aerts, J.7
Andrews, T.D.8
Barnes, C.9
Campbell, P.10
Fitzgerald, T.11
Hu, M.12
Ihm, C.H.13
Kristiansson, K.14
Macarthur, D.G.15
Macdonald, J.R.16
Onyiah, I.17
Pang, A.W.18
Robson, S.19
Stirrups, K.20
Valsesia, A.21
Walter, K.22
Wei, J.23
Tyler-Smith, C.24
Carter, N.P.25
Lee, C.26
Scherer, S.W.27
Hurles, M.E.28
more..
-
68
-
-
70350455320
-
Experimental aspects of copy number variant assays at CCL3L1
-
Field SF, Howson JM, Maier LM, Walker S, Walker NM, Smyth DJ, Armour JA, Clayton DG, Todd JA. Experimental aspects of copy number variant assays at CCL3L1. Nat Med 2009;15:1115-1117
-
(2009)
Nat Med
, vol.15
, pp. 1115-1117
-
-
Field, S.F.1
Howson, J.M.2
Maier, L.M.3
Walker, S.4
Walker, N.M.5
Smyth, D.J.6
Armour, J.A.7
Clayton, D.G.8
Todd, J.A.9
-
69
-
-
65949107547
-
Common genetic variation and human traits
-
Goldstein DB. Common genetic variation and human traits. N Engl J Med 2009;360:1696-1698
-
(2009)
N Engl J Med
, vol.360
, pp. 1696-1698
-
-
Goldstein, D.B.1
-
70
-
-
66449085624
-
Diabetes: A virus-gene collaboration
-
von Herrath M. Diabetes: a virus-gene collaboration. Nature 2009;459:518-519
-
(2009)
Nature
, vol.459
, pp. 518-519
-
-
Von Herrath, M.1
-
71
-
-
34347341846
-
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
-
Genetics of Type 1 Diabetes in Finland, Wellcome Trust Case Control Consortium
-
Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C, Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC, Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007;39:857-864
-
(2007)
Nat Genet
, vol.39
, pp. 857-864
-
-
Todd, J.A.1
Walker, N.M.2
Cooper, J.D.3
Smyth, D.J.4
Downes, K.5
Plagnol, V.6
Bailey, R.7
Nejentsev, S.8
Field, S.F.9
Payne, F.10
Lowe, C.E.11
Szeszko, J.S.12
Hafler, J.P.13
Zeitels, L.14
Yang, J.H.15
Vella, A.16
Nutland, S.17
Stevens, H.E.18
Schuilenburg, H.19
Coleman, G.20
Maisuria, M.21
Meadows, W.22
Smink, L.J.23
Healy, B.24
Burren, O.S.25
Lam, A.A.26
Ovington, N.R.27
Allen, J.28
Adlem, E.29
Leung, H.T.30
Wallace, C.31
Howson, J.M.32
Guja, C.33
Ionescu- Tîrgovişte, C.34
Simmonds, M.J.35
Heward, J.M.36
Gough, S.C.37
Dunger, D.B.38
Wicker, L.S.39
Clayton, D.G.40
more..
-
72
-
-
66649132790
-
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis
-
Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA, Bugliani M, Marchetti P, Eizirik DL. PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes 2009;58:1283-1291
-
(2009)
Diabetes
, vol.58
, pp. 1283-1291
-
-
Moore, F.1
Colli, M.L.2
Cnop, M.3
Esteve, M.I.4
Cardozo, A.K.5
Cunha, D.A.6
Bugliani, M.7
Marchetti, P.8
Eizirik, D.L.9
-
73
-
-
42349106044
-
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
-
Wellcome Trust Case Control Consortium
-
Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ, Wellcome Trust Case Control Consortium, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008;40:638-645
-
(2008)
Nat Genet
, vol.40
, pp. 638-645
-
-
Zeggini, E.1
Scott, L.J.2
Saxena, R.3
Voight, B.F.4
Marchini, J.L.5
Hu, T.6
De Bakker, P.I.7
Abecasis, G.R.8
Almgren, P.9
Andersen, G.10
Ardlie, K.11
Boström, K.B.12
Bergman, R.N.13
Bonnycastle, L.L.14
Borch-Johnsen, K.15
Burtt, N.P.16
Chen, H.17
Chines, P.S.18
Daly, M.J.19
Deodhar, P.20
Ding, C.J.21
Doney, A.S.22
Duren, W.L.23
Elliott, K.S.24
Erdos, M.R.25
Frayling, T.M.26
Freathy, R.M.27
Gianniny, L.28
Grallert, H.29
Grarup, N.30
Groves, C.J.31
Guiducci, C.32
Hansen, T.33
Herder, C.34
Hitman, G.A.35
Hughes, T.E.36
Isomaa, B.37
Jackson, A.U.38
Jørgensen, T.39
Kong, A.40
Kubalanza, K.41
Kuruvilla, F.G.42
Kuusisto, J.43
Langenberg, C.44
Lango, H.45
Lauritzen, T.46
Li, Y.47
Lindgren, C.M.48
Lyssenko, V.49
Marvelle, A.F.50
Meisinger, C.51
Midthjell, K.52
Mohlke, K.L.53
Morken, M.A.54
Morris, A.D.55
Narisu, N.56
Nilsson, P.57
Owen, K.R.58
Palmer, C.N.59
Payne, F.60
Perry, J.R.61
Pettersen, E.62
Platou, C.63
Prokopenko, I.64
Qi, L.65
Qin, L.66
Rayner, N.W.67
Rees, M.68
Roix, J.J.69
Sandbaek, A.70
Shields, B.71
Sjögren, M.72
Steinthorsdottir, V.73
Stringham, H.M.74
Swift, A.J.75
Thorleifsson, G.76
Thorsteinsdottir, U.77
Timpson, N.J.78
Tuomi, T.79
Tuomilehto, J.80
Walker, M.81
Watanabe, R.M.82
Weedon, M.N.83
Willer, C.J.84
Illig, T.85
Hveem, K.86
Hu, F.B.87
Laakso, M.88
Stefansson, K.89
Pedersen, O.90
Wareham, N.J.91
Barroso, I.92
Hattersley, A.T.93
Collins, F.S.94
Groop, L.95
McCarthy, M.I.96
Boehnke, M.97
Altshuler, D.98
more..
-
74
-
-
58149091678
-
Shared and distinct genetic variants in type 1 diabetes and celiac disease
-
Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med 2008;359:2767-2777
-
(2008)
N Engl J Med
, vol.359
, pp. 2767-2777
-
-
Smyth, D.J.1
Plagnol, V.2
Walker, N.M.3
Cooper, J.D.4
Downes, K.5
Yang, J.H.6
Howson, J.M.7
Stevens, H.8
McManus, R.9
Wijmenga, C.10
Heap, G.A.11
Dubois, P.C.12
Clayton, D.G.13
Hunt, K.A.14
Van Heel, D.A.15
Todd, J.A.16
-
75
-
-
33749137515
-
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC
-
de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, Hart J, Hafler DA, Pericak-Vance M, Todd JA, Daly MJ, Trowsdale J, Wijmenga C, Vyse TJ, Beck S, Murray SS, Carrington M, Gregory S, Deloukas P, Rioux JD. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet 2006;38:1166-1172
-
(2006)
Nat Genet
, vol.38
, pp. 1166-1172
-
-
De Bakker, P.I.1
McVean, G.2
Sabeti, P.C.3
Miretti, M.M.4
Green, T.5
Marchini, J.6
Ke, X.7
Monsuur, A.J.8
Whittaker, P.9
Delgado, M.10
Morrison, J.11
Richardson, A.12
Walsh, E.C.13
Gao, X.14
Galver, L.15
Hart, J.16
Hafler, D.A.17
Pericak-Vance, M.18
Todd, J.A.19
Daly, M.J.20
Trowsdale, J.21
Wijmenga, C.22
Vyse, T.J.23
Beck, S.24
Murray, S.S.25
Carrington, M.26
Gregory, S.27
Deloukas, P.28
Rioux, J.D.29
more..
-
76
-
-
0742305866
-
Network biology: Understanding the cell's functional organization
-
Barabási AL, Oltvai ZN. Network biology: understanding the cell's functional organization. Nat Rev Genet 2004;5:101-113
-
(2004)
Nat Rev Genet
, vol.5
, pp. 101-113
-
-
Barabási, A.L.1
Oltvai, Z.N.2
-
77
-
-
67650917380
-
Expression profiling of human genetic and protein interaction networks in type 1 diabetes
-
Bergholdt R, Brorsson C, Lage K, Nielsen JH, Brunak S, Pociot F. Expression profiling of human genetic and protein interaction networks in type 1 diabetes. PLoS One 2009;4:e6250
-
(2009)
PLoS One
, vol.4
-
-
Bergholdt, R.1
Brorsson, C.2
Lage, K.3
Nielsen, J.H.4
Brunak, S.5
Pociot, F.6
-
78
-
-
46349086693
-
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
-
DOI 10.1186/gb-2007-8-11-r253
-
Bergholdt R, Storling ZM, Lage K, Karlberg EO, Olason PI, Aalund M, Nerup J, Brunak S, Workman CT, Pociot F. Integrative analysis for finding genes and networks involved in diabetes and other complex diseases. Genome Biol 2007;8:R253 (Pubitemid 351917496)
-
(2007)
Genome Biology
, vol.8
, Issue.11
-
-
Bergholdt, R.1
Storling, Z.M.2
Lage, K.3
Karlberg, E.O.4
Olason, P.I.5
Aalund, M.6
Nerup, J.7
Brunak, S.8
Workman, C.T.9
Pociot, F.10
-
79
-
-
59649105735
-
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
-
Oresic M, Simell S, Sysi-Aho M, Näntö-Salonen K, Seppänen-Laakso T, Parikka V, Katajamaa M, Hekkala A, Mattila I, Keskinen P, Yetukuri L, Reinikainen A, Lähde J, Suortti T, Hakalax J, Simell T, Hyöty H, Veijola R, Ilonen J, Lahesmaa R, Knip M, Simell O. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 2008;205:2975-2984
-
(2008)
J Exp Med
, vol.205
, pp. 2975-2984
-
-
Oresic, M.1
Simell, S.2
Sysi-Aho, M.3
Näntö-Salonen, K.4
Seppänen-Laakso, T.5
Parikka, V.6
Katajamaa, M.7
Hekkala, A.8
Mattila, I.9
Keskinen, P.10
Yetukuri, L.11
Reinikainen, A.12
Lähde, J.13
Suortti, T.14
Hakalax, J.15
Simell, T.16
Hyöty, H.17
Veijola, R.18
Ilonen, J.19
Lahesmaa, R.20
Knip, M.21
Simell, O.22
more..
-
80
-
-
34547140875
-
The human disease network
-
Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabási AL. The human disease network. Proc Natl Acad Sci U S A 2007;104:8685-8690
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 8685-8690
-
-
Goh, K.I.1
Cusick, M.E.2
Valle, D.3
Childs, B.4
Vidal, M.5
Barabási, A.L.6
-
81
-
-
0032830568
-
Onset of type 1 diabetes: A dynamical instability
-
DOI 10.2337/diabetes.48.9.1677
-
Freiesleben De Blasio B, Bak P, Pociot F, Karlsen AE, Nerup J. Onset of type 1 diabetes: a dynamical instability. Diabetes 1999;48:1677-1685 (Pubitemid 29415183)
-
(1999)
Diabetes
, vol.48
, Issue.9
, pp. 1677-1685
-
-
De Blasio, B.F.1
Bak, P.2
Pociot, F.3
Karlsen, A.E.4
Nerup, J.5
-
82
-
-
63449085198
-
Detailed transcriptome atlas of the pancreatic beta cell
-
Kutlu B, Burdick D, Baxter D, Rasschaert J, Flamez D, Eizirik DL, Welsh N, Goodman N, Hood L. Detailed transcriptome atlas of the pancreatic beta cell. BMC Med Genomics 2009;2:3
-
(2009)
BMC Med Genomics
, vol.2
, pp. 3
-
-
Kutlu, B.1
Burdick, D.2
Baxter, D.3
Rasschaert, J.4
Flamez, D.5
Eizirik, D.L.6
Welsh, N.7
Goodman, N.8
Hood, L.9
|