Metabolic cleavage of cell-penetrating peptides in contact with epithelial models: Human calcitonin (hCT)-derived peptides, Tat(47-57) and penetratin(43-58)

Biochemical Journal

Volumn 382, Issue 3, 2004, Pages 945-956

  Tréhin, Rachel ^a   Nielsen, Hanne M ^a,b   Jahnke, Heinz Georg ^a,c   Krauss, Ulrike ^c   Beck Sickinger, Annette G ^c   Merkle, Hans P ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Cell penetrating peptides; Epithelial delivery; Human calcitonin; Metabolic cleavage; Penetratin; Tat

Indexed keywords

BIOLOGICAL ORGANS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PROTEINS;

CELL-PENETRATING PEPTIDES; PROTEOLYTIC ACTIVITY;

CELLS;

AMINOPEPTIDASE; CALCITONIN[9-32]; CARBONYL DERIVATIVE; CARBOXYPEPTIDASE; PENETRATIN[43-58]; PEPTIDE; PEPTIDE FRAGMENT; PEPTIDE HORMONE; PROTEIN TAT[47-57]; PROTEINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; KINETICS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN TRANSPORT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BIOTRANSFORMATION; CALCITONIN; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG CARRIERS; EPITHELIAL CELLS; GENE PRODUCTS, TAT; HOMEODOMAIN PROTEINS; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 4744368322     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040238     Document Type: Article

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