Quantitative expression of human drug transporter proteins in lung tissues: Analysis of regional, gender, and interindividual differences by liquid chromatography-tandem mass spectrometry

Journal of Pharmaceutical Sciences

Volumn 102, Issue 9, 2013, Pages 3395-3406

  Sakamoto, Atsushi ^a,b   Matsumaru, Takehisa ^a   Yamamura, Norio ^a   Uchida, Yasuo ^b   Tachikawa, Masanori ^b   Ohtsuki, Sumio ^c   Terasaki, Tetsuya ^b  

^a NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Analytical biochemistry; Drug transport; LC MS; Mass spectrometry; Membrane transporter; MRP1; OATP2B1; OCTN1; Pulmonary drug delivery; Targeted proteomics

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; MULTIDRUG RESISTANCE PROTEIN 6; MULTIDRUG RESISTANCE PROTEIN 8; OATP1A2 PROTEIN; OATP1B3 PROTEIN; OATP2B1 PROTEIN; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 1; PEPTIDE TRANSPORTER 2; PROSTAGLANDIN TRANSPORTER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; DRUG DESIGN; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LUNG PARENCHYMA; MALE; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; SEX DIFFERENCE; TANDEM MASS SPECTROMETRY;

ANALYTICAL BIOCHEMISTRY; DRUG TRANSPORT; LC-MS; MASS SPECTROMETRY; MEMBRANE TRANSPORTER; MRP1; OATP2B1; OCTN1; PULMONARY DRUG DELIVERY; TARGETED PROTEOMICS;

ADOLESCENT; ADULT; AGED; CELLS, CULTURED; CHROMATOGRAPHY, LIQUID; EPITHELIAL CELLS; FEMALE; HUMANS; LUNG; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; TANDEM MASS SPECTROMETRY;

EID: 84881616582     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23606     Document Type: Article

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