-
1
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helixloop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helixloop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92: 5510-5514.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
2
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997; 11: 72-82.
-
(1997)
Genes Dev
, vol.11
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
-
3
-
-
0036359548
-
Hypoxia - a key regulatory factor in tumour growth
-
Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
4
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
6
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995; 270: 1230-1237.
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
7
-
-
0027184569
-
PAS is a dimerization domain common to Drosophila period and several transcription factors
-
Huang ZJ, Edery I, Rosbash M. PAS is a dimerization domain common to Drosophila period and several transcription factors. Nature 1993; 364: 259-262.
-
(1993)
Nature
, vol.364
, pp. 259-262
-
-
Huang, Z.J.1
Edery, I.2
Rosbash, M.3
-
8
-
-
0030851024
-
The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins
-
Zelzer E, Wappner P, Shilo BZ. The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins. Genes Dev 1997; 11: 2079-2089.
-
(1997)
Genes Dev
, vol.11
, pp. 2079-2089
-
-
Zelzer, E.1
Wappner, P.2
Shilo, B.Z.3
-
9
-
-
0032493368
-
Regulation of hypoxian-inducible factor 1alpha is mediated by an O2- dependent degradation domain via the ubiquitin-proteasome pathway
-
Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxian-inducible factor 1alpha is mediated by an O2- dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 1998; 95 7987-7992.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
10
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
-
Huang LE, Arany Z, Livingston DM, Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 1996; 271: 32253-32259.
-
(1996)
J Biol Chem
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
11
-
-
0030937718
-
Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit
-
Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. J Biol Chem 1997; 272: 11205-11214.
-
(1997)
J Biol Chem
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
12
-
-
0033525830
-
Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
-
Kallio PJ, Wilson WJ, O'Brien S, Makino Y, Poellinger L. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J Biol Chem 1999; 274: 6519-6525.
-
(1999)
J Biol Chem
, vol.274
, pp. 6519-6525
-
-
Kallio, P.J.1
Wilson, W.J.2
O'Brien, S.3
Makino, Y.4
Poellinger, L.5
-
13
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399: 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
-
14
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 20OO; 2: 423-427.
-
Nat Cell Biol 20OO
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
-
15
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein
-
Tanimoto K, Makino Y, Pereira T, Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J 2000; 19: 4298-4309.
-
(2000)
EMBO J
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
Poellinger, L.4
-
18
-
-
0035859692
-
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu F, White SB, Zhao Q, Lee FS. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 2001; 98: 9630-9635.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
-
19
-
-
17944375360
-
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001; 107: 43-54.
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001; 107: 43-54.
-
-
-
-
20
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001, 294: 1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
21
-
-
22244440847
-
Proline hydroxylation and gene expression
-
Kaelin WG. Proline hydroxylation and gene expression. Annu Rev Biochem 2005; 74: 115-128.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 115-128
-
-
Kaelin, W.G.1
-
22
-
-
0029803552
-
An essential role for p300/CBP in the cellular response to hypoxia
-
Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA et al. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 1996; 93: 12969-12973.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12969-12973
-
-
Arany, Z.1
Huang, L.E.2
Eckner, R.3
Bhattacharya, S.4
Jiang, C.5
Goldberg, M.A.6
-
23
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 2002; 295: 858-861.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
24
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 2002; 16: 1466-1471.
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
25
-
-
18544386401
-
Hypoxia inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW et al. Hypoxia inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem 2002; 277: 26351-26355.
-
(2002)
J Biol Chem
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.M.4
Bullock, A.N.5
Welford, R.W.6
-
26
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J 2004; 23: 1949-1956.
-
(2004)
EMBO J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
27
-
-
15244344206
-
HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression
-
Koshiji M, To KK, Hammer S, Kumamoto K, Harris AL, Modrich P et al HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol Cell 2005; 17: 793-803.
-
(2005)
Mol Cell
, vol.17
, pp. 793-803
-
-
Koshiji, M.1
To, K.K.2
Hammer, S.3
Kumamoto, K.4
Harris, A.L.5
Modrich, P.6
-
28
-
-
34047156190
-
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
-
Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007; 11: 335-347.
-
(2007)
Cancer Cell
, vol.11
, pp. 335-347
-
-
Gordan, J.D.1
Bertout, J.A.2
Hu, C.J.3
Diehl, J.A.4
Simon, M.C.5
-
29
-
-
34247614521
-
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
-
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI et al HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007; 11: 407-420.
-
(2007)
Cancer Cell
, vol.11
, pp. 407-420
-
-
Zhang, H.1
Gao, P.2
Fukuda, R.3
Kumar, G.4
Krishnamachary, B.5
Zeller, K.I.6
-
30
-
-
0032905924
-
c-Myc target genes involved in cell growth, apoptosis, and metabolism
-
Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999; 19: 1-11.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1-11
-
-
Dang, C.V.1
-
32
-
-
23144464363
-
Transcriptional regulation and transformation by Myc proteins
-
Adhikary S, Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 2005; 6: 635-645.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 635-645
-
-
Adhikary, S.1
Eilers, M.2
-
33
-
-
18644371442
-
Negative regulation of the mammalian UV response by Myc through association with Miz-1
-
Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T et al Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol Cell 2002; 10: 509-521.
-
(2002)
Mol Cell
, vol.10
, pp. 509-521
-
-
Herold, S.1
Wanzel, M.2
Beuger, V.3
Frohme, C.4
Beul, D.5
Hillukkala, T.6
-
34
-
-
0037126303
-
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
-
Seoane J, Le HV, Massague J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 2002; 419: 729-734.
-
(2002)
Nature
, vol.419
, pp. 729-734
-
-
Seoane, J.1
Le, H.V.2
Massague, J.3
-
35
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394: 485-490.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
-
36
-
-
0037214282
-
Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia
-
Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson RS. Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol 2003; 23: 359-369.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 359-369
-
-
Goda, N.1
Ryan, H.E.2
Khadivi, B.3
McNulty, W.4
Rickert, R.C.5
Johnson, R.S.6
-
37
-
-
18944376218
-
Decreased growth of Vhl-/ - fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27
-
Mack FA, Patel JH, Biju MP, Haase VH, Simon MC. Decreased growth of Vhl-/ - fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol 2005; 25: 4565-4578.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4565-4578
-
-
Mack, F.A.1
Patel, J.H.2
Biju, M.P.3
Haase, V.H.4
Simon, M.C.5
-
38
-
-
27544473311
-
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation
-
Adhikary S, Marinoni F, Hock A, Hulleman E, Popov N, Beier R et al The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell 2005; 123: 409-421.
-
(2005)
Cell
, vol.123
, pp. 409-421
-
-
Adhikary, S.1
Marinoni, F.2
Hock, A.3
Hulleman, E.4
Popov, N.5
Beier, R.6
-
39
-
-
33750202279
-
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
-
To KK, Sedelnikova OA, Samons M, Bonner WM, Huang LE. The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J 2006; 25: 4784-4794.
-
(2006)
EMBO J
, vol.25
, pp. 4784-4794
-
-
To, K.K.1
Sedelnikova, O.A.2
Samons, M.3
Bonner, W.M.4
Huang, L.E.5
-
40
-
-
34548292555
-
Hypoxic suppression of the cell cycle gene CDC25A in tumor cells
-
Hammer S, To KK, Yoo YG, Koshiji M, Huang LE. Hypoxic suppression of the cell cycle gene CDC25A in tumor cells. Cell Cycle 2007; 6: 1919-1926.
-
(2007)
Cell Cycle
, vol.6
, pp. 1919-1926
-
-
Hammer, S.1
To, K.K.2
Yoo, Y.G.3
Koshiji, M.4
Huang, L.E.5
-
41
-
-
31144478127
-
Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis
-
Com PG, Ricci MS, Scata KA, Arsham AM, Simon MC, Dicker DT et al. Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biol Ther 2005; 4 1285-1294.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 1285-1294
-
-
Com, P.G.1
Ricci, M.S.2
Scata, K.A.3
Arsham, A.M.4
Simon, M.C.5
Dicker, D.T.6
-
42
-
-
0032213236
-
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
-
Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 1998; 12: 3320-3324.
-
(1998)
Genes Dev
, vol.12
, pp. 3320-3324
-
-
Tian, H.1
Hammer, R.E.2
Matsumoto, A.M.3
Russell, D.W.4
McKnight, S.L.5
-
43
-
-
0035983324
-
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
-
Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H et al Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 2002; 8: 702-710.
-
(2002)
Nat Med
, vol.8
, pp. 702-710
-
-
Compernolle, V.1
Brusselmans, K.2
Acker, T.3
Hoet, P.4
Tjwa, M.5
Beck, H.6
-
44
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002; 1: 237-246.
-
(2002)
Cancer Cell
, vol.1
, pp. 237-246
-
-
Kondo, K.1
Klco, J.2
Nakamura, E.3
Lechpammer, M.4
Kaelin, W.G.5
-
45
-
-
0344826529
-
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species mice
-
Scortegagna M, Ding K, Oktay Y, Gaur A, Thurmond F, Yan LJ et al. Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species mice. Nat Genet 2003; 35 331-340.
-
(2003)
Nat Genet
, vol.35
, pp. 331-340
-
-
Scortegagna, M.1
Ding, K.2
Oktay, Y.3
Gaur, A.4
Thurmond, F.5
Yan, L.J.6
-
46
-
-
33644747418
-
HIF-2alpha regulates Oct-4: Effects of hypoxia on stem cell function, embryonic development, and tumor growth
-
Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ et al. HIF-2alpha regulates Oct-4: Effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev 2006; 20: 557-570.
-
(2006)
Genes Dev
, vol.20
, pp. 557-570
-
-
Covello, K.L.1
Kehler, J.2
Yu, H.3
Gordan, J.D.4
Arsham, A.M.5
Hu, C.J.6
-
47
-
-
33847796951
-
Acute postnatal ablation of Hif-2alpha results in anemia
-
Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci USA 2007; 104: 2301-2306.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2301-2306
-
-
Gruber, M.1
Hu, C.J.2
Johnson, R.S.3
Brown, E.J.4
Keith, B.5
Simon, M.C.6
-
48
-
-
20744445650
-
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
-
Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 2005; 25: 5675-5686.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5675-5686
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.3
Sowter, H.M.4
Mandriota, S.J.5
Li, J.L.6
-
49
-
-
34147124264
-
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
-
Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest 2007; 117: 1068-1077.
-
(2007)
J Clin Invest
, vol.117
, pp. 1068-1077
-
-
Rankin, E.B.1
Biju, M.P.2
Liu, Q.3
Unger, T.L.4
Rha, J.5
Johnson, R.S.6
-
50
-
-
33745274488
-
Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection
-
Aprelikova O, Wood M, Tackett S, Chandramouli GV, Barrett JC. Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. Cancer Res 2006; 66: 5641-5647.
-
(2006)
Cancer Res
, vol.66
, pp. 5641-5647
-
-
Aprelikova, O.1
Wood, M.2
Tackett, S.3
Chandramouli, G.V.4
Barrett, J.C.5
-
51
-
-
0036174191
-
Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: Characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc
-
Mazure NM, Chauvet C, Bois-Joyeux B, Bernard MA, Nacer-Cherif H, Danan JL. Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: Characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc. Cancer Res 2002; 62: 1158-1165.
-
(2002)
Cancer Res
, vol.62
, pp. 1158-1165
-
-
Mazure, N.M.1
Chauvet, C.2
Bois-Joyeux, B.3
Bernard, M.A.4
Nacer-Cherif, H.5
Danan, J.L.6
-
52
-
-
33947217823
-
Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
-
Kaidi A, Williams AC, Paraskeva C. Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat Cell Biol 2007; 9: 210-217.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 210-217
-
-
Kaidi, A.1
Williams, A.C.2
Paraskeva, C.3
-
53
-
-
35649014840
-
HIF-1 and dysregulated c-Myc cooperatively induces VEGF and metabolic switches, HK2 and PDK1
-
Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. HIF-1 and dysregulated c-Myc cooperatively induces VEGF and metabolic switches, HK2 and PDK1. Mol Cell Biol 2007; 27: 7381-7393.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7381-7393
-
-
Kim, J.W.1
Gao, P.2
Liu, Y.C.3
Semenza, G.L.4
Dang, C.V.5
-
54
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3: 177-185.
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
55
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Caims RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006; 3: 187-197.
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Caims, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
56
-
-
33845187907
-
Global mapping of c-Myc binding sites and target gene networks in human B cells
-
Zeller KI, Zhao X, Lee CW, Chiu KP, Yao F, Yustein JT et al. Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci USA 2006; 103: 17834-17839.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 17834-17839
-
-
Zeller, K.I.1
Zhao, X.2
Lee, C.W.3
Chiu, K.P.4
Yao, F.5
Yustein, J.T.6
-
57
-
-
13144275217
-
Dynamic balancing of the dual nature of HIF-1alpha for cell survival
-
Koshiji M, Huang LE. Dynamic balancing of the dual nature of HIF-1alpha for cell survival. Cell Cycle 2004; 3: 853-854.
-
(2004)
Cell Cycle
, vol.3
, pp. 853-854
-
-
Koshiji, M.1
Huang, L.E.2
-
58
-
-
25444432052
-
Genetic instability: The dark side of the hypoxic response
-
To KK, Koshiji M, Hammer S, Huang LE. Genetic instability: The dark side of the hypoxic response. Cell Cycle 2005; 4: 881-882.
-
(2005)
Cell Cycle
, vol.4
, pp. 881-882
-
-
To, K.K.1
Koshiji, M.2
Hammer, S.3
Huang, L.E.4
-
59
-
-
34547580590
-
HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation
-
Gordan JD, Thompson CB, Simon MC. HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 2007; 12: 108-113.
-
(2007)
Cancer Cell
, vol.12
, pp. 108-113
-
-
Gordan, J.D.1
Thompson, C.B.2
Simon, M.C.3
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