MicroRNA-145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling

Biochemical and Biophysical Research Communications

Volumn 446, Issue 4, 2014, Pages 1255-1260

  Wang, Yelin ^a,b   Hu, Chen ^a,b   Cheng, Jun ^a,b   Chen, Binquan ^a   Ke, Qinghong ^a,b   Lv, Zhen ^a,b   Wu, Jian ^a,b   Zhou, Yanfeng ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b BEIJING HOSPITAL   (China)

Author keywords

Akt; Forkhead box protein O1 (FOXO1); Hepatocellular carcinoma (HCC); Insulin receptor substrate 1 (IRS1); MicroRNA 145

Indexed keywords

AKT; FORKHEAD BOX PROTEIN O1 (FOXO1); HEPATOCELLULAR CARCINOMA (HCC); INSULIN RECEPTOR SUBSTRATE 1 (IRS1); MICRORNA-145;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; LIVER; LIVER NEOPLASMS; MICRORNAS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84899490560     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.03.107     Document Type: Article

References (28)

1. A. Forner, J.M. Llovet, and J. Bruix Hepatocellular carcinoma Lancet 379 2012 1245 1255
2. H.B. El-Serag, and K.L. Rudolph Hepatocellular carcinoma: epidemiology and molecular carcinogenesis Gastroenterology 132 2007 2557 2576
3. E. Callegari, B.K. Elamin, S. Sabbioni, L. Gramantieri, and M. Negrini Role of microRNAs in hepatocellular carcinoma: a clinical perspective Onco Targets Ther. 6 2013 1167 1178
4. G.A. Calin MicroRNA-cancer connection: the beginning of a new tale Cancer Res. 66 2006 7390 7394
5. O. Vaksman, H.T. Stavnes, J. Kaern, C.G. Trope, B. Davidson, and R. Reich miRNA profiling along tumour progression in ovarian carcinoma J. Cell. Mol. Med. 15 2011 1593 1602
6. Y. Akao, Y. Nakagawa, and T. Naoe MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers Oncol. Rep. 16 2006 845 850
7. Z. Wang, X. Zhang, Z. Yang, H. Du, Z. Wu, J. Gong, J. Yan, and Q. Zheng MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells Biochem. Biophys. Res. Commun. 427 2012 444 449
8. W.C. Cho, A.S. Chow, and J.S. Au Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation Eur. J. Cancer 45 2009 2197 2206
9. T. Chiyomaru, H. Enokida, S. Tatarano, K. Kawahara, Y. Uchida, K. Nishiyama, L. Fujimura, N. Kikkawa, N. Seki, and M. Nakagawa miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer Br. J. Cancer 102 2010 883 891
10. J.H. Noh, Y.G. Chang, M.G. Kim, K.H. Jung, J.K. Kim, H.J. Bae, J.W. Eun, Q. Shen, S.J. Kim, S.H. Kwon, W.S. Park, J.Y. Lee, and S.W. Nam MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer Cancer Lett. 335 2013 455 462
11. H. Varnholt, U. Drebber, F. Schulze, I. Wedemeyer, P. Schirmacher, H.P. Dienes, and M. Odenthal MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma Hepatology 47 2008 1223 1232
12. P.T. Law, A.K. Ching, A.W. Chan, Q.W. Wong, C.K. Wong, K.F. To, and N. Wong MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma Carcinogenesis 33 2012 1134 1141
13. Y. Yin, Z.P. Yan, N.N. Lu, Q. Xu, J. He, X. Qian, J. Yu, X. Guan, B.H. Jiang, and L.Z. Liu Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1 Biochim. Biophys. Acta 1829 2013 239 247
14. C. Freise, M. Ruehl, U. Erben, U. Neumann, D. Seehofer, K.Y. Kim, W. Trowitzsch-Kienast, T. Stroh, M. Zeitz, and R. Somasundaram A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines BMC Complement. Altern. Med. 11 2011 39
15. J.G. Scharf, W. Schmidt-Sandte, S.A. Pahernik, G. Ramadori, T. Braulke, and H. Hartmann Characterization of the insulin-like growth factor axis in a human hepatoma cell line (PLC) Carcinogenesis 19 1998 2121 2128
16. B.D. Manning, and L.C. Cantley AKT/PKB signaling: navigating downstream Cell 129 2007 1261 1274
17. N. Xu, T. Papagiannakopoulos, G. Pan, J.A. Thomson, and K.S. Kosik MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells Cell 137 2009 647 658
18. C. Zhang MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease Cell Cycle 8 2009 3469 3473
19. Y. Yumoto, T. Hanafusa, H. Hada, T. Morita, S. Ooguchi, N. Shinji, T. Mitani, K. Hamaya, N. Koide, and T. Tsuji Loss of heterozygosity and analysis of mutation of p53 in hepatocellular carcinoma J. Gastroenterol. Hepatol. 10 1995 179 185
20. M. Nishiyama, and J.R. Wands Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma Biochem. Biophys. Res. Commun. 183 1992 280 285
21. S. Tanaka, L. Mohr, E.V. Schmidt, K. Sugimachi, and J.R. Wands Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes Hepatology 26 1997 598 604
22. E. Aleem, D. Nehrbass, F. Klimek, D. Mayer, and P. Bannasch Upregulation of the insulin receptor and type I insulin-like growth factor receptor are early events in hepatocarcinogenesis Toxicol. Pathol. 39 2011 524 543
23. J.G. Scharf, and T. Braulke The role of the IGF axis in hepatocarcinogenesis Horm. Metab. Res. 35 2003 685 693
24. J.G. Scharf, F. Dombrowski, and G. Ramadori The IGF axis and hepatocarcinogenesis Mol. Pathol. 54 2001 138 144
25. H. Huang, and D.J. Tindall Dynamic FoxO transcription factors J. Cell Sci. 120 2007 2479 2487
26. I.K. Guttilla, and B.A. White Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells J. Biol. Chem. 284 2009 23204 23216
27. W.H. Biggs 3rd, J. Meisenhelder, T. Hunter, W.K. Cavenee, and K.C. Arden Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 Proc. Natl. Acad. Sci. U.S.A. 96 1999 7421 7426
28. D. Accili, and K.C. Arden FoxOs at the crossroads of cellular metabolism, differentiation, and transformation Cell 117 2004 421 426