메뉴 건너뛰기




Volumn 19, Issue Part A, 2014, Pages 29-38

MicroRNA regulation of cancer metabolism: Role in tumour suppression

Author keywords

Cancer bioenergetics; MicroRNA; Mitochondria; Tumour suppression

Indexed keywords

MICRORNA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR;

EID: 84911410683     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2014.06.004     Document Type: Article
Times cited : (31)

References (154)
  • 1
    • 33845447175 scopus 로고    scopus 로고
    • LOT1 (ZAC1/PLAGL1) and its family members: mechanisms and functions
    • Abdollahi A. LOT1 (ZAC1/PLAGL1) and its family members: mechanisms and functions. J. Cell. Physiol. 2007, 210:16-25.
    • (2007) J. Cell. Physiol. , vol.210 , pp. 16-25
    • Abdollahi, A.1
  • 2
    • 0034680825 scopus 로고    scopus 로고
    • The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia
    • Agani F.H., Pichiule P., Chavez J.C., LaManna J.C. The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J. Biol. Chem. 2000, 275:35863-35867.
    • (2000) J. Biol. Chem. , vol.275 , pp. 35863-35867
    • Agani, F.H.1    Pichiule, P.2    Chavez, J.C.3    LaManna, J.C.4
  • 4
    • 84911401583 scopus 로고    scopus 로고
    • MicroRNA-338 regulates the axonal expression of multiple nuclear-encoded mitochondrial mRNAs encoding subunits of the oxidative phosphorylation machinery
    • Aschrafi A., Kar A.N., Natera-Naranjo O., Macgibeny M.A., Gioio A.E., Kaplan B.B. MicroRNA-338 regulates the axonal expression of multiple nuclear-encoded mitochondrial mRNAs encoding subunits of the oxidative phosphorylation machinery. Cell. Mol. Life Sci. 2014, (in press).
    • (2014) Cell. Mol. Life Sci.
    • Aschrafi, A.1    Kar, A.N.2    Natera-Naranjo, O.3    Macgibeny, M.A.4    Gioio, A.E.5    Kaplan, B.B.6
  • 5
    • 79960140833 scopus 로고    scopus 로고
    • MiR-335 and miR-34a promote renal senescence by suppressing mitochondrial antioxidative enzymes
    • Bai X.Y., Ma Y., Ding R., Fu B., Shi S., Chen X.M. miR-335 and miR-34a promote renal senescence by suppressing mitochondrial antioxidative enzymes. J. Am. Soc. Nephrol. 2011, 22:1252-1261.
    • (2011) J. Am. Soc. Nephrol. , vol.22 , pp. 1252-1261
    • Bai, X.Y.1    Ma, Y.2    Ding, R.3    Fu, B.4    Shi, S.5    Chen, X.M.6
  • 10
    • 30544433533 scopus 로고    scopus 로고
    • ATP citrate lyase is an important component of cell growth and transformation
    • Bauer D.E., Hatzivassiliou G., Zhao F., Andreadis C., Thompson C.B. ATP citrate lyase is an important component of cell growth and transformation. Oncogene 2005, 24:6314-6322.
    • (2005) Oncogene , vol.24 , pp. 6314-6322
    • Bauer, D.E.1    Hatzivassiliou, G.2    Zhao, F.3    Andreadis, C.4    Thompson, C.B.5
  • 13
    • 77956343851 scopus 로고    scopus 로고
    • Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions
    • Bian Z., Li L.M., Tang R., Hou D.X., Chen X., Zhang C.Y., Zen K. Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Cell Res. 2010, 20:1076-1078.
    • (2010) Cell Res. , vol.20 , pp. 1076-1078
    • Bian, Z.1    Li, L.M.2    Tang, R.3    Hou, D.X.4    Chen, X.5    Zhang, C.Y.6    Zen, K.7
  • 18
    • 77953483108 scopus 로고    scopus 로고
    • MicroRNA-210: A unique and pleiotropic hypoxamir
    • Chan S.Y., Loscalzo J. MicroRNA-210: A unique and pleiotropic hypoxamir. Cell Cycle 2010, 9:1072-1083.
    • (2010) Cell Cycle , vol.9 , pp. 1072-1083
    • Chan, S.Y.1    Loscalzo, J.2
  • 19
    • 79955649353 scopus 로고    scopus 로고
    • Cancer microRNAs: From subtype profiling to predictors of response to therapy
    • Chan E., Prado D.E., Weidhaas J.B. Cancer microRNAs: From subtype profiling to predictors of response to therapy. Trends Mol. Med. 2011, 17:235-243.
    • (2011) Trends Mol. Med. , vol.17 , pp. 235-243
    • Chan, E.1    Prado, D.E.2    Weidhaas, J.B.3
  • 20
    • 70349478990 scopus 로고    scopus 로고
    • MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
    • Chan S.Y., Zhang Y.Y., Hemann C., Mahoney C.E., Zweier J.L., Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab. 2012, 10:273-284.
    • (2012) Cell Metab. , vol.10 , pp. 273-284
    • Chan, S.Y.1    Zhang, Y.Y.2    Hemann, C.3    Mahoney, C.E.4    Zweier, J.L.5    Loscalzo, J.6
  • 23
    • 84899481430 scopus 로고    scopus 로고
    • Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis
    • Chang S.H., Hla T. Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis. Curr. Opin. Hematol. 2014, 21:235-240.
    • (2014) Curr. Opin. Hematol. , vol.21 , pp. 235-240
    • Chang, S.H.1    Hla, T.2
  • 24
    • 84906086597 scopus 로고    scopus 로고
    • Activation of PI3K/Akt/MTOR pathway and dual inhibitors of PI3K and MTOR in endometrial cancer
    • Chen J., Zhao K.N., Li R., Shao R., Chen C. Activation of PI3K/Akt/MTOR pathway and dual inhibitors of PI3K and MTOR in endometrial cancer. Curr. Med. Chem. 2014, (in press).
    • (2014) Curr. Med. Chem.
    • Chen, J.1    Zhao, K.N.2    Li, R.3    Shao, R.4    Chen, C.5
  • 25
    • 84863661689 scopus 로고    scopus 로고
    • Therapeutic targets in cancer cell metabolism and autophagy
    • Cheong H., Lu C., Lindsten T., Thompson C.B. Therapeutic targets in cancer cell metabolism and autophagy. Nat. Biotechnol. 2012, 30:671-678.
    • (2012) Nat. Biotechnol. , vol.30 , pp. 671-678
    • Cheong, H.1    Lu, C.2    Lindsten, T.3    Thompson, C.B.4
  • 26
    • 84877599439 scopus 로고    scopus 로고
    • Tumor hypoxia and metabolism - towards novel anticancer approaches
    • Chiche J., Ricci J.E., Pouysségur J. Tumor hypoxia and metabolism - towards novel anticancer approaches. Ann. Endocrinol. 2013, 74:111-114.
    • (2013) Ann. Endocrinol. , vol.74 , pp. 111-114
    • Chiche, J.1    Ricci, J.E.2    Pouysségur, J.3
  • 33
    • 79952137486 scopus 로고    scopus 로고
    • MiR-210: More than a silent player in hypoxia
    • Devlin C., Greco S., Martelli F., Ivan M. miR-210: More than a silent player in hypoxia. IUBMB Life 2011, 63:94-100.
    • (2011) IUBMB Life , vol.63 , pp. 94-100
    • Devlin, C.1    Greco, S.2    Martelli, F.3    Ivan, M.4
  • 34
    • 84883514161 scopus 로고    scopus 로고
    • Targeting lactate metabolism for cancer therapeutics
    • Doherty J.R., Cleveland J.L. Targeting lactate metabolism for cancer therapeutics. J. Clin. Invest. 2013, 123:3685-3692.
    • (2013) J. Clin. Invest. , vol.123 , pp. 3685-3692
    • Doherty, J.R.1    Cleveland, J.L.2
  • 35
    • 45549090182 scopus 로고    scopus 로고
    • Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
    • Dong X.C., Copps K.D., Guo S., Li Y., Kollipara R., De Pinho R.A., White M.F. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008, 8:65-76.
    • (2008) Cell Metab. , vol.8 , pp. 65-76
    • Dong, X.C.1    Copps, K.D.2    Guo, S.3    Li, Y.4    Kollipara, R.5    De Pinho, R.A.6    White, M.F.7
  • 36
    • 84883488437 scopus 로고    scopus 로고
    • MicroRNAs and metabolism crosstalk in energy homeostasis
    • Dumortier O., Hinault C., Van Obberghen E. MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab. 2013, 18:312-324.
    • (2013) Cell Metab. , vol.18 , pp. 312-324
    • Dumortier, O.1    Hinault, C.2    Van Obberghen, E.3
  • 37
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
    • Ebert M.S., Neilson J.R., Sharp P.A. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat. Methods 2007, 4:721-726.
    • (2007) Nat. Methods , vol.4 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 39
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - microRNAs with a role in cancer
    • Esquela-Kerscher A., Slack F.J. Oncomirs - microRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6:259-269.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 42
    • 84862784999 scopus 로고    scopus 로고
    • MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression
    • Fei X., Qi M., Wu B., Song Y., Wang Y., Li T. MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression. FEBS Lett. 2012, 586:392-397.
    • (2012) FEBS Lett. , vol.586 , pp. 392-397
    • Fei, X.1    Qi, M.2    Wu, B.3    Song, Y.4    Wang, Y.5    Li, T.6
  • 44
    • 84865313576 scopus 로고    scopus 로고
    • Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
    • Filipp F.V., Scott D.A., Ronai Z.A., Osterman A.L., Smith J.W. Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells. Pigment Cell Melanoma Res. 2012, 25:375-383.
    • (2012) Pigment Cell Melanoma Res. , vol.25 , pp. 375-383
    • Filipp, F.V.1    Scott, D.A.2    Ronai, Z.A.3    Osterman, A.L.4    Smith, J.W.5
  • 46
    • 84864573730 scopus 로고    scopus 로고
    • MicroRNAs and the Warburg Effect: new players in an old arena
    • Gao P., Sun L., He X., Cao Y., Zhang H. MicroRNAs and the Warburg Effect: new players in an old arena. Curr. Gene Ther. 2012, 12:285-291.
    • (2012) Curr. Gene Ther. , vol.12 , pp. 285-291
    • Gao, P.1    Sun, L.2    He, X.3    Cao, Y.4    Zhang, H.5
  • 49
    • 34047234959 scopus 로고    scopus 로고
    • Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis
    • Gibson S.L., Ma Z., Shaw L.M. Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis. Cell Cycle 2007, 6:631-637.
    • (2007) Cell Cycle , vol.6 , pp. 631-637
    • Gibson, S.L.1    Ma, Z.2    Shaw, L.M.3
  • 53
    • 52249096359 scopus 로고    scopus 로고
    • The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers
    • Guo C., Sah J.F., Beard L., Willson J.K., Markowitz S.D., Guda K. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Gene Chromosome Cancer 2008, 47:939-946.
    • (2008) Gene Chromosome Cancer , vol.47 , pp. 939-946
    • Guo, C.1    Sah, J.F.2    Beard, L.3    Willson, J.K.4    Markowitz, S.D.5    Guda, K.6
  • 55
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 56
    • 84883742865 scopus 로고    scopus 로고
    • MicroRNA-126 and epidermal growth factor-like domain 7-an angiogenic couple of importance in metastatic colorectal cancer. Results from the Nordic ACT trial
    • Hansen T.F., Christensen R.D., Andersen R.F., Sørensen F.B., Johnsson A., Jakobsen A. MicroRNA-126 and epidermal growth factor-like domain 7-an angiogenic couple of importance in metastatic colorectal cancer. Results from the Nordic ACT trial. Br. J. Cancer 2013, 109:1243-1251.
    • (2013) Br. J. Cancer , vol.109 , pp. 1243-1251
    • Hansen, T.F.1    Christensen, R.D.2    Andersen, R.F.3    Sørensen, F.B.4    Johnsson, A.5    Jakobsen, A.6
  • 57
    • 84864663987 scopus 로고    scopus 로고
    • MicroRNA-30b-mediated regulation of catalase expression in human ARPE-19 cells
    • Haque R., Chun E., Howell J.C., Sengupta T., Chen D., Kim H. MicroRNA-30b-mediated regulation of catalase expression in human ARPE-19 cells. PLoS One 2012, 7:e42542.
    • (2012) PLoS One , vol.7 , pp. e42542
    • Haque, R.1    Chun, E.2    Howell, J.C.3    Sengupta, T.4    Chen, D.5    Kim, H.6
  • 60
    • 40949108800 scopus 로고    scopus 로고
    • Carrot and stick: HIF-α engages c-Myc in hypoxic adaptation
    • Huang L.E. Carrot and stick: HIF-α engages c-Myc in hypoxic adaptation. Cell Death Differ. 2008, 15:672-677.
    • (2008) Cell Death Differ. , vol.15 , pp. 672-677
    • Huang, L.E.1
  • 61
    • 84904263339 scopus 로고    scopus 로고
    • Repression of miR-126 and upregulation of adrenomedullin in the stromal endothelium by cancer-stromal cross talks confers angiogenesis of cervical cancer
    • Huang T.H., Chu T.Y. Repression of miR-126 and upregulation of adrenomedullin in the stromal endothelium by cancer-stromal cross talks confers angiogenesis of cervical cancer. Oncogene 2014, (in press).
    • (2014) Oncogene
    • Huang, T.H.1    Chu, T.Y.2
  • 62
    • 77952111459 scopus 로고    scopus 로고
    • MiR-210-micromanager of the hypoxia pathway
    • Huang X., Le Q.T., Giaccia A.J. MiR-210-micromanager of the hypoxia pathway. Trends Mol. Med. 2010, 16:230-237.
    • (2010) Trends Mol. Med. , vol.16 , pp. 230-237
    • Huang, X.1    Le, Q.T.2    Giaccia, A.J.3
  • 63
    • 84862243555 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation
    • Iorio M.V., Croce C.M. Causes and consequences of microRNA dysregulation. Cancer J. 2012, 18:215-222.
    • (2012) Cancer J. , vol.18 , pp. 215-222
    • Iorio, M.V.1    Croce, C.M.2
  • 64
    • 84902765817 scopus 로고    scopus 로고
    • The effects of environmental chemical carcinogens on the microRNA machinery
    • Izzotti A., Pulliero A. The effects of environmental chemical carcinogens on the microRNA machinery. Int. J. Hyg. Environ. Health 2014, 217(6):601-627.
    • (2014) Int. J. Hyg. Environ. Health , vol.217 , Issue.6 , pp. 601-627
    • Izzotti, A.1    Pulliero, A.2
  • 65
    • 82755189770 scopus 로고    scopus 로고
    • Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung
    • Izzotti A., Larghero P., Longobardi M., Cartiglia C., Camoirano A., Steele V.E., De Flora S. Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung. Mutat. Res. 2011, 717:9-16.
    • (2011) Mutat. Res. , vol.717 , pp. 9-16
    • Izzotti, A.1    Larghero, P.2    Longobardi, M.3    Cartiglia, C.4    Camoirano, A.5    Steele, V.E.6    De Flora, S.7
  • 66
    • 84880476558 scopus 로고    scopus 로고
    • The induction of miR-96 by mitochondrial dysfunction causes impaired glycogen synthesis through translational epression of IRS-1 in SK-Hep1 cells
    • Jeong H.J., Park S.Y., Yang W.M., Lee W. The induction of miR-96 by mitochondrial dysfunction causes impaired glycogen synthesis through translational epression of IRS-1 in SK-Hep1 cells. Biochem. Biophys. Res. Commun. 2013, 434:503-508.
    • (2013) Biochem. Biophys. Res. Commun. , vol.434 , pp. 503-508
    • Jeong, H.J.1    Park, S.Y.2    Yang, W.M.3    Lee, W.4
  • 70
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    • Kim J.W., Tchernyshyov I., Semenza G.L., Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006, 3:177-185.
    • (2006) Cell Metab. , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 71
    • 40949126440 scopus 로고    scopus 로고
    • Mitochondrial complex III regulates hypoxic activation of HIF
    • Klimova T., Chandel N.S. Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ. 2008, 15:660-666.
    • (2008) Cell Death Differ. , vol.15 , pp. 660-666
    • Klimova, T.1    Chandel, N.S.2
  • 72
    • 33947520506 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
    • Koivunen P., Hirsilä M., Remes A.M., Hassinen I.E., Kivirikko K.I., Myllyharju J. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J. Biol. Chem. 2007, 282:4524-4532.
    • (2007) J. Biol. Chem. , vol.282 , pp. 4524-4532
    • Koivunen, P.1    Hirsilä, M.2    Remes, A.M.3    Hassinen, I.E.4    Kivirikko, K.I.5    Myllyharju, J.6
  • 73
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • Kondo K., Klco J., Nakamura E., Lechpammer M., Kaelin W.G. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002, 1:237-246.
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin, W.G.5
  • 75
    • 62549157379 scopus 로고    scopus 로고
    • MicroRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis
    • Kren B.T., Wong P.Y., Sarver A., Zhang X., Zeng Y., Steer C.J. MicroRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis. RNA Biol. 2009, 6:65-72.
    • (2009) RNA Biol. , vol.6 , pp. 65-72
    • Kren, B.T.1    Wong, P.Y.2    Sarver, A.3    Zhang, X.4    Zeng, Y.5    Steer, C.J.6
  • 77
    • 34547134517 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
    • Land S.C., Tee A.R. Hypoxia-inducible factor 1 alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J. Biol. Chem. 2007, 282:20534-20543.
    • (2007) J. Biol. Chem. , vol.282 , pp. 20534-20543
    • Land, S.C.1    Tee, A.R.2
  • 78
    • 70449602451 scopus 로고    scopus 로고
    • Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration
    • Lei Z., Li B., Yang Z., Fang H., Zhang G.M., Feng Z.H., Huang B. Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One 2009, 4:e7629.
    • (2009) PLoS One , vol.4 , pp. e7629
    • Lei, Z.1    Li, B.2    Yang, Z.3    Fang, H.4    Zhang, G.M.5    Feng, Z.H.6    Huang, B.7
  • 79
    • 84857546393 scopus 로고    scopus 로고
    • Control of mitochondrial activity by miRNAs
    • Li P., Jiao J., Gao G., Prabhakar B.S. Control of mitochondrial activity by miRNAs. J. Cell. Biochem. 2012, 113:1104-1110.
    • (2012) J. Cell. Biochem. , vol.113 , pp. 1104-1110
    • Li, P.1    Jiao, J.2    Gao, G.3    Prabhakar, B.S.4
  • 80
    • 84866515571 scopus 로고    scopus 로고
    • MicroRNA-145 protects cardiomyocytes against hydrogen heroxide-induced apoptosis through targeting the mitochondria apoptotic pathway
    • Li R., Yan G., Li Q., Sun H., Hu Y., Sun J., Xu B. MicroRNA-145 protects cardiomyocytes against hydrogen heroxide-induced apoptosis through targeting the mitochondria apoptotic pathway. PLoS One 2012, 7:e44907.
    • (2012) PLoS One , vol.7 , pp. e44907
    • Li, R.1    Yan, G.2    Li, Q.3    Sun, H.4    Hu, Y.5    Sun, J.6    Xu, B.7
  • 81
    • 84894521534 scopus 로고    scopus 로고
    • Epigenetic silencing of MicroRNA-503 regulates FANCA expression in non-small cell lung cancer cell
    • Li N., Zhang F., Li S., Zhou S. Epigenetic silencing of MicroRNA-503 regulates FANCA expression in non-small cell lung cancer cell. Biochem. Biophys. Res. Commun. 2014, 444(4):611-666.
    • (2014) Biochem. Biophys. Res. Commun. , vol.444 , Issue.4 , pp. 611-666
    • Li, N.1    Zhang, F.2    Li, S.3    Zhou, S.4
  • 84
    • 84920166969 scopus 로고    scopus 로고
    • The Warburg effect in tumour progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism
    • Lu J., Tan M., Cai Q. The Warburg effect in tumour progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism. Cancer Lett. 2014, (in press).
    • (2014) Cancer Lett.
    • Lu, J.1    Tan, M.2    Cai, Q.3
  • 86
    • 21844449964 scopus 로고    scopus 로고
    • Human mitochondrial tRNAMet is exported to the cytoplasm and associates with the Argonaute 2 protein
    • Maniataki E., Mourelatos Z. Human mitochondrial tRNAMet is exported to the cytoplasm and associates with the Argonaute 2 protein. RNA 2005, 11:849-852.
    • (2005) RNA , vol.11 , pp. 849-852
    • Maniataki, E.1    Mourelatos, Z.2
  • 88
    • 84861962359 scopus 로고    scopus 로고
    • Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1
    • Meng S., Cao J.T., Zhang B., Zhou Q., Shen C.X., Wang C.Q. Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1. J. Mol. Cell. Cardiol. 2012, 53:64-72.
    • (2012) J. Mol. Cell. Cardiol. , vol.53 , pp. 64-72
    • Meng, S.1    Cao, J.T.2    Zhang, B.3    Zhou, Q.4    Shen, C.X.5    Wang, C.Q.6
  • 91
    • 80053259947 scopus 로고    scopus 로고
    • MicroRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects
    • Mutharasan R.K., Nagpal V., Ichikawa Y., Ardehali H. microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects. Am. J. Physiol. 2011, 301:H1519-H1530.
    • (2011) Am. J. Physiol. , vol.301 , pp. H1519-H1530
    • Mutharasan, R.K.1    Nagpal, V.2    Ichikawa, Y.3    Ardehali, H.4
  • 92
    • 84858376953 scopus 로고    scopus 로고
    • Mitochondria: in sickness and in health
    • Nunnari J., Suomalainen A. Mitochondria: in sickness and in health. Cell 2012, 148:1145-1159.
    • (2012) Cell , vol.148 , pp. 1145-1159
    • Nunnari, J.1    Suomalainen, A.2
  • 94
    • 33846630894 scopus 로고    scopus 로고
    • Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro
    • Pan Y., Mansfield K.D., Bertozzi C.C., Rudenko V., Chan D.A., Giaccia A.J., Simon M.C. Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol. Cell. Biol. 2007, 27:912-925.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 912-925
    • Pan, Y.1    Mansfield, K.D.2    Bertozzi, C.C.3    Rudenko, V.4    Chan, D.A.5    Giaccia, A.J.6    Simon, M.C.7
  • 95
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I., Cairns R.A., Fontana L., Lim A.L., Denko N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006, 3:187-197.
    • (2006) Cell Metab. , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 98
    • 84857640868 scopus 로고    scopus 로고
    • The insulin and insulin-like growth factor receptor family in neoplasia: an update
    • Pollak M. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat. Rev. Cancer 2012, 12:159-169.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 159-169
    • Pollak, M.1
  • 102
    • 84881235291 scopus 로고    scopus 로고
    • The growing complexity of HIF-1α's role in tumorigenesis: DNA repair and beyond
    • Rohwer N., Zasada C., Kempa S., Cramer T. The growing complexity of HIF-1α's role in tumorigenesis: DNA repair and beyond. Oncogene 2012, 32:3569-3576.
    • (2012) Oncogene , vol.32 , pp. 3569-3576
    • Rohwer, N.1    Zasada, C.2    Kempa, S.3    Cramer, T.4
  • 103
    • 84858776574 scopus 로고    scopus 로고
    • MicroRNAs in metabolism and metabolic disorders
    • Rottiers V., Näär A.M. MicroRNAs in metabolism and metabolic disorders. Nat. Rev. Mol. Cell Biol. 2012, 13:239-250.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 239-250
    • Rottiers, V.1    Näär, A.M.2
  • 104
    • 79953048345 scopus 로고    scopus 로고
    • The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes
    • Ryu H.S., Park S.Y., Ma D., Zhang J., Lee W. The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes. PLoS One 2011, 6:e17343.
    • (2011) PLoS One , vol.6 , pp. e17343
    • Ryu, H.S.1    Park, S.Y.2    Ma, D.3    Zhang, J.4    Lee, W.5
  • 105
    • 58549108465 scopus 로고    scopus 로고
    • Epigenetic therapy upregulates the tumour suppressor microRNA-126 and its host gene EGFL7 in human cancer cells
    • Saito Y., Friedman J.M., Chihara Y., Egger G., Chuang J.C., Liang G. Epigenetic therapy upregulates the tumour suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem. Biophys. Res. Commun. 2009, 379:726-731.
    • (2009) Biochem. Biophys. Res. Commun. , vol.379 , pp. 726-731
    • Saito, Y.1    Friedman, J.M.2    Chihara, Y.3    Egger, G.4    Chuang, J.C.5    Liang, G.6
  • 106
    • 0036470213 scopus 로고    scopus 로고
    • Insulin signaling pathways in time and space
    • Saltiel A.R., Pessin J.E. Insulin signaling pathways in time and space. Trends Cell Biol. 2002, 12:65-71.
    • (2002) Trends Cell Biol. , vol.12 , pp. 65-71
    • Saltiel, A.R.1    Pessin, J.E.2
  • 111
    • 34347227058 scopus 로고    scopus 로고
    • Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
    • Semenza G.L. Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. Biochem. J. 2007, 405:1-9.
    • (2007) Biochem. J. , vol.405 , pp. 1-9
    • Semenza, G.L.1
  • 112
    • 80051625243 scopus 로고    scopus 로고
    • Oxygen sensing, homeostasis, and disease
    • Semenza G.L. Oxygen sensing, homeostasis, and disease. N. Engl. J. Med. 2011, 365:537-547.
    • (2011) N. Engl. J. Med. , vol.365 , pp. 537-547
    • Semenza, G.L.1
  • 113
    • 84902533403 scopus 로고    scopus 로고
    • MicroRNAs as therapeutic targets in human cancers
    • Shah M.Y., Calin G.A. MicroRNAs as therapeutic targets in human cancers. Wiley Interdiscip. Rev. 2014, 5(4):537-548.
    • (2014) Wiley Interdiscip. Rev. , vol.5 , Issue.4 , pp. 537-548
    • Shah, M.Y.1    Calin, G.A.2
  • 114
    • 84894387582 scopus 로고    scopus 로고
    • Hypoxia-inducible factors link iron homeostasis and erythropoiesis
    • Shah Y.M., Xie L. Hypoxia-inducible factors link iron homeostasis and erythropoiesis. Gastroenterology 2014, 146:630-642.
    • (2014) Gastroenterology , vol.146 , pp. 630-642
    • Shah, Y.M.1    Xie, L.2
  • 116
    • 36348994146 scopus 로고    scopus 로고
    • MicroRNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells
    • Shi B., Sepp-Lorenzino L., Prisco M., Linsley P., de Angelis T., Baserga R. MicroRNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. J. Biol. Chem. 2007, 282:32582-32590.
    • (2007) J. Biol. Chem. , vol.282 , pp. 32582-32590
    • Shi, B.1    Sepp-Lorenzino, L.2    Prisco, M.3    Linsley, P.4    de Angelis, T.5    Baserga, R.6
  • 117
    • 84865107292 scopus 로고    scopus 로고
    • MicroRNA-214 downregulation contributes to tumour angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma
    • Shih T.C., Tien Y.J., Wen C.J., Yeh T.S., Yu M.C., Huang C.H., Lee Y.S., Yen T.C., Hsieh S.Y. MicroRNA-214 downregulation contributes to tumour angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J. Hepatol. 2012, 57:584-591.
    • (2012) J. Hepatol. , vol.57 , pp. 584-591
    • Shih, T.C.1    Tien, Y.J.2    Wen, C.J.3    Yeh, T.S.4    Yu, M.C.5    Huang, C.H.6    Lee, Y.S.7    Yen, T.C.8    Hsieh, S.Y.9
  • 119
    • 84886443752 scopus 로고    scopus 로고
    • MicroRNAs in the tumour microenvironment: big role for small players
    • Soon P., Kiaris H. MicroRNAs in the tumour microenvironment: big role for small players. Endocr. Relat. Cancer 2013, 20:R257-R267.
    • (2013) Endocr. Relat. Cancer , vol.20 , pp. R257-R267
    • Soon, P.1    Kiaris, H.2
  • 120
  • 121
    • 84899073542 scopus 로고    scopus 로고
    • MicroRNA-126 modulates the tumour microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1)
    • Sun X., Wang Z.M., Song Y., Tai X.H., Ji W.Y., Gu H. MicroRNA-126 modulates the tumour microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1). Int. J. Oncol. 2014, 44:1678-1684.
    • (2014) Int. J. Oncol. , vol.44 , pp. 1678-1684
    • Sun, X.1    Wang, Z.M.2    Song, Y.3    Tai, X.H.4    Ji, W.Y.5    Gu, H.6
  • 122
    • 48649102010 scopus 로고    scopus 로고
    • Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster
    • Taguchi A., Yanagisawa K., Tanaka M., Cao K., Matsuyama Y., Goto H., Takahashi T. Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res. 2008, 68:5540-5545.
    • (2008) Cancer Res. , vol.68 , pp. 5540-5545
    • Taguchi, A.1    Yanagisawa, K.2    Tanaka, M.3    Cao, K.4    Matsuyama, Y.5    Goto, H.6    Takahashi, T.7
  • 124
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: insights into insulin action
    • Taniguchi C.M., Emanuelli B., Kahn C.R. Critical nodes in signalling pathways: insights into insulin action. Nat. Rev. Mol. Cell Biol. 2006, 7:85-96.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 126
    • 84895544208 scopus 로고    scopus 로고
    • MicroRNAs as regulators of mitochondrial function: role in cancer suppression
    • Tomasetti M., Neuzil J., Dong L. MicroRNAs as regulators of mitochondrial function: role in cancer suppression. Biochim. Biophys. Acta 2014, 1840:1441-1453.
    • (2014) Biochim. Biophys. Acta , vol.1840 , pp. 1441-1453
    • Tomasetti, M.1    Neuzil, J.2    Dong, L.3
  • 128
    • 34547660196 scopus 로고    scopus 로고
    • FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system
    • Tothova Z., Gilliland D.G. FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system. Cell Stem Cell 2007, 1:140-152.
    • (2007) Cell Stem Cell , vol.1 , pp. 140-152
    • Tothova, Z.1    Gilliland, D.G.2
  • 131
    • 80052242132 scopus 로고    scopus 로고
    • Targeting cancer metabolism: a therapeutic window opens
    • Vander Heiden M.G. Targeting cancer metabolism: a therapeutic window opens. Nat. Rev. Drug Discov. 2011, 10:671-684.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 671-684
    • Vander Heiden, M.G.1
  • 133
    • 84899490560 scopus 로고    scopus 로고
    • MicroRNA-145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling
    • Wang Y., Hu C., Cheng J., Chen B., Ke Q., Lv Z., Wu J., Zhou Y. MicroRNA-145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling. Biochem. Biophys. Res. Commun. 2014, 446(4):1255-1260.
    • (2014) Biochem. Biophys. Res. Commun. , vol.446 , Issue.4 , pp. 1255-1260
    • Wang, Y.1    Hu, C.2    Cheng, J.3    Chen, B.4    Ke, Q.5    Lv, Z.6    Wu, J.7    Zhou, Y.8
  • 134
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate
    • Ward P.S., Thompson C.B. Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 2012, 21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 135
    • 79952167247 scopus 로고    scopus 로고
    • Hypoxia. 2. Hypoxia regulates cellular metabolism
    • Wheaton W.W., Chandel N.S. Hypoxia. 2. Hypoxia regulates cellular metabolism. Am. J. Physiol. 2011, 300:C385-C393.
    • (2011) Am. J. Physiol. , vol.300 , pp. C385-C393
    • Wheaton, W.W.1    Chandel, N.S.2
  • 136
    • 84896737116 scopus 로고    scopus 로고
    • The role of the tumour-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets
    • Wood S.L., Pernemalm M., Crosbie P.A., Whetton A.D. The role of the tumour-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. Cancer Treat. Rev. 2014, 40:558-566.
    • (2014) Cancer Treat. Rev. , vol.40 , pp. 558-566
    • Wood, S.L.1    Pernemalm, M.2    Crosbie, P.A.3    Whetton, A.D.4
  • 138
    • 79956359793 scopus 로고    scopus 로고
    • MicroRNA-22 regulates hypoxia signaling in colon cancer cells
    • Yamakuchi M., Yagi S., Ito T., Lowenstein C.J. MicroRNA-22 regulates hypoxia signaling in colon cancer cells. PLoS One 2011, 6:e20291.
    • (2011) PLoS One , vol.6 , pp. e20291
    • Yamakuchi, M.1    Yagi, S.2    Ito, T.3    Lowenstein, C.J.4
  • 142
    • 84890498926 scopus 로고    scopus 로고
    • Hypoxia-induced deregulation of miR-126 and its regulative effect on VEGF and MMP-9 expression
    • Ye P., Liu J., He F., Xu W., Yao K. Hypoxia-induced deregulation of miR-126 and its regulative effect on VEGF and MMP-9 expression. Int. J. Med. Sci. 2013, 11:17-23.
    • (2013) Int. J. Med. Sci. , vol.11 , pp. 17-23
    • Ye, P.1    Liu, J.2    He, F.3    Xu, W.4    Yao, K.5
  • 143
    • 84878830070 scopus 로고    scopus 로고
    • MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α
    • Yeh Y.M., Chuang C.M., Chao K.C., Wang L.H. MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α. Int. J. Cancer 2013, 133(4):867-878.
    • (2013) Int. J. Cancer , vol.133 , Issue.4 , pp. 867-878
    • Yeh, Y.M.1    Chuang, C.M.2    Chao, K.C.3    Wang, L.H.4
  • 144
    • 34247614521 scopus 로고    scopus 로고
    • HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    • Zhang H., Gao P., Fukuda R., Kumar G., Krishnamachary B., Zeller K.I., Dang C.V., Semenza G.L. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007, 11:407-420.
    • (2007) Cancer Cell , vol.11 , pp. 407-420
    • Zhang, H.1    Gao, P.2    Fukuda, R.3    Kumar, G.4    Krishnamachary, B.5    Zeller, K.I.6    Dang, C.V.7    Semenza, G.L.8
  • 147
    • 84882686726 scopus 로고    scopus 로고
    • Epigenetic silencing of miR-126 contributes to tumour invasion and angiogenesis in colorectal cancer
    • Zhang Y., Wang X., Xu B., Wang B., Wang Z., Liang Y., Zhou J., Hu J., Jiang B. Epigenetic silencing of miR-126 contributes to tumour invasion and angiogenesis in colorectal cancer. Oncol. Rep. 2013, 30:1976-1984.
    • (2013) Oncol. Rep. , vol.30 , pp. 1976-1984
    • Zhang, Y.1    Wang, X.2    Xu, B.3    Wang, B.4    Wang, Z.5    Liang, Y.6    Zhou, J.7    Hu, J.8    Jiang, B.9
  • 150
    • 84875890762 scopus 로고    scopus 로고
    • Targeting cellular metabolism to improve cancer therapeutics
    • Zhao Y., Butler E.B., Tan M. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis. 2013, 4:e532.
    • (2013) Cell Death Dis. , vol.4 , pp. e532
    • Zhao, Y.1    Butler, E.B.2    Tan, M.3
  • 153
    • 79953702227 scopus 로고    scopus 로고
    • Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2
    • Zhu N., Zhang D., Xie H., Zhou Z., Chen H., Hu T., Bai Y., Shen Y., Yuan W., Jing Q., Qin Y. Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2. Mol. Cell. Biochem. 2011, 351:157-164.
    • (2011) Mol. Cell. Biochem. , vol.351 , pp. 157-164
    • Zhu, N.1    Zhang, D.2    Xie, H.3    Zhou, Z.4    Chen, H.5    Hu, T.6    Bai, Y.7    Shen, Y.8    Yuan, W.9    Jing, Q.10    Qin, Y.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.