Multi-site control and regulation of mitochondrial energy production

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1797, Issue 6-7, 2010, Pages 698-709

  Benard, G ^a,b   Bellance, N ^a,b   Jose, C ^a,b   Melser, S ^a,b   Nouette Gaulain, K ^a,b,c   Rossignol, R ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c BORDEAUX UNIVERSITY HOSPITAL   (France)

Author keywords

Biogenesis; Dynamics; Energy metabolism; Mitochondria; Oxidative phosphorylation; Regulation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL PROTEIN; MITOFUSIN 2; PARAPLEGIN; PHOSPHOLIPID; PROTEIN BAX; PROTEIN BCL 2; PROTEIN DRP1; PROTEIN OPA1; PROTEIN OPA2; UNCLASSIFIED DRUG;

APOPTOSIS; CELL MOTILITY; CYTOLOGY; ENERGY METABOLISM; ENERGY YIELD; GLIOBLASTOMA; HEREDITARY MOTOR SENSORY NEUROPATHY; HOMEOSTASIS; HUMAN; KIDNEY CARCINOMA; LIPOGENESIS; METABOLIC DISORDER; MICROFILAMENT; MICROTUBULE; MITOCHONDRIAL RESPIRATION; NEUROLOGIC DISEASE; NONHUMAN; OPTIC NERVE DISEASE; PARAGANGLIOMA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SPASTIC PARAPLEGIA;

EID: 77953812057     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2010.02.030     Document Type: Review

References (156)

1. Chance B., Williams G.R. The respiratory chain and oxidative phophorylation. Adv. Enzymol. 1956, 17:65-134.
2. Groen A.K., Wanders R.J.A., Westerhoff H.V., Van der meer R., Tager J.M. Quantification of the contribution of various steps to the control of mitochondrial respiration. J. Biol. Chem. 1982, 257:2754-2757.
3. Letellier T., Malgat M., Mazat J.P. Control of oxidative phosphorylation in rat muscle mitochondria: implications for mitochondrial myopathies. Biochim. Biophys. Acta 1993, 1141:58-64.
4. Moreno-Sanchez R., Devars S., Lopez-Gomez F., Uribe A., Corona N. Distribution of control of oxidative phosphorylation in mitochondria oxidizing NAD-linked substrates. Biochim. Biophys. Acta 1991, 1060:284-292.
5. Rossignol R., Letellier T., Malgat M., Rocher C., Mazat J.P. Tissue variation in the control of oxidative phosphorylation: implication for mitochondrial diseases. Biochem. J. 2000, 347(Pt 1):45-53.
6. Heinrich R., Rapoport T.A. A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur. J. Biochem. 1974, 42:89-95.
7. Kacser H., Burns J.A. The control of flux. Rate Control of Biological Processes 1973, 65-104. Cambridge University Press. D.D. D. (Ed.).
8. Fell D. Metabolic control analysis: a survey of its theoretical and experimental development. Biochem. J. 1992, 286:313-330.
9. Benard G., Faustin B., Passerieux E., Galinier A., Rocher C., Bellance N., Delage J.P., Casteilla L., Letellier T., Rossignol R. Physiological diversity of mitochondrial oxidative phosphorylation. Am. J. Physiol. Cell Physiol. 2006, 1172-1182.
10. Leverve X.M., Fontaine E. Role of substrates in the regulation of mitochondrial function in situ. IUBMB Life 2001, 52:221-229.
11. Pfeiffer T., Schuster S., Bonhoeffer S. Cooperation and competition in the evolution of ATP-producing pathways. Science 2001, 292:504-507.
12. Taylor S.W., Fahy E., Zhang B., Glenn G.M., Warnock D.E., Wiley S., Murphy A.N., Gaucher S.P., Capaldi R.A., Gibson B.W., Ghosh S.S. Characterization of the human heart mitochondrial proteome. Nat. Biotechnol. 2003, 21:281-286.
13. Mootha V.K., Bunkenborg J., Olsen J.V., Hjerrild M., Wisniewski J.R., Stahl E., Bolouri M.S., Ray H.N., Sihag S., Kamal M., Patterson N., Lander E.S., Mann M. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 2003, 115:629-640.
14. Forner F., Foster L.J., Campanaro S., Valle G., Mann M. Quantitative proteomic comparison of rat mitochondria from muscle, heart, and liver. Mol. Cell. Proteomics 2006, 5:608-619.
15. Foster L.J., de Hoog C.L., Zhang Y., Xie X., Mootha V.K., Mann M. A mammalian organelle map by protein correlation profiling. Cell 2006, 125:187-199.
16. Aijaz S., Erskine L., Jeffery G., Bhattacharya S.S., Votruba M. Developmental expression profile of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer. Investig. Ophthalmol. Vis. Sci. 2004, 45:1667-1673.
17. Santel A., Frank S., Gaume B., Herrler M., Youle R.J., Fuller M.T. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J. Cell Sci. 2003, 116:2763-2774.
18. Beuste C., Miraux S., Deschodt-Arsac V.J., Thiaudiere E., Franconi J.M., Diolez P., Arsac L.M. Modular regulation analysis of integrative effects of hypoxia on the energetics of contracting skeletal muscle in vivo. Biochem. J. 2009, 420:67-72.
19. Aguilar V., Alliouachene S., Sotiropoulos A., Sobering A., Athea Y., Djouadi F., Miraux S., Thiaudiere E., Foretz M., Viollet B., Diolez P., Bastin J., Benit P., Rustin P., Carling D., Sandri M., Ventura-Clapier R., Pende M. S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metab. 2007, 5:476-487.
20. Um S.H., D'Alessio D., Thomas G. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab. 2006, 3:393-402.
21. Hardie D.G. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. 2007, 8:774-785.
22. Canto C., Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr. Opin. Lipidol. 2009, 20:98-105.
23. Canto C., Gerhart-Hines Z., Feige J.N., Lagouge M., Noriega L., Milne J.C., Elliott P.J., Puigserver P., Auwerx J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009, 458:1056-1060.
24. Greer E.L., Oskoui P.R., Banko M.R., Maniar J.M., Gygi M.P., Gygi S.P., Brunet A. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J. Biol. Chem. 2007, 282:30107-30119.
25. Greer E.L., Dowlatshahi D., Banko M.R., Villen J., Hoang K., Blanchard D., Gygi S.P., Brunet A. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr. Biol. 2007, 17:1646-1656.
26. Zhang B.B., Zhou G., Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009, 9:407-416.
27. Capaldi R.A., Halphen D.G., Zhang Y.Z., Yanamura W. Complexity and tissue specificity of the mitochondrial respiratory chain. J. Bioenerg. Biomembr. 1988, 20:291-311.
28. Piccoli C., Scrima R., Boffoli D., Capitanio N. Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state. Biochem. J. 2006, 396:573-583.
29. Dalmonte M.E., Forte E., Genova M.L., Giuffre A., Sarti P., Lenaz G. Control of respiration by cytochrome c oxidase in intact cells: role of the membrane potential. J. Biol. Chem. 2009, 284:32331-32335.
30. Carroll J., Fearnley I.M., Skehel J.M., Runswick M.J., Shannon R.J., Hirst J., Walker J.E. The post-translational modifications of the nuclear encoded subunits of complex I from bovine heart mitochondria. Mol. Cell. Proteomics 2005, 4:693-699.
31. Das T.K., Pecoraro C., Tomson F.L., Gennis R.B., Rousseau D.L. The post-translational modification in cytochrome c oxidase is required to establish a functional environment of the catalytic site. Biochemistry 1998, 37:14471-14476.
32. Arachiche A., Augereau O., Decossas M., Pertuiset C., Gontier E., Letellier T., Dachary-Prigent J. Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences. J. Biol. Chem. 2008, 283:24406-24411.
33. Acin-Perez R., Salazar E., Brosel S., Yang H., Schon E.A., Manfredi G. Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects. EMBO Mol. Med. 2009, 1:392-406.
34. Acin-Perez R., Salazar E., Kamenetsky M., Buck J., Levin L.R., Manfredi G. Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab. 2009, 9:265-276.
35. Beauvoit B., Rigoulet M. Regulation of cytochrome c oxidase by adenylic nucleotides. Is oxidative phosphorylation feedback regulated by its end-products?. IUBMB Life 2001, 52:143-152.
36. Hansford R.G., Chappell J.B. The effect of Ca2+ on the oxidation of glycerol phosphate by blowfly flight-muscle mitochondria. Biochem. Biophys. Res. Commun. 1967, 27:686-692.
37. Denton R.M., Randle P.J., Martin B.R. Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase. Biochem. J. 1972, 128:161-163.
38. Denton R.M., Richards D.A., Chin J.G. Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues. Biochem. J. 1978, 176:899-906.
39. McCormack J.G., Denton R.M. The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex. Biochem. J. 1979, 180:533-544.
40. Jouaville L.S., Pinton P., Bastianutto C., Rutter G.A., Rizzuto R. Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:13807-13812.
41. Visch H.J., Koopman W.J., Leusink A., van Emst-de Vries S.E., van den Heuvel L.W., Willems P.H., Smeitink J.A. Decreased agonist-stimulated mitochondrial ATP production caused by a pathological reduction in endoplasmic reticulum calcium content in human complex I deficiency. Biochim. Biophys. Acta 2006, 1762:115-123.
42. Parker N., Crichton P.G., Vidal-Puig A.J., Brand M.D. Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria. J. Bioenerg. Biomembr. 2009, 41:335-342.
43. Gnaiger E., Mendez G., Hand S.C. High phosphorylation efficiency and depression of uncoupled respiration in mitochondria under hypoxia. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:11080-11085.
44. D'Aurelio M., Gajewski C.D., Lenaz G., Manfredi G. Respiratory chain supercomplexes set the threshold for respiration defects in human mtDNA mutant cybrids. Hum. Mol. Genet. 2006, 15:2157-2169.
45. Bianchi C., Genova M.L., Parenti Castelli G., Lenaz G. The mitochondrial respiratory chain is partially organized in a supercomplex assembly: kinetic evidence using flux control analysis. J. Biol. Chem. 2004, 279:36562-36569.
46. Benard G., Bellance N., James D., Parrone P., Fernandez H., Letellier T., Rossignol R. Mitochondrial bioenergetics and structural network organization. J. Cell Sci. 2007, 120:838-848.
47. Choi S.Y., Huang P., Jenkins G.M., Chan D.C., Schiller J., Frohman M.A. A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Nat. Cell Biol. 2006, 1255-1262.
48. Furt F., Moreau P. Importance of lipid metabolism for intracellular and mitochondrial membrane fusion/fission processes. Int. J. Biochem. Cell Biol. 2009, 41:1828-1836.
49. Hackenbrock C.R. Ultrastructural bases for metabolically linked mechanical activity in mitochondria: II. Electron transport-linked ultrastructural transformations in mitochondria. J. Cell Biol. 1968, 37:345-369.
50. Hackenbrock C.R., Rehn T.G., Weinbach E.C., Lemasters J.J. Oxidative phosphorylation and ultrastructural transformation in mitochondria in the intact ascites tumor cell. J. Cell Biol. 1971, 51:123-137.
51. Arany Z., He H., Lin J., Hoyer K., Handschin C., Toka O., Ahmad F., Matsui T., Chin S., Wu P.H., Rybkin I.I., Shelton J.M., Manieri M., Cinti S., Schoen F.J., Bassel-Duby R., Rosenzweig A., Ingwall J.S., Spiegelman B.M. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 2005, 1:259-271.
52. Ventura-Clapier R., Garnier A., Veksler V. Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. Cardiovasc. Res. 2008, 79:208-217.
53. De Rasmo D., Signorile A., Roca E., Papa S. cAMP response element-binding protein (CREB) is imported into mitochondria and promotes protein synthesis. FEBS J. 2009, 276:4325-4333.
54. Semenza G.L. Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov. Today 2007, 12:853-859.
55. Twig G., Elorza A., Molina A.J., Mohamed H., Wikstrom J.D., Walzer G., Stiles L., Haigh S.E., Katz S., Las G., Alroy J., Wu M., Py B.F., Yuan J., Deeney J.T., Corkey B.E., Shirihai O.S. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008, 27:433-446.
56. Narendra D.P., Jin S.M., Tanaka A., Suen D.F., Gautier C.A., Shen J., Cookson M.R., Youle R.J. PINK1 is selectively stabilized on impaired mitochondria to activate parkin. PLoS Biol. 2010, 8:e1000298.
57. Gnaiger E. Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int. J. Biochem. Cell Biol. 2009, 41(10):1837-1845.
58. Koziel K., Lebiedzinska M., Szabadkai G., Onopiuk M., Brutkowski W., Wierzbicka K., Wilczynski G., Pinton P., Duszynski J., Zablocki K., Wieckowski M.R. Plasma membrane associated membranes (PAM) from Jurkat cells contain STIM1 protein is PAM involved in the capacitative calcium entry?. Int. J. Biochem. Cell Biol. 2009, 41:2440-2449.
59. de Brito O.M., Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008, 456:605-610.
60. Korzeniewski B. Regulation of ATP supply in mammalian skeletal muscle during resting state-intensive work transition. Biophys. Chem. 2000, 83:19-34.
61. Korzeniewski B., Mazat J. Theoretical studies on control of oxidative phosphorylation in muscle mitochondria at different energy demands and oxygen concentrations. Acta Biotheor. 1996, 44:263-269.
62. Tondera D., Grandemange S., Jourdain A., Karbowski M., Mattenberger Y., Herzig S., Da Cruz S., Clerc P., Raschke I., Merkwirth C., Ehses S., Krause F., Chan D.C., Alexander C., Bauer C., Youle R., Langer T., Martinou J.C. SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J. 2009, 28:1589-1600.
63. Bach D., Naon D., Pich S., Soriano F.X., Vega N., Rieusset J., Laville M., Guillet C., Boirie Y., Wallberg-Henriksson H., Manco M., Calvani M., Castagneto M., Palacin M., Mingrone G., Zierath J.R., Vidal H., Zorzano A. Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Diabetes 2005, 54:2685-2693.
64. Soriano F.X., Liesa M., Bach D., Chan D.C., Palacin M., Zorzano A. Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2. Diabetes 2006, 55:1783-1791.
65. Benard G., Rossignol R. Ultrastructure of the mitochondrion and its bearing on function and bioenergetics. Antioxid. Redox Signal. 2008, 10:1313-1342.
66. Rossignol R., Gilkerson R., Aggeler R., Yamagata K., Remington S.J., Capaldi R.A. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res. 2004, 64:985-993.
67. Partikian A., Olveczky B., Swaminathan R., Li Y., Verkman A.S. Rapid diffusion of green fluorescent protein in the mitochondrial matrix. J. Cell Biol. 1998, 140:821-829.
68. Twig G., Graf S.A., Wikstrom J.D., Mohamed H., Haigh S.E., Elorza A., Deutsch M., Zurgil N., Reynolds N., Shirihai O.S. Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP. Am. J. Physiol. Cell Physiol. 2006, 291:C176-C184.
69. Collins T.J., Berridge M.J., Lipp P., Bootman M.D. Mitochondria are morphologically and functionally heterogeneous within cells. EMBO J. 2002, 21:1616-1627.
70. Nakada K., Inoue K., Ono T., Isobe K., Ogura A., Goto Y.I., Nonaka I., Hayashi J.I. Inter-mitochondrial complementation: mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. Nat. Med. 2001, 7:934-940.
71. Wikstrom J.D., Twig G., Shirihai O.S. What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy?. Int. J. Biochem. Cell Biol. 2009, 41:1914-1927.
72. Jezek P., Plecita-Hlavata L. Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia. Int. J. Biochem. Cell Biol. 2009, 41:1790-1804.
73. Lacombe M.L., Milon L., Munier A., Mehus J.G., Lambeth D.O. The human Nm23/nucleoside diphosphate kinases. J. Bioenerg. Biomembr. 2000, 32:247-258.
74. Milon L., Meyer P., Chiadmi M., Munier A., Johansson M., Karlsson A., Lascu I., Capeau J., Janin J., Lacombe M.L. The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. J. Biol. Chem. 2000, 275:14264-14272.
75. Tsuiki H., Nitta M., Furuya A., Hanai N., Fujiwara T., Inagaki M., Kochi M., Ushio Y., Saya H., Nakamura H. A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis. J. Cell. Biochem. 1999, 76:254-269.
76. Karbowski M., Neutzner A., Youle R.J. The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J. Cell Biol. 2007, 178:71-84.
77. Ishihara N., Jofuku A., Eura Y., Mihara K. Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells. Biochem. Biophys. Res. Commun. 2003, 301:891-898.
78. Figueroa-Romero C., Iniguez-Lluhi J.A., Stadler J., Chang C.R., Arnoult D., Keller P.J., Hong Y., Blackstone C., Feldman E.L. SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. FASEB J. 2009, 23:3917-3927.
79. Nakamura N., Kimura Y., Tokuda M., Honda S., Hirose S. MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology. EMBO Rep. 2006, 7:1019-1022.
80. Braschi E., Zunino R., McBride H.M. MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep. 2009, 10:748-754.
81. Bellance N., Benard G., Furt F., Begueret H., Smolkova K., Passerieux E., Delage J., Baste J., Moreau P., Rossignol R. Bioenergetics of lung tumors: alteration of mitochondrial biogenesis and respiratory capacity. Int. J. Biochem. Cell Biol. 2009, 41(12):2566-2577.
82. Margineantu D., Cox W., Sundell L., Sherwood S., Beechen J., Capaldi R. Cell cycle dependent morphology changes and associated mitochondrial DNA redistribution in mitochondria of human cell lines. Mitochondrion 2002, 1:397-478.
83. Chang C.R., Blackstone C. Drp1 phosphorylation and mitochondrial regulation. EMBO Rep. 2007, 8:1088-1089. author reply 1089-1090.
84. Cho D.H., Nakamura T., Fang J., Cieplak P., Godzik A., Gu Z., Lipton S.A. S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 2009, 324:102-105.
85. Duvezin-Caubet S., Jagasia R., Wagener J., Hofmann S., Trifunovic A., Hansson A., Chomyn A., Bauer M.F., Attardi G., Larsson N.G., Neupert W., Reichert A.S. Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology. J. Biol. Chem. 2006, 281:37972-37979.
86. Legros F., Lombes A., Frachon P., Rojo M. Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol. Biol. Cell 2002, 13:4343-4354.
87. Schwer B., Guthrie C. A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. EMBO J. 1992, 11:5033-5039.
88. Chen H., Chomyn A., Chan D.C. Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J. Biol. Chem. 2005, 280:26185-26192.
89. Chevrollier A., Guillet V., Loiseau D., Gueguen N., de Crescenzo M.A., Verny C., Ferre M., Dollfus H., Odent S., Milea D., Goizet C., Amati-Bonneau P., Procaccio V., Bonneau D., Reynier P. Hereditary optic neuropathies share a common mitochondrial coupling defect. Ann. Neurol. 2008, 63:794-798.
90. Olichon A., Baricault L., Gas N., Guillou E., Valette A., Belenguer P., Lenaers G. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J. Biol. Chem. 2003, 278:7743-7746.
91. Bach D., Pich S., Soriano F.X., Vega N., Baumgartner B., Oriola J., Daugaard J.R., Lloberas J., Camps M., Zierath J.R., Rabasa-Lhoret R., Wallberg-Henriksson H., Laville M., Palacin M., Vidal H., Rivera F., Brand M., Zorzano A. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J. Biol. Chem. 2003, 278:17190-17197.
92. Zorzano A., Sebastian D., Segales J., Palacin M. The molecular machinery of mitochondrial fusion and fission: an opportunity for drug discovery?. Curr. Opin Drug Discov. Dev. 2009, 12:597-606.
93. Guillet V., Gueguen N., Verny C., Ferre M., Homedan C., Loiseau D., Procaccio V., Amati-Bonneau P., Bonneau D., Reynier P., Chevrollier A. Adenine nucleotide translocase is involved in a mitochondrial coupling defect in MFN2-related Charcot-Marie-Tooth type 2A disease. Neurogenetics 2010, 11:127-133.
94. Cassidy-Stone A., Chipuk J.E., Ingerman E., Song C., Yoo C., Kuwana T., Kurth M.J., Shaw J.T., Hinshaw J.E., Green D.R., Nunnari J. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev. Cell 2008, 14:193-204.
95. Brooks C., Wei Q., Cho S.G., Dong Z. Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J. Clin. Invest. 2009, 119:1275-1285.
96. Karbowski M., Norris K.L., Cleland M.M., Jeong S.Y., Youle R.J. Role of Bax and Bak in mitochondrial morphogenesis. Nature 2006, 443:658-662.
97. Chen Z.X., Pervaiz S. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. Cell Death Differ. 2010, 17(3):408-420.
98. Chen Z.X., Pervaiz S. Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells. Cell Death Differ. 2007, 14:1617-1627.
99. Rossignol R., Karbowski M. Editorial of the directed issue on mitochondrial dynamics in biology and medicine. Int. J. Biochem. Cell Biol. 2009, 41:1748-1749.
100. Vankoningsloo S., De Pauw A., Houbion A., Tejerina S., Demazy C., de Longueville F., Bertholet V., Renard P., Remacle J., Holvoet P., Raes M., Arnould T. CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytes. J. Cell Sci. 2006, 119:1266-1282.
101. Mercy L., Pauw A., Payen L., Tejerina S., Houbion A., Demazy C., Raes M., Renard P., Arnould T. Mitochondrial biogenesis in mtDNA-depleted cells involves a Ca2+-dependent pathway and a reduced mitochondrial protein import. FEBS J. 2005, 272:5031-5055.
102. Franko A., Mayer S., Thiel G., Mercy L., Arnould T., Hornig-Do H.T., Wiesner R.J., Goffart S. CREB-1alpha is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation. Mol. Cell. Biol. 2008, 28:2446-2459.
103. Niwano K., Arai M., Koitabashi N., Hara S., Watanabe A., Sekiguchi K., Tanaka T., Iso T., Kurabayashi M. Competitive binding of CREB and ATF2 to cAMP/ATF responsive element regulates eNOS gene expression in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2006, 26:1036-1042.
104. Hock M.B., Kralli A. Transcriptional control of mitochondrial biogenesis and function. Annu. Rev. Physiol. 2009, 71:177-203.
105. Nisoli E., Carruba M.O. Nitric oxide and mitochondrial biogenesis. J. Cell Sci. 2006, 119:2855-2862.
106. Nisoli E., Tonello C., Cardile A., Cozzi V., Bracale R., Tedesco L., Falcone S., Valerio A., Cantoni O., Clementi E., Moncada S., Carruba M.O. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005, 310:314-317.
107. Raharijaona M., Le Pennec S., Poirier J., Mirebeau-Prunier D., Rouxel C., Jacques C., Fontaine J.F., Malthiery Y., Houlgatte R., Savagner F. PGC-1-related coactivator modulates mitochondrial-nuclear crosstalk through endogenous nitric oxide in a cellular model of oncocytic thyroid tumours. PLoS ONE 2009, 4:e7964.
108. Zippin J.H., Levin L.R., Buck J. CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor. Trends Endocrinol. Metab. 2001, 12:366-370.
109. St-Pierre J., Drori S., Uldry M., Silvaggi J.M., Rhee J., Jager S., Handschin C., Zheng K., Lin J., Yang W., Simon D.K., Bachoo R., Spiegelman B.M. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006, 127:397-408.
110. Chevtzoff C., Yoboue E.D., Galinier A., Casteilla L., Daignan-Fornier B., Rigoulet M., Devin A. Reactive oxygen species-mediated regulation of mitochondrial biogenesis in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 2010, 285:1733-1742.
111. Brown G.C., Borutaite V. Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols. Biochim. Biophys. Acta 2004, 1658:44-49.
112. Papa S., De Rasmo D., Scacco S., Signorile A., Technikova-Dobrova Z., Palmisano G., Sardanelli A.M., Papa F., Panelli D., Scaringi R., Santeramo A. Mammalian complex I: a regulable and vulnerable pacemaker in mitochondrial respiratory function. Biochim. Biophys. Acta 2008, 1777:719-728.
113. Zhang D.W., Shao J., Lin J., Zhang N., Lu B.J., Lin S.C., Dong M.Q., Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009, 325:332-336.
114. Hervouet E., Cizkova A., Demont J., Vojtiskova A., Pecina P., Franssen-van Hal N.L., Keijer J., Simonnet H., Ivanek R., Kmoch S., Godinot C., Houstek J. HIF and reactive oxygen species regulate oxidative phosphorylation in cancer. Carcinogenesis 2008, 29:1528-1537.
115. Rezvani H.R., Dedieu S., North S., Belloc F., Rossignol R., Letellier T., de Verneuil H., Taieb A., Mazurier F. Hypoxia-inducible factor-1alpha, a key factor in the keratinocyte response to UVB exposure. J. Biol. Chem. 2007, 282:16413-16422.
116. Balaban R.S. The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work. Biochim. Biophys. Acta 2009, 1787:1334-1341.
117. Kavanagh N.I., Ainscow E.K., Brand M.D. Calcium regulation of oxidative phosphorylation in rat skeletal muscle mitochondria. Biochim. Biophys. Acta 2000, 1457:57-70.
118. Ahn B.H., Kim H.S., Song S., Lee I.H., Liu J., Vassilopoulos A., Deng C.X., Finkel T. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:14447-14452.
119. Haigis M.C., Mostoslavsky R., Haigis K.M., Fahie K., Christodoulou D.C., Murphy A.J., Valenzuela D.M., Yancopoulos G.D., Karow M., Blander G., Wolberger C., Prolla T.A., Weindruch R., Alt F.W., Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 2006, 126:941-954.
120. Schlicker C., Gertz M., Papatheodorou P., Kachholz B., Becker C.F., Steegborn C. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J. Mol. Biol. 2008, 382:790-801.
121. Nakamura Y., Ogura M., Tanaka D., Inagaki N. Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5. Biochem. Biophys. Res. Commun. 2008, 366:174-179.
122. Yorimitsu T., Klionsky D.J. Endoplasmic reticulum stress: a new pathway to induce autophagy. Autophagy 2007, 3:160-162.
123. Stephenson L.M., Miller B.C., Ng A., Eisenberg J., Zhao Z., Cadwell K., Graham D.B., Mizushima N.N., Xavier R., Virgin H.W., Swat W. Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy 2009, 5:625-635.
124. Mijaljica D., Prescott M., Klionsky D.J., Devenish R.J. Autophagy and vacuole homeostasis: a case for self-degradation?. Autophagy 2007, 3:417-421.
125. Kanki T., Klionsky D.J. Mitophagy in yeast occurs through a selective mechanism. J. Biol. Chem. 2008, 283:32386-32393.
126. Maiuri M.C., Criollo A., Tasdemir E., Vicencio J.M., Tajeddine N., Hickman J.A., Geneste O., Kroemer G. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 2007, 3:374-376.
127. Maiuri M.C., Le Toumelin G., Criollo A., Rain J.C., Gautier F., Juin P., Tasdemir E., Pierron G., Troulinaki K., Tavernarakis N., Hickman J.A., Geneste O., Kroemer G. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J. 2007, 26:2527-2539.
128. Priault M., Salin B., Schaeffer J., Vallette F.M., di Rago J.P., Martinou J.C. Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast. Cell Death Differ. 2005, 12:1613-1621.
129. Rodriguez-Hernandez A., Cordero M.D., Salviati L., Artuch R., Pineda M., Briones P., Gomez Izquierdo L., Cotan D., Navas P., Sanchez-Alcazar J.A. Coenzyme Q deficiency triggers mitochondria degradation by mitophagy. Autophagy 2009, 5:19-32.
130. Teckman J.H., An J.K., Blomenkamp K., Schmidt B., Perlmutter D. Mitochondrial autophagy and injury in the liver in alpha 1-antitrypsin deficiency. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 286:G851-G862.
131. Gosselin K., Deruy E., Martien S., Vercamer C., Bouali F., Dujardin T., Slomianny C., Houel-Renault L., Chelli F., De Launoit Y., Abbadie C. Senescent keratinocytes die by autophagic programmed cell death. Am. J. Pathol. 2009, 174:423-435.
132. Zhu J.H., Horbinski C., Guo F., Watkins S., Uchiyama Y., Chu C.T. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am. J. Pathol. 2007, 170:75-86.
133. Hickson-Bick D.L., Jones C., Buja L.M. Stimulation of mitochondrial biogenesis and autophagy by lipopolysaccharide in the neonatal rat cardiomyocyte protects against programmed cell death. J. Mol. Cell. Cardiol. 2008, 44:411-418.
134. Narendra D., Tanaka A., Suen D.F., Youle R.J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 2008, 183:795-803.
135. Scherz-Shouval R., Shvets E., Fass E., Shorer H., Gil L., Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 2007, 26:1749-1760.
136. Geng J., Klionsky D.J. The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep. 2008, 9:859-864.
137. Katzmann D.J., Babst M., Emr S.D. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 2001, 106:145-155.
138. Sutovsky P., Moreno R.D., Ramalho-Santos J., Dominko T., Simerly C., Schatten G. Ubiquitin tag for sperm mitochondria. Nature 1999, 402:371-372.
139. Fisk H.A., Yaffe M.P. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. J. Cell Biol. 1999, 145:1199-1208.
140. Pollard P.J., Briere J.J., Alam N.A., Barwell J., Barclay E., Wortham N.C., Hunt T., Mitchell M., Olpin S., Moat S.J., Hargreaves I.P., Heales S.J., Chung Y.L., Griffiths J.R., Dalgleish A., McGrath J.A., Gleeson M.J., Hodgson S.V., Poulsom R., Rustin P., Tomlinson I.P. Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum. Mol. Genet. 2005, 14:2231-2239.
141. Hatzivassiliou G., Zhao F., Bauer D.E., Andreadis C., Shaw A.N., Dhanak D., Hingorani S.R., Tuveson D.A., Thompson C.B. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 2005, 8:311-321.
142. Wellen K.E., Hatzivassiliou G., Sachdeva U.M., Bui T.V., Cross J.R., Thompson C.B. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009, 324:1076-1080.
143. Ishikawa K., Takenaga K., Akimoto M., Koshikawa N., Yamaguchi A., Imanishi H., Nakada K., Honma Y., Hayashi J. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 2008, 320:661-664.
144. Bellance N., Lestienne P., Rossignol R. Mitochondria: from bioenergetics to the metabolic regulation of carcinogenesis. Front. Biosci. Jan 1 2009, 4015-4034.
145. Niemann S., Muller U. Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nat. Genet. 2000, 26:268-270.
146. Ducray F., Marie Y., Sanson M. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 2009, 360:2248. author reply 2249.
147. De Carli E., Wang X., Puget S. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 2009, 360:2248. author reply 2249.
148. Yan H., Parsons D.W., Jin G., McLendon R., Rasheed B.A., Yuan W., Kos I., Batinic-Haberle I., Jones S., Riggins G.J., Friedman H., Friedman A., Reardon D., Herndon J., Kinzler K.W., Velculescu V.E., Vogelstein B., Bigner D.D. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 2009, 360:765-773.
149. Kim J.W., Tchernyshyov I., Semenza G.L., Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006, 3:177-185.
150. Christofk H.R., Vander Heiden M.G., Harris M.H., Ramanathan A., Gerszten R.E., Wei R., Fleming M.D., Schreiber S.L., Cantley L.C. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008, 452:230-233.
151. Christofk H.R., Vander Heiden M.G., Wu N., Asara J.M., Cantley L.C. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008, 452:181-186.
152. Gao P., Tchernyshyov I., Chang T.C., Lee Y.S., Kita K., Ochi T., Zeller K.I., De Marzo A.M., Van Eyk J.E., Mendell J.T., Dang C.V. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458:762-765.
153. Shakya A., Cooksey R., Cox J.E., Wang V., McClain D.A., Tantin D. Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat. Cell Biol. 2009, 11:320-327.
154. Ferre M., Bonneau D., Milea D., Chevrollier A., Verny C., Dollfus H., Ayuso C., Defoort S., Vignal C., Zanlonghi X., Charlin J.F., Kaplan J., Odent S., Hamel C.P., Procaccio V., Reynier P., Amati-Bonneau P. Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations. Hum. Mutat. 2009, 30:E692-E705.
155. Loiseau D., Chevrollier A., Douay O., Vavasseur F., Renier G., Reynier P., Malthiery Y., Stepien G. Oxygen consumption and expression of the adenine nucleotide translocator in cells lacking mitochondrial DNA. Exp. Cell Res. 2002, 278:12-18.
156. Nolden M., Ehses S., Koppen M., Bernacchia A., Rugarli E.I., Langer T. The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondria. Cell 2005, 123:277-289.