Permeability characteristics of Calu-3 human bronchial epithelial cells: In vitro-in vitro correlation to predict lung absorption in rats

Journal of Drug Targeting

Volumn 10, Issue 1, 2002, Pages 31-40

  Mathias, Neil R ^a   Timoszyk, Julita ^a   Stetsko, Paul I ^a   Megill, John R ^b   Smith, Ronald L ^a   Wall, Doris A ^a  

^a Bristol Myers ^*  (United Kingdom)

^b Bldg 105/1157   (United States)

Author keywords

Calu 3; Drug transport; Human bronchial epithelial cells; In vitro in vivo correlation; Permeability

Indexed keywords

4 AMINOHIPPURIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ADENOSINE TRIPHOSPHATASE INHIBITOR; AMILORIDE; AMINO ACID; ANION; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CAFFEINE; CATION; COLLAGEN; CROMOGLYCATE DISODIUM; DEXAMETHASONE; DIPEPTIDE DERIVATIVE; FLUORESCEIN SODIUM; FUROSEMIDE; INULIN; LEUCINE; LUCIFER YELLOW; MANNITOL; NUCLEOSIDE; OUABAIN; PHENAZONE; PROPRANOLOL; SALBUTAMOL; SODIUM CHANNEL BLOCKING AGENT; TETRYLAMMONIUM BROMIDE; THEOPHYLLINE; UNINDEXED DRUG; URIDINE;

ACTIVE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS MUCOSA; CELL DIFFERENTIATION; CELL GROWTH; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; CELL POLARITY; CELL TRANSPORT; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; ELECTRIC RESISTANCE; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; LUNG FUNCTION; MEMBRANE FILTER; MICROVILLUS; MOLECULAR SIZE; MONOLAYER CULTURE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RABBIT; RAT; SOLUTE; TRACHEA MUCOSA;

ABSORPTION; ADMINISTRATION, INHALATION; ALGORITHMS; ANIMALS; BIOLOGICAL TRANSPORT; BRONCHI; CELL LINE; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CHEMISTRY, PHYSICAL; EPITHELIAL CELLS; HALF-LIFE; HUMANS; LUNG; MICROSCOPY, ELECTRON; PATCH-CLAMP TECHNIQUES; PHARMACEUTICAL PREPARATIONS; RATS;

EID: 0036125277     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10611860290007504     Document Type: Article

References (33)

1. "Studies on the factors affecting pulmonary absorption of xanthine derivatives in the rat"
2. "Correlation between oral drug absorption in humans and apparent permeability coefficients in human intestinal epithelial (Caco-2) cells"
3. "Respiratory carcinoma cell lines. MUC genes and glycoconjugates"
4. "Dose-response relation of liquid aerosol inhaled insulin in type I diabetic patients"
5. "Absorption of corticosteroids from the rat lung"
6. "Transepithelial transport of fluoroquinolone ciprofloxacin by human airway epithelial Calu-3 cells"
7. "Absorption of drugs from the rat lung"
8. "Absorption of saccharides and urea from the rat lung"
9. "Reverse transcription-polymerase chain reaction (RT-PCR) phenotypic analysis of cell cultures of human tracheal epithelium, tracheobronchial glands, and lung carcinomas"
10. "Human airway epithelial cell lines for in vitro drug transport and metabolism studies"
11. "Characterization of A549 cell line as a type II pulmonary epithelial cell model for drug metabolism"
12. "Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery"
13. "Absorption of disodium cromoglycate from the rat lung: Evidence of carrier transport"
14. "Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: Comparison with the parental Caco-2 cell line"
15. Comprehensive Medicinal Chemistry: The Rational Design, Mechanistic Study and Therapeutic Application of Chemical Compounds
16. "MDCK (Madin-Darby Canine Kidney) cells: A tool for membrane permeability screening"
17. "Permeability of peptides and proteins in human cultured alveolar A549 cell monolayer"
18. "Intratracheal delivery of peptide and protein agents: Absorption from solution and drug powder by rat lung"
19. "Time to peak insulin level, relative bioavailability, and effect of site of deposition of nebulized insulin in patients with non-insulin-dependent diabetes mellitus"
20. "Pulmonary absorption of amino acids in the rat: Evidence of carrier transport"
21. "Vectorial transport of dimeric IgA by the Calu-3 human lung epithelial cell line: Upregulation by IFN-gamma"
22. "Nucleoside and nucleoside analog transport in airway epithelial cell cultured monolayers"
23. "Targeted delivery to the respiratory tract: Solute permeability of air-interfaced cultured rabbit tracheal epithelial cell monolayers"
24. "Size-dependent dextran transport across rat alveolar epithelial cell monolayers"
25. "Effects of various absorption promoters on pulmonary absorption of drugs with different molecular weights"
26. "Filtration, diffusion and molecular sieving through porous cellulose membranes"
27. "Species comparison of drug absorption from the lung after aerosol inhalation or intratracheal injection"
28. - secretion"
29. --secretion"
30. "Tracheal epithelial permeability to non-electrolytes: Species difference"
31. "Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability"
32. "In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery"
33. "Dipeptide uptake and transport characteristics in rabbit tracheal epithelial cell layers cultured at an air interface"