메뉴 건너뛰기




Volumn 9, Issue 6, 2012, Pages 1717-1726

Deposition, diffusion and transport mechanism of dry powder microparticulate salbutamol, at the respiratory epithelia

Author keywords

air interface model; Calu 3 epithelial cell line; dry powder inhaler; organic cation transporters (OCT); salbutamol

Indexed keywords

ORGANIC CATION TRANSPORTER; POLYESTER; SALBUTAMOL; SALBUTAMOL SULFATE; TRIETHYLAMINE;

EID: 84862001733     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200620m     Document Type: Article
Times cited : (50)

References (43)
  • 1
    • 33644617924 scopus 로고    scopus 로고
    • Dry powder inhaler formulation
    • Telko, M. J.; Hickey, A. Dry Powder Inhaler Formulation. Respir. Care 2005, 50 (9), 1209-1227. (Pubitemid 46187575)
    • (2005) Respiratory Care , vol.50 , Issue.9 , pp. 1209-1227
    • Telko, M.J.1    Hickey, A.J.2
  • 2
    • 0036773382 scopus 로고    scopus 로고
    • Regulation of the depth and composition of airway surface liquid
    • DOI 10.1046/j.1469-7580.2002.00098.x
    • Widdicombe, J. H. Regulation of the Depth and Composition of Airway Surface Liquid. J. Anat. 2002, 201 (4), 313-318. (Pubitemid 35244050)
    • (2002) Journal of Anatomy , vol.201 , Issue.4 , pp. 313-318
    • Widdicombe, J.H.1
  • 3
    • 33845906339 scopus 로고    scopus 로고
    • Inhaling medicines: Delivering drugs to the body through the lungs
    • DOI 10.1038/nrd2153, PII NRD2153
    • Patton, J. S.; Byron, P. R. Inhaling Medicines: Delivering Drugs to the Body Through the Lungs. Nat. Rev. Drug Discovery 2007, 6 (1), 67-74. (Pubitemid 46020287)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.1 , pp. 67-74
    • Patton, J.S.1    Byron, P.R.2
  • 4
    • 59849094684 scopus 로고    scopus 로고
    • The Permeability of Large Molecular Weight Solutes Following Particle Delivery to Air-Interfaced Cells That Model the Respiratory Mucosa
    • Grainger, C. I.; Greenwell, L. L.; Martin, G. P.; Forbes, B. The Permeability of Large Molecular Weight Solutes Following Particle Delivery to Air-Interfaced Cells That Model the Respiratory Mucosa. Eur. J. Pharm. Biopharm. 2009, 71 (2), 318-324.
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , Issue.2 , pp. 318-324
    • Grainger, C.I.1    Greenwell, L.L.2    Martin, G.P.3    Forbes, B.4
  • 6
    • 68949114238 scopus 로고    scopus 로고
    • Recent Advances in Controlled Release Pulmonary Therapy
    • Salama, R. Recent Advances in Controlled Release Pulmonary Therapy. Curr. Drug Delivery 2009, 6 (4), 404-414.
    • (2009) Curr. Drug Delivery , vol.6 , Issue.4 , pp. 404-414
    • Salama, R.1
  • 8
    • 0030588585 scopus 로고    scopus 로고
    • Carrier-mediated transport and efflux mechanisms of Caco-2 cells
    • DOI 10.1016/S0169-409X(96)00414-0, PII S0169409X96004140
    • Hidalgo, I. J.; Li, J. Carrier-mediated Transport and Efflux Mechanisms in Caco-2 Cells. Adv. Drug Delivery Rev. 1996, 22 (1-2), 53-66. (Pubitemid 26423597)
    • (1996) Advanced Drug Delivery Reviews , vol.22 , Issue.1-2 , pp. 53-66
    • Hidalgo, I.J.1    Li, J.2
  • 9
    • 0027161229 scopus 로고
    • Preparation, characterization, and dissolution kinetics of two novel albuterol salts
    • Jashnani, R. N.; Dalby, R. N.; Byron, P. R. Preparation, Characterization, and Dissolution Kinetics of Two Novel Albuterol Salts. J. Pharm. Sci. 1993, 82 (6), 613-616. (Pubitemid 23216007)
    • (1993) Journal of Pharmaceutical Sciences , vol.82 , Issue.6 , pp. 613-616
    • Jashnani, R.N.1    Dalby, R.N.2    Byron, P.R.3
  • 10
    • 26944439522 scopus 로고    scopus 로고
    • The Lungs as a Portal of Entry for Systemic Drug Delivery
    • Patton, J. S.; Fishburn, C. S.; Weers, J. G. The Lungs as a Portal of Entry for Systemic Drug Delivery. Proc. Am. Thorac. Soc. 2004, 1 (4), 338-344.
    • (2004) Proc. Am. Thorac. Soc. , vol.1 , Issue.4 , pp. 338-344
    • Patton, J.S.1    Fishburn, C.S.2    Weers, J.G.3
  • 11
    • 67349272759 scopus 로고    scopus 로고
    • Sparing Methylation of [beta]- Cyclodextrin Mitigates Cytotoxicity and Permeability Induction in Respiratory Epithelial Cell Layers in Vitro
    • Salem, L. B.; Bosquillon, C.; Dailey, L. A.; Delattre, L.; Martin, G. P.; Evrard, B.; Forbes, B. Sparing Methylation of [beta]- Cyclodextrin Mitigates Cytotoxicity and Permeability Induction in Respiratory Epithelial Cell Layers In Vitro. J. Controlled Release 2009, 136 (2), 110-116.
    • (2009) J. Controlled Release , vol.136 , Issue.2 , pp. 110-116
    • Salem, L.B.1    Bosquillon, C.2    Dailey, L.A.3    Delattre, L.4    Martin, G.P.5    Evrard, B.6    Forbes, B.7
  • 12
    • 0036282607 scopus 로고    scopus 로고
    • Insulin aggregation and asymmetric transport across human bronchial epithelial cell monolayers (Calu-3)
    • DOI 10.1002/jps.10114
    • Pezron, I.; Mitra, R.; Pal, D.; Mitra, A. K. Insulin Aggregation and Asymmetric Transport Across Human Bronchial Epithelial Cell Monolayers (Calu-3). J. Pharm. Sci. 2002, 91 (4), 1135-1146. (Pubitemid 34640938)
    • (2002) Journal of Pharmaceutical Sciences , vol.91 , Issue.4 , pp. 1135-1146
    • Pezron, I.1    Mitra, R.2    Pal, D.3    Mitra, A.K.4
  • 13
    • 0029090267 scopus 로고
    • The Controlled Delivery of Drugs to the Lung
    • Zeng, X. M.; Martin, G. P.; Marriott, C. The Controlled Delivery of Drugs to the Lung. Int. J. Pharm. 1995, 124 (2), 149-164.
    • (1995) Int. J. Pharm. , vol.124 , Issue.2 , pp. 149-164
    • Zeng, X.M.1    Martin, G.P.2    Marriott, C.3
  • 14
    • 50149083441 scopus 로고    scopus 로고
    • Preparation and Characterisation of Controlled Release Co-Spray Dried Drug-Polymer Microparticles for Inhalation 2: Evaluation of in Vitro Release Profiling Methodologies for Controlled Release Respiratory Aerosols
    • Salama, R. O.; Traini, D.; Chan, H.-K.; Young, P. M. Preparation and Characterisation of Controlled Release Co-Spray Dried Drug-Polymer Microparticles for Inhalation 2: Evaluation of In Vitro Release Profiling Methodologies for Controlled Release Respiratory Aerosols. Eur. J. Pharm. Biopharm. 2008, 70 (1), 145-152.
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , Issue.1 , pp. 145-152
    • Salama, R.O.1    Traini, D.2    Chan, H.-K.3    Young, P.M.4
  • 15
    • 0016610679 scopus 로고
    • Percutaneous Absorption. On the Relevance of in Vitro Data
    • Franz, T. J. Percutaneous Absorption. On the Relevance of In Vitro Data. J. Invest. Dermatol. 1975, 64 (3), 190-195.
    • (1975) J. Invest. Dermatol. , vol.64 , Issue.3 , pp. 190-195
    • Franz, T.J.1
  • 16
    • 74949121129 scopus 로고    scopus 로고
    • Controlled Release Antibiotics for Dry Powder Lung Delivery
    • Adi, H.; Young, P. M.; Chan, H.-K.; Salama, R.; Traini, D. Controlled Release Antibiotics for Dry Powder Lung Delivery. Drug Dev. Ind. Pharm. 2010, 36 (1), 119-126.
    • (2010) Drug Dev. Ind. Pharm. , vol.36 , Issue.1 , pp. 119-126
    • Adi, H.1    Young, P.M.2    Chan, H.-K.3    Salama, R.4    Traini, D.5
  • 17
    • 18144385104 scopus 로고    scopus 로고
    • Novel sustained release microspheres for pulmonary drug delivery
    • DOI 10.1016/j.jconrel.2005.01.003
    • Cook, R. O.; Pannu, R. K.; Kellaway, I. W. Novel Sustained Release Microspheres for Pulmonary Drug Delivery. J. Controlled Release 2005, 104 (1), 79-90. (Pubitemid 40615237)
    • (2005) Journal of Controlled Release , vol.104 , Issue.1 , pp. 79-90
    • Cook, R.O.1    Pannu, R.K.2    Kellaway, I.W.3
  • 18
    • 73349132967 scopus 로고    scopus 로고
    • Development of an in Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles
    • Salama, R.; Ladd, L.; Chan, H.-K.; Traini, D.; Young, P. Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles. AAPS J. 2009, 11 (3), 465-468.
    • (2009) AAPS J. , vol.11 , Issue.3 , pp. 465-468
    • Salama, R.1    Ladd, L.2    Chan, H.-K.3    Traini, D.4    Young, P.5
  • 19
    • 0033959120 scopus 로고    scopus 로고
    • Human airway epithelial cell lines for in vitro drug transport and metabolism studies
    • DOI 10.1016/S1461-5347(99)00231-X, PII S146153479900231X
    • Forbes, B. Human Airway Epithelial Cell Lines for In Vitro Drug Transport and Metabolism Studies. Pharm. Sci. Technol. Today 2000, 3 (1), 18-27. (Pubitemid 30066491)
    • (2000) Pharmaceutical Science and Technology Today , vol.3 , Issue.1 , pp. 18-27
    • Forbes, B.1
  • 20
    • 0036282759 scopus 로고    scopus 로고
    • Transport and Local Metabolism of Budesonide and Fluticasone Propionate in a Human Bronchial Epithelial Cell Line (Calu-3)
    • Borchard, G.; Cassara, M. L.; Roemele, P. E. H.; Florea, B. I.; Junginger, H. E. Transport and Local Metabolism of Budesonide and Fluticasone Propionate in a Human Bronchial Epithelial Cell Line (Calu-3). J. Pharm. Sci. 2002, 91 (6), 1561-7.
    • (2002) J. Pharm. Sci. , vol.91 , Issue.6 , pp. 1561-1567
    • Borchard, G.1    Cassara, M.L.2    Roemele, P.E.H.3    Florea, B.I.4    Junginger, H.E.5
  • 21
    • 0037458930 scopus 로고    scopus 로고
    • Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3
    • DOI 10.1016/S0168-3659(02)00356-5
    • Florea, B. I.; Cassara, M. L.; Junginger, H. E.; Borchard, G. Drug Transport and Metabolism Characteristics of the Human Airway Epithelial Cell Line Calu-3. J. Controlled Release 2003, 87 (1-3), 131-8. (Pubitemid 36255450)
    • (2003) Journal of Controlled Release , vol.87 , Issue.1-3 , pp. 131-138
    • Florea, B.I.1    Cassara, M.L.2    Junginger, H.E.3    Borchard, G.4
  • 22
    • 0036125277 scopus 로고    scopus 로고
    • Permeability characteristics of Calu-3 human bronchial epithelial cells: In vitro-in vitro correlation to predict lung absorption in rats
    • DOI 10.1080/10611860290007504
    • Mathias, N. R.; Timoszyk, J.; Stetsko, P. I.; Megill, J. R.; Smith, R. L.; Wall, D. A. Permeability Characteristics of Calu-3 Human Bronchial Epithelial Cells: In Vitro-In Vivo Correlation to Predict Lung Absorption in Rats. J. Drug Targeting 2002, 10 (1), 31-40. (Pubitemid 34223847)
    • (2002) Journal of Drug Targeting , vol.10 , Issue.1 , pp. 31-40
    • Mathias, N.R.1    Timoszyk, J.2    Stetsko, P.I.3    Megill, J.R.4    Smith, R.L.5    Wall, D.A.6
  • 23
    • 77956419131 scopus 로고    scopus 로고
    • Time- and Passage-Dependent Characteristics of a Calu-3 Respiratory Epithelial Cell Model
    • Haghi, M.; Young, P. M.; Traini, D.; Jaiswal, R.; Gong, J.; Bebawy, M. Time- and Passage-Dependent Characteristics of a Calu-3 Respiratory Epithelial Cell Model. Drug Dev. Ind. Pharm. 2010, 36 (10), 1207-1214.
    • (2010) Drug Dev. Ind. Pharm. , vol.36 , Issue.10 , pp. 1207-1214
    • Haghi, M.1    Young, P.M.2    Traini, D.3    Jaiswal, R.4    Gong, J.5    Bebawy, M.6
  • 26
    • 85047683608 scopus 로고    scopus 로고
    • RTPCR Analysis of ABC, SLC and SLCO Drug Transporters in Human Lung Epithelial Cell Models
    • Endter, S.; Francombe, D.; Ehrhardt, C.; Gumbleton, M. RTPCR Analysis of ABC, SLC and SLCO Drug Transporters in Human Lung Epithelial Cell Models. J. Pharm. Pharmacol. 2009, 61 (5), 583-591.
    • (2009) J. Pharm. Pharmacol. , vol.61 , Issue.5 , pp. 583-591
    • Endter, S.1    Francombe, D.2    Ehrhardt, C.3    Gumbleton, M.4
  • 27
    • 76249120508 scopus 로고    scopus 로고
    • Transport of Ipratropium, an Anti-Chronic Obstructive Pulmonary Disease Drug, Is Mediated by Organic Cation/Carnitine Transporters in Human Bronchial Epithelial Cells: Implications for Carrier-Mediated Pulmonary Absorption
    • Nakamura, T.; Nakanishi, T.; Haruta, T.; Shirasaka, Y.; Keogh, J. P.; Tamai, I. Transport of Ipratropium, an Anti-Chronic Obstructive Pulmonary Disease Drug, Is Mediated by Organic Cation/Carnitine Transporters in Human Bronchial Epithelial Cells: Implications for Carrier-Mediated Pulmonary Absorption. Mol. Pharmaceutics 2009, 7 (1), 187-195.
    • (2009) Mol. Pharmaceutics , vol.7 , Issue.1 , pp. 187-195
    • Nakamura, T.1    Nakanishi, T.2    Haruta, T.3    Shirasaka, Y.4    Keogh, J.P.5    Tamai, I.6
  • 28
    • 33751578245 scopus 로고    scopus 로고
    • Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition
    • DOI 10.1080/00498250600861751, PII L824361NNW681368
    • Bleasby, K.; Castle, J. C.; Roberts, C. J.; Cheng, C.; Bailey, W. J.; Sina, J. F.; Kulkarni, A. V.; Hafey, M. J.; Evers, R.; Johnson, J. M.; Ulrich, R. G.; Slatter, J. G. Expression Profiles of 50 Xenobiotic Transporter Genes in Humans and Pre-clinical Species: A Resource for Investigations into Drug Disposition. Xenobiotica 2006, 36 (10-11), 963-988. (Pubitemid 44844110)
    • (2006) Xenobiotica , vol.36 , Issue.10-11 , pp. 963-988
    • Bleasby, K.1    Castle, J.C.2    Roberts, C.J.3    Cheng, C.4    Bailey, W.J.5    Sina, J.F.6    Kulkarni, A.V.7    Hafey, M.J.8    Evers, R.9    Johnson, J.M.10    Ulrich, R.G.11    Slatter, J.G.12
  • 29
    • 33745630072 scopus 로고    scopus 로고
    • Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier
    • DOI 10.1007/s11095-006-0255-0
    • Grainger, C.; Greenwell, L.; Lockley, D.; Martin, G.; Forbes, B. Culture of Calu-3 Cells at the Air Interface Provides a Representative Model of the Airway Epithelial Barrier. Pharm. Res. 2006, 23 (7), 1482-1490. (Pubitemid 43993811)
    • (2006) Pharmaceutical Research , vol.23 , Issue.7 , pp. 1482-1490
    • Grainger, C.I.1    Greenwell, L.L.2    Lockley, D.J.3    Martin, G.P.4    Forbes, B.5
  • 30
    • 67349171605 scopus 로고    scopus 로고
    • Novel Cell, A Compatible Impingement System to Study in Vitro Drug Absorption from Dry Powder Aerosol Formulations
    • Bur, M.; Rothen-Rutishauser, B.; Huwer, H.; Lehr, C.-M.; Novel Cell, A Compatible Impingement System to Study In Vitro Drug Absorption from Dry Powder Aerosol Formulations. Eur. J. Pharm. Biopharm. 2009, 72 (2), 350-357.
    • (2009) Eur. J. Pharm. Biopharm. , vol.72 , Issue.2 , pp. 350-357
    • Bur, M.1    Rothen-Rutishauser, B.2    Huwer, H.3    Lehr, C.-M.4
  • 31
    • 78650715310 scopus 로고    scopus 로고
    • A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to Evaluate Pulmonary Drug Absorption for Metered Dose Dry Powder Formulations
    • Hein, S.; Bur, M.; Schaefer, U. F.; Lehr, C. M. A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to Evaluate Pulmonary Drug Absorption for Metered Dose Dry Powder Formulations. Eur. J. Pharm. Biopharm. 2011, 77 (1), 132-138.
    • (2011) Eur. J. Pharm. Biopharm. , vol.77 , Issue.1 , pp. 132-138
    • Hein, S.1    Bur, M.2    Schaefer, U.F.3    Lehr, C.M.4
  • 32
    • 0242584998 scopus 로고    scopus 로고
    • Large porous particle impingement on lung epithelial cell monolayers - Toward improved particle characterization in the lung
    • DOI 10.1023/A:1023441804464
    • Fiegel, J.; Ehrhardt, C.; Schaefer, U. F.; Lehr, C. M.; Hanes, J. Large Porous Particle Impingement on Lung Epithelial Cell Monolayers - Toward Improved Particle Characterization in the Lung. Pharm. Res. 2003, 20 (5), 788-796. (Pubitemid 36515312)
    • (2003) Pharmaceutical Research , vol.20 , Issue.5 , pp. 788-796
    • Fiegel, J.1    Ehrhardt, C.2    Schaefer, U.F.3    Lehr, C.-M.4    Hanes, J.5
  • 33
    • 14644421632 scopus 로고    scopus 로고
    • Development of a size-dependent aerosol deposition model utilising human airway epithelial cells for evaluating aerosol drug delivery
    • Cooney, D.; Kazantseva, M.; Hickey, A. J. Development of a Size-Dependent Aerosol Deposition Model Utilising Human Airway Epithelial Cells for Evaluating Aerosol Drug Delivery. Altern. Lab. Anim. 2004, 32 (6), 581-590. (Pubitemid 40321537)
    • (2004) ATLA Alternatives to Laboratory Animals , vol.32 , Issue.6 , pp. 581-590
    • Cooney, D.1    Kazantseva, M.2    Hickey, A.J.3
  • 35
    • 77953954921 scopus 로고    scopus 로고
    • Drug Transport Across Pulmonary Epithelial Cell Monolayers: Effects of Particle Size, Apical Liquid Volume, and Deposition Technique
    • Bur, M.; Huwer, H.; Muys, L.; Lehr, C. M. Drug Transport Across Pulmonary Epithelial Cell Monolayers: Effects of Particle Size, Apical Liquid Volume, and Deposition Technique. J. Aerosol Med. Pulm. Drug Delivery 2010, 23 (3), 119-127.
    • (2010) J. Aerosol Med. Pulm. Drug Delivery , vol.23 , Issue.3 , pp. 119-127
    • Bur, M.1    Huwer, H.2    Muys, L.3    Lehr, C.M.4
  • 36
    • 0012521621 scopus 로고
    • A Method for Viable Cell Count
    • Tolnai, S. A Method for Viable Cell Count. Methods Cell Sci. 1975, 1 (1), 37-38.
    • (1975) Methods Cell Sci. , vol.1 , Issue.1 , pp. 37-38
    • Tolnai, S.1
  • 39
    • 33847239180 scopus 로고    scopus 로고
    • Solid-State Characterization of Two Polymorphic Forms of R-Albuterol Sulfate
    • Palacio, M. A.; Cuffini, S.; Badini, R.; Karlsson, A.; Palacios, S. M. Solid-State Characterization of Two Polymorphic Forms of R-Albuterol Sulfate. J. Pharm. Biomed. 2007, 43 (4), 1531-1534.
    • (2007) J. Pharm. Biomed. , vol.43 , Issue.4 , pp. 1531-1534
    • Palacio, M.A.1    Cuffini, S.2    Badini, R.3    Karlsson, A.4    Palacios, S.M.5
  • 40
    • 0025258947 scopus 로고
    • Studies of Cyclodextrin Inclusion Complexes 0.1. The Salbutamol- Cyclodextrin Complex as Studied by Phase Solubility and DSC
    • Marques, H. M. C.; Hadgraft, J.; Kellaway, I. W. Studies of Cyclodextrin Inclusion Complexes 0.1. The Salbutamol-Cyclodextrin Complex as Studied by Phase Solubility and DSC. Int. J. Pharm. 1990, 63 (3), 259-266.
    • (1990) Int. J. Pharm. , vol.63 , Issue.3 , pp. 259-266
    • Marques, H.M.C.1    Hadgraft, J.2    Kellaway, I.W.3
  • 41
    • 84872607317 scopus 로고    scopus 로고
    • Part II, Official Standards, Solubility
    • Pharmacopoeia, B., Part II, Official Standards, Solubility. In British Pharmacopoeia Volume I & II; http://www.pharmacopoeia.co. uk: 2011.
    • (2011) British Pharmacopoeia , vol.1-2
    • Pharmacopoeia, B.1
  • 42
    • 0037436978 scopus 로고    scopus 로고
    • A novel method for assessing dissolution of aerosol inhaler products
    • DOI 10.1016/S0378-5173(03)00091-7
    • Davies, N. M.; Feddah, M. R. A Novel Method for Assessing Dissolution of Aerosol Inhaler Products. Int. J. Pharm. 2003, 255 (1-2), 175-187. (Pubitemid 36369601)
    • (2003) International Journal of Pharmaceutics , vol.255 , Issue.1-2 , pp. 175-187
    • Davies, N.M.1    Feddah, M.R.2
  • 43
    • 23844469187 scopus 로고    scopus 로고
    • Transport of Anti-Allergic Drugs Across the Passage Cultured Human Nasal Epithelial Cell Monolayer
    • Lin, H.; Yoo, J. W.; Roh, H. J.; Lee, M. K.; Chung, S. J.; Shim, C. K.; Kim, D. D. Transport of Anti-Allergic Drugs Across the Passage Cultured Human Nasal Epithelial Cell Monolayer. Eur. J. Pharm. Sci. 2005, 26 (2), 203-210.
    • (2005) Eur. J. Pharm. Sci. , vol.26 , Issue.2 , pp. 203-210
    • Lin, H.1    Yoo, J.W.2    Roh, H.J.3    Lee, M.K.4    Chung, S.J.5    Shim, C.K.6    Kim, D.D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.