In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation

Cell Metabolism

Volumn 17, Issue 3, 2013, Pages 372-385

  Gameiro, Paulo A ^a,b,c,d   Yang, Juanjuan ^a,b   Metelo, Ana M ^a,b   Pérez Carro, Rocio ^f   Baker, Rania ^a,b   Wang, Zongwei ^b   Arreola, Alexandra ^e   Rathmell, W Kimryn ^e   Olumi, Aria ^b   López Larrubia, Pilar ^f   Stephanopoulos, Gregory ^c   Iliopoulos, Othon ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Massachusetts Institute of Technology   (United States)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; ACETIC ACID; CITRIC ACID; GLUCOSE TRANSPORTER 1; HEXOKINASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; LACTATE DEHYDROGENASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; VON HIPPEL LINDAU PROTEIN;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXYLATION; CARCINOMA CELL; CELL GROWTH; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SPACE; KIDNEY CARCINOMA; LIPOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTIVE CARBOXYLATION; REGULATORY MECHANISM; TUMOR XENOGRAFT;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARBON ISOTOPES; CARBOXYLIC ACIDS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CITRATES; EXTRACELLULAR FLUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTAMINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84875354450     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.02.002     Document Type: Article

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