MiR-126 functions as a tumour suppressor in human gastric cancer

Cancer Letters

Volumn 298, Issue 1, 2010, Pages 50-63

  Feng, Runhua ^a   Chen, Xuehua ^a   Yu, Yingyan ^a   Su, Liping ^a   Yu, Beiqin ^a   Li, Jianfang ^a   Cai, Qu ^a   Yan, Min ^a   Liu, Bingya ^a   Zhu, Zhenggang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Crk; Gastric cancer; Invasion; MicroRNA; Proliferation

Indexed keywords

ADAPTOR PROTEIN; CRK PROTEIN; MICRORNA; MICRORNA 126; UNCLASSIFIED DRUG; CRK PROTEIN, HUMAN; MIRN126 MICRORNA, HUMAN; ONCOPROTEIN;

ADULT; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INVASION; CANCER STAGING; CARCINOGENICITY; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS POTENTIAL; PRIORITY JOURNAL; STOMACH CANCER; TUMOR SUPPRESSOR GENE; TUMOR VOLUME; ANIMAL; BIOSYNTHESIS; CELL CYCLE; CELL GROWTH; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; MOUSE; NUDE MOUSE; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE;

ANIMALS; CELL CYCLE; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MICE; MICE, NUDE; MICRORNAS; PROTO-ONCOGENE PROTEINS C-CRK; STOMACH NEOPLASMS; TRANSFECTION;

EID: 77956915352     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.06.004     Document Type: Article

References (36)

1. Kamangar F., Dores G.M., Anderson W.F. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J. Clin. Oncol. 2006, 24:2137-2150.
2. Moon Y.W., Jeung H.C., Rha S.Y., Yoo N.C., Roh J.K., Noh S.H., Kim B.S., Chung H.C. Changing patterns of prognosticators during 15-year follow-up of advanced gastric cancer after radical gastrectomy and adjuvant chemotherapy: a 15-year follow-up study at a single Korean institute. Ann. Surg. Oncol. 2007, 14:2730-2737.
3. Liu J. Control of protein synthesis and mRNA degradation by microRNAs. Curr. Opin. Cell Biol. 2008, 20:214-221.
4. Ambros V. The functions of animal microRNAs. Nature 2004, 431:350-355.
5. Calin G.A., Dumitru C.D., Shimizu M., Bichi R., Zupo S., Noch E., Aldler H., Rattan S., Keating M., Rai K., Rassenti L., Kipps T., Negrini M., Bullrich F., Croce C.M. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 2002, 99:15524-15529.
6. Nasser M.W., Datta J., Nuovo G., Kutay H., Motiwala T., Majumder S., Wang B., Suster S., Jacob S.T., Ghoshal K. Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J. Biol. Chem. 2008, 283:33394-33405.
7. Tazawa H., Tsuchiya N., Izumiya M., Nakagama H. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc. Natl. Acad. Sci. USA 2007, 104:15472-15477.
8. Ma L., Teruya-Feldstein J., Weinberg R.A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007, 449:682-688.
9. Bonci D., Coppola V., Musumeci M., Addario A., Giuffrida R., Memeo L., D'Urso L., Pagliuca A., Biffoni M., Labbaye C., Bartucci M., Muto G., Peschle C., De Maria R. The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat. Med. 2008, 14:1271-1277.
10. Yao J., Liang L., Huang S., Ding J., Tan N., Zhao Y., Yan M., Ge C., Zhang Z., Chen T., Wan D., Yao M., Li J., Gu J., He X. MicroRNA-30d promotes tumor invasion and metastasis by targeting Galphai2 in hepatocellular carcinoma. Hepatology 2010, 51:846-856.
11. Yang H., Kong W., He L., Zhao J.J., O'Donnell J.D., Wang J., Wenham R.M., Coppola D., Kruk P.A., Nicosia S.V., Cheng J.Q. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res. 2008, 68:425-433.
12. Crawford M., Brawner E., Batte K., Yu L., Hunter M.G., Otterson G.A., Nuovo G., Marsh C.B., Nana-Sinkam S.P. MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem. Biophys. Res. Commun. 2008, 373:607-612.
13. Wang Y.W., Qu Y., Li J.F., Chen X.H., Liu B.Y., Gu Q.L., Zhu Z.G. In vitro and in vivo evidence of metallopanstimulin-1 in gastric cancer progression and tumorigenicity. Clin. Cancer Res. 2006, 12:4965-4973.
14. Koohdani F., Sasani F., Mohammad K., Mehdipour P. Comparison of Ki-67 antigen expression and K-ras mutation in lung tumours induced by urethane in mice. Singapore Med. J. 2009, 50:729-733.
15. Xiao B., Guo J., Miao Y., Jiang Z., Huan R., Zhang Y., Li D., Zhong J. Detection of miR-106a in gastric carcinoma and its clinical significance. Clin. Chim. Acta 2009, 400:97-102.
16. Du Y., Xu Y., Ding L., Yao H., Yu H., Zhou T., Si J. Down-regulation of miR-141 in gastric cancer and its involvement in cell growth. J. Gastroenterol. 2009, 44:556-561.
17. Takagi T., Iio A., Nakagawa Y., Naoe T., Tanigawa N., Akao Y. Decreased expression of microRNA-143 and -145 in human gastric cancers. Oncology 2009, 77:12-21.
18. Gao C., Zhang Z., Liu W., Xiao S., Gu W., Lu H. Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer. Cancer 2010, 116:41-49.
19. Zhang Y., Guo J., Li D., Xiao B., Miao Y., Jiang Z., Zhuo H. Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance. Med. Oncol. 2009, 10.1007/s12032-009-9269-x.
20. Zhang H.H., Wang X.J., Li G.X., Yang E., Yang N.M. Detection of let-7a microRNA by real-time PCR in gastric carcinoma. World J. Gastroenterol. 2007, 13:2883-2888.
21. Petrocca F., Visone R., Onelli M.R., Shah M.H., Nicoloso M.S., de Martino I., Iliopoulos D., Pilozzi E., Liu C.G., Negrini M., Cavazzini L., Volinia S., Alder H., Ruco L.P., Baldassarre G., Croce C.M., Vecchione A. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 2008, 13:272-286.
22. Birge R.B., Kalodimos C., Inagaki F., Tanaka S. Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun. Signal. 2009, 7:13.
23. Yilmaz M., Adli M., Celen Z., Zincirkeser S., Dirier A. FDG PET-CT in cervical cancer: relationship between primary tumor FDG uptake and metastatic potential. Nucl. Med. Commun. 2010, 31:526-531.
24. Rodrigues S.P., Fathers K.E., Chan G., Zuo D., Halwani F., Meterissian S., Park M. Crk I and Crk II function as key signaling integrators for migration and invasion of cancer cells. Mol. Cancer Res. 2005, 3:183-194.
25. Tavazoie S.F., Alarcón C., Oskarsson T., Padua D., Wang Q., Bos P.D., Gerald W.L., Massagué J. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008, 451:147-152.
26. Liu B., Peng X.C., Zheng X.L., Wang J., Qin Y.W. miR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer 2009, 66:169-175.
27. Yan L.X., Huang X.F., Shao Q., Huang M.Y., Deng L., Wu Q.L., Zeng Y.X., Shao J.Y. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA 2008, 14:2348-2360.
28. Li X.H., Zhang Y., Zhang Y.F., Ding J., Wu K.C., Fan D.M. Survival prediction of gastric cancer by a seven-microRNA signature. Gut 2009, 59:579-585.
29. Chekulaeva M., Filipowicz W. Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. Curr. Opin. Cell Biol. 2009, 21:452-460.
30. Sethupathy P., Megraw M., Hatzigeorgiou A.G. A guide through present computational approaches for the identification of mammalian microRNA targets. Nat. Methods 2006, 3:881-886.
31. Watanabe T., Tsuda M., Makino Y., Konstantinou T., Nishihara H., Majima T., Minami A., Feller S.M., Tanaka S. Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration. Cell Res. 2009, 19:638-650.
32. Nishihara H., Tanaka S., Tsuda M., Oikawa S., Maeda M., Shimizu M., Shinomiya H., Tanigami A., Sawa H., Nagashima K. Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers. Cancer Lett. 2002, 180:55-61.
33. Miller C.T., Chen G., Gharib T.G., Wang H., Thomas D.G., Misek D.E., Giordano T.J., Yee J., Orringer M.B., Hanash S.M., Beer D.G. Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas. Oncogene 2003, 22:7950-7957.
34. Linghu H., Tsuda M., Makino Y., Sakai M., Watanabe T., Ichihara S., Sawa H., Nagashima K., Mochizuki N., Tanaka S. Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS. Oncogene 2006, 25:3547-3556.
35. Wang L., Tabu K., Kimura T., Tsuda M., Linghu H., Tanino M., Kaneko S., Nishihara H., Tanaka S. Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4. Biochem. Biophys. Res. Commun. 2007, 362:976-981.
36. Suzuki M., Mimuro H., Suzuki T., Park M., Yamamoto T., Sasakawa C. Interaction of CagA with Crk plays an important role in helicobacter pylori-induced loss of gastric epithelial cell adhesion. J. Exp. Med. 2005, 202:1235-1247.