메뉴 건너뛰기




Volumn 59, Issue 7, 2010, Pages 1561-1571

Genetics of type 1 diabetes: What's next?

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; INSULIN;

EID: 77954288805     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0076     Document Type: Review
Times cited : (257)

References (82)
  • 2
    • 0038049458 scopus 로고    scopus 로고
    • Genetic epidemiology of type 1 diabetes
    • Hirschhorn JN. Genetic epidemiology of type 1 diabetes. Pediatr Diabetes 2003;4:87-100
    • (2003) Pediatr Diabetes , vol.4 , pp. 87-100
    • Hirschhorn, J.N.1
  • 3
    • 0345505676 scopus 로고    scopus 로고
    • Genetic liability of type 1 diabetes and the onset age among 22, 650 young Finnish twin pairs: A nationwide follow-up study
    • DOI 10.2337/diabetes.52.4.1052
    • Hyttinen V, Kaprio J, Kinnunen L, Koskenvuo M, Tuomilehto J. Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes 2003;52:1052-1055 (Pubitemid 36384278)
    • (2003) Diabetes , vol.52 , Issue.4 , pp. 1052-1055
    • Hyttinen, V.1    Kaprio, J.2    Kinnunen, L.3    Koskenvuo, M.4    Tuomilehto, J.5
  • 4
    • 25844441709 scopus 로고    scopus 로고
    • Type 1 diabetes: Evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families
    • Type 1 Diabetes Genetics Consortium
    • Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F, Todd JA, Rich SS, Type 1 Diabetes Genetics Consortium. Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes 2005;54:2995-3001
    • (2005) Diabetes , vol.54 , pp. 2995-3001
    • Concannon, P.1    Erlich, H.A.2    Julier, C.3    Morahan, G.4    Nerup, J.5    Pociot, F.6    Todd, J.A.7    Rich, S.S.8
  • 5
    • 0025094344 scopus 로고
    • Mapping genes in diabetes. Genetic epidemiological perspective
    • Rich SS. Mapping genes in diabetes: genetic epidemiological perspective. Diabetes 1990;39:1315-1319 (Pubitemid 20372217)
    • (1990) Diabetes , vol.39 , Issue.11 , pp. 1315-1319
    • Rich, S.S.1
  • 7
    • 0344721480 scopus 로고    scopus 로고
    • Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium
    • The MHC sequencing consortium
    • The MHC sequencing consortium. Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium. Nature 1999;401:921-923
    • (1999) Nature , vol.401 , pp. 921-923
  • 8
    • 34548783929 scopus 로고    scopus 로고
    • The Environmental Determinants of Diabetes in the Young (TEDDY) study: Study design
    • TEDDY Study Group
    • TEDDY Study Group. The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Pediatr Diabetes 2007;8:286-298
    • (2007) Pediatr Diabetes , vol.8 , pp. 286-298
  • 9
    • 0029616384 scopus 로고
    • The Diabetes Prevention Trial-Type 1 diabetes (DPT-1): Implementation of screening and staging of relatives
    • DPT-1 Study Group
    • The Diabetes Prevention Trial-Type 1 diabetes (DPT-1): implementation of screening and staging of relatives. DPT-1 Study Group. Transplant Proc 1995;27:3377
    • (1995) Transplant Proc , vol.27 , pp. 3377
  • 13
    • 58549090910 scopus 로고    scopus 로고
    • Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A
    • Howson JM, Walker NM, Clayton D, Todd JA. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab 2009;11(Suppl. 1):31-45
    • (2009) Diabetes Obes Metab , vol.11 , Issue.SUPPL. 1 , pp. 31-45
    • Howson, J.M.1    Walker, N.M.2    Clayton, D.3    Todd, J.A.4
  • 15
    • 58549097473 scopus 로고    scopus 로고
    • MHC-environment interactions leading to type 1 diabetes: Feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth
    • Badenhoop K, Kahles H, Seidl C, Kordonouri O, Lopez ER, Walter M, Rosinger S, Ziegler A, Bohm BO. MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth. Diabetes Obes Metab 2009; 11(Suppl. 1):88-91
    • (2009) Diabetes Obes Metab , vol.11 , Issue.SUPPL. 1 , pp. 88-91
    • Badenhoop, K.1    Kahles, H.2    Seidl, C.3    Kordonouri, O.4    Lopez, E.R.5    Walter, M.6    Rosinger, S.7    Ziegler, A.8    Bohm, B.O.9
  • 16
    • 58549090344 scopus 로고    scopus 로고
    • Analysis of maternaloffspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes
    • Bronson PG, Ramsay PP, Thomson G, Barcellos LF. Analysis of maternaloffspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes. Diabetes Obes Metab 2009;11(Suppl. 1):74-83
    • (2009) Diabetes Obes Metab , vol.11 , Issue.SUPPL. 1 , pp. 74-83
    • Bronson, P.G.1    Ramsay, P.P.2    Thomson, G.3    Barcellos, L.F.4
  • 18
    • 58549091324 scopus 로고    scopus 로고
    • Association of MHC SNP genotype with susceptibility to type 1 diabetes: A modified survival approach
    • McKinnon E, Morahan G, Nolan D, James I. Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach. Diabetes Obes Metab 2009;11(Suppl. 1):92-100
    • (2009) Diabetes Obes Metab , vol.11 , Issue.SUPPL. 1 , pp. 92-100
    • McKinnon, E.1    Morahan, G.2    Nolan, D.3    James, I.4
  • 19
    • 0035380479 scopus 로고    scopus 로고
    • Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes
    • Lee KH, Wucherpfennig KW, Wiley DC. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol 2001;2:501-507
    • (2001) Nat Immunol , vol.2 , pp. 501-507
    • Lee, K.H.1    Wucherpfennig, K.W.2    Wiley, D.C.3
  • 21
    • 49649104814 scopus 로고    scopus 로고
    • The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes
    • Fourlanos S, Varney MD, Tait BD, Morahan G, Honeyman MC, Colman PG, Harrison LC. The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. Diabetes Care 2008;31:1546-1549
    • (2008) Diabetes Care , vol.31 , pp. 1546-1549
    • Fourlanos, S.1    Varney, M.D.2    Tait, B.D.3    Morahan, G.4    Honeyman, M.C.5    Colman, P.G.6    Harrison, L.C.7
  • 22
  • 24
    • 0021343570 scopus 로고
    • A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
    • Bell GI, Horita S, Karam JH. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 1984;33:176-183
    • (1984) Diabetes , vol.33 , pp. 176-183
    • Bell, G.I.1    Horita, S.2    Karam, J.H.3
  • 27
    • 18744385526 scopus 로고    scopus 로고
    • Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
    • DOI 10.1038/nature03625
    • Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005;435:224-228 (Pubitemid 40685950)
    • (2005) Nature , vol.435 , Issue.7039 , pp. 224-228
    • Kent, S.C.1    Chen, Y.2    Bregoli, L.3    Clemmings, S.M.4    Kenyon, N.S.5    Ricordi, C.6    Hering, B.J.7    Hafler, D.A.8
  • 29
    • 0034139830 scopus 로고    scopus 로고
    • CTLA-4 in autoimmune diseases: A general susceptibility gene to autoimmunity?
    • Kristiansen OP, Larsen ZM, Pociot F. CTLA-4 in autoimmune diseases: a general susceptibility gene to autoimmunity? Genes Immun 2000;1:170-184
    • (2000) Genes Immun , vol.1 , pp. 170-184
    • Kristiansen, O.P.1    Larsen, Z.M.2    Pociot, F.3
  • 37
    • 70049095101 scopus 로고    scopus 로고
    • How do regulatory T cells work?
    • Corthay A. How do regulatory T cells work? Scand J Immunol 2009;70: 326-336
    • (2009) Scand J Immunol , vol.70 , pp. 326-336
    • Corthay, A.1
  • 38
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • Malek TR, Bayer AL. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 2004;4:665-674
    • (2004) Nat Rev Immunol , vol.4 , pp. 665-674
    • Malek, T.R.1    Bayer, A.L.2
  • 39
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000;12:431-440
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3    Ashourian, N.4    Singh, B.5    Sharpe, A.6    Bluestone, J.A.7
  • 44
    • 0036688819 scopus 로고    scopus 로고
    • Genetics of type 1 diabetes mellitus
    • Pociot F, McDermott MF. Genetics of type 1 diabetes mellitus. Genes Immun 2002;3:235-249
    • (2002) Genes Immun , vol.3 , pp. 235-249
    • Pociot, F.1    McDermott, M.F.2
  • 45
    • 75649122271 scopus 로고    scopus 로고
    • Analysis of 55 autoimmune disease and type II diabetes loci: Further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1
    • Type I Diabetes Genetics Consortium
    • Cooper JD, Walker NM, Healy BC, Smyth DJ, Downes K, Todd JA, Type I Diabetes Genetics Consortium. Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1. Genes Immun 2009;10:S95-S120
    • (2009) Genes Immun , vol.10
    • Cooper, J.D.1    Walker, N.M.2    Healy, B.C.3    Smyth, D.J.4    Downes, K.5    Todd, J.A.6
  • 46
    • 75649103221 scopus 로고    scopus 로고
    • Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families
    • Type I Diabetes Genetics Consortium
    • Cooper JD, Walker NM, Smyth DJ, Downes K, Healy BC, Todd JA, Type I Diabetes Genetics Consortium. Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families. Genes Immun 2009;10:S85-S94
    • (2009) Genes Immun , vol.10
    • Cooper, J.D.1    Walker, N.M.2    Smyth, D.J.3    Downes, K.4    Healy, B.C.5    Todd, J.A.6
  • 55
    • 0035212224 scopus 로고    scopus 로고
    • A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: Identification of new loci with evidence of interactions
    • European Consortium for IDDM Studies
    • Nerup J, Pociot F, European Consortium for IDDM Studies. A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions. Am J Hum Genet 2001;69:1301-1313
    • (2001) Am J Hum Genet , vol.69 , pp. 1301-1313
    • Nerup, J.1    Pociot, F.2
  • 58
    • 65249131713 scopus 로고    scopus 로고
    • Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    • Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009;324:387-389
    • (2009) Science , vol.324 , pp. 387-389
    • Nejentsev, S.1    Walker, N.2    Riches, D.3    Egholm, M.4    Todd, J.A.5
  • 59
    • 34347335667 scopus 로고    scopus 로고
    • Guilt beyond a reasonable doubt
    • Altshuler D, Daly M. Guilt beyond a reasonable doubt. Nat Genet 2007;39:813-815
    • (2007) Nat Genet , vol.39 , pp. 813-815
    • Altshuler, D.1    Daly, M.2
  • 60
    • 65249164859 scopus 로고    scopus 로고
    • Validating, augmenting and refining genome-wide association signals
    • Ioannidis JP, Thomas G, Daly MJ. Validating, augmenting and refining genome-wide association signals. Nat Rev Genet 2009;10:318-329
    • (2009) Nat Rev Genet , vol.10 , pp. 318-329
    • Ioannidis, J.P.1    Thomas, G.2    Daly, M.J.3
  • 63
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-678
    • (2007) Nature , vol.447 , pp. 661-678
  • 64
    • 75649147430 scopus 로고    scopus 로고
    • Evidence for association of the TCF7 locus with type I diabetes
    • Type I Diabetes Genetics Consortium
    • Erlich HA, Valdes AM, Julier C, Mirel D, Noble JA, Type I Diabetes Genetics Consortium. Evidence for association of the TCF7 locus with type I diabetes. Genes Immun 2009;10:S54-S59
    • (2009) Genes Immun , vol.10
    • Erlich, H.A.1    Valdes, A.M.2    Julier, C.3    Mirel, D.4    Noble, J.A.5
  • 65
    • 68249108329 scopus 로고    scopus 로고
    • Prediction and interaction in complex disease genetics: Experience in type 1 diabetes
    • Clayton DG. Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet 2009;5:e1000540
    • (2009) PLoS Genet , vol.5
    • Clayton, D.G.1
  • 66
    • 29444452159 scopus 로고    scopus 로고
    • Defining a genomic radius for long-range enhancer action: Duplicated conserved non-coding elements hold the key
    • Vavouri T, McEwen GK, Woolfe A, Gilks WR, Elgar G. Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key. Trends Genet 2006;22:5-10
    • (2006) Trends Genet , vol.22 , pp. 5-10
    • Vavouri, T.1    McEwen, G.K.2    Woolfe, A.3    Gilks, W.R.4    Elgar, G.5
  • 69
    • 65949107547 scopus 로고    scopus 로고
    • Common genetic variation and human traits
    • Goldstein DB. Common genetic variation and human traits. N Engl J Med 2009;360:1696-1698
    • (2009) N Engl J Med , vol.360 , pp. 1696-1698
    • Goldstein, D.B.1
  • 70
    • 66449085624 scopus 로고    scopus 로고
    • Diabetes: A virus-gene collaboration
    • von Herrath M. Diabetes: a virus-gene collaboration. Nature 2009;459:518-519
    • (2009) Nature , vol.459 , pp. 518-519
    • Von Herrath, M.1
  • 76
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: Understanding the cell's functional organization
    • Barabási AL, Oltvai ZN. Network biology: understanding the cell's functional organization. Nat Rev Genet 2004;5:101-113
    • (2004) Nat Rev Genet , vol.5 , pp. 101-113
    • Barabási, A.L.1    Oltvai, Z.N.2
  • 77
    • 67650917380 scopus 로고    scopus 로고
    • Expression profiling of human genetic and protein interaction networks in type 1 diabetes
    • Bergholdt R, Brorsson C, Lage K, Nielsen JH, Brunak S, Pociot F. Expression profiling of human genetic and protein interaction networks in type 1 diabetes. PLoS One 2009;4:e6250
    • (2009) PLoS One , vol.4
    • Bergholdt, R.1    Brorsson, C.2    Lage, K.3    Nielsen, J.H.4    Brunak, S.5    Pociot, F.6
  • 81
    • 0032830568 scopus 로고    scopus 로고
    • Onset of type 1 diabetes: A dynamical instability
    • DOI 10.2337/diabetes.48.9.1677
    • Freiesleben De Blasio B, Bak P, Pociot F, Karlsen AE, Nerup J. Onset of type 1 diabetes: a dynamical instability. Diabetes 1999;48:1677-1685 (Pubitemid 29415183)
    • (1999) Diabetes , vol.48 , Issue.9 , pp. 1677-1685
    • De Blasio, B.F.1    Bak, P.2    Pociot, F.3    Karlsen, A.E.4    Nerup, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.