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Volumn 300, Issue 3, 2011, Pages

Hypoxia. 2. Hypoxia regulates cellular metabolism

Author keywords

Electron transport chain; Oxygen levels; Sodium potassium ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; HYPOXIA INDUCIBLE FACTOR 1; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

EID: 79952167247     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00485.2010     Document Type: Review
Times cited : (319)

References (113)
  • 3
    • 0025788018 scopus 로고
    • Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swine
    • Arai AE, Pantely GA, Anselone CG, Bristow J, Bristow JD. Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swine. Circ Res 69: 1458-1469, 1991.
    • (1991) Circ Res , vol.69 , pp. 1458-1469
    • Arai, A.E.1    Pantely, G.A.2    Anselone, C.G.3    Bristow, J.4    Bristow, J.D.5
  • 4
    • 0042031047 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
    • DOI 10.1074/jbc.M212770200
    • Arsham AM, Howell JJ, Simon MC. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem 278: 29655-29660, 2003. (Pubitemid 36962350)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.32 , pp. 29655-29660
    • Arsham, A.M.1    Howell, J.J.2    Simon, M.C.3
  • 5
    • 0023198917 scopus 로고
    • Suppression of mitochondrial respiratory function after short-term anoxia
    • Aw TY, Andersson BS, Jones DP. Suppression of mitochondrial respiratory function after short-term anoxia. Am J Physiol Cell Physiol 252: C362-C368, 1987.
    • (1987) Am J Physiol Cell Physiol , vol.252
    • Aw, T.Y.1    Andersson, B.S.2    Jones, D.P.3
  • 7
    • 0020313890 scopus 로고
    • 2 concentration
    • Aw TY, Jones DP. Secondary bioenergetic hypoxia. Inhibition of sulfation and glucuronidation reactions in isolated hepatocytes at low O2 concentration. J Biol Chem 257: 8997-9004, 1982. (Pubitemid 12001868)
    • (1982) Journal of Biological Chemistry , vol.257 , Issue.15 , pp. 8997-9004
    • Aw, T.Y.1    Jones, D.P.2
  • 10
    • 34250745912 scopus 로고    scopus 로고
    • o site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
    • DOI 10.1083/jcb.200609074
    • Bell EL, Klimova TA, Eisenbart J, Moraes CT, Murphy MP, Budinger GR, Chandel NS. The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol 177: 1029-1036, 2007. (Pubitemid 46955707)
    • (2007) Journal of Cell Biology , vol.177 , Issue.6 , pp. 1029-1036
    • Bell, E.L.1    Klimova, T.A.2    Eisenbart, J.3    Moraes, C.T.4    Murphy, M.P.5    Budinger, G.R.S.6    Chandel, N.S.7
  • 14
    • 0031008228 scopus 로고    scopus 로고
    • The ATP synthase - A splendid molecular machine
    • DOI 10.1146/annurev.biochem.66.1.717
    • Boyer PD. The ATP synthase-a splendid molecular machine. Annu Rev Biochem 66: 717-749, 1997. (Pubitemid 27274672)
    • (1997) Annual Review of Biochemistry , vol.66 , pp. 717-749
    • Boyer, P.D.1
  • 15
    • 0028134892 scopus 로고
    • Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
    • DOI 10.1016/0014-5793(94)01290-3
    • Brown GC, Cooper CE. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 356: 295-298, 1994. (Pubitemid 24376992)
    • (1994) FEBS Letters , vol.356 , Issue.2-3 , pp. 295-298
    • Brown, G.C.1
  • 16
    • 0025238865 scopus 로고
    • A 'top-down' approach to the determination of control coefficients in metabolic control theory
    • Brown GC, Hafner RP, Brand MD. A 'top-down' approach to the determination of control coefficients in metabolic control theory. Eur J Biochem 188: 321-325, 1990. (Pubitemid 20106244)
    • (1990) European Journal of Biochemistry , vol.188 , Issue.2 , pp. 321-325
    • Brown, G.C.1    Hafner, R.P.2    Brand, M.D.3
  • 17
    • 0025007883 scopus 로고
    • Control of respiration and oxidative phosphorylation in isolated rat liver cells
    • DOI 10.1111/j.1432-1033.1990.tb19234.x
    • Brown GC, Lakin-Thomas PL, Brand MD. Control of respiration and oxidative phosphorylation in isolated rat liver cells. Eur J Biochem 192: 355-362, 1990. (Pubitemid 20283502)
    • (1990) European Journal of Biochemistry , vol.192 , Issue.2 , pp. 355-362
    • Brown, G.C.1    Lakin-Thomas, P.L.2    Brand, M.D.3
  • 18
    • 1642328617 scopus 로고    scopus 로고
    • Stimulation of the AMP-activated Protein Kinase Leads to Activation of Eukaryotic Elongation Factor 2 Kinase and to Its Phosphorylation at a Novel Site, Serine 398
    • DOI 10.1074/jbc.M309773200
    • Browne GJ, Finn SG, Proud CG. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J Biol Chem 279: 12220-12231, 2004. (Pubitemid 38445787)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.13 , pp. 12220-12231
    • Browne, G.J.1    Finn, S.G.2    Proud, C.G.3
  • 20
    • 0041920901 scopus 로고    scopus 로고
    • TSC2 regulates VEGF through mTOR-dependent and -independent pathways
    • DOI 10.1016/S1535-6108(03)00187-9
    • Brugarolas JB, Vazquez F, Reddy A, Sellers WR, Kaelin WG Jr. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell 4: 147-158, 2003. (Pubitemid 37045363)
    • (2003) Cancer Cell , vol.4 , Issue.2 , pp. 147-158
    • Brugarolas, J.B.1    Vazquez, F.2    Reddy, A.3    Sellers, W.R.4    Kaelin Jr., W.G.5
  • 21
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • DOI 10.1126/science.1066373
    • Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337-1340, 2001. (Pubitemid 33063099)
    • (2001) Science , vol.294 , Issue.5545 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 24
    • 38349070256 scopus 로고    scopus 로고
    • Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury
    • Burwell LS, Brookes PS. Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury. Antioxid Redox Signal 10: 579-599, 2008.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 579-599
    • Burwell, L.S.1    Brookes, P.S.2
  • 25
    • 0038163900 scopus 로고    scopus 로고
    • Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury
    • DOI 10.1161/01.CIR.0000078635.89229.8A
    • Cai Z, Manalo DJ, Wei G, Rodriguez ER, Fox-Talbot K, Lu H, Zweier JL, Semenza GL. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation 108: 79-85, 2003. (Pubitemid 36859024)
    • (2003) Circulation , vol.108 , Issue.1 , pp. 79-85
    • Cai, Z.1    Manalo, D.J.2    Wei, G.3    Rodriguez, E.R.4    Fox-Talbot, K.5    Lu, H.6    Zweier, J.L.7    Semenza, G.L.8
  • 26
    • 38849182762 scopus 로고    scopus 로고
    • Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1alpha
    • DOI 10.1093/cvr/cvm035
    • Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, Semenza GL. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovasc Res 77: 463-470, 2008. (Pubitemid 351197653)
    • (2008) Cardiovascular Research , vol.77 , Issue.3 , pp. 463-470
    • Cai, Z.1    Zhong, H.2    Bosch-Marce, M.3    Fox-Talbot, K.4    Wang, L.5    Wei, C.6    Trush, M.A.7    Semenza, G.L.8
  • 28
    • 70349478990 scopus 로고    scopus 로고
    • MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
    • Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 10: 273-284, 2009.
    • (2009) Cell Metab , vol.10 , pp. 273-284
    • Chan, S.Y.1    Zhang, Y.Y.2    Hemann, C.3    Mahoney, C.E.4    Zweier, J.L.5    Loscalzo, J.6
  • 29
  • 31
    • 0030855493 scopus 로고    scopus 로고
    • Cellular respiration during hypoxia: Role of cytochrome oxidase as the oxygen sensor in hepatocytes
    • DOI 10.1074/jbc.272.30.18808
    • Chandel NS, Budinger GR, Choe SH, Schumacker PT. Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes. J Biol Chem 272: 18808-18816, 1997. (Pubitemid 27318228)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.30 , pp. 18808-18816
    • Chandel, N.S.1    Budinger, G.R.S.2    Choe, S.H.3    Schumacker, P.T.4
  • 33
    • 77955170881 scopus 로고    scopus 로고
    • Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression
    • Chen Z, Li Y, Zhang H, Huang P, Luthra R. Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression. Oncogene 29: 4362-4368.
    • Oncogene , vol.29 , pp. 4362-4368
    • Chen, Z.1    Li, Y.2    Zhang, H.3    Huang, P.4    Luthra, R.5
  • 34
    • 0033593228 scopus 로고    scopus 로고
    • Dopamine-induced endocytosis of Na+, K+-ATPase is initiated by phosphorylation of Ser-18 in the rat alpha subunit and Is responsible for the decreased activity in epithelial cells
    • Chibalin AV, Ogimoto G, Pedemonte CH, Pressley TA, Katz AI, Feraille E, Berggren PO, Bertorello AM. Dopamine-induced endocytosis of Na+, K+-ATPase is initiated by phosphorylation of Ser-18 in the rat alpha subunit and Is responsible for the decreased activity in epithelial cells. J Biol Chem 274: 1920-1927, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 1920-1927
    • Chibalin, A.V.1    Ogimoto, G.2    Pedemonte, C.H.3    Pressley, T.A.4    Katz, A.I.5    Feraille, E.6    Berggren, P.O.7    Bertorello, A.M.8
  • 35
    • 28044464985 scopus 로고
    • Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases
    • Cleeter MW, Cooper JM, Darley-Usmar VM, Moncada S, Schapira AH. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett 345: 50-54, 1994.
    • (1994) FEBS Lett , vol.345 , pp. 50-54
    • Cleeter, M.W.1    Cooper, J.M.2    Darley-Usmar, V.M.3    Moncada, S.4    Schapira, A.H.5
  • 38
    • 0037380667 scopus 로고    scopus 로고
    • Hypoxia-induced endocytosis, of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta
    • DOI 10.1172/JCI200316826
    • Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI. Hypoxia-induced endocytosis of Na, K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta. J Clin Invest 111: 1057-1064, 2003. (Pubitemid 36397482)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.7 , pp. 1057-1064
    • Dada, L.A.1    Chandel, N.S.2    Ridge, K.M.3    Pedemonte, C.4    Bertorello, A.M.5    Sznajder, J.I.6
  • 40
    • 77950221998 scopus 로고    scopus 로고
    • Human brown adipose tissue
    • Enerback S. Human brown adipose tissue. Cell Metab 11: 248-252.
    • Cell Metab , vol.11 , pp. 248-252
    • Enerback, S.1
  • 43
    • 0029101515 scopus 로고
    • Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements
    • Firth JD, Ebert BL, Ratcliffe PJ. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J Biol Chem 270: 21021-21027, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 21021-21027
    • Firth, J.D.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 44
    • 33947724515 scopus 로고    scopus 로고
    • HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
    • DOI 10.1016/j.cell.2007.01.047, PII S0092867407003078
    • Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129: 111-122, 2007. (Pubitemid 46507584)
    • (2007) Cell , vol.129 , Issue.1 , pp. 111-122
    • Fukuda, R.1    Zhang, H.2    Kim, J.-W.3    Shimoda, L.4    Dang, C.V.5    Semenza, G.6
  • 46
    • 67650032833 scopus 로고    scopus 로고
    • Alpha1-AMP-activated protein kinase regulates hypoxia- Induced Na, K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta
    • Gusarova GA, Dada LA, Kelly AM, Brodie C, Witters LA, Chandel NS, Sznajder JI. Alpha1-AMP-activated protein kinase regulates hypoxia- induced Na, K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta. Mol Cell Biol 29: 3455-3464, 2009.
    • (2009) Mol Cell Biol , vol.29 , pp. 3455-3464
    • Gusarova, G.A.1    Dada, L.A.2    Kelly, A.M.3    Brodie, C.4    Witters, L.A.5    Chandel, N.S.6    Sznajder, J.I.7
  • 47
    • 77956186783 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
    • Hamanaka RB, Chandel NS. Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci 35: 505-513.
    • Trends Biochem Sci , vol.35 , pp. 505-513
    • Hamanaka, R.B.1    Chandel, N.S.2
  • 48
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
    • DOI 10.1038/nrm2249, PII NRM2249
    • Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 8: 774-785, 2007. (Pubitemid 47462132)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.10 , pp. 774-785
    • Hardie, D.G.1
  • 49
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2: 28, 2003.
    • (2003) J Biol , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 50
    • 23044432463 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
    • DOI 10.1016/j.cmet.2005.05.009, PII S155041310500166X
    • Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2: 9-19, 2005. (Pubitemid 43239821)
    • (2005) Cell Metabolism , vol.2 , Issue.1 , pp. 9-19
    • Hawley, S.A.1    Pan, D.A.2    Mustard, K.J.3    Ross, L.4    Bain, J.5    Edelman, A.M.6    Frenguelli, B.G.7    Hardie, D.G.8
  • 51
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 18: 1926-1945, 2004.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 52
    • 0022590628 scopus 로고
    • Defense strategies against hypoxia and hypothermia
    • Hochachka PW. Defense strategies against hypoxia and hypothermia. Science 231: 234-241, 1986. (Pubitemid 16160071)
    • (1986) Science , vol.231 , Issue.4735 , pp. 234-241
    • Hochachka, P.W.1
  • 54
    • 0346158376 scopus 로고    scopus 로고
    • Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
    • Holness MJ, Sugden MC. Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans 31: 1143-1151, 2003. (Pubitemid 38030927)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.6 , pp. 1143-1151
    • Holness, M.J.1    Sugden, M.C.2
  • 56
    • 0037143449 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
    • DOI 10.1016/S0960-9822(02)01077-1, PII S0960982202010771
    • Horman S, Browne G, Krause U, Patel J, Vertommen D, Bertrand L, Lavoinne A, Hue L, Proud C, Rider M. Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr Biol 12: 1419-1423, 2002. (Pubitemid 34915545)
    • (2002) Current Biology , vol.12 , Issue.16 , pp. 1419-1423
    • Horman, S.1    Browne, G.J.2    Krause, U.3    Patel, J.V.4    Vertommen, D.5    Bertrand, L.6    Lavoinne, A.7    Hue, L.8    Proud, C.G.9    Rider, M.H.10
  • 59
    • 0036275356 scopus 로고    scopus 로고
    • Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR) -dependent signaling
    • DOI 10.1096/fj.01-0658com
    • Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 16: 771-780, 2002. (Pubitemid 34615125)
    • (2002) FASEB Journal , vol.16 , Issue.8 , pp. 771-780
    • Humar, R.O.K.1    Kiefer, F.N.2    Berns, H.3    Resink, T.J.4    Battegay, E.J.5
  • 60
    • 77951552411 scopus 로고    scopus 로고
    • Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury
    • Hyvarinen J, Hassinen IE, Sormunen R, Maki JM, Kivirikko KI, Koivunen P, Myllyharju J. Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem 285: 13646-13657.
    • J Biol Chem , vol.285 , pp. 13646-13657
    • Hyvarinen, J.1    Hassinen, I.E.2    Sormunen, R.3    Maki, J.M.4    Kivirikko, K.I.5    Koivunen, P.6    Myllyharju, J.7
  • 64
    • 0026780292 scopus 로고
    • Coordinated multisite regulation of cellular energy metabolism
    • Jones DP, Shan X, Park Y. Coordinated multisite regulation of cellular energy metabolism. Annu Rev Nutr 12: 327-343, 1992.
    • (1992) Annu Rev Nutr , vol.12 , pp. 327-343
    • Jones, D.P.1    Shan, X.2    Park, Y.3
  • 65
    • 0033976342 scopus 로고    scopus 로고
    • Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes
    • Jung F, Palmer LA, Zhou N, Johns RA. Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes. Circ Res 86: 319-325, 2000. (Pubitemid 30108826)
    • (2000) Circulation Research , vol.86 , Issue.3 , pp. 319-325
    • Jung, F.1    Palmer, L.A.2    Zhou, N.3    Johns, R.A.4
  • 67
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
    • DOI 10.1016/j.molcel.2008.04.009, PII S109727650800292X
    • Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30: 393-402, 2008. (Pubitemid 351681994)
    • (2008) Molecular Cell , vol.30 , Issue.4 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 68
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
    • Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1: 15-25, 2005. (Pubitemid 43960587)
    • (2005) Cell Metabolism , vol.1 , Issue.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 69
    • 0035997378 scopus 로고    scopus 로고
    • Biochemistry of Na, K-ATPase
    • Kaplan JH. Biochemistry of Na, K-ATPase. Annu Rev Biochem 71: 511-535, 2002.
    • (2002) Annu Rev Biochem , vol.71 , pp. 511-535
    • Kaplan, J.H.1
  • 70
    • 28244446238 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse
    • DOI 10.1016/j.jacc.2005.08.045, PII S0735109705022047
    • Kido M, Du L, Sullivan CC, Li X, Deutsch R, Jamieson SW, Thistlethwaite PA. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol 46: 2116-2124, 2005. (Pubitemid 41713601)
    • (2005) Journal of the American College of Cardiology , vol.46 , Issue.11 , pp. 2116-2124
    • Kido, M.1    Du, L.2    Sullivan, C.C.3    Li, X.4    Deutsch, R.5    Jamieson, S.W.6    Thistlethwaite, P.A.7
  • 71
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3: 177-185, 2006.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 73
    • 0036837864 scopus 로고    scopus 로고
    • Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha
    • Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol 22: 7405-7416, 2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 7405-7416
    • Koumenis, C.1    Naczki, C.2    Koritzinsky, M.3    Rastani, S.4    Diehl, A.5    Sonenberg, N.6    Koromilas, A.7    Wouters, B.G.8
  • 75
    • 85047677588 scopus 로고
    • Downregulation of oxygen demand in isoprenaline stimulated canine myocardium
    • Lee SC, Downey HF. Downregulation of oxygen demand in isoprenaline stimulated canine myocardium. Cardiovasc Res 27: 1542-1550, 1993. (Pubitemid 23265079)
    • (1993) Cardiovascular Research , vol.27 , Issue.8 , pp. 1542-1550
    • Lee, S.-C.1    Downey, H.F.2
  • 77
    • 32444433450 scopus 로고    scopus 로고
    • Hypoxia-induced energy stress regulates mRNA translation and cell growth
    • DOI 10.1016/j.molcel.2006.01.010, PII S1097276506000116
    • Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 21: 521-531, 2006. (Pubitemid 43228007)
    • (2006) Molecular Cell , vol.21 , Issue.4 , pp. 521-531
    • Liu, L.1    Cash, T.P.2    Jones, R.G.3    Keith, B.4    Thompson, C.B.5    Simon, M.C.6
  • 78
    • 20544465985 scopus 로고    scopus 로고
    • Regulation of transcription and translation by hypoxia
    • Liu L, Simon MC. Regulation of transcription and translation by hypoxia. Cancer Biol Ther 3: 492-497, 2004. (Pubitemid 41351114)
    • (2004) Cancer Biology and Therapy , vol.3 , Issue.6 , pp. 492-497
    • Liu, L.1    Simon, M.C.2
  • 79
    • 57649221592 scopus 로고    scopus 로고
    • Hypoxic reactive oxygen species regulate the integrated stress response and cell survival
    • Liu L, Wise DR, Diehl JA, Simon MC. Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J Biol Chem 283: 31153-31162, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 31153-31162
    • Liu, L.1    Wise, D.R.2    Diehl, J.A.3    Simon, M.C.4
  • 80
    • 0029981670 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose
    • Lizasoain I, Moro MA, Knowles RG, Darley-Usmar V, Moncada S. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. Biochem J 314: 877-880, 1996. (Pubitemid 26097750)
    • (1996) Biochemical Journal , vol.314 , Issue.3 , pp. 877-880
    • Lizasoain, I.1    Moro, M.A.2    Knowles, R.G.3    Darley-Usmar, V.4    Moncada, S.5
  • 83
    • 0035903468 scopus 로고    scopus 로고
    • Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
    • DOI 10.1093/emboj/20.18.5197
    • Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J 20: 5197-5206, 2001. (Pubitemid 32910914)
    • (2001) EMBO Journal , vol.20 , Issue.18 , pp. 5197-5206
    • Masson, N.1    Willam, C.2    Maxwell, P.H.3    Pugh, C.W.4    Ratcliffe, P.J.5
  • 85
    • 0030911247 scopus 로고    scopus 로고
    • Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine
    • DOI 10.1074/jbc.272.18.12236
    • Melillo G, Taylor LS, Brooks A, Musso T, Cox GW, Varesio L. Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine. J Biol Chem 272: 12236-12243, 1997. (Pubitemid 27202810)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.18 , pp. 12236-12243
    • Melillo, G.1    Taylor, L.S.2    Brooks, A.3    Musso, T.4    Cox, G.W.5    Varesio, L.6
  • 86
    • 0022137012 scopus 로고
    • Energy costs of ion pumping by animal tissues
    • Milligan LP, McBride BW. Energy costs of ion pumping by animal tissues. J Nutr 115: 1374-1382, 1985.
    • (1985) J Nutr , vol.115 , pp. 1374-1382
    • Milligan, L.P.1    McBride, B.W.2
  • 87
    • 39749087544 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury
    • DOI 10.1097/FJC.0b013e31815f248d, PII 0000534420080200000010
    • Natarajan R, Salloum FN, Fisher BJ, Kukreja RC, Fowler AA 3rd. Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury. J Cardiovasc Pharmacol 51: 178-187, 2008. (Pubitemid 351301479)
    • (2008) Journal of Cardiovascular Pharmacology , vol.51 , Issue.2 , pp. 178-187
    • Natarajan, R.1    Salloum, F.N.2    Fisher, B.J.3    Kukreja, R.C.4    Fowler III, A.A.5
  • 88
    • 0028959699 scopus 로고
    • Hibernating myocardium: A hypometabolic state for energy conservation
    • Pantely GA, Bristow JD. Hibernating myocardium: a hypometabolic state for energy conservation. Basic Res Cardiol 90: 23-25, 1995.
    • (1995) Basic Res Cardiol , vol.90 , pp. 23-25
    • Pantely, G.A.1    Bristow, J.D.2
  • 89
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3: 187-197, 2006.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 93
    • 0033525924 scopus 로고    scopus 로고
    • Oxidative phosphorylation at the fin de siecle
    • DOI 10.1126/science.283.5407.1488
    • Saraste M. Oxidative phosphorylation at the fin de siecle. Science 283: 1488-1493, 1999. (Pubitemid 29133351)
    • (1999) Science , vol.283 , Issue.5407 , pp. 1488-1493
    • Saraste, M.1
  • 95
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • DOI 10.1146/annurev.biochem.73.011303.074134
    • Schroder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem 74: 739-789, 2005. (Pubitemid 40995523)
    • (2005) Annual Review of Biochemistry , vol.74 , pp. 739-789
    • Schroder, M.1    Kaufman, R.J.2
  • 97
    • 35148888161 scopus 로고    scopus 로고
    • Life with oxygen
    • DOI 10.1126/science.1147949
    • Semenza GL. Life with oxygen. Science 318: 62-64, 2007. (Pubitemid 47538005)
    • (2007) Science , vol.318 , Issue.5847 , pp. 62-64
    • Semenza, G.L.1
  • 98
    • 34347227058 scopus 로고    scopus 로고
    • Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
    • DOI 10.1042/BJ20070389
    • Semenza GL. Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. Biochem J 405: 1-9, 2007. (Pubitemid 46999919)
    • (2007) Biochemical Journal , vol.405 , Issue.1 , pp. 1-9
    • Semenza, G.L.1
  • 99
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40. 310-322.
    • Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 100
    • 63849149937 scopus 로고    scopus 로고
    • LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
    • Shaw RJ. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) 196: 65-80, 2009.
    • (2009) Acta Physiol (Oxf) , vol.196 , pp. 65-80
    • Shaw, R.J.1
  • 103
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033, 2009.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 104
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270: 1230-1237, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 105
    • 3342938491 scopus 로고    scopus 로고
    • Calcium, mitochondria and oxygen sensing in the pulmonary circulation
    • DOI 10.1016/j.ceca.2004.02.017, PII S0143416004000594
    • Ward JP, Snetkov VA, Aaronson PI. Calcium, mitochondria and oxygen sensing in the pulmonary circulation. Cell Calcium 36: 209-220, 2004. (Pubitemid 38992348)
    • (2004) Cell Calcium , vol.36 , Issue.3-4 , pp. 209-220
    • Ward, J.P.T.1    Snetkov, V.A.2    Aaronson, P.I.3
  • 106
    • 0037131391 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes
    • DOI 10.1161/01.RES.0000036751.04896.F1
    • Waypa GB, Marks JD, Mack MM, Boriboun C, Mungai PT, Schumacker PT. Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ Res 91: 719-726, 2002. (Pubitemid 35204955)
    • (2002) Circulation Research , vol.91 , Issue.8 , pp. 719-726
    • Waypa, G.B.1    Marks, J.D.2    Mack, M.M.3    Boriboun, C.4    Mungai, P.T.5    Schumacker, P.T.6
  • 107
    • 78649391422 scopus 로고    scopus 로고
    • Cellular metabolic stress: Considering how cells respond to nutrient excess
    • Wellen KE, Thompson CB. Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell 40: 323-332.
    • Mol Cell , vol.40 , pp. 323-332
    • Wellen, K.E.1    Thompson, C.B.2
  • 109
    • 0023869404 scopus 로고
    • The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration
    • Wilson DF, Rumsey WL, Green TJ, Vanderkooi JM. The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration. J Biol Chem 263: 2712-2718, 1988. (Pubitemid 18062915)
    • (1988) Journal of Biological Chemistry , vol.263 , Issue.6 , pp. 2712-2718
    • Wilson, D.F.1    Rumsey, W.L.2    Green, T.J.3    Vanderkooi, J.M.4
  • 112
    • 77955283596 scopus 로고    scopus 로고
    • Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function
    • Wu IC, Ohsawa I, Fuku N, Tanaka M. Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function. Ann NY Acad Sci 1201: 111-120.
    • Ann NY Acad Sci , vol.1201 , pp. 111-120
    • Wu, I.C.1    Ohsawa, I.2    Fuku, N.3    Tanaka, M.4
  • 113


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