Drug absorption by the respiratory mucosa: Cell culture models and particulate drug carriers

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 15, Issue 2, 2002, Pages 131-139

  Ehrhardt, C ^a   Fiegel, J ^b   Fuchs, S ^a   Abu Dahab, R ^a   Schaefer, U F ^a   Hanes, J ^b,c   Lehr, Claus M ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Johns Hopkins University   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Air interface culture; Alveolar epithelial cells; Bronchial epithelial cells; Lectins; Liposomes; Microparticles

Indexed keywords

ACID ANHYDRIDE; DRUG CARRIER; LECTIN; LIPOSOME; LUNG SURFACTANT EXTRACT; MICROSPHERE; POLY(SEBACIC ANHYDRIDE); POLYMER; SEBACIC ACID; UNCLASSIFIED DRUG;

BIODEGRADABILITY; BRONCHUS MUCOSA; CELL CULTURE; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; CELL POLARITY; CONFERENCE PAPER; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG TARGETING; DRY DEPOSITION; EPITHELIUM CELL; GENE THERAPY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG HEMODYNAMICS; MACROMOLECULE; MICROPARTICLE ENZYME IMMUNOASSAY; RESPIRATORY TRACT MUCOSA;

EID: 0036321111     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/089426802320282257     Document Type: Conference Paper

References (41)

1. Inhaled insulin
2. Pulmonary delivery of drugs for bone disorders
3. Routes of delivery: Case studies (2). Pulmonary delivery of peptides and proteins for systemic action
4. Drug delivery and targeting
5. Large porous particles for pulmonary drug delivery
6. Lectin-mediated drug delivery: The second generation of bioadhesives
7. Lectin enhancement of the lipofectin efficiency in human lung carcinoma cells
8. Lectin conjugate directed gene transfer to airway epithelial cells
9. The controlled delivery of drugs to the lung
10. Controlled delivery of an antitumor drug: Localized action of liposome encapsulated cytosine arabinoside administered via the respiratory system
11. Disposition of aerosolized liposomal amphotericin B
12. Regional lung disposition of nebulized liposomes encapsulated ciprofloxacin
13. Delivery of superoxide dismutase to pulmonary epithelium via pH-sensitive liposomes
14. Comparison between intratracheal and intravenous administration of liposome-DNA complexes for cystic fibrosis
15. The effects of jet nebulisation on cationic liposome-mediated gene transfer in vitro
16. Airway-to-biophase transfer of inhaled oligonucleotides
17. Sustained bronchodilation with isoproterenol poly(glycolide-co-lactide) microspheres
18. The controlled delivery of drugs to the lung
19. The cost of delivering drugs without needles
20. Physico-chemical principals in aerosol delivery
21. Effect of the size and surface-charge of polymer microspheres on their phagocytosis by macrophage
22. Relating the phagocytosis of microparticles by alveolar macrophages to surface chemistry: The effects of 1,2-dipalmitoylphosphatidylcholine
23. Monolayers of human alveolar epithelial cells in primary culture for pulmonary absorption and transport studies
24. Serial culturing of human bronchial epithelial cells derived from biopsies
25. Isolation and culture of alveolar type II cells
26. - secretion
27. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells
28. The epithelial cancer cell line Calu-3: Characterisation as an in vitro model for drug absorption in the upper airways
29. Respiratory epithelial cell culture models for evaluation of ion and drug transport
30. Human airway epithelial cell lines for in vitro drug transport and metabolism studies
31. Phospholipid biosynthesis and secretion by a cell line (A549) which resembles type II alveolar epithelial cells
32. Formation of tight monolayers of guinea pig epithelial cells cultured in an air-interface: Bioelectrical properties
33. Lectin-functionalized liposomes for pulmonary drug delivery: Interaction with human alveolar epithelial cells
34. Lectin-functionalized liposomes for pulmonary drug delivery: Effect of nebulization on stability and bioadhesion
35. Large, light polyether-anhydride microspheres: A new carrier for pulmonary drug delivery
36. Loss of epithelial integrity resulting from E-cadherin dysfunction predisposes airway epithelial cells to adenoviral infection
37. Comparison of the effectiveness of inhaler devices in asthma and chronic obstructive airways disease: A systematic review of the literature
38. Treatment strategies for bronchial asthma: An update
39. Coarse spray delivery to a localized region of the pulmonary airways for gene therapy
40. Optimization of aerosol deposition by pressure support in children with cystic fibrosis
41. Aerosolized recombinant human DNase I for the treatment of cystic fibrosis