Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery

International Journal of Pharmaceutics

Volumn 208, Issue 1-2, 2000, Pages 1-11

  Foster, Kimberly A ^a,b   Avery, Michael L ^c   Yazdanian, Mehran ^b   Audus, Kenneth L ^c,d  

^a UNIVERSITY OF KANSAS   (United States)

^b Pharmaceutical Sciences   (United States)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^d 236B Simons ^*  (United States)

Author keywords

Calu 3; P450; Respiratory epithelium; TEER; Transport

Indexed keywords

DRUG; XENOBIOTIC AGENT;

ARTICLE; CELL GROWTH; CELL LINE; DRUG TRANSPORT; HUMAN; HUMAN CELL; MONOLAYER CULTURE; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM;

ADMINISTRATION, INHALATION; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; FLUORESCENT DYES; HUMANS; ISOQUINOLINES; OXIDOREDUCTASES, N-DEMETHYLATING; RESPIRATORY MUCOSA;

EID: 0034605705     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00452-X     Document Type: Article

References (19)

1. Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers
2. Ethoxyresorufin: Direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene
3. Xenobiotic metabolism by isolated pulmonary cells
4. Reverse trancscription-polymerase chain reaction (RT-PCR) phenotypic analysis of cell cultures of human tracheal epithelium, tracheobronchial glands, and lung carcinomas
5. Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism
6. - conductance
7. Evidence that Calu-3 human airway cells secrete bicarbonate
8. Vectorial transcytosis of dimeric IgA by the Calu-3 human lung epithelial cell line: Upregulation by IFN-γ
9. Drug metabolism and enzyme kinetics in the lung
10. Localization of metabolic activation and deactivation systems in the lung: Significance to the pulmonary toxicity of xenobiotics
11. The use of surfactants to enhance the permeability of peptides and proteins through Caco-2 cells by inhibition of an apically polarized efflux system
12. Recycling kinetics and trancytosis of transferrin in primary cultures of bovine brain microvessel endothelial cells
13. Expression of xenobiotic-metabolizing cytochrome P450s in human pulmonary tissues
14. The distribution of cytochrome P-450 monooxygenase in cells of the rabbit lung: An ultrastructural immunocytochemical characterization
15. - secretion
16. - secretion
17. Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability
18. The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers