LOT1 (ZAC1/PLAGL1) and its family members: Mechanisms and functions

Journal of Cellular Physiology

Volumn 210, Issue 1, 2007, Pages 16-25

  Abdollahi, Abbas ^a  

^a Temple University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; GENE PRODUCT; LIGAND; PROTEIN LOT1; PROTEIN PLAG1; PROTEIN PLAGL2; TUMOR SUPPRESSOR PROTEIN; ZINC FINGER PROTEIN;

AMINO TERMINAL SEQUENCE; CHROMOSOME 6Q; CHROMOSOME 8Q; CHROMOSOME DELETION; CHROMOSOME REARRANGEMENT; DEVELOPMENTAL DISORDER; DIABETES MELLITUS; GENE; GENE EXPRESSION REGULATION; GENE LOCATION; GENE SILENCING; GENETIC EPIGENESIS; GENETIC LINKAGE; GENOME IMPRINTING; GROWTH RETARDATION; HETEROZYGOSITY LOSS; HUMAN; LOT1 GENE; MAMMAL CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLAG1 GENE; PLEOMORPHIC ADENOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTO ONCOGENE; REGULATORY MECHANISM; REVIEW; SALIVARY GLAND TUMOR; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ZINC FINGER MOTIF;

ANIMALS; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PROTEIN CONFORMATION; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; ZINC FINGERS;

MAMMALIA;

EID: 33845447175     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20835     Document Type: Review

References (87)

1. Abdollahi A, Bao R, Hamilton TC. 1999. LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein. Oncogene 18:6477-6487.
2. Abdollahi A, Godwin A, Miller P, Getts L, Schultz D, Taguchi T, Testa J, Hamilton TC. 1997a. Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells. Cancer Res 57:2029-2034.
3. Abdollahi A, Roberts D, Godwin A, Schultz D, Sonoda G, Testa J, Hamilton TC. 1997b. Identification of a zinc-finger gene at 6q25: A chromosomal region implicated in development of many solid tumors. Oncogene 14:1973-1979.
4. Abdollahi A, Gruver BN, Patriotis C, Hamilton TC. 2003a. Identification of epidermal growth factor-responsive genes in normal rat ovarian surface epithelial cells. Biochem Biophys Res Commun 307:188-197.
5. Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton TC. 2003b. LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer. J Biol Chem 278:6041-6049.
6. Alam S, Zinyk D, Ma L, Schuurmans C. 2005. Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous system. Dev Dyn 234:772-782.
7. Arima T, Drewell RA, Oshimura M, Wake N, Surani MA. 2000. A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC. Genomics 67(3):248-255.
8. Arima T, Drewell RA, Arney KL, Inoue J, Makita Y, Hata A, Oshimura M, Wake N, Surani MA. 2001. A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. Hum Mol Genet 10(14):1475-1483.
9. Arima T, Kamikihara T, Hayashida T, Kato K, Inoue T, Shirayoshi Y, Oshimura M, Soejima H, Mukai T, Wake N. 2005. LOT1, LIT1 (KCNQ1OT1) and p57 are in an imprinted gene network that may play a role in Beckwith-Widemann syndrome. Nucleic Acid Res 33:2650-2660.
10. Arima T, Wake N. 2006. Establishment of the primary imprint of the HYMAI/PLAGL1 imprint control region during oogenesis. Cytogenet Genome Res 113(1-4):247-252.
11. Asp J, Persson F, Kost-Alimova M, Stenman G. 2006. CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. Genes Chromosomes Cancer [Epub ahead of print].
12. Astrom AK, Voz ML, Kas K, Roijer E, Wedell B, Mandahl N, Van de Ven W, Mark J, Stenman G. 1999. Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: Identification of SII as a new fusion partner gene. Cancer Res 59(4):918-923.
13. Basyuk E, Coulon V, Le Digarcher A, Coisy-Quivy M, Moles J, Gandarillas A, Journot L. 2005. The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas. Mol Cancer Res 3:483-492.
14. Bilanges B, Varrault A, Basyuk E, Rodriguez C, Mazumdar A, Pantaloni C, Bockaert J, Theillet C, Spengler D, Journot L. 1999. Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors. Oncogene 18:3979-3988.
15. Bilanges B, Varrault A, Mazumdar A, Pantaloni C, Hoffmann A, Bockaert J, Spengler D, Journot L. 2001. Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities. Oncogene 20(10):1246-1253.
16. Brandal P, Bjerkehagen B, Heim S. 2006. Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology. J Pathol 208(3):388-394.
17. Castilla LH, Perrat P, Martinez NJ, Landrette SF, Keys R, Oikemus S, Flanegan J, Heilman S, Garrett L, Dutra A, Anderson S, Pihan GA, Wolff L, Liu PP. 2004. Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia. Proc Natl Acad Sci USA 101(14):4924-4929.
18. Ciani E, Hoffmann A, Schmidt P, Journot L, Spengler D. 1999. Induction of the PAC1-R (PACAP-type I receptor) gene by p53 and Zac. Brain Res Mol Brain Res 69:290-294.
19. Ciani E, Frenquelli M, Contestabile A. 2003. Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cells. Brain Res Dev Brain Res 142:193-202.
20. Contestabile A, Fila T, Bartesaghi R, Ciani E. 2005. Cyclic AMP-mediated regulation of transcription factor Lot1 expression in cerebellar granule cells. J Biol Chem 280:33541-33551.
21. Cvetkovic D, Pisarcik D, Lee C, Hamilton TC, Abdollahi A. 2004. Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer. Gynecol Oncol 95:449-455.
22. Declercq J, Hensen K, Van De Ven WJ, Chavez M. 2003. PLAG proteins: How they influence apoptosis and cell proliferation. Ann NY Acad Sci 1010:264-265.
23. Declercq J, Van Dyck F, Braem CV, Van Valckenborgh IC, Voz M, Wassef M, Schoonjans L, Van Damme B, Fiette L, Van de Ven WJ. 2005. Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression. Cancer Res 65(11):4544-4553.
24. El Kharroubi A, Piras G, Stewart CL. 2001. DNA demethylation reactivates a subset of imprinted genes in uniparental mouse embryonic fibroblasts. J Biol Chem 276(12):8674-8680.
25. Enlund F, Persson F, Stenman G. 2004. Molecular analyses of the candidate tumor suppressor gene, PLAGL1, in benign and malignant salivary gland tumors. Eur J Oral Sci 112(6):545-547.
26. Foa C, Mainguene C, Dupre F, Coindre JM, Huguet C, Kober C, Pedeutour F. 2002. Rearrangement involving chromosomes 1 and 8 in a retroperitoneal lipoma. Cancer Genet Cytogenet 133:156-159.
27. Furukawa T, Adachi Y, Fujisawa J, Kambe T, Yamaguchi-Iwai Y, Sasaki R, Kuwahara J, Ikehara S, Tokunaga R, Taketani S. 2001. Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines. Oncogene 20(34):4718-4727.
28. Gardner RJ, Mungall AJ, Dunham I, Barber JC, Shield JP, Temple IK, Robinson DO. 1999. Localisation of a gene for transient neonatal diabetes mellitus to an 18.72 cR3000 (approximately 5.4 Mb) interval on chromosome 6q. J Med Genet 36:192-196.
29. Gardner R, Mackay D, Mungall A, Polychronakos C, Siebert R, Shield J, Temple I, Robinson D. 2000. An imprinted locus associated with transient neonatal diabetes mellitus. Hum Mol Genet 9:589-596.
30. Gillardon F, Hata R, Hossmann KA. 1998. Delayed up-regulation of Zac1 and PACAP type I receptor after transient focal cerebral ischemia in mice. Brain Res Mol Brain Res 61(1-2):207-210.
31. Gisselsson D, Hibbard MK, Dal Cin P, Sciot R, Hsi BL, Kozakewich HP, Fletcher JA. 2001. PLAG1 alterations in lipoblastoma: Involvement in varied mesenchymal cell types and evidence for alternative oncogenic mechanisms. Am J Pathol 159(3):955-962.
32. Hensen K, Van Valckenborgh IC, Kas K, Van de Ven WJ, Voz ML. 2002. The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. Cancer Res 62(5):1510-1517.
33. Hensen K, Braem C, Declercq J, Van Dyck F, Dewerchin M, Fiette L, Denef C, Van de Ven WJ. 2004. Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility. Dev Growth Differ 46(5):459-470.
34. Hibbard MK, Kozakewich HP, Dal Cin P, Sciot R, Tan X, Xiao S, Fletcher JA. 2000. PLAG1 fusion oncogenes in lipoblastoma. Cancer Res 60:4869-4872.
35. Hiura H, Obata Y, Komiyama J, Shirai M, Kono T. 2006. Oocyte growth-dependent progression of maternal imprinting in mice. Genes Cells 11(4):353-361.
36. Hoffmann A, Ciani E, Houssami S, Brabet P, Journot L, Spengler D. 1998. Induction of type I PACAP receptor expression by the new zinc finger protein Zac1 and p53. Ann NY Acad Sci 865:49-58.
37. Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L, Spengler D. 2003. Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding. Mol Cell Biol 23(3):988-1003.
38. 2 zinc fingers link Zac DNA binding to coordinated regulation of p300-histone acetyltransferase activity. Mol Cell Biol 26(14):5544-5557.
39. Huang SM, Stallcup MR. 2000. Mouse Zac1. a transcriptional coactivator and repressor for nuclear receptors. Mol Cell Biol 20(5):1855-1867.
40. Huang SM, Schonthal AH, Stallcup MR. 2001. Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1. Oncogene 20(17):2134-2143.
41. Kamikihara T, Arima T, Kato K, Matsuda T, Kato H, Douchi T, Nagata Y, Nakao M, Wake N. 2005. Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer. Int J Cancer 115:690-700.
42. Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, Satomura K, Hermann R, Bonthron D, Hayashizaki Y. 2000. The cell cycle control gene ZAC/PLAGL1 is imprinted - A strong candidate gene for transient neonatal diabetes. Hum Mol Genet 9:453-460.
43. Kas K, Voz M, Roijer E, Astrom AK, Meyen E, Stenman G, Van de Ven W. 1997. Promoter swapping between the genes for a novel zinc finger protein and b-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Nat Genet 15:170-174.
44. Kas K, Voz M, Hensen K, Meyen E, Van de Ven W. 1998. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J Biol Chem 273:23026-23032.
45. Koy S, Hauses M, Appelt H, Friedrich K, Schackert H, Eckelt U. 2004. Loss of expression of ZAC/LOT1 in squamous cell carcinomas of head and neck. Head Neck 26:338-344.
46. Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH. 2005. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. Blood 105(7):2900-2907.
47. Lemeta S, Salmenkivi K, Pylkkanen L, Sainio M, Saarikoski ST, Arola J, Heikkila P, Haglund C, Husgafvel-Pursiainen K, Bohling T. 2006. Frequent loss of heterozygosity at 6q in pheochromocytoma. Hum Pathol 37(6):749-754.
48. Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin RR, Rutter GA, Kelsey G. 2004. Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. J Clin Invest 114(3):339-348.
49. Mackay DJ, Coupe AM, Shield JP, Storr JN, Temple IK, Robinson DO. 2002. Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus. Hum Genet 110:139-144.
50. Mackay DJ, Hahnemann JM, Boonen SE, Poerksen S, Bunyan DJ, White HE, Durston VJ, Thomas NS, Robinson DO, Shield JP, Clayton-Smith J, Temple IK. 2006. Epimutation of the TNDM locus and the Beckwith-Wiedemann syndrome centromeric locus in individuals with transient neonatal diabetes mellitus. Hum Genet 119(1-2):179-184.
51. McMinn J, Wei M, Schupf N, Cusmai J, Johnson EB, Smith AC, Weksberg R, Thaker HM, Tycko B. 2005. Unbalanced placental expression of imprinted genes in human intrauterine growth restriction. Placenta 27(6-7):540-549.
52. Midorikawa Y, Yamamoto S, Ishikawa S, Kamimura N, Igarashi H, Sugimura H, Makuuchi M, Aburatani H. 2006. Molecular karyotyping of human hepatocellular carcinoma using single-nucleotide polymorphism arrays. Oncogene [Epub ahead of print].
53. Mizutani A, Furukawa T, Adachi Y, Ikehara S, Taketani S. 2002. A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis. J Biol Chem 277(18):15851-15858.
54. Morerio C, Rapella A, Rosanda C, Tassano E, Gambini C, Romagnoli G, Panarello C. 2005. PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement. Cancer Genet Cytogenet 156(2):183-184.
55. Ordway JM, Williams K, Curran T. 2004. Transcription repression in oncogenic transformation: Common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1. Oncogene 23(21):3737-3748.
56. Pagotto U, Arzberger T, Ciani E, Lezoualc'h F, Pilon C, Journot L, Spengler D, Stalla G. 1999. Inhibition of Zac1, a new gene differentially expressed in the anterior pituitary, increases cell proliferation. Endocrinology 140:987-996.
57. Pagotto U, Arzberger T, Theodoropoulou M, Grubler Y, Pantaloni C, Saeger W, Losa M, Journot L, Stalla G, Spengler D. 2000. The expression of the antiproliferative gene ZAC1 is lost or highly reduced in nonfunctioning pituitary adenomas. Cancer Res 60:6794-6799.
58. Pendeville H, Peers B, Kas K, Voz ML. 2006. Cloning and embryonic expression of zebrafish PLAG genes. Gene Expr Patterns 6(3):267-276.
59. Piras G, El Kharroubi A, Kozlov S, Escalante-Alcalde D, Hernandez L, Copeland N, Gilbert D, Jenkins N, Stewart C. 2000. Zac1 (Lot1), a potential tumor suppressor gene, and the gene for epsilon-sarcoglycan are maternally imprinted genes: Identification by a subtractive screen of novel uniparental fibroblast lines. Mol Cell Biol 20:3308-3315.
60. Poulin H, Labelle Y. 2005. The PLAGL1 gene is down-regulated in human extraskeletal myxoid chondrosarcoma tumors. Cancer Lett 227:185-191.
61. Rozenfeld-Granot G, Krishnamurthy J, Kannan K, Toren A, Amariglio N, Givol D, Rechavi G. 2002. A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1. Oncogene 21(10):1469-1476.
62. Rutherford S, Yu Y, Kumpel CA, Frierson HF Jr, Moskaluk CA. 2005. Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma. Cancer Lett [Epub ahead of print].
63. Seitz S, Korsching E, Weimer J, Jacobsen A, Arnold N, Meindl A, Arnold W, Gustavus D, Klebig C, Petersen I, Scherneck S. 2006. Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression. Genes Chromosomes Cancer 45(6):612-627.
64. Shapiro M, Senapathy P. 1987. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res 15:7155-7174.
65. Singhal S, Amin KM, Kruklitis R, DeLong P, Friscia ME, Litzky LA, Putt ME, Kaiser LR, Albelda SM. 2003. Alterations in cell cycle genes in early stage lung adenocarcinoma identified by expression profiling. Cancer Biol Ther 2(3):291-298.
66. Smith RJ, Arnaud P, Konfortova G, Dean WL, Beechey CV, Kelsey G. 2002. The mouse Zac1 locus: Basis for imprinting and comparison with human ZAC. Gene 292:101-112.
67. Spengler D, Villalba M, Hoffman A, Pantaloni C, Houssami S, Bockaert J, Journet L. 1997. Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J 16:2814-2825.
68. Szpirer C, Kas K, Laes JF, Riviere M, Van Vooren P, Szpirer J. 2001. Assignment of the rat pleiomorphic adenoma genes (Plag1, Plagl1, Plagl2) by in situ hybridization and radiation hybrid mapping. Cytogenet Cell Genet 94(1-2):94-95.
69. Tchernitsa OI, Sers C, Zuber J, Hinzmann B, Grips M, Schramme A, Lund P, Schwendel A, Rosenthal A, Schafer R. 2004. Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells. Oncogene 23:4536-4555.
70. Temple IK, James RS, Crolla JA, Sitch FL, Jacobs PA, Howell WM, Betts P, Baum JD, Shield JP. 1995. An imprinted gene(s) for diabetes? Nat Genet 9(2):110-112.
71. Temple IK, Gardner RJ, Robinson DO, Kibirige MS, Ferguson AW, Baum JD, Barber JC, James RS, Shield JP. 1996. Further evidence for an imprinted gene for neonatal diabetes localised to chromosome 6q22-q23. Hum Mol Genet 5:1117-1121.
72. Temple IK, Shield JP. 2002. Transient neonatal diabetes, a disorder of imprinting. J Med Genet 39(12):872-875.
73. Theodoropoulou M, Zhang J, Laupheimer S, Paez-Pereda M, Erneux C, Florio T, Pagotto U, Stalla GK. 2006. Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing zac1 expression. Cancer Res 66(3):1576-1582.
74. Tsuda T, Markova D, Wang H, Evangelisti L, Pan T, Chu M. 2004. Zinc finger protein Zac1 is expressed in chondrogenic sites of the mouse. Dev Dyn 2004:340-348.
75. Valente T, Auladell C. 2001. Expression pattern of Zac1 mouse gene, a new zinc-finger protein that regulates apoptosis and cellular cycle arrest, in both adult brain and along development. Mech Dev 108:207-211.
76. Valente T, Dominguez M, Bellman A, Journot L, Ferrer I, Auladel C. 2004. ZAC1 is up-regulated in neural cells of the limbic system of mouse brain following seizures that provoke strong cell activation. Neurosci 128:323-336.
77. Valente T, Junyent F, Auladell C. 2005. Zac1 is expressed in progenitor/stem cells of the neuroectoderm and mesoderm during embryogenesis: Differential phenotype of the Zac1-expressing cells during development. Dev Dyn 233:667-679.
78. Van Dyck F, Delvaux EL, Van de Ven WJ, Chavez MV. 2004. Repression of the transactivating capacity of the oncoprotein PLAG1 by sumoylation. J Biol Chem 279(34):36121-36131.
79. Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L. 1998. hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Proc Natl Acad Sci USA 95(15):8835-8840.
80. Varrault A, Bilanges B, Mackay DJ, Basyuk E, Ahr B, Fernandez C, Robinson DO, Bockaert J, Journot L. 2001. Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus. J Biol Chem 276(22):18653-18656.
81. Voz ML, Astrom AK, Kas K, Mark J, Stenman G, Van de Ven WJ. 1998. The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter. Oncogene 16(11):1409-1416.
82. Voz ML, Agten NS, Van de Ven WJ, Kas K. 2000. PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Cancer Res 60(1):106-113.
83. Voz ML, Mathys J, Hensen K, Pendeville H, Van Valckenborgh I, Van Huffel C, Chavez M, Van Damme B, De Moor B, Moreau Y, Van de Ven WJ. 2004. Microarray screening for target genes of the proto-oncogene PLAG1. Oncogene 23(1):179-191.
84. Wan M, Sun T, Vyas R, Zheng J, Granada E, Dubeau L. 1999. Suppression of tumorigenicity in human ovarian cancer cell lines is controlled by a 2 cM fragment in chromosomal region 6q24-q25. Oncogene 18:1545-1551.
85. Yang MC, Weissler JC, Terada LS, Deng F, Yang YS. 2005. Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter. Am J Respir Cell Mol Biol 32(1):35-43.
86. Zhao X, Ren W, Yang W, Wang Y, Kong H, Wang L, Yan L, Xu G, Fei J, Fu J, Zhang C, Wang Z. 2006. Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice. Int J Cancer 118(3):643-648.
87. Zheng G, Yang YC. 2005. Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2. J Biol Chem 280(49):40773-40781.