Temporal dependence of ectopeptidase expression in alveolar epithelial cell culture: Implications for study of peptide absorption

International Journal of Pharmaceutics

Volumn 180, Issue 2, 1999, Pages 225-234

  Forbes, B ^a   Wilson, C G ^b   Gumbleton, M ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL PEPTIDASE IV; MEMBRANE METALLOENDOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE; PEPTIDASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; ENZYME ACTIVITY; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; RAT;

ABSORPTION; ANIMALS; ANTIGENS, CD13; ANTIGENS, CD26; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CELLS, CULTURED; EPITHELIAL CELLS; MACROPHAGES, ALVEOLAR; MALE; METALLOENDOPEPTIDASES; PEPTIDE HYDROLASES; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; PULMONARY ALVEOLI; RATS; TIME FACTORS;

EID: 0032964522     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00009-5     Document Type: Article

References (45)

1. Adamson I.Y.R., Bowden D.H. The type II cell as a progenitor of alveolar epithelial regeneration. Lab. Invest. 30:1974;35-42.
2. Adjei A., Garren J. Pulmonary delivery of peptide drugs: effects of particle size on bioavailability of leuprolide acetate in healthy male volunteers. Pharm. Res. 7:1990;565-569.
3. Bai, J.P.F., Kowsar, N., 1993. Subcellular distribution of proteolytic activities degrading peptide drugs in the lung: implication for pulmonary drug delivery. Pharm. Res. 10, S287.
4. Bai J.P.F. Distribution of brush border membrane peptidases along the rat intestine. Pharm. Res. 11:1994;897-900.
5. Brain J.D., Frank N.R. Recovery of free cells from rat lungs by repeated washings. J. Appl. Physiol. 25:1968;63-69.
6. Cheek J.M., Evans M.J., Cranfall E.D. Type I cell-like morphology in tight alveolar epithelial monolayers. Exp. Lung Res. 184:1989;375-387.
7. Choi H.-O., Wang Q. Control of pulmonary enzymatic barriers: inhibition of peptide degradation in rat lung homogenates. Pharm. Res. 10:1993;290.
8. Danto S.I., Zabski S.M., Crandall E.D. Reactivity of alveolar epithelial cells in primary culture with type I cell monoclonal antibodies. Am. J. Respir. Cell Mol. Biol. 6:1992;296-306.
9. Dobbs L.G., Williams M.C., Gonzalez R. Monoclonal antibodies specific to apical surfaces of rat alveolar type II cells bind to surfaces of cultured, but not freshly isolated, type II cells. Biochem. Biophys. Acta. 970:1988;146-156.
10. Edelson J.D., Shannon J.M., Mason R.J. Alkaline phosphatase: a marker of alveolar type II epithelial cell differentiation. Am. Rev. Respir. Dis. 138:1988;1268-1275.
11. Forbes B.J., Wilson C.G., Gumbleton M. Extraction of peptidase substrates by the isolated perfused rat lung. Pharm. Sci. 1:1995;569-572.
12. Foster K., Audus K. Characterisation of the A549 cell line as a model to study pulmonary permeability. Pharm. Res. 13:1996;249.
13. Fukuda Y., Tsuji Y., Fujita T., Yamamoto A., Muranishi S. Susceptibility of insulin to proteolysis in rat lung homogenate and its protection from proteolysis by various protease inhibitors. Biol. Pharm. Bull. 18:1995;891-894.
14. Funkhouser J.D., Tangada S.D., Peterson R.D.A. Ectopeptidases of alveolar epithelium: candidates for roles in alveolar regulatory mechanisms. Am. J. Physiol. 260:1991;L381-L385.
15. Green, D.E., Mii, S., Kohout, P.M. 1955. Studies on the terminal electron transport system. I. Succinic dehydrogenase. J. Biol. Chem. 217, 551-567.
16. Howell S., Kenny A.J., Turner A.J. A survey of membrane peptidases in two human colonic cell lines, Caco-2 and HT-29. Biochem. J. 284:1992;595-601.
17. Jackman H.L., Tan F., Schraufnagel D., Dragovic T., Dezso B., Becker R.P., Erdos E.G. Plasma membrane-bound and lysosomal peptidases in human alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 13:1995;196-204.
18. Johnson A.R., Ashton J., Schulz W.W., Erdos E.G. Neutral metalloendopeptidase in human lung tissue and cultured cells. Am. Rev. Respir. Dis. 132:1985;564-568.
19. Kenny A.J., Hooper N.M. Peptidases involved in the metabolism of bioactive peptides. Hendrickson J.H. Degradation of bioactive substances: physiology and pathophysiology of peptides involved in metabolism of bioactive substances. 1991;47-79 CRC Press, Boca Raton, FL.
20. Kobayashi S., Kondo S., Juni K. Study on pulmonary delivery of salmon calcitonin in rats: effects of protease inhibitors and absorption enhancers. Pharm. Res. 11:1994;1239-1243.
21. Kobayashi S., Kondo S., Juni K. Permeability of peptides and proteins in human cultured alveolar A549 cell monolayer. Pharm. Res. 12:1995;1115-1119.
22. Kobayashi S., Kondo S., Juni K. Critical factors on pulmonary absorption of peptides and proteins (diffusional barrier and metabolic barrier). Eur. J. Pharm. Sci. 4:1996;367-372.
23. Krepela E., Viccar J., Zizkova L., Kasafirek E., Kolar Z., Lichnovsky V. Dipeptidyl peptidase IV in mammalian lungs. Lung. 163:1985;33-54.
24. Mathias N.R. Respiratory epithelial cell culture models for evaluation of ion and drug transport. Adv. Drug Del. Rev. 22:1996;215-249.
25. Morimoto K., Yamahara H., Lee V.H.L., Kim K.-J. Dipeptide transport across rat alveolar epithelial cell monolayers. Pharm. Res. 10:1993;1668-1674.
26. Morita T., Yamamoto A., Takakura Y., Hashida M., Sezaki H. Improvement of the pulmonary absorption of (Asu1,7)-eel calcitonin by various protease inhibitors in rats. Pharm. Res. 11:1994;909-913.
27. Nagae A., Abe M., Becker R.P., Deddish P.A., Skidgel R.A., Erdos E.G. High concentration of carboxypeptidase M in lungs: presence of the enzyme in alveolar type I cells. Am. J. Respir. Cell Mol. Biol. 9:1993;221-229.
28. Orawski A.T., Susz J.P., Simmons W.H. Metabolism of bradykinin by multiple coexisting membrane-bound peptidases in lung: techniques for investigating the role of each peptidase using specific inhibitors. Adv. Exp. Med. Biol. 247:1989;355-364.
29. Patton J.S. Mechanisms of macromolecule absorption by the lungs. Adv. Drug Del. Rev. 19:1996;3-36.
30. Peterson G.L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83:1977;346-356.
31. Phillips A.H., Langdon R.G. Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterisation, and kinetic studies. J. Biol. Chem. 237:1962;2652-2660.
32. Proud D., Subuaste M.C., Ward P. Glucocorticoids do not alter peptidase expression on a human bronchial epithelial cell line. Am. J. Respir. Cell Mol. Biol. 11:1994;57-65.
33. Richards R.J., Davies N., Atkins J., Oreffo V.I.C. Isolation, biochemical characterisation and culture of lung type II cells of the rat. Lung. 165:1987;143-158.
34. Sayani A.P., Chien Y.W. Systemic delivery of peptides and proteins across absorptive mucosae. Crit. Rev. Drug Carrier Syst. 13:1996;85-184.
35. Smith B.T. Cell line A549: a model system for the study of alveolar type II cell function. Am. Rev. Respir. Dis. 115:1977;285-293.
36. Wall D.A., Lanutti A.T. High levels of exopeptidase activity are present in rat and canine bronchoalveolar lavage fluid. Int. J. Pharm. 97:1993;171-181.
37. Wall D.A. Pulmonary absorption of peptides and proteins. Drug Delivery. 2:1995;1-20.
38. Wang L., Toledo-Velasquez D., Schwegler-Berry D., Ma J.K.H., Rojanasakul Y. Transport and hydrolysis of enkephalins in cultured alveolar epithelial monolayers. Pharm. Res. 11:1993;1662-1667.
39. Yamahara H., Lehr C.M., Lee V.H.L., Kim K.J. Fate of insulin during transit across rat alveolar epithelial cell monolayers. Eur. J. Pharm. Biopharm. 40:1994;294-298.
40. Yamahara H., Morimoto K., Lee V.H.L., Kim K.-J. Effects of protease inhibitors on vasopressin transport across rat alveolar epithelial cell monolayers. Pharm. Res. 11:1994;1617-1622.
41. Yamamoto A., Fujita T., Muranishi S. Pulmonary absorption enhancement of peptides and proteins by absorption enhancers and protease inhibitors. J. Control. Release. 41:1996;57-67.
42. Yang Z., Wang L., Bhat M., Rojanasakul Y., Ma J.K.H. Effect of cell differentiation on proteolytic activity of type II pneumocytes. Pharm. Res. 13:1996;170.
43. Yang X., Rojanasakul Y., Ma J.K.A. Luteinising hormone releasing hormone degradation in type II cell-derived epithelia. Pharm. Res. 14:1997;136.
44. Yu J.W., Chien Y.W. Pulmonary drug delivery: physiologic and mechanistic aspects. Crit. Rev. Drug Carrier Syst. 14:1997;395-453.
45. Zhou X.H. Overcoming enzymatic and absorption barriers to non-parenterally administered protein and peptide drugs. J. Control. Release. 29:1994;239-252.