The secretome in cancer progression

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1834, Issue 11, 2013, Pages 2233-2241

  Paltridge, James L ^a,b   Belle, Leila ^a   Khew Goodall, Yeesim ^a,b  

^a CENTRE FOR CANCER BIOLOGY   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Cancer; Cancer associated fibroblast; Cancer stem cell; Metastatic niche; Microenvironment; Secretome

Indexed keywords

ACTIVIN; CATHEPSIN L; CD133 ANTIGEN; COPPER ZINC SUPEROXIDE DISMUTASE; CYSTATIN C; DICKKOPF 3 PROTEIN; ENZYME; FRUCTOSE BISPHOSPHATE ALDOLASE; GELATINASE A; GELATINASE B; GLYCOPROTEIN; LIPOCORTIN 5; LOXL2 ENZYME; MICRORNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROCOLLAGEN C PROTEINASE; PROTEIN; PROTEIN NODAL; PROTEIN P53; PROTEIN TYROSINE KINASE; SECRETED FRIZZLED RELATED PROTEIN 1; SECRETOME; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 6; SOMATOMEDIN BINDING PROTEIN 7; STABLE ISOTOPE; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG; VASCULOTROPIN; WNT PROTEIN;

ANGIOGENESIS; APOPTOSIS; BREAST CANCER; BREAST EPITHELIUM; CANCER GROWTH; CANCER STEM CELL; CARCINOGENESIS; CELL COMMUNICATION; CELL CYCLE ARREST; CELL HYPOXIA; CELL MIGRATION; CELL PROLIFERATION; COLORECTAL CANCER; DNA DAMAGE; DOWN REGULATION; FIBROBLAST; GENE MUTATION; GENE OVEREXPRESSION; GLIOBLASTOMA; HUMAN; INTRACELLULAR SIGNALING; KIDNEY CARCINOMA; METASTASIS; NASOPHARYNX CARCINOMA; NONHUMAN; ONCOGENE C MYC; OVARY CANCER; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN SECRETION; REGULATORY MECHANISM; REVIEW; SENESCENCE; SKIN CANCER; STEM CELL NICHE; TUMOR ESCAPE; TUMOR INVASION; TUMOR MICROENVIRONMENT; WNT SIGNALING PATHWAY;

CANCER; CANCER ASSOCIATED FIBROBLAST; CANCER STEM CELL; METASTATIC NICHE; MICROENVIRONMENT; SECRETOME;

ANIMALS; HUMANS; NEOPLASM METASTASIS; NEOPLASMS; NEOPLASTIC STEM CELLS; PROTEOME; SECRETORY PATHWAY; TUMOR MICROENVIRONMENT;

EUKARYOTA;

EID: 84884817862     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2013.03.014     Document Type: Review

References (84)

1. H. Tjalsma, A. Bolhuis, J.D.H. Jongbloed, and J.M. Van Dijl Signal peptide-dependent protein transport in Bacillus subtilis: a genome-based survey of the secretome Microbiol. Mol. Biol. Rev. 64 2000 515 547
2. G.K. Agrawal, N.-S. Jwa, M.-H. Lebrun, D. Job, and R. Rakwal Plant secretome: unlocking secrets of the secreted proteins Proteomics 10 2010 799 827
3. Y. Hathout Approaches to the study of the cell secretome Expert Rev. Proteomics 4 2007 239 (4.2 (Apr. 2007): P239)
4. M. Stastna, and J.E. Van Eyk Secreted proteins as a fundamental source for biomarker discovery Proteomics 12 2012 722 735
5. M. Makridakis, and A. Vlahou Secretome proteomics for discovery of cancer biomarkers J. Proteomics 73 2010 2291 2305
6. P. Dowling, and M. Clynes Conditioned media from cell lines: a complementary model to clinical specimens for the discovery of disease-specific biomarkers Proteomics 11 2011 794 804
7. D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70 (Pubitemid 30046295)
8. D. Hanahan, and L.M. Coussens Accessories to the crime: functions of cells recruited to the tumor microenvironment Cancer Cell 21 2012 309 322
9. H. Peinado, S. Lavotshkin, and D. Lyden The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts Semin. Cancer Biol. 21 2011 139 146
10. B. Psaila, and D. Lyden The metastatic niche: adapting the foreign soil Nat. Rev. Cancer 9 2009 285 293
11. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
12. M.C.S. Lee, E.A. Miller, J. Goldberg, L. Orci, and R. Schekman Bi-directional protein transport between the ER and Golgi Annu. Rev. Cell Dev. Biol. 20 2004 87 123 (Pubitemid 39488634)
13. I. Mellman, and G. Warren The road taken: past and future foundations of membrane traffic Cell 100 2000 99 112 (Pubitemid 30046299)
14. C.E.L. Chua, Y.S. Lim, M.G. Lee, and B.L. Tang Non-classical membrane trafficking processes galore J. Cell. Physiol. 227 2012 3722 3730
15. E. Cocucci, G. Racchetti, and J. Meldolesi Shedding microvesicles: artefacts no more Trends Cell Biol. 19 2009 43 51
16. A.V. Vlassov, S. Magdaleno, R. Setterquist, and R. Conrad Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials Biochim. Biophys. Acta 1820 2012 940 948
17. L. Sepiashvili, A. Hui, V. Ignatchenko, W. Shi, S. Su, W. Xu, S.H. Huang, B. O'Sullivan, J. Waldron, J.C. Irish, B. Perez-Ordonez, F. Liu, and T. Kislinger Potentially novel candidate biomarkers for head and neck squamous cell carcinoma identified using an integrated cell line-based discovery strategy Mol. Cell. Proteomics 11 2012 1404 1415
18. R. Beroukhim, C.H. Mermel, D. Porter, G. Wei, J. Donovan, J. Barretina, J.S. Boehm, J. Dobson, M. Urashima, K.T.M. Henry, R.M. Pinchback, A.H. Ligon, L. Haery, H. Greulich, M. Reich, W. Winckler, S. Michael, B.A. Weir, K.E. Tanaka, and D.Y. Chiang The landscape of somatic copy-number alteration across human cancers Nature 463 2010 899 905
19. G. Pocsfalvi, G. Votta, A. De Vincenzo, I. Fiume, D.A.A. Raj, G. Marra, M.P. Stoppelli, and I. Iaccarino Analysis of secretome changes uncovers an autocrine/paracrine component in the modulation of cell proliferation and motility by c-Myc J. Proteome Res. 10 2011 5326 5337
20. B. Vogelstein, D. Lane, and A.J. Levine Surfing the p53 network Nature 408 2000 307 310
21. P.M. Neilsen, J.E. Noll, R.J. Suetani, R.B. Schulz, F. Al-ejeh, A. Evdokiou, D.P. Lane, and D.F. Callen Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome Oncotarget 2 2011 1203 1217
22. N.R. Leslie, and C.P. Downes PTEN function: how normal cells control it and tumour cells lose it Biochem. J. 11 2004 1 11 (Pubitemid 39141560)
23. A. Bronisz, J. Godlewski, J.A. Wallace, A.S. Merchant, M.O. Nowicki, and H. Mathsyaraja Reprogramming of the tumour microenvironment by stromal Pten-regulated miR-320 Nat. Cell Biol. 14 2012 159 167
24. M.V. Iorio, and C.M. Croce microRNA involvement in human cancer Carcinogenesis 33 2012 1126 1133
25. P.A. Gregory, A.G. Bert, E.L. Paterson, S.C. Barry, A. Tsykin, G. Farshid, M.A. Vadas, Y. Khew-Goodall, and G.J. Goodall The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 Nat. Cell Biol. 10 2008 593 601 (Pubitemid 351627379)
26. S. Spaderna, O. Schmalhofer, M. Wahlbuhl, A. Dimmler, K. Bauer, A. Sultan, F. Hlubek, A. Jung, D. Strand, A. Eger, T. Kirchner, J. Behrens, and T. Brabletz The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer Cancer Res. 68 2008 537 544 (Pubitemid 351380082)
27. S. Park, A.B. Gaur, E. Lengyel, and M.E. Peter The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2 Genes Dev. 22 2008 894 907 (Pubitemid 351482843)
28. J.C. Tse, and R. Kalluri Mechanisms of metastasis: epithelial-to- mesenchymal transition and contribution of tumor microenvironment J. Cell. Biochem. 101 2007 816 829 (Pubitemid 47040864)
29. M. Korpal, B.J. Ell, F.M. Buffa, T. Ibrahim, M.A. Blanco, T. Celià-Terrassa, L. Mercatali, Z. Khan, H. Goodarzi, Y. Hua, Y. Wei, G. Hu, B.A. Garcia, J. Ragoussis, D. Amadori, A.L. Harris, and Y. Kang Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization Nat. Med. 17 2011 1101 1108
30. Y. Khew-Goodall, and G.J. Goodall Stromal miR-320 keeps an oncogenic secretome in check Nat. Cell Biol. 14 2012 124 125
31. G.L. Semenza Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling J. Cell. Biochem. 102 2007 840 847 (Pubitemid 350036924)
32. S. Rey, and G.L. Semenza Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling Cardiovasc. Res. 86 2010 236 242
33. A.L. Harris Hypoxia - a key regulatory factor in tumour growth Nat. Rev. Cancer 2 2002 38 47 (Pubitemid 37328806)
34. P. Michieli Hypoxia, angiogenesis and cancer therapy: to breathe or not to breathe Cell Cycle 8 2009 3291 3296
35. K. De Bock, M. Mazzone, and P. Carmeliet Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not? Nat. Rev. Clin. Oncol. 8 2011 393 404
36. S. Hung, J.H. Ho, Y.V. Shih, T. Lo, and O.K. Lee Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells J. Orthop. Res. 30 2012 260 266
37. S.P. Hung, M.H. Yang, K.F. Tseng, and O.K. Lee Hypoxia-induced secretion of TGF-beta 1 in mesenchymal stem cell promotes breast cancer cell progression Cell Transplant. 2012 10.3727/096368912X657954 (Epub ahead of print, in press)
38. F.T. Martin, R.M. Dwyer, J. Kelly, S. Khan, J.M. Murphy, C. Curran, N. Miller, E. Hennessy, P. Dockery, F.P. Barry, T. O'Brien, and M.J. Kerin Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT) Breast Cancer Res. Treat. 124 2010 317 326
39. Q. Xu, L. Wang, H. Li, Q. Han, J. Li, X. Qu, S. Huang, and R.C. Zhao Mesenchymal stem cells play a potential role in regulating the establishment and maintenance of epithelial-mesenchymal transition in MCF7 human breast cancer cells by paracrine and induced autocrine TGF-β Int. J. Oncol. 41 2012 959 968
40. S. Ge, Y. Mao, Y. Yi, D. Xie, Z. Chen, and Z. Xiao Comparative proteomic analysis of secreted proteins from nasopharyngeal carcinoma-associated stromal fibroblasts and normal fibroblasts Exp. Ther. Med. 3 2012 857 860
41. S. Tyan, W. Kuo, C. Huang, C. Pan, J. Shew, K. Chang, E.Y. Lee, and W. Lee Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis PLoS One 6 2011 e15313
42. A. Orimo, P.B. Gupta, D.C. Sgroi, F. Arenzana-Seisdedos, T. Delaunay, R. Naeem, V.J. Carey, A.L. Richardson, and R.A. Weinberg Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion Cell 121 2005 335 348 (Pubitemid 40692295)
43. P.J. Mishra, P.J. Mishra, R. Humeniuk, D.J. Medina, G. Alexe, J.P. Mesirov, S. Ganesan, J.W. Glod, and D. Banerjee Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells Cancer Res. 68 2008 4331 4339
44. A. De Boeck, A. Hendrix, D. Maynard, M. Van Bockstal, A. Daniëls, P. Pauwels, C. Gespach, M. Bracke, and O. De Wever Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression Proteomics 2012 1 25
45. D. Bonnet, and J. Dick Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell Nat. Med. 3 1997 730 737 (Pubitemid 27298715)
46. C.A. O'Brien, A. Pollett, S. Gallinger, and J.E. Dick A human colon cancer cell capable of initiating tumour growth in immunodeficient mice Nature 445 2007 106 110 (Pubitemid 46067310)
47. M. Al-Hajj, M.S. Wicha, A. Benito-Hernandez, S.J. Morrison, and M.F. Clarke Prospective identification of tumorigenic breast cancer cells Proc. Natl. Acad. Sci. U.S.A. 100 2003 3983 3988 (Pubitemid 36418143)
48. S. Lang, F. Frame, and A. Collins Prostate cancer stem cells J. Pathol. 217 2009 299 306
49. S. Zhang, C. Balch, M.W. Chan, H.-C. Lai, D. Matei, J.M. Schilder, P.S. Yan, T.H.-M. Huang, and K.P. Nephew Identification and characterization of ovarian cancer-initiating cells from primary human tumors Cancer Res. 68 2008 4311 4320
50. T. Schatton, G.F. Murphy, N.Y. Frank, K. Yamaura, A.M. Waaga-Gasser, M. Gasser, Q. Zhan, S. Jordan, L.M. Duncan, C. Weishaupt, R.C. Fuhlbrigge, T.S. Kupper, M.H. Sayegh, and M.H. Frank Identification of cells initiating human melanomas Nature 451 2008 345 349
51. E. Sugihara, and H. Saya Complexity of cancer stem cells Int. J. Cancer 132 2012 1249 1259
52. P. Valent, D. Bonnet, R. De Maria, T. Lapidot, M. Copland, J.V. Melo, C. Chomienne, F. Ishikawa, J.J. Schuringa, G. Stassi, B. Huntly, H. Herrmann, J. Soulier, A. Roesch, G.J. Schuurhuis, S. Wöhrer, M. Arock, J. Zuber, S. Cerny-Reiterer, and H.E. Johnsen Cancer stem cell definitions and terminology: the devil is in the details Nat. Rev. Cancer 12 2012 767 775
53. A. Fábián, G. Vereb, and J. Szöllosi The hitchhikers guide to cancer stem cell theory: markers, pathways and therapy Cytometry A 2012 16 21
54. E. Lonardo, P.C. Hermann, M.-T. Mueller, S. Huber, A. Balic, I. Miranda-Lorenzo, S. Zagorac, S. Alcala, I. Rodriguez-Arabaolaza, J.C. Ramirez, R. Torres-Ruíz, E. Garcia, M. Hidalgo, D.Á. Cebrián, R. Heuchel, M. Löhr, F. Berger, P. Bartenstein, A. Aicher, and C. Heeschen Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy Cell Stem Cell 9 2011 433 446
55. E. Lonardo, J. Frias-Aldeguer, P.C. Hermann, and C. Heeschen Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness Cell Cycle 11 2012 1282 1290
56. H. Clevers Wnt/beta-catenin signaling in development and disease Cell 127 2006 469 480
57. L. Vermeulen, F. De Sousa E Melo, M. van der Heijden, K. Cameron, J.H. de Jong, T. Borovski, J.B. Tuynman, M. Todaro, C. Merz, H. Rodermond, M.R. Sprick, K. Kemper, D.J. Richel, G. Stassi, and J.P. Medema Wnt activity defines colon cancer stem cells and is regulated by the microenvironment Nat. Cell Biol. 12 2010 468 476
58. A.-R. Choi, J.-R. Park, R.-J. Kim, S.-R. Kim, S.-D. Cho, J.-Y. Jung, and J.-S. Nam Inhibition of Wnt1 expression reduces the enrichment of cancer stem cells in a mouse model of breast cancer Biochem. Biophys. Res. Commun. 425 2012 436 442
59. N. Takebe, P.J. Harris, R.Q. Warren, and S.P. Ivy Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways Nat. Rev. Clin. Oncol. 8 2011 97 106
60. S. Bao, Q. Wu, S. Sathornsumetee, Y. Hao, Z. Li, A.B. Hjelmeland, Q. Shi, R.E. McLendon, D.D. Bigner, and J.N. Rich Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor Cancer Res. 66 2006 7843 7848 (Pubitemid 44299144)
61. C. Grange, M. Tapparo, F. Collino, L. Vitillo, C. Damasco, M.C. Deregibus, C. Tetta, B. Bussolati, and G. Camussi Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche Cancer Res. 71 2011 5346 5356
62. K. Al-Nedawi, B. Meehan, R.S. Kerbel, A.C. Allison, and J. Rak Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR Proc. Natl. Acad. Sci. U.S.A. 106 2009 3794 3799
63. J.L. Hood, H. Pan, G.M. Lanza, and S.A. Wickline Paracrine induction of endothelium by tumor exosomes Lab. Invest. 89 2009 1317 1328
64. M. Shipitsin, L.L. Campbell, P. Argani, S. Weremowicz, N. Bloushtain-Qimron, J. Yao, T. Nikolskaya, T. Serebryiskaya, R. Beroukhim, M. Hu, M.K. Halushka, S. Sukumar, L.M. Parker, K.S. Anderson, L.N. Harris, J.E. Garber, A.L. Richardson, S.J. Schnitt, Y. Nikolsky, and R.S. Gelman Molecular definition of breast tumor heterogeneity Cancer Cell 11 2007 259 273 (Pubitemid 46349843)
65. S.A. Mani, W. Guo, M. Liao, E.N. Eaton, A.Y. Zhou, M. Brooks, F. Reinhard, C.C. Zhang, L.L. Campbell, K. Polyak, C. Brisken, J. Yang, and R.A. Weinberg The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 2009 704 715 (Pubitemid 351636299)
66. R. Liu, X. Wang, G.Y. Chen, P. Dalerba, A. Gurney, T. Hoey, G. Sherlock, J. Lewicki, K. Shedden, and M.F. Clarke The prognostic role of a gene signature from tumorigenic breast-cancer cells N. Engl. J. Med. 356 2007 217 226 (Pubitemid 46143225)
67. J.P. Thiery Epithelial-mesenchymal transitions in tumour progression Nat. Rev. Cancer 2 2002 442 454
68. F. Artacho-Cordón, S. Ríos-Arrabal, P.C. Lara, A. Artacho-Cordón, I. Calvente, and M.I. Núñez Matrix metalloproteinases: potential therapy to prevent the development of second malignancies after breast radiotherapy Surg. Oncol. 21 2012 e143 e151
69. J.A. Joyce, and J.W. Pollard Microenvironmental regulation of metastasis Nat. Rev. Cancer 9 2009 239 252
70. G.P. Gupta, and J. Massagué Cancer metastasis: building a framework Cell 127 2006 679 695 (Pubitemid 44781029)
71. L. Bubendorf, A. Schöpfer, U. Wagner, G. Sauter, H. Moch, N. Willi, T.C. Gasser, and M.J. Mihatsch Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients Hum. Pathol. 31 2000 578 583 (Pubitemid 30323983)
72. A.C. Chiang, and J. Massagué Molecular basis of metastasis N. Engl. J. Med. 359 2008 2814 2823
73. Y. Kang, P.M. Siegel, W. Shu, M. Drobnjak, S.M. Kakonen, C. Cordón-Cardo, T.A. Guise, and J. Massagué A multigenic program mediating breast cancer metastasis to bone Cancer Cell 3 2003 537 549 (Pubitemid 36808649)
74. A.P. Molloy, F.T. Martin, R.M. Dwyer, T.P. Griffin, M. Murphy, F.P. Barry, T. O'Brien, and M.J. Kerin Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells Int. J. Cancer 124 2009 326 332
75. M. Kinder, E. Chislock, K.M. Bussard, L. Shuman, and A.M. Mastro Metastatic breast cancer induces an osteoblast inflammatory response Exp. Cell Res. 314 2008 173 183 (Pubitemid 350182446)
76. B.A. Kerr, R. Miocinovic, A.K. Smith, and E.A. Klein Comparison of tumor and microenvironment secretomes in plasma and in platelets during prostate cancer growth in a xenograft model Neoplasia 12 2010 388 396
77. Y. Lee, C. Cheng, M.A. Bilen, J. Lu, R.L. Satcher, L. Yu-Lee, G.E. Gallick, S.N. Maity, and S. Lin BMP4 promotes prostate tumor growth in bone through osteogenesis Cancer Res. 71 2011 5194 5203
78. R.N. Kaplan, R.D. Riba, S. Zacharoulis, H. Anna, L. Vincent, C. Costa, D.D. Macdonald, D.K. Jin, S.A. Kerns, Z. Zhu, D. Hicklin, Y. Wu, J.L. Port, E.R. Port, D. Ruggero, S.V. Shmelkov, K.K. Jensen, S. Rafii, and D. Lyden VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche Nature 438 2005 820 827 (Pubitemid 41753060)
79. S. Hiratsuka, A. Watanabe, H. Aburatani, and Y. Maru Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis Nat. Cell Biol. 8 2006 1369 1375 (Pubitemid 44835111)
80. J.T. Erler, K.L. Bennewith, T.R. Cox, G. Lang, D. Bird, A. Koong, Q.-T. Le, and A.J. Giaccia Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche Cancer Cell 15 2009 35 44
81. B.A. Kerr, N.P. McCabe, W. Feng, and T.V. Byzova Platelets govern pre-metastatic tumor communication to bone Oncogene 2012 1 6
82. T. Jung, D. Castellana, P. Klingbeil, and E. Al CD44v6 dependence of premetastatic niche preparation by exosomes Neoplasia 11 2009 1093 1105
83. H. Peinado, M. Alečković, S. Lavotshkin, I. Matei, B. Costa-Silva, G. Moreno-Bueno, M. Hergueta-Redondo, C. Williams, G. García-Santos, C. Ghajar, A. Nitadori-Hoshino, C. Hoffman, K. Badal, B.A. Garcia, M.K. Callahan, J. Yuan, V.R. Martins, J. Skog, R.N. Kaplan, and M.S. Brady Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET Nat. Med. 18 2012 883 891
84. D. Garnier, N. Magnus, T.H. Lee, V. Bentley, B. Meehan, C. Milsom, L. Montermini, T. Kislinger, and J. Rak Cancer cells induced to express mesenchymal phenotype release exosome-like extracellular vesicles carrying tissue factor J. Biol. Chem. 287 2012 43565 43572