MicroRNAs and metabolism crosstalk in energy homeostasis

Cell Metabolism

Volumn 18, Issue 3, 2013, Pages 312-324

  Dumortier, Olivier ^a,b   Hinault, Charlotte ^a,b,c   Van Obberghen, Emmanuel ^a,b,c  

^a UNIVERSITY OF NICE SOPHIA ANTIPOLIS   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c UNIVERSITY HOSPITAL OF NICE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HORMONE; MICRORNA; MIRAVIRSEN;

ARTICLE; CROSS REACTION; DIABETES MELLITUS; DISEASE MARKER; ENERGY METABOLISM; EXON; GENE EXPRESSION; GENOMICS; GLUCOSE METABOLISM; HEPATITIS C; HOMEOSTASIS; HUMAN; INFLAMMATION; INTRON; LIPID METABOLISM; NONHUMAN; NUTRIENT; PATHOGENESIS; PRIORITY JOURNAL; STRESS;

BIOLOGICAL MARKERS; CYTOKINES; DIABETES MELLITUS; ENERGY METABOLISM; HORMONES; HUMANS; MICRORNAS;

EID: 84883488437     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.06.004     Document Type: Review

References (99)

1. E. Arner, N. Mejhert, A. Kulyté, P.J. Balwierz, M. Pachkov, M. Cormont, S. Lorente-Cebrián, A. Ehrlund, J. Laurencikiene, and P. Hedén Adipose tissue microRNAs as regulators of CCL2 production in human obesity Diabetes 61 2012 1986 1993
2. T. Avnit-Sagi, L. Kantorovich, S. Kredo-Russo, E. Hornstein, and M.D. Walker The promoter of the pri-miR-375 gene directs expression selectively to the endocrine pancreas PLoS ONE 4 2009 e5033
3. M. Balasubramanyam, S. Aravind, K. Gokulakrishnan, P. Prabu, C. Sathishkumar, H. Ranjani, and V. Mohan Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes Mol. Cell. Biochem. 351 2011 197 205
4. N. Baroukh, M.A. Ravier, M.K. Loder, E.V. Hill, A. Bounacer, R. Scharfmann, G.A. Rutter, and E. Van Obberghen MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines J. Biol. Chem. 282 2007 19575 19588
5. D.P. Bartel MicroRNAs: target recognition and regulatory functions Cell 136 2009 215 233
6. N. Becker, and C.M. Lockwood Pre-analytical variables in miRNA analysis Clin. Biochem. 46 2013 861 868
7. M. Boehm, and F. Slack A developmental timing microRNA and its target regulate life span in C. elegans Science 310 2005 1954 1957
8. C. Bolmeson, J.L. Esguerra, A. Salehi, D. Speidel, L. Eliasson, and C.M. Cilio Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects Biochem. Biophys. Res. Commun. 404 2011 16 22
9. â̂ - Proc. Natl. Acad. Sci. USA 109 2012 15330 15335
10. Y. Chang, W. Yan, X. He, L. Zhang, C. Li, H. Huang, G. Nace, D.A. Geller, J. Lin, and A. Tsung miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions Gastroenterology 143 2012 177 187 e8
11. X. Chen, H. Liang, C.Y. Zhang, and K. Zen miRNA regulates noncoding RNA: a noncanonical function model Trends Biochem. Sci. 37 2012 457 459
12. D.R. Cochrane, N.S. Spoelstra, and J.K. Richer The role of miRNAs in progesterone action Mol. Cell. Endocrinol. 357 2012 50 59
13. A. Dávalos, L. Goedeke, P. Smibert, C.M. Ramírez, N.P. Warrier, U. Andreo, D. Cirera-Salinas, K. Rayner, U. Suresh, and J.C. Pastor-Pareja miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling Proc. Natl. Acad. Sci. USA 108 2011 9232 9237
14. S. Daya, and K.I. Berns Gene therapy using adeno-associated virus vectors Clin. Microbiol. Rev. 21 2008 583 593
15. M.Y. Donath, and S.E. Shoelson Type 2 diabetes as an inflammatory disease Nat. Rev. Immunol. 11 2011 98 107
16. M.J. Drummond, J.J. McCarthy, M. Sinha, H.M. Spratt, E. Volpi, K.A. Esser, and B.B. Rasmussen Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis Physiol. Genomics 43 2011 595 603
17. O. Dumortier, and E. Van Obberghen MicroRNAs in pancreas development Diabetes Obes. Metab. 14 Suppl 3 2012 22 28
18. M.S. Ebert, and P.A. Sharp Roles for microRNAs in conferring robustness to biological processes Cell 149 2012 515 524
19. A. El Ouaamari, N. Baroukh, G.A. Martens, P. Lebrun, D. Pipeleers, and E. Van Obberghen miR-375 targets 3′-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells Diabetes 57 2008 2708 2717
20. C. Esau, S. Davis, S.F. Murray, X.X. Yu, S.K. Pandey, M. Pear, L. Watts, S.L. Booten, M. Graham, and R. McKay miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting Cell Metab. 3 2006 87 98
21. E.F. Finnegan, and A.E. Pasquinelli MicroRNA biogenesis: regulating the regulators Crit. Rev. Biochem. Mol. Biol. 48 2013 51 68
22. J.E. Fish, M.M. Santoro, S.U. Morton, S. Yu, R.F. Yeh, J.D. Wythe, K.N. Ivey, B.G. Bruneau, D.Y. Stainier, and D. Srivastava miR-126 regulates angiogenic signaling and vascular integrity Dev. Cell 15 2008 272 284
23. N.H. Foley, and L.A. O'Neill miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes J. Leukoc. Biol. 92 2012 521 527
24. R.J. Frost, and E.N. Olson Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs Proc. Natl. Acad. Sci. USA 108 2011 21075 21080
25. I.J. Gallagher, C. Scheele, P. Keller, A.R. Nielsen, J. Remenyi, C.P. Fischer, K. Roder, J. Babraj, C. Wahlestedt, and G. Hutvagner Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes Genome Med. 2 2010 9
26. L. García-Segura, M. Pérez-Andrade, and J. Miranda-Ríos The emerging role of MicroRNAs in the regulation of gene expression by nutrients J Nutrigenet. Nutrigenomics 6 2013 16 31
27. D. Gibbings, S. Mostowy, F. Jay, Y. Schwab, P. Cossart, and O. Voinnet Selective autophagy degrades DICER and AGO2 and regulates miRNA activity Nat. Cell Biol. 14 2012 1314 1321
28. A. Granjon, M.P. Gustin, J. Rieusset, E. Lefai, E. Meugnier, I. Güller, C. Cerutti, C. Paultre, E. Disse, and R. Rabasa-Lhoret The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway Diabetes 58 2009 2555 2564
29. J. Grillari, M. Hackl, and R. Grillari-Voglauer miR-17-92 cluster: ups and downs in cancer and aging Biogerontology 11 2010 501 506
30. C.E. Grueter, E. van Rooij, B.A. Johnson, S.M. DeLeon, L.B. Sutherland, X. Qi, L. Gautron, J.K. Elmquist, R. Bassel-Duby, and E.N. Olson A cardiac microRNA governs systemic energy homeostasis by regulation of MED13 Cell 149 2012 671 683
31. C. Guay, C. Jacovetti, V. Nesca, A. Motterle, K. Tugay, and R. Regazzi Emerging roles of non-coding RNAs in pancreatic β-cell function and dysfunction Diabetes Obes. Metab. 14 Suppl 3 2012 12 21
32. H. Guo, N.T. Ingolia, J.S. Weissman, and D.P. Bartel Mammalian microRNAs predominantly act to decrease target mRNA levels Nature 466 2010 835 840
33. T.B. Hansen, T.I. Jensen, B.H. Clausen, J.B. Bramsen, B. Finsen, C.K. Damgaard, and J. Kjems Natural RNA circles function as efficient microRNA sponges Nature 495 2013 384 388
34. A. He, L. Zhu, N. Gupta, Y. Chang, and F. Fang Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes Mol. Endocrinol. 21 2007 2785 2794
35. B.M. Herrera, H.E. Lockstone, J.M. Taylor, Q.F. Wills, P.J. Kaisaki, A. Barrett, C. Camps, C. Fernandez, J. Ragoussis, and D. Gauguier MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes BMC Med. Genomics 2 2009 54
36. M. Hulsmans, D. De Keyzer, and P. Holvoet MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis FASEB J. 25 2011 2515 2527
37. M. Hulsmans, E. Van Dooren, C. Mathieu, and P. Holvoet Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin PLoS ONE 7 2012 e32794
38. D. Iliopoulos, K. Drosatos, Y. Hiyama, I.J. Goldberg, and V.I. Zannis MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism J. Lipid Res. 51 2010 1513 1523
39. C. Jacovetti, A. Abderrahmani, G. Parnaud, J.C. Jonas, M.L. Peyot, M. Cornu, R. Laybutt, E. Meugnier, S. Rome, and B. Thorens MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity J. Clin. Invest. 122 2012 3541 3551
40. H.L. Janssen, H.W. Reesink, E.J. Lawitz, S. Zeuzem, M. Rodriguez-Torres, K. Patel, A.J. van der Meer, A.K. Patick, A. Chen, and Y. Zhou Treatment of HCV infection by targeting microRNA N. Engl. J. Med. 368 2013 1685 1694
41. V. Jimenez, E. Ayuso, C. Mallol, J. Agudo, A. Casellas, M. Obach, S. Muñoz, A. Salavert, and F. Bosch In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9 Diabetologia 54 2011 1075 1086
42. S.D. Jordan, M. Krüger, D.M. Willmes, N. Redemann, F.T. Wunderlich, H.S. Brönneke, C. Merkwirth, H. Kashkar, V.M. Olkkonen, and T. Böttger Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism Nat. Cell Biol. 13 2011 434 446
43. R. Kang, H.J. Zeh, M.T. Lotze, and D. Tang The Beclin 1 network regulates autophagy and apoptosis Cell Death Differ. 18 2011 571 580
44. D.M. Keller, E.A. Clark, and R.H. Goodman Regulation of microRNA-375 by cAMP in pancreatic β-cells Mol. Endocrinol. 26 2012 989 999
45. C. Kenyon, J. Chang, E. Gensch, A. Rudner, and R. Tabtiang A C. elegans mutant that lives twice as long as wild type Nature 366 1993 461 464
46. V.N. Kim, J. Han, and M.C. Siomi Biogenesis of small RNAs in animals Nat. Rev. Mol. Cell Biol. 10 2009 126 139
47. C.M. Klinge Estrogen Regulation of MicroRNA Expression Curr. Genomics 10 2009 169 183
48. C.M. Klinge miRNAs and estrogen action Trends Endocrinol. Metab. 23 2012 223 233
49. N. Klöting, S. Berthold, P. Kovacs, M.R. Schön, M. Fasshauer, K. Ruschke, M. Stumvoll, and M. Blüher MicroRNA expression in human omental and subcutaneous adipose tissue PLoS ONE 4 2009 e4699
50. S. Kojima, D.L. Shingle, and C.B. Green Post-transcriptional control of circadian rhythms J. Cell Sci. 124 2011 311 320
51. L. Kong, J. Zhu, W. Han, X. Jiang, M. Xu, Y. Zhao, Q. Dong, Z. Pang, Q. Guan, and L. Gao Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study Acta Diabetol. 48 2011 61 69
52. J.W. Kornfeld, C. Baitzel, A.C. Könner, H.T. Nicholls, M.C. Vogt, K. Herrmanns, L. Scheja, C. Haumaitre, A.M. Wolf, and U. Knippschild Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b Nature 494 2013 111 115
53. V. Kovaleva, R. Mora, Y.J. Park, C. Plass, A.I. Chiramel, R. Bartenschlager, H. Döhner, S. Stilgenbauer, A. Pscherer, P. Lichter, and M. Seiffert miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells Cancer Res. 72 2012 1763 1772
54. A. Krek, D. Grün, M.N. Poy, R. Wolf, L. Rosenberg, E.J. Epstein, P. MacMenamin, I. da Piedade, K.C. Gunsalus, M. Stoffel, and N. Rajewsky Combinatorial microRNA target predictions Nat. Genet. 37 2005 495 500
55. G. Kroemer, G. Mariño, and B. Levine Autophagy and the integrated stress response Mol. Cell 40 2010 280 293
56. J. Krützfeldt, N. Rajewsky, R. Braich, K.G. Rajeev, T. Tuschl, M. Manoharan, and M. Stoffel Silencing of microRNAs in vivo with 'antagomirs' Nature 438 2005 685 689
57. P. Landgraf, M. Rusu, R. Sheridan, A. Sewer, N. Iovino, A. Aravin, S. Pfeffer, A. Rice, A.O. Kamphorst, and M. Landthaler A mammalian microRNA expression atlas based on small RNA library sequencing Cell 129 2007 1401 1414
58. C. Langer, F.G. Rücker, C. Buske, H. Döhner, and F. Kuchenbauer Targeted therapies through microRNAs: pulp or fiction? Ther. Adv. Hematol. 3 2012 97 104
59. A.K. Leung, and P.A. Sharp MicroRNA functions in stress responses Mol. Cell 40 2010 205 215
60. X. Li, J.J. Cassidy, C.A. Reinke, S. Fischboeck, and R.W. Carthew A microRNA imparts robustness against environmental fluctuation during development Cell 137 2009 273 282
61. J. Liang, C. Liu, A. Qiao, Y. Cui, H. Zhang, A. Cui, S. Zhang, Y. Yang, X. Xiao, and Y. Chen MicroRNA-29a-c decrease fasting blood glucose levels by negatively regulating hepatic gluconeogenesis J. Hepatol. 58 2013 535 542
62. P. Lovis, S. Gattesco, and R. Regazzi Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs Biol. Chem. 389 2008 305 312
63. P. Lovis, E. Roggli, D.R. Laybutt, S. Gattesco, J.Y. Yang, C. Widmann, A. Abderrahmani, and R. Regazzi Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction Diabetes 57 2008 2728 2736
64. N. Ma, X. Wang, Y. Qiao, F. Li, Y. Hui, C. Zou, J. Jin, G. Lv, Y. Peng, and L. Wang Coexpression of an intronic microRNA and its host gene reveals a potential role for miR-483-5p as an IGF2 partner Mol. Cell. Endocrinol. 333 2011 96 101
65. J.T. Mendell, and E.N. Olson MicroRNAs in stress signaling and human disease Cell 148 2012 1172 1187
66. B.D. Mersey, P. Jin, and D.J. Danner Human microRNA (miR29b) expression controls the amount of branched chain alpha-ketoacid dehydrogenase complex in a cell Hum. Mol. Genet. 14 2005 3371 3377
67. M.A. Mori, P. Raghavan, T. Thomou, J. Boucher, S. Robida-Stubbs, Y. Macotela, S.J. Russell, J.L. Kirkland, T.K. Blackwell, and C.R. Kahn Role of microRNA processing in adipose tissue in stress defense and longevity Cell Metab. 16 2012 336 347
68. S.H. Najafi-Shoushtari, F. Kristo, Y. Li, T. Shioda, D.E. Cohen, R.E. Gerszten, and A.M. Näär MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis Science 328 2010 1566 1569
69. A.K. Pandey, G. Verma, S. Vig, S. Srivastava, A.K. Srivastava, and M. Datta miR-29a levels are elevated in the db/db mice liver and its overexpression leads to attenuation of insulin action on PEPCK gene expression in HepG2 cells Mol. Cell. Endocrinol. 332 2011 125 133
70. L. Pawlikowska, D. Hu, S. Huntsman, A. Sung, C. Chu, J. Chen, A.H. Joyner, N.J. Schork, W.C. Hsueh, A.P. Reiner Study of Osteoporotic Fractures Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity Aging Cell 8 2009 460 472
71. V. Plaisance, A. Abderrahmani, V. Perret-Menoud, P. Jacquemin, F. Lemaigre, and R. Regazzi MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells J. Biol. Chem. 281 2006 26932 26942
72. M.N. Poy, L. Eliasson, J. Krutzfeldt, S. Kuwajima, X. Ma, P.E. Macdonald, S. Pfeffer, T. Tuschl, N. Rajewsky, P. Rorsman, and M. Stoffel A pancreatic islet-specific microRNA regulates insulin secretion Nature 432 2004 226 230
73. M.N. Poy, M. Spranger, and M. Stoffel microRNAs and the regulation of glucose and lipid metabolism Diabetes Obes. Metab. 9 Suppl 2 2007 67 73
74. M.N. Poy, J. Hausser, M. Trajkovski, M. Braun, S. Collins, P. Rorsman, M. Zavolan, and M. Stoffel miR-375 maintains normal pancreatic alpha- and beta-cell mass Proc. Natl. Acad. Sci. USA 106 2009 5813 5818
75. D. Quiat, and E.N. Olson MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment J. Clin. Invest. 123 2013 11 18
76. D. Ramachandran, U. Roy, S. Garg, S. Ghosh, S. Pathak, and U. Kolthur-Seetharam Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets FEBS J. 278 2011 1167 1174
77. C.M. Ramirez, A. Dávalos, L. Goedeke, A.G. Salerno, N. Warrier, D. Cirera-Salinas, Y. Suárez, and C. Fernández-Hernando MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1 Arterioscler. Thromb. Vasc. Biol. 31 2011 2707 2714
78. A. Rodriguez, S. Griffiths-Jones, J.L. Ashurst, and A. Bradley Identification of mammalian microRNA host genes and transcription units Genome Res. 14 10A 2004 1902 1910
79. E. Roggli, A. Britan, S. Gattesco, N. Lin-Marq, A. Abderrahmani, P. Meda, and R. Regazzi Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells Diabetes 59 2010 978 986
80. E. Roggli, S. Gattesco, D. Caille, C. Briet, C. Boitard, P. Meda, and R. Regazzi Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice Diabetes 61 2012 1742 1751
81. S.A. Ross, and C.D. Davis MicroRNA, nutrition, and cancer prevention Adv. Nutr. 2 2011 472 485
82. V. Rottiers, and A.M. Näär MicroRNAs in metabolism and metabolic disorders Nat. Rev. Mol. Cell Biol. 13 2012 239 250
83. H.S. Ryu, S.Y. Park, D. Ma, J. Zhang, and W. Lee The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes PLoS ONE 6 2011 e17343
84. T. Smith-Vikos, and F.J. Slack MicroRNAs and their roles in aging J. Cell Sci. 125 2012 7 17
85. C.M. Taniguchi, B. Emanuelli, and C.R. Kahn Critical nodes in signalling pathways: insights into insulin action Nat. Rev. Mol. Cell Biol. 7 2006 85 96
86. M. Trajkovski, J. Hausser, J. Soutschek, B. Bhat, A. Akin, M. Zavolan, M.H. Heim, and M. Stoffel MicroRNAs 103 and 107 regulate insulin sensitivity Nature 474 2011 649 653
87. M. Trajkovski, K. Ahmed, C.C. Esau, and M. Stoffel MyomiR-133 regulates brown fat differentiation through Prdm16 Nat. Cell Biol. 14 2012 1330 1335
88. A. Turchinovich, L. Weiz, A. Langheinz, and B. Burwinkel Characterization of extracellular circulating microRNA Nucleic Acids Res. 39 2011 7223 7233
89. J. Vijg, and J. Campisi Puzzles, promises and a cure for ageing Nature 454 2008 1065 1071
90. S. Wang, A.B. Aurora, B.A. Johnson, X. Qi, J. McAnally, J.A. Hill, J.A. Richardson, R. Bassel-Duby, and E.N. Olson The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis Dev. Cell 15 2008 261 271
91. H. Wu, F. Wang, S. Hu, C. Yin, X. Li, S. Zhao, J. Wang, and X. Yan MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts Cell. Signal. 24 2012 2179 2186
92. K. Yamagata, S. Fujiyama, S. Ito, T. Ueda, T. Murata, M. Naitou, K. Takeyama, Y. Minami, B.W. O'Malley, and S. Kato Maturation of microRNA is hormonally regulated by a nuclear receptor Mol. Cell 36 2009 340 347
93. L. Yang, M.P. Boldin, Y. Yu, C.S. Liu, C.K. Ea, P. Ramakrishnan, K.D. Taganov, J.L. Zhao, and D. Baltimore miR-146a controls the resolution of T cell responses in mice J. Exp. Med. 209 2012 1655 1670
94. A. Zampetaki, S. Kiechl, I. Drozdov, P. Willeit, U. Mayr, M. Prokopi, A. Mayr, S. Weger, F. Oberhollenzer, and E. Bonora Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes Circ. Res. 107 2010 810 817
95. A. Zernecke, K. Bidzhekov, H. Noels, E. Shagdarsuren, L. Gan, B. Denecke, M. Hristov, T. Köppel, M.N. Jahantigh, and E. Lutgens Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection Sci. Signal. 2 2009 ra81
96. H. Zhai, A. Fesler, and J. Ju MicroRNA: a third dimension in autophagy Cell Cycle 12 2013 246 250
97. L. Zhang, D. Hou, X. Chen, D. Li, L. Zhu, Y. Zhang, J. Li, Z. Bian, X. Liang, and X. Cai Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA Cell Res. 22 2012 107 126
98. H. Zhao, J. Guan, H.M. Lee, Y. Sui, L. He, J.J. Siu, P.P. Tse, P.C. Tong, F.M. Lai, and J.C. Chan Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition Pancreas 39 2010 843 846
99. H. Zhu, N. Shyh-Chang, A.V. Segrè, G. Shinoda, S.P. Shah, W.S. Einhorn, A. Takeuchi, J.M. Engreitz, J.P. Hagan, M.G. Kharas DIAGRAM Consortium MAGIC Investigators The Lin28/let-7 axis regulates glucose metabolism Cell 147 2011 81 94