Across the pulmonary epithelial barrier: Integration of physicochemical properties and human cell models to study pulmonary drug formulations

Pharmacology and Therapeutics

Volumn 144, Issue 3, 2014, Pages 235-252

  Haghi, Mehra ^a,b   Ong, Hui Xin ^a,b   Traini, Daniela ^a,b   Young, Paul ^a,b  

^a WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Absorption; Cell culture; Deposition; Epithelia; Pulmonary delivery; Transport

Indexed keywords

BIOLOGICAL FACTOR; BREAST CANCER RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN; ORGANIC ANION TRANSPORTER; RESPIRATORY TRACT AGENT; SURFACTANT; XENOBIOTIC AGENT; DRUG;

ACTIVE TRANSPORT; CONTROLLED RELEASE FORMULATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISPOSITION; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; DRY POWDER; DRY POWDER INHALER; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; LIPOPHILICITY; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; METERED DOSE INHALER; MUCOCILIARY CLEARANCE; PARTICLE SIZE; PATHOGENESIS; PATHOPHYSIOLOGY; PHYSICAL CHEMISTRY; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT DISEASE; REVIEW; ABSORPTION; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; EPITHELIUM CELL; MEDICINAL CHEMISTRY; METABOLISM; PERMEABILITY; PHARMACOKINETICS; RESPIRATORY TRACT MUCOSA; SURFACE PROPERTY; TRANSPORT AT THE CELLULAR LEVEL;

ABSORPTION, PHYSIOLOGICAL; BIOLOGICAL TRANSPORT; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; EPITHELIAL CELLS; HUMANS; MACROPHAGES, ALVEOLAR; MODELS, BIOLOGICAL; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PHYSICOCHEMICAL PHENOMENA; RESPIRATORY MUCOSA; SURFACE PROPERTIES;

EID: 84910036519     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2014.05.003     Document Type: Review

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